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This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009] See more...
Aliases for DSN1 Gene
Aliases for DSN1 Gene
External Ids for DSN1 Gene
- HGNC: 16165
- Entrez Gene: 79980
- Ensembl: ENSG00000149636
- OMIM: 609175
- UniProtKB: Q9H410
Previous HGNC Symbols for DSN1 Gene
- C20orf172
Previous GeneCards Identifiers for DSN1 Gene
- GC20M034815
- GC20M035380
- GC20M032116
Summaries for DSN1 Gene
-
This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
GeneCards Summary for DSN1 Gene
DSN1 (DSN1 Component Of MIS12 Kinetochore Complex) is a Protein Coding gene. Diseases associated with DSN1 include Arts Syndrome. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.
UniProtKB/Swiss-Prot Summary for DSN1 Gene
-
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
Additional gene information for DSN1 Gene
- HGNC(16165)
- Entrez Gene(79980)
- Ensembl(ENSG00000149636)
- OMIM(609175)
- UniProtKB(Q9H410)
- Open Targets Platform(ENSG00000149636)
- Search for DSN1 at DataMed
- Search for DSN1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DSN1 Gene
Genomics for DSN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DSN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DSN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DSN1
- Top Transcription factor binding sites by QIAGEN in the DSN1 gene promoter:
-
- AREB6
- GR
- GR-alpha
- GR-beta
- HNF-3beta
Genomic Locations for DSN1 Gene
Genomic Locations for DSN1 Gene
- chr20:36,751,791-36,773,818
- (GRCh38/hg38)
- Size:
- 22,028 bases
- Orientation:
- Minus strand
- chr20:35,380,194-35,402,230
- (GRCh37/hg19)
- Size:
- 22,037 bases
- Orientation:
- Minus strand
Genomic View for DSN1 Gene
Genes around DSN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
DSN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DSN1 Gene
Proteins for DSN1 Gene
-
Protein details for DSN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H410-DSN1_HUMAN
- Recommended name:
- Kinetochore-associated protein DSN1 homolog
- Protein Accession:
- Q9H410
- B4DWT2
- E1P5U9
- Q5JW55
- Q5JW56
- Q9H8P4
Protein attributes for DSN1 Gene
- Size:
- 356 amino acids
- Molecular mass:
- 40067 Da
- Quaternary structure:
-
- Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3 and CBX5. Interacts with KNSTRN.
- SequenceCaution:
-
- Sequence=BAB14564.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for DSN1 Gene
Post-translational modifications for DSN1 Gene
Other Protein References for DSN1 Gene
Antibody Products
- HUABIO Anti-DSN1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for DSN1
- Novus Biologicals Antibodies for DSN1
-
Abcam antibodies for DSN1
- Invitrogen Antibodies for DSN1 (AFLGC-DSN1)
-
Biorbyt antibodies for DSN1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DSN1
- Origene Custom Protein Services for DSN1
- antibodies-online: Show 7 available DSN1 Proteins ranked by validation data
- Compare Top DSN1 Proteins
-
Quality Products:
-
Signalway Proteins for DSN1
-
Abcam proteins for DSN1
Assay Products
- antibodies-online: Show 4 available DSN1 Elisa Kits ranked by validation data
- Compare Top DSN1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for DSN1 Gene
Domains & Families for DSN1 Gene
Gene Families for DSN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DSN1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DSN1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ59091 (B4DWT2_HUMAN)
- Kinetochore-associated protein DSN1 homolog (DSN1_HUMAN)
- DSN1 protein (Q4G1A1_HUMAN)
- cDNA FLJ59094 (Q5JW55_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DSN1 Gene
Function for DSN1 Gene
Molecular function for DSN1 Gene
- UniProtKB/Swiss-Prot Function:
- Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
Phenotypes From GWAS Catalog for DSN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15502821 |
Phenotypes for DSN1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DSN1 - Select products 50% OFF >
- * DSN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DSN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DSN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DSN1
miRNA for DSN1 Gene
- miRTarBase miRNAs that target DSN1
-
- hsa-miR-193b-3p (MIRT016359)
- hsa-miR-215-5p (MIRT024556)
- hsa-miR-192-5p (MIRT026495)
- hsa-miR-19a-3p (MIRT295902)
- hsa-miR-19b-3p (MIRT295903)
- hsa-miR-4698 (MIRT295913)
- hsa-miR-6807-5p (MIRT537938)
- hsa-miR-3157-5p (MIRT537939)
- hsa-miR-7151-3p (MIRT537940)
- hsa-miR-5095 (MIRT537941)
- hsa-miR-1287-5p (MIRT537942)
- hsa-miR-3135b (MIRT537943)
- hsa-miR-6778-3p (MIRT537944)
- hsa-miR-6839-5p (MIRT537945)
- hsa-miR-378j (MIRT537946)
- hsa-miR-150-5p (MIRT537947)
- hsa-miR-186-3p (MIRT537948)
- hsa-miR-3934-5p (MIRT537949)
- hsa-miR-6504-3p (MIRT537950)
- hsa-miR-552-3p (MIRT537951)
- hsa-miR-374b-5p (MIRT550223)
- hsa-miR-374a-5p (MIRT550224)
- hsa-miR-340-5p (MIRT550225)
- hsa-miR-655-3p (MIRT550226)
- hsa-miR-374c-5p (MIRT550227)
- hsa-miR-455-5p (MIRT550228)
- hsa-miR-5692c (MIRT550229)
- hsa-miR-5692b (MIRT550230)
- hsa-miR-369-3p (MIRT550231)
- hsa-miR-208b-5p (MIRT550232)
- hsa-miR-5683 (MIRT550233)
- hsa-miR-208a-5p (MIRT550234)
- hsa-miR-590-3p (MIRT550235)
- hsa-miR-944 (MIRT550236)
- hsa-miR-7-2-3p (MIRT550237)
- hsa-miR-7-1-3p (MIRT550238)
- hsa-miR-7977 (MIRT633457)
- hsa-miR-1295a (MIRT633458)
- hsa-miR-5704 (MIRT633459)
- hsa-miR-24-3p (MIRT633460)
- hsa-miR-4284 (MIRT633461)
- hsa-miR-564 (MIRT633462)
- hsa-miR-4755-3p (MIRT633463)
- hsa-miR-4670-3p (MIRT633464)
- hsa-miR-4673 (MIRT633465)
- hsa-miR-4645-5p (MIRT633466)
- hsa-miR-6715b-5p (MIRT633467)
- hsa-miR-4269 (MIRT633468)
- hsa-miR-15a-3p (MIRT633469)
- hsa-miR-4717-5p (MIRT633470)
- hsa-miR-3622a-5p (MIRT633471)
- hsa-miR-4763-5p (MIRT658876)
- hsa-miR-642a-5p (MIRT658877)
- hsa-miR-4290 (MIRT658878)
- hsa-miR-2276-5p (MIRT658879)
- hsa-miR-6892-3p (MIRT658880)
- hsa-miR-4687-5p (MIRT658881)
- hsa-miR-6513-5p (MIRT661963)
- hsa-miR-887-5p (MIRT661964)
- hsa-miR-6741-5p (MIRT661965)
- hsa-miR-6736-5p (MIRT661966)
- hsa-miR-4701-3p (MIRT661967)
- hsa-miR-1262 (MIRT661968)
- hsa-miR-6788-5p (MIRT661969)
- hsa-miR-30c-2-3p (MIRT661970)
- hsa-miR-30c-1-3p (MIRT661971)
- hsa-miR-4483 (MIRT661972)
- hsa-miR-1293 (MIRT661973)
- hsa-miR-6766-5p (MIRT661974)
- hsa-miR-6756-5p (MIRT661975)
- hsa-miR-6745 (MIRT661976)
- hsa-miR-363-5p (MIRT661977)
- hsa-miR-6799-5p (MIRT661978)
- hsa-miR-6883-5p (MIRT661979)
- hsa-miR-6785-5p (MIRT661980)
- hsa-miR-4728-5p (MIRT661981)
- hsa-miR-149-3p (MIRT661982)
- hsa-miR-7106-5p (MIRT661983)
- hsa-miR-3975 (MIRT661984)
- hsa-miR-4259 (MIRT661985)
- hsa-miR-382-5p (MIRT661986)
- hsa-miR-495-5p (MIRT661987)
- hsa-miR-498 (MIRT676475)
- hsa-miR-4279 (MIRT676476)
- hsa-miR-1976 (MIRT676477)
- hsa-miR-6862-3p (MIRT676478)
- hsa-miR-6784-3p (MIRT676479)
- hsa-miR-1281 (MIRT676480)
- hsa-miR-6747-3p (MIRT676481)
- hsa-miR-6727-3p (MIRT676482)
- hsa-miR-4722-3p (MIRT676483)
- hsa-miR-3927-5p (MIRT676484)
- hsa-miR-4485-5p (MIRT676485)
- hsa-miR-4667-3p (MIRT676486)
- hsa-miR-4532 (MIRT676487)
- hsa-miR-1247-3p (MIRT676488)
- hsa-miR-3620-3p (MIRT676489)
- hsa-miR-6865-3p (MIRT676490)
- hsa-miR-5571-5p (MIRT676491)
- hsa-miR-3653-5p (MIRT679766)
- hsa-miR-3913-5p (MIRT690831)
- hsa-miR-3122 (MIRT690832)
- hsa-miR-450a-1-3p (MIRT690833)
- hsa-miR-6780a-5p (MIRT690834)
- hsa-miR-6779-5p (MIRT690835)
- hsa-miR-3689c (MIRT690836)
- hsa-miR-3689b-3p (MIRT690837)
- hsa-miR-3689a-3p (MIRT690838)
- hsa-miR-30b-3p (MIRT690839)
- hsa-miR-1273h-5p (MIRT690840)
- hsa-miR-383-3p (MIRT690841)
- hsa-miR-1827 (MIRT763038)
- hsa-miR-183-5p (MIRT763162)
- hsa-miR-1910-3p (MIRT763280)
- hsa-miR-2467-3p (MIRT764079)
- hsa-miR-3612 (MIRT765901)
- hsa-miR-3650 (MIRT766251)
- hsa-miR-377-5p (MIRT767383)
- hsa-miR-4257 (MIRT768119)
- hsa-miR-4327 (MIRT768666)
- hsa-miR-4497 (MIRT769743)
- hsa-miR-4537 (MIRT770142)
- hsa-miR-455-3p (MIRT770303)
- hsa-miR-4722-5p (MIRT771542)
- hsa-miR-4768-3p (MIRT772073)
- hsa-miR-4790-3p (MIRT772347)
- hsa-miR-5186 (MIRT773486)
- hsa-miR-5197-5p (MIRT773660)
- hsa-miR-5690 (MIRT774989)
- hsa-miR-605-5p (MIRT775424)
- hsa-miR-6086 (MIRT775514)
- hsa-miR-6499-3p (MIRT776238)
- hsa-miR-650 (MIRT776659)
- hsa-miR-6511a-5p (MIRT776778)
- hsa-miR-6516-5p (MIRT777100)
- hsa-miR-6746-5p (MIRT778217)
- hsa-miR-6771-5p (MIRT778674)
- hsa-miR-6808-5p (MIRT779658)
- hsa-miR-6893-5p (MIRT781191)
- hsa-miR-940 (MIRT782885)
- hsa-miR-3119 (MIRT784563)
- hsa-miR-4775 (MIRT786719)
- hsa-miR-8055 (MIRT789668)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DSN1
- Browse OriGene Inhibitory RNA Products For DSN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSN1
Clone Products
- Applied Biological Materials (abm): Clones for DSN1 - Select products 50% OFF >
- * DSN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205256
- MR205256
- MR205256L3
- MR205256L4
- RC216609
- RC216609L3
- RC216609L4
- RC226604
- RC226604L3
- RC226604L4
- RC226614
- RC226614L1
- RC226614L2
- RC226614L3
- RC226614L4
- RC226634
- RC226634L3
- RC226634L4
- RC226656
- RC226656L3
- RC226656L4
- RG216609
- RG226604
- RG226614
- RG226634
- RG226656
- RR201036
- RR201036L3
- RR201036L4
- MR205256L3V
- MR205256L4V
- RC216609L3V
- RC216609L4V
- RC226604L3V
- RC226604L4V
- RC226614L1V
- RC226614L2V
- RC226614L3V
- RC226614L4V
- RC226634L3V
- RC226634L4V
- RC226656L3V
- RC226656L4V
- RR201036L3V
- RR201036L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DSN1
- Addgene plasmids for DSN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DSN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DSN1 Gene
Localization for DSN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DSN1 Gene
- Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. {ECO:0000269 PubMed:15502821, ECO:0000269 PubMed:16585270}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytoskeleton | 4 |
| cytosol | 4 |
| lysosome | 4 |
| mitochondrion | 0 |
| peroxisome | 0 |
- Nucleoplasm (4)
- Nuclear bodies (3)
- Cytosol (2)
- Nucleoli fibrillar center (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000444 | MIS12/MIND type complex | IDA | 16585270 |
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000777 | condensed chromosome kinetochore | IDA | 15371340 |
| GO:0000818 | nuclear MIS12/MIND complex | IBA | 21873635 |
Pathways & Interactions for DSN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
| 4 | Mitotic Prometaphase | ||
| 5 | Signaling by Rho GTPases | ||
Pathways by source for DSN1 Gene
15 Reactome pathways for DSN1 Gene
Interacting Proteins for DSN1 Gene
Selected Interacting proteins:
Q9H410-DSN1_HUMAN
ENSP00000389810
for DSN1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DSN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000070 | mitotic sister chromatid segregation | IBA | 21873635 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007059 | chromosome segregation | IEA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0051301 | cell division | IEA | -- |
Transcripts for DSN1 Gene
mRNA/cDNA for DSN1 Gene
- 5 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000373740 1922 nts (view in UCSC)
- ENST00000448110 2129 nts (view in UCSC)
- ENST00000473615 2075 nts (view in UCSC)
- ENST00000480153 2447 nts (view in UCSC)
- ENST00000373750 2233 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DSN1 - Select products 50% OFF >
- * DSN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DSN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DSN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DSN1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DSN1
- Browse OriGene Inhibitory RNA Products For DSN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSN1
Clone Products
- Applied Biological Materials (abm): Clones for DSN1 - Select products 50% OFF >
- * DSN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205256
- MR205256
- MR205256L3
- MR205256L4
- RC216609
- RC216609L3
- RC216609L4
- RC226604
- RC226604L3
- RC226604L4
- RC226614
- RC226614L1
- RC226614L2
- RC226614L3
- RC226614L4
- RC226634
- RC226634L3
- RC226634L4
- RC226656
- RC226656L3
- RC226656L4
- RG216609
- RG226604
- RG226614
- RG226634
- RG226656
- RR201036
- RR201036L3
- RR201036L4
- MR205256L3V
- MR205256L4V
- RC216609L3V
- RC216609L4V
- RC226604L3V
- RC226604L4V
- RC226614L1V
- RC226614L2V
- RC226614L3V
- RC226614L4V
- RC226634L3V
- RC226634L4V
- RC226656L3V
- RC226656L4V
- RR201036L3V
- RR201036L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DSN1
- Addgene plasmids for DSN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DSN1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - |
Relevant External Links for DSN1 Gene
- GeneLoc Exon Structure for
- DSN1
Expression for DSN1 Gene
This gene is overexpressed in Breast (18.3), Peripheral blood mononuclear cells (15.0), and Retina (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DSN1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DSN1
SOURCE GeneReport for Unigene cluster for DSN1 Gene:
Hs.632268Evidence on tissue expression from TISSUES for DSN1 Gene
- Skin(4.5)
Primer Products
-
OriGene qPCR primer pairs for DSN1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DSN1 Gene
Orthologs for DSN1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DSN1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DSN1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DSN1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dsn1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dsn1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DSN1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DSN1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DSN1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487901 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100002916 30 |
|
||
| DSN1 31 |
|
OneToOne |
- Species where no ortholog for DSN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DSN1 Gene
- ENSEMBL:
- Gene Tree for DSN1 (if available)
- TreeFam:
- Gene Tree for DSN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DSN1: view image
Paralogs for DSN1 Gene
Pseudogenes.org Pseudogenes for DSN1 Gene
No data available for Paralogs for DSN1 Gene
Variants for DSN1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1057192 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.89;
35.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DSN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DSN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DSN1 Gene
Disorders for DSN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| arts syndrome |
|
|
Search DSN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DSN1
No data available for UniProtKB/Swiss-Prot and Genatlas for DSN1 Gene
Publications for DSN1 Gene
- The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PMID: 16585270) Kline SL … Desai A (The Journal of cell biology 2006) 2 3 4
- The MIS12 complex is a protein interaction hub for outer kinetochore assembly. (PMID: 20819937) Petrovic A … Musacchio A (The Journal of cell biology 2010) 2 3
- Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. (PMID: 17981135) Kiyomitsu T … Yanagida M (Developmental cell 2007) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for DSN1 Gene
- Custom Antibody ServicesOriGene Antibodies for DSN1
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DSN1
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for DSN1
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for DSN1 (AFLGC-DSN1)
- VectorBuilder Custom and pre-made DNA vectors for DSN1 (ie. gene expression, shRNA knockdown, CRISPR)
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- Addgene plasmids for DSN1
- antibodies-online: Show 14 available DSN1 Antibodies ranked by validation data
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- antibodies-online: Show 7 available DSN1 Proteins ranked by validation data
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- Quality Products:
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DSN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DSN1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DSN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSN1
- Biorbyt antibodies for DSN1
- Signalway Proteins for DSN1
Sources for DSN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB