Aliases for DSG3 Gene
External Ids for DSG3 Gene
Previous GeneCards Identifiers for DSG3 Gene
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]
GeneCards Summary for DSG3 Gene
DSG3 (Desmoglein 3) is a Protein Coding gene. Diseases associated with DSG3 include Blistering, Acantholytic, Of Oral And Laryngeal Mucosa and Pemphigus. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptotic cleavage of cellular proteins. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DSG4.
UniProtKB/Swiss-Prot Summary for DSG3 Gene
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.