Aliases for DSCR10 Gene

Subcategory (RNA class) for DSCR10 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for DSCR10 Gene

  • Down Syndrome Critical Region 10 2 3 5
  • DSCR10 2 5 165
  • Down Syndrome Critical Region 10 (Non-Protein Coding) 2 3
  • Down Syndrome Critical Region Gene 10 (Non-Protein Coding) 3
  • Down Syndrome Critical Region Protein 10 4
  • NONHSAG032834.2 91
  • HSALNG0133048 164

External Ids for DSCR10 Gene

Previous GeneCards Identifiers for DSCR10 Gene

  • GC21U990114
  • GC21P036238
  • GC21P038498
  • GC21P038500
  • GC21P039578
  • GC21P025047

Summaries for DSCR10 Gene

GeneCards Summary for DSCR10 Gene

DSCR10 (Down Syndrome Critical Region 10) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DSCR10 include Down Syndrome.

Additional gene information for DSCR10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DSCR10 Gene

Genomics for DSCR10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DSCR10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J038205 Enhancer 0.3 Ensembl 600.7 +0.2 245 0.8 ZIC2 DSCR10 ENSG00000270835 LOC100288590 KCNJ15 HSALNG0133049 ERG
GH21J038212 Enhancer 0.3 Ensembl 0.4 +6.6 6646 0.8 HLF KCNJ15 HSALNG0133049 DSCR10 ERG
GH21J038208 Enhancer 0.2 Ensembl 0.7 +3.4 3445 3.2 KCNJ15 DSCR10 HSALNG0133049 ERG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DSCR10 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the DSCR10 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • POU6F1 (c2)
  • RORalpha1

Genomic Locations for DSCR10 Gene

Genomic Locations for DSCR10 Gene
chr21:38,206,155-38,208,644
(GRCh38/hg38)
Size:
2,490 bases
Orientation:
Plus strand
chr21:39,578,250-39,580,738
(GRCh37/hg19)
Size:
2,489 bases
Orientation:
Plus strand

Genomic View for DSCR10 Gene

Genes around DSCR10 on UCSC Golden Path with GeneCards custom track
DSCR10 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
DSCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSCR10 Gene

Proteins for DSCR10 Gene

  • Protein details for DSCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59022-DSC10_HUMAN
    Recommended name:
    Down syndrome critical region protein 10
    Protein Accession:
    P59022
    Secondary Accessions:
    • Q52LN2

    Protein attributes for DSCR10 Gene

    Size:
    87 amino acids
    Molecular mass:
    9286 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DSCR10 Gene

Post-translational modifications for DSCR10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DSCR10 Gene

Domains & Families for DSCR10 Gene

Gene Families for DSCR10 Gene

Protein Domains for DSCR10 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DSCR10 Gene

GenScript: Design optimal peptide antigens:
  • Down syndrome critical region protein 10 (DSC10_HUMAN)
genes like me logo Genes that share domains with DSCR10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DSCR10 Gene

Function for DSCR10 Gene

Gene Ontology (GO) - Molecular Function for DSCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DSCR10: view
genes like me logo Genes that share phenotypes with DSCR10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSCR10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DSCR10 Gene

Localization for DSCR10 Gene

Gene Ontology (GO) - Cellular Components for DSCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DSCR10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DSCR10 Gene

Pathways & Interactions for DSCR10 Gene

PathCards logo

SuperPathways for DSCR10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DSCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DSCR10: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for DSCR10 Gene

Drugs & Compounds for DSCR10 Gene

No Compound Related Data Available

Transcripts for DSCR10 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for DSCR10 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000018E2F9_9606 lncRNA 860 6

HGNC: 16302,

RefSeq: NR_027695,

Ensembl: ENST00000432141 (view in UCSC) ,

LncBook: HSALNT0273467,

LNCipedia: DSCR10:1,

NONCODE: NONHSAT082079.2,

URS0000EB4183_9606 lncRNA 863 1

LncBook: HSALNT0289477,

URS00008B2587_9606 lncRNA 326 1

LNCipedia: DSCR10:2,

DSCR10 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for DSCR10 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSCR10

Alternative Splicing Database (ASD) splice patterns (SP) for DSCR10 Gene

No ASD Table

Relevant External Links for DSCR10 Gene

GeneLoc Exon Structure for
DSCR10

Expression for DSCR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DSCR10 Gene

mRNA differential expression in normal tissues according to GTEx for DSCR10 Gene

This gene is overexpressed in Testis (x51.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DSCR10

SOURCE GeneReport for Unigene cluster for DSCR10 Gene:

Hs.147695

mRNA Expression by UniProt/SwissProt for DSCR10 Gene:

P59022-DSC10_HUMAN
Tissue specificity: Expressed in placenta and testis.
genes like me logo Genes that share expression patterns with DSCR10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DSCR10 Gene

Orthologs for DSCR10 Gene

Evolution for DSCR10 Gene

ENSEMBL:
Gene Tree for DSCR10 (if available)
TreeFam:
Gene Tree for DSCR10 (if available)

No data available for Orthologs for DSCR10 Gene

Paralogs for DSCR10 Gene

No data available for Paralogs for DSCR10 Gene

Variants for DSCR10 Gene

Additional dbSNP identifiers (rs#s) for DSCR10 Gene

Structural Variations from Database of Genomic Variants (DGV) for DSCR10 Gene

Variant ID Type Subtype PubMed ID
nsv1058886 CNV gain 25217958
nsv1072602 CNV deletion 25765185
nsv1122042 CNV deletion 24896259

Additional Variant Information for DSCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DSCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for DSCR10 Gene

Disorders for DSCR10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DSCR10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • trisomy 21
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DSCR10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DSCR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DSCR10 Gene

Publications for DSCR10 Gene

  1. Identification of two novel primate-specific genes in DSCR. (PMID: 12168953) Takamatsu K … Takeda T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 2 3 4
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for DSCR10 Gene

Sources for DSCR10 Gene