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DSCR10 Gene(RNA Gene)

Down Syndrome Critical Region 10

GCID:
GC21P038206
GIFtS:
26
Genes Participants
UDN Logo

Aliases for DSCR10 Gene

Subcategory (RNA class) for DSCR10 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for DSCR10 Gene

  • Down Syndrome Critical Region 10 2 3
  • Down Syndrome Critical Region 10 (Non-Protein Coding) 2 3 5
  • Down Syndrome Critical Region Gene 10 (Non-Protein Coding) 3

External Ids for DSCR10 Gene

Previous GeneCards Identifiers for DSCR10 Gene

  • GC21U990114
  • GC21P036238
  • GC21P038498
  • GC21P038500
  • GC21P039578
  • GC21P025047

Summaries for DSCR10 Gene

GeneCards Summary for DSCR10 Gene

DSCR10 (Down Syndrome Critical Region 10) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with DSCR10 include Down Syndrome.

Additional gene information for DSCR10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DSCR10 Gene

Genomics for DSCR10 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for DSCR10 Gene

Promoters and enhancers for DSCR10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH21J038983 Enhancer 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14.6 +783.3 783269 11.3 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A YBX1 FEZF1 ZNF2 HMGN1 RNF6P1 MYL6P2 DSCR10 LOC100288590 DSCR4 DSCR4-IT1 DSCR8 ETS2 ENSG00000235888
GH21J039181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 +977.3 977270 3.3 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PSMG1 ENSG00000272991 HMGN1 RNF6P1 MYL6P2 DSCR10 LOC100288590 WRB BRWD1 SH3BGR
GH21J038906 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +705.3 705274 9.7 HDGF PKNOX1 CLOCK FOXA2 MLX NEUROD1 SIN3A YBX1 ZBTB7B YY1 HMGN1 LCA5L RNF6P1 DSCR10 LOC100288590 DSCR4 MYL6P2 DSCR4-IT1 PSMG1 DSCR8
GH21J038733 Enhancer 1.3 Ensembl ENCODE dbSUPER 14.6 +529.1 529115 3.5 ARID4B SIN3A ZNF2 IRF4 YY1 ARID2 ZNF143 RXRA MXD4 REST RNF6P1 DSCR4 LOC100288590 DSCR10 MYL6P2 DSCR4-IT1 ERG RPSAP64 DSCR8 KCNJ6
GH21J038219 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +14.0 14030 2.4 ARNT RAD21 CHAMP1 ZNF280A TCF12 CBX5 ZNF350 ZNF143 ATF7 IKZF2 ENSG00000242553 KCNJ15 DSCR10 GC21M038236
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DSCR10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DSCR10 gene promoter:
  • RORalpha1
  • POU6F1 (c2)
  • c-Jun
  • c-Fos
  • AP-1
  • C/EBPalpha
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1

Genomic Locations for DSCR10 Gene

Genomic Locations for DSCR10 Gene
chr21:38,206,156-38,208,644
(GRCh38/hg38)
Size:
2,489 bases
Orientation:
Plus strand
chr21:39,578,250-39,580,738
(GRCh37/hg19)
Size:
2,489 bases
Orientation:
Plus strand

Genomic View for DSCR10 Gene

Genes around DSCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DSCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSCR10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DSCR10 Gene

Proteins for DSCR10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DSCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59022-DSC10_HUMAN
    Recommended name:
    Down syndrome critical region protein 10
    Protein Accession:
    P59022
    Secondary Accessions:
    • Q52LN2

    Protein attributes for DSCR10 Gene

    Size:
    87 amino acids
    Molecular mass:
    9286 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DSCR10 Gene

Post-translational modifications for DSCR10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DSCR10 Gene

Domains & Families for DSCR10 Gene

Protein Domains for DSCR10 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DSCR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DSCR10: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DSCR10 Gene

Function for DSCR10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for DSCR10 Gene

Gene Ontology (GO) - Molecular Function for DSCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DSCR10: view
genes like me logo Genes that share phenotypes with DSCR10: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DSCR10 Gene

Localization for DSCR10 Gene

Gene Ontology (GO) - Cellular Components for DSCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DSCR10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DSCR10 Gene

Pathways & Interactions for DSCR10 Gene

SuperPathways for DSCR10 Gene

PathCards logo More details on SuperPathways for DSCR10
No Data Available

Interacting Proteins for DSCR10 Gene

Selected Interacting proteins: P59022-DSC10_HUMAN for DSCR10 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for DSCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DSCR10: view

No data available for Pathways by source and SIGNOR curated interactions for DSCR10 Gene

Drugs & Compounds for DSCR10 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DSCR10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DSCR10 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(1) RNA Central transcripts :

Unigene Clusters for DSCR10 Gene

Down syndrome critical region gene 10 (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DSCR10 Gene

No ASD Table

Relevant External Links for DSCR10 Gene

GeneLoc Exon Structure for
DSCR10
ECgene alternative splicing isoforms for
DSCR10

Expression for DSCR10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DSCR10 Gene

mRNA expression in normal human tissues for DSCR10 Gene
mRNA expression by GTEx for DSCR10 Gene

mRNA differential expression in normal tissues according to GTEx for DSCR10 Gene

This gene is overexpressed in Testis (x51.6).

NURSA nuclear receptor signaling pathways regulating expression of DSCR10 Gene:

DSCR10

SOURCE GeneReport for Unigene cluster for DSCR10 Gene:

Hs.147695

mRNA Expression by UniProt/SwissProt for DSCR10 Gene:

P59022-DSC10_HUMAN
Tissue specificity: Expressed in placenta and testis.
genes like me logo Genes that share expression patterns with DSCR10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DSCR10 Gene

Orthologs for DSCR10 Gene

Evolution for DSCR10 Gene

ENSEMBL:
Gene Tree for DSCR10 (if available)
TreeFam:
Gene Tree for DSCR10 (if available)

No data available for Orthologs for DSCR10 Gene

Paralogs for DSCR10 Gene

No data available for Paralogs for DSCR10 Gene

Variants for DSCR10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for DSCR10 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000436063 -- 38,205,762(+) A/G upstream_transcript_variant
rs1000891752 -- 38,205,432(+) G/T upstream_transcript_variant
rs1001280491 -- 38,205,689(+) C/T upstream_transcript_variant
rs1001513706 -- 38,204,845(+) C/G/T upstream_transcript_variant
rs1001948560 -- 38,205,874(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DSCR10 Gene

Variant ID Type Subtype PubMed ID
nsv1058886 CNV gain 25217958
nsv1072602 CNV deletion 25765185
nsv1122042 CNV deletion 24896259

Additional Variant Information for DSCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DSCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DSCR10 Gene

Disorders for DSCR10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DSCR10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • trisomy 21
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DSCR10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DSCR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DSCR10 Gene

Publications for DSCR10 Gene

  1. Identification of two novel primate-specific genes in DSCR. (PMID: 12168953) Takamatsu K … Takeda T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 2 3 4 58
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for DSCR10 Gene

Sources for DSCR10 Gene

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