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Aliases for DSCR10 Gene
Subcategory (RNA class) for DSCR10 Gene
lncRNA
Number of RNA Genes sources:
3 / 17
Aliases for DSCR10 Gene
External Ids for DSCR10 Gene
- HGNC: 16302
- Entrez Gene: 259234
- Ensembl: ENSG00000233316
- UniProtKB: P59022
Previous GeneCards Identifiers for DSCR10 Gene
- GC21U990114
- GC21P036238
- GC21P038498
- GC21P038500
- GC21P039578
- GC21P025047
Summaries for DSCR10 Gene
GeneCards Summary for DSCR10 Gene
DSCR10 (Down Syndrome Critical Region 10) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DSCR10 include Down Syndrome.
Additional gene information for DSCR10 Gene
- HGNC(16302)
- Entrez Gene(259234)
- Ensembl(ENSG00000233316)
- UniProtKB(P59022)
- Open Targets Platform(ENSG00000233316)
- Search for DSCR10 at DataMed
- Search for DSCR10 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DSCR10 Gene
Genomics for DSCR10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DSCR10 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21J038205 | Enhancer | 0.3 | Ensembl | 600.7 | +0.2 | 245 | 0.8 | ZIC2 | DSCR10 ENSG00000270835 LOC100288590 KCNJ15 HSALNG0133049 ERG | |
| GH21J038212 | Enhancer | 0.3 | Ensembl | 0.4 | +6.6 | 6646 | 0.8 | HLF | KCNJ15 HSALNG0133049 DSCR10 ERG | |
| GH21J038208 | Enhancer | 0.2 | Ensembl | 0.7 | +3.4 | 3445 | 3.2 | KCNJ15 DSCR10 HSALNG0133049 ERG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DSCR10 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the DSCR10 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- C/EBPalpha
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- POU6F1 (c2)
- RORalpha1
Genomic Locations for DSCR10 Gene
Genomic Locations for DSCR10 Gene
- chr21:38,206,155-38,208,644
- (GRCh38/hg38)
- Size:
- 2,490 bases
- Orientation:
- Plus strand
- chr21:39,578,250-39,580,738
- (GRCh37/hg19)
- Size:
- 2,489 bases
- Orientation:
- Plus strand
Genomic View for DSCR10 Gene
Genes around DSCR10 on UCSC Golden Path with GeneCards custom track
DSCR10 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 21q22.13 by HGNC
- 21q22.13 by Entrez Gene
- 21q22.13 by Ensembl
DSCR10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DSCR10 Gene
Proteins for DSCR10 Gene
-
Protein details for DSCR10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59022-DSC10_HUMAN
- Recommended name:
- Down syndrome critical region protein 10
- Protein Accession:
- P59022
- Q52LN2
Protein attributes for DSCR10 Gene
- Size:
- 87 amino acids
- Molecular mass:
- 9286 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for DSCR10 Gene
No Post-translational modifications
Antibody Products
Protein Products
-
OriGene Purified Proteins for DSCR10
- Search Origene for MassSpec and Protein Over-expression Lysates for DSCR10
- Origene Custom Protein Services for DSCR10
- Novus Biologicals lysates for DSCR10
No data available for DME Specific Peptides for DSCR10 Gene
Domains & Families for DSCR10 Gene
Gene Families for DSCR10 Gene
Protein Domains for DSCR10 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for DSCR10 Gene
- GenScript: Design optimal peptide antigens:
-
- Down syndrome critical region protein 10 (DSC10_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DSCR10 Gene
Function for DSCR10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for DSCR10 Gene
- GenomeRNAi human phenotypes for DSCR10:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DSCR10 - Select products 50% OFF >
- * DSCR10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DSCR10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DSCR10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DSCR10
- Browse OriGene Inhibitory RNA Products For DSCR10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSCR10
Clone Products
- Applied Biological Materials (abm): Clones for DSCR10 - Select products 50% OFF >
- * DSCR10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DSCR10
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DSCR10 Gene
Localization for DSCR10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DSCR10 Gene
Pathways & Interactions for DSCR10 Gene
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for DSCR10 Gene
Transcripts for DSCR10 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for DSCR10 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000018E2F9_9606 | lncRNA | 860 | 6 |
HGNC: 16302, RefSeq: NR_027695, Ensembl: ENST00000432141 (view in UCSC) , LncBook: HSALNT0273467, LNCipedia: DSCR10:1, NONCODE: NONHSAT082079.2, |
| URS0000EB4183_9606 | lncRNA | 863 | 1 |
LncBook: HSALNT0289477, |
| URS00008B2587_9606 | lncRNA | 326 | 1 |
LNCipedia: DSCR10:2, |
DSCR10 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for DSCR10 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DSCR10 - Select products 50% OFF >
- * DSCR10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DSCR10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DSCR10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DSCR10
- Browse OriGene Inhibitory RNA Products For DSCR10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSCR10
Clone Products
- Applied Biological Materials (abm): Clones for DSCR10 - Select products 50% OFF >
- * DSCR10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DSCR10
Relevant External Links for DSCR10 Gene
- GeneLoc Exon Structure for
- DSCR10
Expression for DSCR10 Gene
mRNA differential expression in normal tissues according to GTEx for DSCR10 Gene
This gene is overexpressed in Testis (x51.6).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DSCR10
SOURCE GeneReport for Unigene cluster for DSCR10 Gene:
Hs.147695mRNA Expression by UniProt/SwissProt for DSCR10 Gene:
P59022-DSC10_HUMAN
Tissue specificity:
Expressed in placenta and testis.
Primer Products
-
OriGene qPCR primer pairs for DSCR10
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DSCR10 Gene
Orthologs for DSCR10 Gene
No data available for Orthologs for DSCR10 Gene
Paralogs for DSCR10 Gene
No data available for Paralogs for DSCR10 Gene
Variants for DSCR10 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1058886 | CNV | gain | 25217958 |
| nsv1072602 | CNV | deletion | 25765185 |
| nsv1122042 | CNV | deletion | 24896259 |
Additional Variant Information for DSCR10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DSCR10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for DSCR10 Gene
Disorders for DSCR10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| down syndrome |
|
|
Search DSCR10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DSCR10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DSCR10 Gene
Publications for DSCR10 Gene
- Identification of two novel primate-specific genes in DSCR. (PMID: 12168953) Takamatsu K … Takeda T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 2 3 4
- Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
ExternalLinks
Products for DSCR10 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DSCR10
- Search Origene for MassSpec and Protein Over-expression Lysates for DSCR10
- Origene Custom Protein Services for DSCR10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DSCR10
- Browse OriGene Inhibitory RNA Products For DSCR10
- OriGene qPCR primer pairs for DSCR10
- OriGene CRISPR knockouts for DSCR10
- OriGene ORF clones in human for DSCR10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DSCR10
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals lysates for DSCR10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder Custom and pre-made DNA vectors for DSCR10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DSCR10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DSCR10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DSCR10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DSCR10
- antibodies-online: Search results for available DSCR10 related products ranked by validation data
- antibodies-online: Search results for available DSCR10 related products ranked by validation data
- antibodies-online: Search results for available DSCR10 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DSCR10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DSCR10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DSCR10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DSCR10
Sources for DSCR10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB