Aliases for DSCAS Gene

Data sources for DSCAS Gene:

Subcategory (RNA class) for DSCAS Gene

lncRNA

Aliases for DSCAS Gene

External Ids for DSCAS Gene

Summaries for DSCAS Gene

GeneCards Summary for DSCAS Gene

DSCAS (DSC1/DSC2 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DSCAS include Arrhythmogenic Right Ventricular Dysplasia, Familial, 11.

Additional gene information for DSCAS Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DSCAS Gene

Genomics for DSCAS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DSCAS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J031097 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -0.6 -633 5.9 TBP MXD4 FEZF1 MNT IKZF1 SMAD5 HES1 MBD2 CTCF BHLHE40 DSC2 DSCAS HSALNG0120717 ENSG00000263924 piR-38351-228 DSC3
GH18J031103 Enhancer 0.7 ENCODE 0.7 +2.4 2439 0.2 ZEB1 JUND ZNF316 PRDM6 NFE2 ZNF24 ZNF362 MAFG ATF2 ZBTB21 DSC2 HSALNG0120717 DSCAS ENSG00000263698 DSC1
GH18J031104 Enhancer 0.4 Ensembl 0.7 +3.3 3347 0.6 SPI1 POLR2A KLF4 DSC3 DSC2 DSCAS ENSG00000263698 DSC1
GH18J031156 Enhancer 0.7 Ensembl ENCODE 0.2 +56.1 56107 1.4 ZNF217 REST CTBP1 PRDM6 SMARCE1 DPF2 PKNOX1 ZHX2 ZNF24 EP300 DSC1 DSC2 HSALNG0120719 ENSG00000263698 DSCAS
GH18J031095 Enhancer 0.3 Ensembl 0.4 -6.1 -6053 0.2 ZNF239 piR-38351-228 DSC2 DSCAS HSALNG0120717 DSC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DSCAS on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for DSCAS Gene

Latest Assembly
chr18:31,101,354-31,175,412
(GRCh38/hg38)
Size:
74,059 bases
Orientation:
Plus strand

Previous Assembly
chr18:28,681,551-28,742,752
(GRCh37/hg19 by Entrez Gene)
Size:
61,202 bases
Orientation:
Plus strand

chr18:28,681,551-28,742,752
(GRCh37/hg19 by Ensembl)
Size:
61,202 bases
Orientation:
Plus strand

Genomic View for DSCAS Gene

Genes around DSCAS on UCSC Golden Path with GeneCards custom track
DSCAS in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
DSCAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DSCAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DSCAS Gene

Proteins for DSCAS Gene

Post-translational modifications for DSCAS Gene

No Post-translational modifications

No data available for DME Specific Peptides for DSCAS Gene

Domains & Families for DSCAS Gene

Gene Families for DSCAS Gene

genes like me logo Genes that share domains with DSCAS: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DSCAS Gene

Function for DSCAS Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DSCAS Gene

Localization for DSCAS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DSCAS gene
Compartment Confidence
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DSCAS Gene

Pathways & Interactions for DSCAS Gene

PathCards logo

SuperPathways for DSCAS Gene

No Data Available

Gene Ontology (GO) - Biological Process for DSCAS Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for DSCAS Gene

Drugs & Compounds for DSCAS Gene

No Compound Related Data Available

Transcripts for DSCAS Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for DSCAS Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000051761A_9606 lncRNA 553 4

RefSeq: NR_110785,

Ensembl: ENST00000581836 (view in UCSC) ,

LncBook: HSALNT0249566,

NONCODE: NONHSAT058808.2,

URS0000EECD1E_9606 lncRNA 953 1

Ensembl: ENST00000654403 (view in UCSC) ,

URS0000D5A2C0_9606 lncRNA 1022 2

LncBook: HSALNT0249564,

LNCipedia: lnc-DSG1-14:1,

URS0000E95981_9606 lncRNA 8121 1

LncBook: HSALNT0249561,

URS0001BF5E93_9606 lncRNA 8120 1

LncBook: HSALNT0249561,

DSCAS in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for DSCAS Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for DSCAS Gene

No ASD Table

Relevant External Links for DSCAS Gene

GeneLoc Exon Structure for
DSCAS

Expression for DSCAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DSCAS Gene

genes like me logo Genes that share expression patterns with DSCAS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DSCAS Gene

Orthologs for DSCAS Gene

Evolution for DSCAS Gene

ENSEMBL:
Gene Tree for DSCAS (if available)
TreeFam:
Gene Tree for DSCAS (if available)

No data available for Orthologs for DSCAS Gene

Paralogs for DSCAS Gene

No data available for Paralogs for DSCAS Gene

Variants for DSCAS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DSCAS Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
889235 Uncertain Significance: Arrhythmogenic right ventricular cardiomyopathy, type 11 31,102,380(+) G/A
NM_024422.6(DSC2):c.-409C>T
FIVE_PRIME_UTR
891405 Uncertain Significance: Cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy, type 11 31,101,958(+) C/A
NM_024422.6(DSC2):c.14G>T (p.Arg5Leu)
MISSENSE
891646 Uncertain Significance: Arrhythmogenic right ventricular cardiomyopathy, type 11 31,102,066(+) G/C
NM_024422.6(DSC2):c.-95C>G
FIVE_PRIME_UTR
891647 Uncertain Significance: Arrhythmogenic right ventricular cardiomyopathy, type 11 31,102,158(+) G/A
NM_024422.6(DSC2):c.-187C>T
FIVE_PRIME_UTR
891648 Uncertain Significance: Arrhythmogenic right ventricular cardiomyopathy, type 11 31,102,248(+) A/T
NM_024422.6(DSC2):c.-277T>A
FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DSCAS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DSCAS Gene

Variant ID Type Subtype PubMed ID
dgv57n6 CNV deletion 16902084
esv2646471 CNV insertion 19546169
esv2675538 CNV deletion 23128226
esv3305216 CNV mobile element insertion 20981092
esv3310011 CNV mobile element insertion 20981092
esv3404918 CNV insertion 20981092
esv3432249 CNV insertion 20981092
esv3642118 CNV loss 21293372
nsv1109142 CNV deletion 24896259
nsv130642 CNV deletion 16902084
nsv476063 CNV novel sequence insertion 20440878
nsv519734 CNV loss 19592680
nsv820166 CNV loss 19587683

Additional Variant Information for DSCAS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DSCAS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DSCAS Gene

Disorders for DSCAS Gene

MalaCards: The human disease database

(1) MalaCards diseases for DSCAS Gene - From: CVR

- elite association - COSMIC cancer census association via MalaCards
Search DSCAS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DSCAS

genes like me logo Genes that share disorders with DSCAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DSCAS Gene

Publications for DSCAS Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for DSCAS Gene

Sources for DSCAS Gene