Aliases for DSCAML1 Gene
External Ids for DSCAML1 Gene
Previous GeneCards Identifiers for DSCAML1 Gene
The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016]
GeneCards Summary for DSCAML1 Gene
DSCAML1 (DS Cell Adhesion Molecule Like 1) is a Protein Coding gene. Diseases associated with DSCAML1 include Down Syndrome and Mannosidosis, Beta A, Lysosomal. Among its related pathways are Cell junction organization. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is NRCAM.
UniProtKB/Swiss-Prot Summary for DSCAML1 Gene
Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).