External Ids for DRP2 Gene
Previous GeneCards Identifiers for DRP2 Gene
Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for DRP2 Gene
DRP2 (Dystrophin Related Protein 2) is a Protein Coding gene. Diseases associated with DRP2 include Charcot-Marie-Tooth Disease, Demyelinating, Type 4F and Hypertrophic Neuropathy Of Dejerine-Sottas. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DMD.
UniProtKB/Swiss-Prot for DRP2 Gene
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.