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Aliases for DROSHA Gene

Aliases for DROSHA Gene

  • Drosha Ribonuclease III 2 3 5
  • Drosha, Double-Stranded RNA-Specific Endoribonuclease 2 3
  • Ribonuclease Type III, Nuclear 2 3
  • Drosha, Ribonuclease Type III 2 2
  • RNase III 3 4
  • RNASE3L 3 4
  • RNASEN 3 4
  • P241 3 4
  • RN3 3 4
  • Putative Protein P241 Which Interacts With Transcription Factor Sp1 3
  • Putative Ribonuclease III 3
  • Nuclear RNase III Drosha 3
  • Ribonuclease III 4
  • Ribonuclease 3 3
  • Protein Drosha 4
  • EC 3.1.26.3 4
  • HSA242976 3
  • RANSE3L 3
  • ETOHI2 3

External Ids for DROSHA Gene

Previous HGNC Symbols for DROSHA Gene

  • RNASEN

Summaries for DROSHA Gene

Entrez Gene Summary for DROSHA Gene

  • This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

CIViC summary for DROSHA Gene

GeneCards Summary for DROSHA Gene

DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Murray Valley Encephalitis. Among its related pathways are Translational Control and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for DROSHA Gene

  • Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Gene Wiki entry for DROSHA Gene

Additional gene information for DROSHA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DROSHA Gene

Genomics for DROSHA Gene

GeneHancer (GH) Regulatory Elements for DROSHA Gene

Promoters and enhancers for DROSHA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J031530 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 678 +0.0 12 3.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B E2F8 DROSHA C5orf22 MTMR12 ENSG00000206682
GH05J032442 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 40.5 -912.7 -912739 5 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZFR DROSHA MTMR12 ENSG00000249572 MIR579 LOC646616
GH05J032217 Enhancer 0.9 Ensembl ENCODE 60.4 -685.9 -685905 0.6 NFIB MZF1 ZNF195 ZNF121 ZNF366 ZBTB48 POLR2A ZSCAN5C ZNF350 ZNF600 PIR52245 DROSHA GOLPH3 MTMR12 RPL27P10 GC05M032181
GH05J032311 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.6 -781.0 -781008 4.3 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 MTMR12 DROSHA GC05P032360
GH05J031361 Enhancer 1 Ensembl ENCODE 38.4 +167.9 167884 6.5 FOS EGR2 ZNF592 AEBP2 ZNF530 HMBOX1 ZSCAN5A ZNF837 GTF2E2 ZNF266 MTMR12 DROSHA GOLPH3 ENSG00000254138 GC05P031506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DROSHA on UCSC Golden Path with GeneCards custom track

Genomic Locations for DROSHA Gene

Genomic Locations for DROSHA Gene
chr5:31,400,494-31,532,196
(GRCh38/hg38)
Size:
131,703 bases
Orientation:
Minus strand
chr5:31,400,601-31,532,303
(GRCh37/hg19)
Size:
131,703 bases
Orientation:
Minus strand

Genomic View for DROSHA Gene

Genes around DROSHA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DROSHA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DROSHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DROSHA Gene

Proteins for DROSHA Gene

  • Protein details for DROSHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR4-RNC_HUMAN
    Recommended name:
    Ribonuclease 3
    Protein Accession:
    Q9NRR4
    Secondary Accessions:
    • E7EMP9
    • Q7Z5V2
    • Q86YH0
    • Q9NW73
    • Q9Y2V9
    • Q9Y4Y0

    Protein attributes for DROSHA Gene

    Size:
    1374 amino acids
    Molecular mass:
    159316 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15589161, PubMed:15574589, PubMed:15531877, PubMed:16751099, PubMed:26027739, PubMed:26748718). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (PubMed:26027739, PubMed:26748718). Interacts with SP1 and SNIP1 (PubMed:10976766, PubMed:18632581). Interacts with SRRT/ARS2 (By similarity).
    SequenceCaution:
    • Sequence=AAD29637.1; Type=Frameshift; Positions=775; Evidence={ECO:0000305}; Sequence=BAA91511.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DROSHA Gene

    Alternative splice isoforms for DROSHA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DROSHA Gene

Post-translational modifications for DROSHA Gene

  • Ubiquitination at posLast=12501250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DROSHA Gene

Domains & Families for DROSHA Gene

Gene Families for DROSHA Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DROSHA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRR4

UniProtKB/Swiss-Prot:

RNC_HUMAN :
  • The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3strand while the domain 2 cleaves the 5strand of pri-miRNAs, independently of each other.
  • Belongs to the ribonuclease III family.
Domain:
  • The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3strand while the domain 2 cleaves the 5strand of pri-miRNAs, independently of each other.
Family:
  • Belongs to the ribonuclease III family.
genes like me logo Genes that share domains with DROSHA: view

Function for DROSHA Gene

Molecular function for DROSHA Gene

UniProtKB/Swiss-Prot Function:
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to 5-phosphomonoester.

Enzyme Numbers (IUBMB) for DROSHA Gene

Phenotypes From GWAS Catalog for DROSHA Gene

Gene Ontology (GO) - Molecular Function for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20180804
GO:0003723 RNA binding HDA 22658674
GO:0003725 double-stranded RNA binding IBA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
genes like me logo Genes that share ontologies with DROSHA: view
genes like me logo Genes that share phenotypes with DROSHA: view

Animal Models for DROSHA Gene

MGI Knock Outs for DROSHA:

Animal Model Products

  • Taconic Biosciences Mouse Models for DROSHA

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DROSHA Gene

Localization for DROSHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DROSHA Gene

Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269 PubMed:10948199, ECO:0000269 PubMed:22118463}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DROSHA gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0014069 postsynaptic density IEA --
GO:0070877 microprocessor complex IDA 15574589
genes like me logo Genes that share ontologies with DROSHA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DROSHA Gene

Pathways & Interactions for DROSHA Gene

genes like me logo Genes that share pathways with DROSHA: view

Pathways by source for DROSHA Gene

1 Cell Signaling Technology pathway for DROSHA Gene

Gene Ontology (GO) - Biological Process for DROSHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA,IEA --
GO:0010468 regulation of gene expression IEA --
GO:0010586 miRNA metabolic process TAS --
GO:0010628 positive regulation of gene expression IEA --
GO:0016075 rRNA catabolic process IEA --
genes like me logo Genes that share ontologies with DROSHA: view

No data available for SIGNOR curated interactions for DROSHA Gene

Drugs & Compounds for DROSHA Gene

(8) Drugs for DROSHA Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3113
Cytarabine Approved, Investigational Pharma 1166
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 291
Mercaptopurine Approved Pharma 0
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1603

(2) Additional Compounds for DROSHA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DROSHA: view

Transcripts for DROSHA Gene

Unigene Clusters for DROSHA Gene

Drosha, ribonuclease type III:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DROSHA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15:

ExUns: 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:
SP14:
SP15:

ExUns: 37b ^ 38 ^ 39a · 39b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for DROSHA Gene

GeneLoc Exon Structure for
DROSHA
ECgene alternative splicing isoforms for
DROSHA

Expression for DROSHA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DROSHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DROSHA Gene

This gene is overexpressed in Lung (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DROSHA Gene



Protein tissue co-expression partners for DROSHA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DROSHA Gene:

DROSHA

SOURCE GeneReport for Unigene cluster for DROSHA Gene:

Hs.97997

mRNA Expression by UniProt/SwissProt for DROSHA Gene:

Q9NRR4-RNC_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DROSHA Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Skin(4.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DROSHA: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DROSHA Gene

Orthologs for DROSHA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DROSHA Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
DROSHA 33
  • 92.52 (n)
chimpanzee
(Pan troglodytes)
Mammalia DROSHA 34 33
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DROSHA 34 33
  • 91.43 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drosha 33
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Drosha 16 34 33
  • 87.8 (n)
oppossum
(Monodelphis domestica)
Mammalia DROSHA 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves DROSHA 34 33
  • 79.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DROSHA 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drosha 33
  • 76.26 (n)
Str.11055 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15543 33
zebrafish
(Danio rerio)
Actinopterygii rnasen 34 33
  • 71.94 (n)
OneToOne
Dr.11510 33
fruit fly
(Drosophila melanogaster)
Insecta drosha 34 33
  • 56.22 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008087 33
  • 53.16 (n)
worm
(Caenorhabditis elegans)
Secernentea drsh-1 34 33
  • 48.97 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNT1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2273 34
  • 58 (a)
OneToOne
Cin.1094 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1094 33
Species where no ortholog for DROSHA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DROSHA Gene

ENSEMBL:
Gene Tree for DROSHA (if available)
TreeFam:
Gene Tree for DROSHA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DROSHA: view image

Paralogs for DROSHA Gene

No data available for Paralogs for DROSHA Gene

Variants for DROSHA Gene

Sequence variations from dbSNP and Humsavar for DROSHA Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs201151813 benign, Abnormality of neuronal migration 31,526,178(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000004054 -- 31,434,005(-) T/C intron_variant
rs1000012067 -- 31,456,674(-) T/G intron_variant
rs1000015415 -- 31,524,005(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000085073 -- 31,456,340(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DROSHA Gene

Variant ID Type Subtype PubMed ID
dgv340n21 CNV loss 19592680
dgv5619n100 CNV gain 25217958
esv2759336 CNV gain 17122850
esv3410696 CNV duplication 20981092
esv34132 CNV loss 18971310
esv3604572 CNV gain 21293372
esv3604580 CNV gain 21293372
nsv475305 CNV novel sequence insertion 20440878
nsv4776 CNV insertion 18451855
nsv819630 CNV gain 19587683
nsv830249 CNV gain 17160897

Variation tolerance for DROSHA Gene

Residual Variation Intolerance Score: 4.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DROSHA Gene

Human Gene Mutation Database (HGMD)
DROSHA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DROSHA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DROSHA Gene

Disorders for DROSHA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DROSHA Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
murray valley encephalitis
  • australian encephalitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DROSHA

genes like me logo Genes that share disorders with DROSHA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DROSHA Gene

Publications for DROSHA Gene

  1. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. (PMID: 10948199) Wu H … Crooke ST (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. (PMID: 15589161) Landthaler M … Tuschl T (Current biology : CB 2004) 3 4 22 58
  3. The Drosha-DGCR8 complex in primary microRNA processing. (PMID: 15574589) Han J … Kim VN (Genes & development 2004) 3 4 22 58
  4. The nuclear RNase III Drosha initiates microRNA processing. (PMID: 14508493) Lee Y … Kim VN (Nature 2003) 3 4 22 58
  5. A novel type of RNase III family proteins in eukaryotes. (PMID: 10713462) Filippov V … Gill SS (Gene 2000) 2 3 22 58

Products for DROSHA Gene

Sources for DROSHA Gene

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