Aliases for DRICH1 Gene

Aliases for DRICH1 Gene

  • Aspartate Rich 1 2 3 5
  • Aspartate-Rich Protein 1 3 4
  • C22orf43 3 4
  • Chromosome 22 Open Reading Frame 43 2
  • KB-208E9.1 3
  • DRICH1 5

External Ids for DRICH1 Gene

Previous HGNC Symbols for DRICH1 Gene

  • C22orf43

Previous GeneCards Identifiers for DRICH1 Gene

  • GC22M023951
  • GC22M023608
  • GC22M023581
  • GC22M023584

Summaries for DRICH1 Gene

GeneCards Summary for DRICH1 Gene

DRICH1 (Aspartate Rich 1) is a Protein Coding gene. Diseases associated with DRICH1 include Childhood Acute Lymphocytic Leukemia and Pelvic Varices. An important paralog of this gene is C22orf42.

Additional gene information for DRICH1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRICH1 Gene

Genomics for DRICH1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DRICH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRICH1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DRICH1

Genomic Locations for DRICH1 Gene

Genomic Locations for DRICH1 Gene
chr22:23,580,872-23,637,732
(GRCh38/hg38)
Size:
56,861 bases
Orientation:
Minus strand
chr22:23,950,639-23,974,508
(GRCh37/hg19)
Size:
23,870 bases
Orientation:
Minus strand

Genomic View for DRICH1 Gene

Genes around DRICH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRICH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRICH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRICH1 Gene

Proteins for DRICH1 Gene

  • Protein details for DRICH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PGQ1-DRIC1_HUMAN
    Recommended name:
    Aspartate-rich protein 1
    Protein Accession:
    Q6PGQ1
    Secondary Accessions:
    • Q6ICJ8
    • Q6P4I3
    • Q9NU31

    Protein attributes for DRICH1 Gene

    Size:
    229 amino acids
    Molecular mass:
    25064 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB75693.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for DRICH1 Gene

Post-translational modifications for DRICH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRICH1 Gene

No data available for DME Specific Peptides for DRICH1 Gene

Domains & Families for DRICH1 Gene

Gene Families for DRICH1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DRICH1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with DRICH1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DRICH1 Gene

Function for DRICH1 Gene

Phenotypes From GWAS Catalog for DRICH1 Gene

Gene Ontology (GO) - Molecular Function for DRICH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DRICH1: view
genes like me logo Genes that share phenotypes with DRICH1: view

Animal Model Products

CRISPR Products

miRNA for DRICH1 Gene

miRTarBase miRNAs that target DRICH1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRICH1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DRICH1 Gene

Localization for DRICH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRICH1 gene
Compartment Confidence
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DRICH1 Gene

Pathways & Interactions for DRICH1 Gene

PathCards logo

SuperPathways for DRICH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRICH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DRICH1 Gene

Drugs & Compounds for DRICH1 Gene

No Compound Related Data Available

Transcripts for DRICH1 Gene

mRNA/cDNA for DRICH1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRICH1

Alternative Splicing Database (ASD) splice patterns (SP) for DRICH1 Gene

No ASD Table

Relevant External Links for DRICH1 Gene

GeneLoc Exon Structure for
DRICH1

Expression for DRICH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRICH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for DRICH1 Gene

This gene is overexpressed in Testis (x30.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DRICH1

genes like me logo Genes that share expression patterns with DRICH1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRICH1 Gene

Orthologs for DRICH1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DRICH1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC748615 30
  • 96.77 (n)
C22orf43 31
  • 94 (a)
OneToOne
Species where no ortholog for DRICH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for DRICH1 Gene

ENSEMBL:
Gene Tree for DRICH1 (if available)
TreeFam:
Gene Tree for DRICH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRICH1: view image

Paralogs for DRICH1 Gene

Paralogs for DRICH1 Gene

Pseudogenes.org Pseudogenes for DRICH1 Gene

genes like me logo Genes that share paralogs with DRICH1: view

Variants for DRICH1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DRICH1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs3827318 - p.Ile4Thr

Additional dbSNP identifiers (rs#s) for DRICH1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DRICH1 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv4529n100 CNV gain 25217958
dgv4530n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
dgv8043n54 CNV gain 21841781
dgv828e214 CNV loss 21293372
esv1552056 CNV deletion 17803354
esv1986399 CNV deletion 18987734
esv2154593 CNV deletion 18987734
esv23191 CNV loss 19812545
esv2724041 CNV deletion 23290073
esv2724056 CNV deletion 23290073
esv2724058 CNV deletion 23290073
esv2724059 CNV deletion 23290073
esv2760716 CNV gain 21179565
esv2762117 CNV gain 21179565
esv3234323 CNV deletion 24192839
esv3557978 CNV deletion 23714750
esv3575443 CNV gain 25503493
esv3647408 CNV gain 21293372
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1056185 CNV gain 25217958
nsv1059951 CNV gain 25217958
nsv1060587 CNV gain+loss 25217958
nsv1062411 CNV gain 25217958
nsv1064874 CNV gain 25217958
nsv1066846 CNV loss 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv1136662 CNV deletion 24896259
nsv191262 CNV deletion 16902084
nsv436353 CNV deletion 17901297
nsv437850 CNV loss 16327808
nsv459677 CNV loss 19166990
nsv459682 CNV gain 19166990
nsv471187 CNV gain 18288195
nsv482072 CNV gain 20164927
nsv520582 CNV gain 19592680
nsv526567 CNV gain 19592680
nsv588601 CNV gain 21841781
nsv588606 CNV loss 21841781
nsv588619 CNV gain+loss 21841781
nsv588623 CNV loss 21841781
nsv588624 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv819745 CNV loss 19587683
nsv953053 CNV deletion 24416366
nsv964606 CNV duplication 23825009
nsv9877 CNV gain 18304495

Variation tolerance for DRICH1 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.44; 81.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRICH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRICH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRICH1 Gene

Disorders for DRICH1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DRICH1 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
childhood acute lymphocytic leukemia
  • childhood acute lymphoblastic leukemia
pelvic varices
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DRICH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRICH1 Gene

Publications for DRICH1 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for DRICH1 Gene

Sources for DRICH1 Gene