Aliases for DRGX Gene

Aliases for DRGX Gene

  • Dorsal Root Ganglia Homeobox 2 3 5
  • Paired-Like Homeodomain Trancription Factor DRG11 2 3
  • Dorsal Root Ganglia Homeobox Protein 3 4
  • Paired Related Homeobox-Like 1 2 3
  • PRRXL1 3 4
  • Paired-Related Homeobox Protein-Like 1 4
  • DRG11 3

External Ids for DRGX Gene

Previous HGNC Symbols for DRGX Gene

  • PRRXL1

Previous GeneCards Identifiers for DRGX Gene

  • GC10M050243
  • GC10M050573
  • GC10M044838

Summaries for DRGX Gene

GeneCards Summary for DRGX Gene

DRGX (Dorsal Root Ganglia Homeobox) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is PHOX2A.

UniProtKB/Swiss-Prot Summary for DRGX Gene

  • Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

Additional gene information for DRGX Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRGX Gene

Genomics for DRGX Gene

GeneHancer (GH) Regulatory Elements for DRGX Gene

Promoters and enhancers for DRGX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J049395 Enhancer 1 VISTA UCNEbase FANTOM5 758.5 -0.5 -468 1.4 EZH2 USF1 POLR2A RCOR1 DRGX ENSG00000235939
GH10J049397 Enhancer 0.3 ENCODE 750.6 -1.4 -1434 0.1 POLR2A EZH2 DRGX ENSG00000235939
GH10J049296 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +97.0 96984 6 ZBTB40 SMARCE1 RUNX1 CC2D1A ELF1 RBM39 L3MBTL2 TEAD4 ZKSCAN8 GTF2F1 C10orf71 C10orf71-AS1 lnc-CHAT-2 TIMM23B-AGAP6 RNA5SP317 AGAP6 WASHC2A DRGX ERCC6
GH10J049309 Enhancer 1 FANTOM5 ENCODE dbSUPER 23 +85.8 85846 1.4 IKZF1 CREB1 ATF1 IKZF2 BCOR CBX1 FOS ZNF513 ZMYM3 DRGX TMEM273 lnc-CHAT-2 C10orf71 lnc-DRGX-1
GH10J049335 Enhancer 0.5 ENCODE 21.6 +60.4 60427 0.9 ZBTB40 NR2C1 EHMT2 GABPA NR2C2 NR2F2 DRGX C10orf71 C10orf71-AS1 PGBD3 lnc-DRGX-1 HSALNG0077874
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRGX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRGX gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Chx10
  • FOXD3
  • GATA-2
  • IRF-2
  • S8

Genomic Locations for DRGX Gene

Genomic Locations for DRGX Gene
chr10:49,364,066-49,396,016
(GRCh38/hg38)
Size:
31,951 bases
Orientation:
Minus strand
chr10:50,572,237-50,603,497
(GRCh37/hg19)
Size:
31,261 bases
Orientation:
Minus strand

Genomic View for DRGX Gene

Genes around DRGX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRGX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRGX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRGX Gene

Proteins for DRGX Gene

  • Protein details for DRGX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNA5-DRGX_HUMAN
    Recommended name:
    Dorsal root ganglia homeobox protein
    Protein Accession:
    A6NNA5

    Protein attributes for DRGX Gene

    Size:
    263 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Interacts with RGMB.

neXtProt entry for DRGX Gene

Post-translational modifications for DRGX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRGX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRGX Gene

Domains & Families for DRGX Gene

Gene Families for DRGX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DRGX Gene

Suggested Antigen Peptide Sequences for DRGX Gene

GenScript: Design optimal peptide antigens:
  • Paired-related homeobox protein-like 1 (DRGX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NNA5

UniProtKB/Swiss-Prot:

DRGX_HUMAN :
  • Belongs to the paired homeobox family.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DRGX: view

Function for DRGX Gene

Molecular function for DRGX Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.

Phenotypes From GWAS Catalog for DRGX Gene

Gene Ontology (GO) - Molecular Function for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DRGX: view
genes like me logo Genes that share phenotypes with DRGX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRGX

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DRGX Gene

Localization for DRGX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRGX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRGX gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with DRGX: view

Pathways & Interactions for DRGX Gene

PathCards logo

SuperPathways for DRGX Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRGX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with DRGX: view

No data available for Pathways by source and SIGNOR curated interactions for DRGX Gene

Drugs & Compounds for DRGX Gene

No Compound Related Data Available

Transcripts for DRGX Gene

mRNA/cDNA for DRGX Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRGX

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRGX Gene

No ASD Table

Relevant External Links for DRGX Gene

GeneLoc Exon Structure for
DRGX
ECgene alternative splicing isoforms for
DRGX

Expression for DRGX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRGX Gene

mRNA differential expression in normal tissues according to GTEx for DRGX Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x22.5), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Cortex (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of DRGX Gene:

DRGX

SOURCE GeneReport for Unigene cluster for DRGX Gene:

Hs.534530
genes like me logo Genes that share expression patterns with DRGX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRGX Gene

Orthologs for DRGX Gene

This gene was present in the common ancestor of animals.

Orthologs for DRGX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRGX 33 32
  • 99.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Drgx 32
  • 89.35 (n)
cow
(Bos Taurus)
Mammalia DRGX 33 32
  • 89.1 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRGX 33
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRGX 33 32
  • 86.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prrxl1 33
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRGX 33
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRG11 33
  • 84 (a)
OneToOne
DRGX 32
  • 76.79 (n)
lizard
(Anolis carolinensis)
Reptilia DRGX 33
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drgx 32
  • 69.11 (n)
zebrafish
(Danio rerio)
Actinopterygii drgx 33 32
  • 72.8 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34340 33
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea alr-1 33
  • 20 (a)
ManyToMany
Species where no ortholog for DRGX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRGX Gene

ENSEMBL:
Gene Tree for DRGX (if available)
TreeFam:
Gene Tree for DRGX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRGX: view image

Paralogs for DRGX Gene

(9) SIMAP similar genes for DRGX Gene using alignment to 2 proteins:

  • DRGX_HUMAN
  • C9JW76_HUMAN
genes like me logo Genes that share paralogs with DRGX: view

Variants for DRGX Gene

Sequence variations from dbSNP and Humsavar for DRGX Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000092203 -- 49,394,607(-) C/T intron_variant
rs1000113564 -- 49,394,888(-) G/A/T intron_variant
rs1000136808 -- 49,379,117(-) AAAAAAAA/AAAAAAA/AAAAAAAAA intron_variant
rs1000184475 -- 49,368,280(-) G/A intron_variant
rs1000223513 -- 49,388,503(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DRGX Gene

Variant ID Type Subtype PubMed ID
nsv1042677 CNV loss 25217958
nsv526843 CNV loss 19592680

Variation tolerance for DRGX Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRGX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRGX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRGX Gene

Disorders for DRGX Gene

Additional Disease Information for DRGX

No disorders were found for DRGX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRGX Gene

Publications for DRGX Gene

  1. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S … Arnett DK (Pharmacogenetics and genomics 2012) 3 43 56
  2. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. (PMID: 7496632) Saito T … Anderson DJ (Molecular and cellular neurosciences 1995) 2 3 56
  3. Genome-wide association analysis of Sasang constitution in the Korean population. (PMID: 22394158) Kim BY … Kim JY (Journal of alternative and complementary medicine (New York, N.Y.) 2012) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 56

Products for DRGX Gene

Sources for DRGX Gene