Aliases for DRG1 Gene

Aliases for DRG1 Gene

  • Developmentally Regulated GTP Binding Protein 1 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 3 3 4
  • Developmentally-Regulated GTP-Binding Protein 1 3 4
  • Translation Factor GTPase DRG1 3 4
  • TRAFAC GTPase DRG1 3 4
  • NEDD-3 3 4
  • NEDD3 3 4
  • DRG-1 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 3 3
  • Developmentally Regulated GTP-Binding Protein 1 2
  • EC 3.6.5.- 4

External Ids for DRG1 Gene

Previous HGNC Symbols for DRG1 Gene

  • NEDD3

Previous GeneCards Identifiers for DRG1 Gene

  • GC22P028491
  • GC22P030120
  • GC22P031795
  • GC22P014757

Summaries for DRG1 Gene

GeneCards Summary for DRG1 Gene

DRG1 (Developmentally Regulated GTP Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is DRG2.

UniProtKB/Swiss-Prot Summary for DRG1 Gene

  • Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).

Gene Wiki entry for DRG1 Gene

Additional gene information for DRG1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRG1 Gene

Genomics for DRG1 Gene

GeneHancer (GH) Regulatory Elements for DRG1 Gene

Promoters and enhancers for DRG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DRG1

Top Transcription factor binding sites by QIAGEN in the DRG1 gene promoter:
  • AP-4
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Gfi-1
  • p53
  • Pbx1a
  • POU3F2 (N-Oct-5b)
  • Sp1
  • XBP-1

Genomic Locations for DRG1 Gene

Genomic Locations for DRG1 Gene
chr22:31,399,553-31,530,634
(GRCh38/hg38)
Size:
131,082 bases
Orientation:
Plus strand
chr22:31,795,509-31,924,726
(GRCh37/hg19)
Size:
129,218 bases
Orientation:
Plus strand

Genomic View for DRG1 Gene

Genes around DRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRG1 Gene

Proteins for DRG1 Gene

  • Protein details for DRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y295-DRG1_HUMAN
    Recommended name:
    Developmentally-regulated GTP-binding protein 1
    Protein Accession:
    Q9Y295
    Secondary Accessions:
    • B2RDS8
    • Q6FGP8
    • Q8WW69
    • Q9UGF2

    Protein attributes for DRG1 Gene

    Size:
    367 amino acids
    Molecular mass:
    40542 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Quaternary structure:
    • Interacts (via its C-terminal) with TAL1. Interacts with DFRP1/ZC3H15; this interaction prevents DRG1 poly-ubiquitination and degradation by the proteasome. DRG1-ZC3H15/DFRP1 complex co-sediments with polysomes (PubMed:19819225). Interacts with STK16 (PubMed:18184589). Interacts with JMJD7 (PubMed:29915238). Associates with microtubules either in an immobile or diffusive manner; in vitro binds to tubulin lacking the negatively charged C-terminal domain (PubMed:28855639).

    Three dimensional structures from OCA and Proteopedia for DRG1 Gene

neXtProt entry for DRG1 Gene

Post-translational modifications for DRG1 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Phosphorylated at Thr-100 by STK16.
  • Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.
  • Polyubiquitinated; this modification induces proteolytic degradation and is impaired by interaction with ZC3H15.
  • Ubiquitination at Lys46, Lys61, Lys112, Lys126, Lys159, Lys186, Lys213, and Lys290
  • Modification sites at PhosphoSitePlus

Other Protein References for DRG1 Gene

No data available for DME Specific Peptides for DRG1 Gene

Domains & Families for DRG1 Gene

Gene Families for DRG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DRG1 Gene

Blocks:
  • GTP-binding protein, HSR1-related
  • GTP1/OBG GTP-binding protein family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRG1 Gene

GenScript: Design optimal peptide antigens:
  • Neural precursor cell expressed developmentally down-regulated protein 3 (DRG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y295

UniProtKB/Swiss-Prot:

DRG1_HUMAN :
  • The ThrRS, GTPase, SpoT (TGS) domain is not necessary for GTP binding nor for the GTPase activity. It appears to play a regulatory role favoring GTP hydrolysis mediated by DFRP1/ZC3H15.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Domain:
  • The ThrRS, GTPase, SpoT (TGS) domain is not necessary for GTP binding nor for the GTPase activity. It appears to play a regulatory role favoring GTP hydrolysis mediated by DFRP1/ZC3H15.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with DRG1: view

Function for DRG1 Gene

Molecular function for DRG1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
The GTPase activity is enhanced by potassium ions as well as by DFRP1 binding.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.25 mM for GTP {ECO:0000269 PubMed:23711155}; Vmax=3.59 nmol/min/mg enzyme {ECO:0000269 PubMed:23711155}; pH dependence: Optimum pH is 8-9. {ECO:0000269 PubMed:23711155}; Temperature dependence: Optimum temperature is 42 degrees Celsius. {ECO:0000269 PubMed:23711155};
UniProtKB/Swiss-Prot Induction:
By androgens.
GENATLAS Biochemistry:
developmentally regulated GTP-binding protein 1,mouse Nedd3 homolog,binding to SCL in clones from human fetal liver and thymus

Enzyme Numbers (IUBMB) for DRG1 Gene

Phenotypes From GWAS Catalog for DRG1 Gene

Gene Ontology (GO) - Molecular Function for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 23711155
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IBA 21873635
GO:0008017 microtubule binding IDA 28855639
GO:0008134 transcription factor binding TAS 9824680
genes like me logo Genes that share ontologies with DRG1: view
genes like me logo Genes that share phenotypes with DRG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DRG1

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DRG1 Gene

Localization for DRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRG1 Gene

Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRG1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 29915238
GO:0005737 cytoplasm IDA,IBA 29915238
GO:0005813 centrosome IEA --
GO:0005829 cytosol IDA --
GO:0005844 polysome IDA 19819225
genes like me logo Genes that share ontologies with DRG1: view

Pathways & Interactions for DRG1 Gene

PathCards logo

SuperPathways for DRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA 21873635
GO:0006351 transcription, DNA-templated TAS 9824680
GO:0007275 multicellular organism development TAS 1280421
GO:0031116 positive regulation of microtubule polymerization IMP 28855639
GO:1901673 regulation of mitotic spindle assembly IMP 28855639
genes like me logo Genes that share ontologies with DRG1: view

No data available for Pathways by source and SIGNOR curated interactions for DRG1 Gene

Drugs & Compounds for DRG1 Gene

(1) Drugs for DRG1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DRG1: view

Transcripts for DRG1 Gene

mRNA/cDNA for DRG1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - -

Relevant External Links for DRG1 Gene

GeneLoc Exon Structure for
DRG1

Expression for DRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRG1 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for DRG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1) and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DRG1 Gene



Protein tissue co-expression partners for DRG1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DRG1

SOURCE GeneReport for Unigene cluster for DRG1 Gene:

Hs.115242

mRNA Expression by UniProt/SwissProt for DRG1 Gene:

Q9Y295-DRG1_HUMAN
Tissue specificity: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.

Evidence on tissue expression from TISSUES for DRG1 Gene

  • Lung(4.2)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with DRG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DRG1 Gene

Orthologs for DRG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRG1 31 30
  • 99.73 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRG1 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 97 (a)
OneToMany
DRG1 31 30
  • 94.37 (n)
OneToMany
dog
(Canis familiaris)
Mammalia DRG1 31 30
  • 94.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Drg1 17 31 30
  • 91.83 (n)
rat
(Rattus norvegicus)
Mammalia Drg1 30
  • 91.73 (n)
oppossum
(Monodelphis domestica)
Mammalia DRG1 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRG1 31 30
  • 81.47 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drg1 30
  • 79.2 (n)
Str.2997 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.92 30
zebrafish
(Danio rerio)
Actinopterygii drg1 31 30
  • 77.53 (n)
OneToOne
wufb06g12 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.102 30
fruit fly
(Drosophila melanogaster)
Insecta 128up 31 32 30
  • 70.75 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010624 30
  • 69.49 (n)
worm
(Caenorhabditis elegans)
Secernentea T28D6.6 31 30
  • 66.3 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23287g 30
  • 63.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBG1 33 31 30
  • 62.58 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR372C 30
  • 61.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39520 30
  • 64.85 (n)
soybean
(Glycine max)
eudicotyledons Gma.4107 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4893 30
rice
(Oryza sativa)
Liliopsida Os07g0627800 30
  • 66.76 (n)
Os.10918 30
barley
(Hordeum vulgare)
Liliopsida Hv.1866 30
wheat
(Triticum aestivum)
Liliopsida Ta.7400 30
corn
(Zea mays)
Liliopsida Zm.6218 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9185 31
  • 81 (a)
OneToOne
Cin.256 30
bread mold
(Neurospora crassa)
Ascomycetes NCU00389 30
  • 61.19 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC9.07c 30
  • 60.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.256 30
Species where no ortholog for DRG1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DRG1 Gene

ENSEMBL:
Gene Tree for DRG1 (if available)
TreeFam:
Gene Tree for DRG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRG1: view image

Paralogs for DRG1 Gene

Paralogs for DRG1 Gene

(2) SIMAP similar genes for DRG1 Gene using alignment to 3 proteins:

  • DRG1_HUMAN
  • F8WEE0_HUMAN
  • H0YI06_HUMAN

Pseudogenes.org Pseudogenes for DRG1 Gene

genes like me logo Genes that share paralogs with DRG1: view

Variants for DRG1 Gene

Additional dbSNP identifiers (rs#s) for DRG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DRG1 Gene

Variant ID Type Subtype PubMed ID
esv1490942 CNV deletion 17803354
esv2656791 CNV deletion 23128226
esv3647585 CNV loss 21293372
nsv1063634 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv834176 CNV loss 17160897

Variation tolerance for DRG1 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DRG1 Gene

Disorders for DRG1 Gene

Additional Disease Information for DRG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRG1 Gene

Publications for DRG1 Gene

  1. DRG represents a family of two closely related GTP-binding proteins. (PMID: 10760581) Li B … Trueb B (Biochimica et biophysica acta 2000) 3 4 23 54
  2. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. (PMID: 29915238) Markolovic S … Schofield CJ (Nature chemical biology 2018) 3 4 54
  3. Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics. (PMID: 28855639) Schellhaus AK … Antonin W (Scientific reports 2017) 3 4 54
  4. Human Drg1 is a potassium-dependent GTPase enhanced by Lerepo4. (PMID: 23711155) Pérez-Arellano I … Bravo J (The FEBS journal 2013) 3 4 54
  5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 41 54

Products for DRG1 Gene

Sources for DRG1 Gene