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Aliases for DRG1 Gene

Aliases for DRG1 Gene

  • Developmentally Regulated GTP Binding Protein 1 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 3 3 4
  • NEDD-3 3 4
  • NEDD3 3 4
  • DRG-1 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 3 3
  • Developmentally-Regulated GTP-Binding Protein 1 3
  • Developmentally Regulated GTP-Binding Protein 1 2

External Ids for DRG1 Gene

Previous HGNC Symbols for DRG1 Gene

  • NEDD3

Previous GeneCards Identifiers for DRG1 Gene

  • GC22P028491
  • GC22P030120
  • GC22P031795
  • GC22P014757

Summaries for DRG1 Gene

GeneCards Summary for DRG1 Gene

DRG1 (Developmentally Regulated GTP Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding.

UniProtKB/Swiss-Prot for DRG1 Gene

  • Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Gene Wiki entry for DRG1 Gene

Additional gene information for DRG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRG1 Gene

Genomics for DRG1 Gene

GeneHancer (GH) Regulatory Elements for DRG1 Gene

Promoters and enhancers for DRG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J031397 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 0.0 -44 3.3 HDGF FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B DRG1 SFI1 LINC01521 PATZ1 ENSG00000240591 EIF4ENIF1 PIK3IP1 PIR44980
GH22J031645 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +247.7 247728 4.1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 GLIS2 ATF7 FOS RUNX3 SFI1 EIF4ENIF1 ENSG00000240591 DRG1 PISD RNF185 PIK3IP1 LIMK2 MIR7109
GH22J031649 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.1 +252.8 252779 5.1 HDGF BATF ATF7 ETV6 IKZF2 RUNX3 SMARCA5 JUNB CEBPB ZNF217 PRR14L DEPDC5 EIF4ENIF1 ENSG00000240591 DRG1 SFI1 PIK3IP1 PISD MIR7109
GH22J031339 Enhancer 1 ENCODE dbSUPER 10.9 -59.9 -59936 0.8 ELF3 FOXA2 ARID4B ZNF48 RARA ZNF614 CREM SP5 MXD4 PPARG DRG1 PIR42273 PIR41427 PATZ1
GH22J031350 Enhancer 0.8 ENCODE 11 -48.9 -48853 0.2 ELF3 ARID4B SIN3A BMI1 RAD21 RARA RCOR1 MIXL1 RXRA REST DRG1 SFI1 LINC01521 RNU6-338P GC22M031389
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRG1 gene promoter:
  • p53
  • Sp1
  • FOXO3b
  • FOXO3a
  • FOXO3
  • Pbx1a
  • XBP-1
  • AP-4
  • Gfi-1
  • POU3F2 (N-Oct-5b)

Genomic Locations for DRG1 Gene

Genomic Locations for DRG1 Gene
chr22:31,399,523-31,530,634
(GRCh38/hg38)
Size:
131,112 bases
Orientation:
Plus strand
chr22:31,795,509-31,924,726
(GRCh37/hg19)
Size:
129,218 bases
Orientation:
Plus strand

Genomic View for DRG1 Gene

Genes around DRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRG1 Gene

Proteins for DRG1 Gene

  • Protein details for DRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y295-DRG1_HUMAN
    Recommended name:
    Developmentally-regulated GTP-binding protein 1
    Protein Accession:
    Q9Y295
    Secondary Accessions:
    • B2RDS8
    • Q6FGP8
    • Q8WW69
    • Q9UGF2

    Protein attributes for DRG1 Gene

    Size:
    367 amino acids
    Molecular mass:
    40542 Da
    Quaternary structure:
    • Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DRG1 Gene

neXtProt entry for DRG1 Gene

Post-translational modifications for DRG1 Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Ubiquitination at posLast=290290, Lys213, Lys186, posLast=159159, posLast=126126, posLast=112112, posLast=6161, and posLast=4646
  • Modification sites at PhosphoSitePlus

Other Protein References for DRG1 Gene

No data available for DME Specific Peptides for DRG1 Gene

Domains & Families for DRG1 Gene

Gene Families for DRG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DRG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y295

UniProtKB/Swiss-Prot:

DRG1_HUMAN :
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Family:
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
genes like me logo Genes that share domains with DRG1: view

Function for DRG1 Gene

Molecular function for DRG1 Gene

UniProtKB/Swiss-Prot Function:
Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.
UniProtKB/Swiss-Prot Induction:
By androgens.
GENATLAS Biochemistry:
developmentally regulated GTP-binding protein 1,mouse Nedd3 homolog,binding to SCL in clones from human fetal liver and thymus

Phenotypes From GWAS Catalog for DRG1 Gene

Gene Ontology (GO) - Molecular Function for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
GO:0008134 transcription factor binding TAS 9824680
GO:0042802 identical protein binding IPI 23711155
genes like me logo Genes that share ontologies with DRG1: view
genes like me logo Genes that share phenotypes with DRG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DRG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DRG1 Gene

Localization for DRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRG1 Gene

Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRG1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005829 cytosol IDA --
GO:0005844 polysome IDA 19819225
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DRG1: view

Pathways & Interactions for DRG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 9824680
GO:0007275 multicellular organism development TAS 1280421
genes like me logo Genes that share ontologies with DRG1: view

No data available for Pathways by source and SIGNOR curated interactions for DRG1 Gene

Drugs & Compounds for DRG1 Gene

(1) Drugs for DRG1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DRG1: view

Transcripts for DRG1 Gene

mRNA/cDNA for DRG1 Gene

Unigene Clusters for DRG1 Gene

Developmentally regulated GTP binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: - -

Relevant External Links for DRG1 Gene

GeneLoc Exon Structure for
DRG1
ECgene alternative splicing isoforms for
DRG1

Expression for DRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRG1 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for DRG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.1) and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DRG1 Gene



Protein tissue co-expression partners for DRG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DRG1 Gene:

DRG1

SOURCE GeneReport for Unigene cluster for DRG1 Gene:

Hs.115242

mRNA Expression by UniProt/SwissProt for DRG1 Gene:

Q9Y295-DRG1_HUMAN
Tissue specificity: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.

Evidence on tissue expression from TISSUES for DRG1 Gene

  • Lung(4.2)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with DRG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DRG1 Gene

Orthologs for DRG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRG1 34 33
  • 99.73 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRG1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToMany
DRG1 34 33
  • 94.37 (n)
OneToMany
dog
(Canis familiaris)
Mammalia DRG1 34 33
  • 94.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Drg1 16 34 33
  • 91.83 (n)
rat
(Rattus norvegicus)
Mammalia Drg1 33
  • 91.73 (n)
oppossum
(Monodelphis domestica)
Mammalia DRG1 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRG1 34 33
  • 81.47 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drg1 33
  • 79.2 (n)
Str.2997 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.92 33
zebrafish
(Danio rerio)
Actinopterygii drg1 34 33
  • 77.53 (n)
OneToOne
wufb06g12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.102 33
fruit fly
(Drosophila melanogaster)
Insecta 128up 34 35 33
  • 70.75 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010624 33
  • 69.49 (n)
worm
(Caenorhabditis elegans)
Secernentea T28D6.6 34 33
  • 66.3 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23287g 33
  • 63.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBG1 36 34 33
  • 62.58 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR372C 33
  • 61.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39520 33
  • 64.85 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4893 33
soybean
(Glycine max)
eudicotyledons Gma.4107 33
rice
(Oryza sativa)
Liliopsida Os07g0627800 33
  • 66.76 (n)
Os.10918 33
wheat
(Triticum aestivum)
Liliopsida Ta.7400 33
corn
(Zea mays)
Liliopsida Zm.6218 33
barley
(Hordeum vulgare)
Liliopsida Hv.1866 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9185 34
  • 81 (a)
OneToOne
Cin.256 33
bread mold
(Neurospora crassa)
Ascomycetes NCU00389 33
  • 61.19 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC9.07c 33
  • 60.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.256 33
Species where no ortholog for DRG1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DRG1 Gene

ENSEMBL:
Gene Tree for DRG1 (if available)
TreeFam:
Gene Tree for DRG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRG1: view image

Paralogs for DRG1 Gene

(2) SIMAP similar genes for DRG1 Gene using alignment to 3 proteins:

  • DRG1_HUMAN
  • F8WEE0_HUMAN
  • H0YI06_HUMAN

Pseudogenes.org Pseudogenes for DRG1 Gene

genes like me logo Genes that share paralogs with DRG1: view

No data available for Paralogs for DRG1 Gene

Variants for DRG1 Gene

Sequence variations from dbSNP and Humsavar for DRG1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000034017 -- 31,408,787(+) T/C intron_variant
rs1000091695 -- 31,403,424(+) T/G intron_variant
rs1000103572 -- 31,398,661(+) A/G upstream_transcript_variant
rs1000106008 -- 31,432,818(+) C/T intron_variant
rs1000114874 -- 31,399,166(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DRG1 Gene

Variant ID Type Subtype PubMed ID
esv1490942 CNV deletion 17803354
esv2656791 CNV deletion 23128226
esv3647585 CNV loss 21293372
nsv1063634 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv834176 CNV loss 17160897

Variation tolerance for DRG1 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRG1 Gene

Disorders for DRG1 Gene

Additional Disease Information for DRG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRG1 Gene

Publications for DRG1 Gene

  1. DRG represents a family of two closely related GTP-binding proteins. (PMID: 10760581) Li B … Trueb B (Biochimica et biophysica acta 2000) 3 4 22 58
  2. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M … van Ree JM (Biological psychiatry 2009) 3 44 58
  3. Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells. (PMID: 19819225) Ishikawa K … Inoue J (Biochemical and biophysical research communications 2009) 3 4 58
  4. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. (PMID: 18184589) Eswaran J … Knapp S (Structure (London, England : 1993) 2008) 3 4 58
  5. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PMID: 17709345) Jakobs A … Niedenthal R (Nucleic acids research 2007) 3 4 58

Products for DRG1 Gene

Sources for DRG1 Gene

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