Aliases for DRG1 Gene
External Ids for DRG1 Gene
Previous HGNC Symbols for DRG1 Gene
Previous GeneCards Identifiers for DRG1 Gene
GeneCards Summary for DRG1 Gene
DRG1 (Developmentally Regulated GTP Binding Protein 1) is a Protein Coding gene. Diseases associated with DRG1 include Charcot-Marie-Tooth Disease, X-Linked Recessive, 5. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is DRG2.
UniProtKB/Swiss-Prot Summary for DRG1 Gene
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).