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Aliases for DRD5 Gene

Aliases for DRD5 Gene

  • Dopamine Receptor D5 2 3 5
  • D1beta Dopamine Receptor 3 4
  • D(5) Dopamine Receptor 3 4
  • Dopamine D5 Receptor 3 4
  • DRD1L2 3 4
  • DRD1B 3 4
  • D(1B) Dopamine Receptor 3
  • Dopamine Receptor D1B 3
  • DBDR 3

External Ids for DRD5 Gene

Previous HGNC Symbols for DRD5 Gene

  • DRD1L2

Previous GeneCards Identifiers for DRD5 Gene

  • GC04P009453
  • GC04M009734
  • GC04P009534
  • GC04P009459
  • GC04P009392
  • GC04P009117

Summaries for DRD5 Gene

Entrez Gene Summary for DRD5 Gene

  • This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD5 Gene

DRD5 (Dopamine Receptor D5) is a Protein Coding gene. Diseases associated with DRD5 include Blepharospasm, Benign Essential and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is DRD1.

UniProtKB/Swiss-Prot for DRD5 Gene

  • Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for DRD5 Gene

  • D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.

Gene Wiki entry for DRD5 Gene

Additional gene information for DRD5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD5 Gene

Genomics for DRD5 Gene

GeneHancer (GH) Regulatory Elements for DRD5 Gene

Promoters and enhancers for DRD5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J009771 Enhancer 0.3 ENCODE 0.4 -10.4 -10382 0.2 NFE2 LOC105374476 DRD5 OR7E35P SLC2A9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DRD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRD5 gene promoter:
  • Sp1
  • LCR-F1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1

Genomic Locations for DRD5 Gene

Genomic Locations for DRD5 Gene
chr4:9,781,634-9,784,009
(GRCh38/hg38)
Size:
2,376 bases
Orientation:
Plus strand
chr4:9,783,258-9,785,633
(GRCh37/hg19)
Size:
2,376 bases
Orientation:
Plus strand

Genomic View for DRD5 Gene

Genes around DRD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD5 Gene

Proteins for DRD5 Gene

  • Protein details for DRD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21918-DRD5_HUMAN
    Recommended name:
    D(1B) dopamine receptor
    Protein Accession:
    P21918
    Secondary Accessions:
    • B2R9S3
    • Q8NEQ8

    Protein attributes for DRD5 Gene

    Size:
    477 amino acids
    Molecular mass:
    52951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DRD5 Gene

Post-translational modifications for DRD5 Gene

No Post-translational modifications

Other Protein References for DRD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD5 Gene

Domains & Families for DRD5 Gene

Gene Families for DRD5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DRD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21918

UniProtKB/Swiss-Prot:

DRD5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD5: view

Function for DRD5 Gene

Molecular function for DRD5 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GENATLAS Biochemistry:
dopamine receptor D5,high affinity,adenylate cyclase stimulating,G protein coupled receptor superfamily,complexing with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions between these receptor systems

Gene Ontology (GO) - Molecular Function for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs TAS 9457173
GO:0001965 G-protein alpha-subunit binding IBA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004952 dopamine neurotransmitter receptor activity IDA 1826762
genes like me logo Genes that share ontologies with DRD5: view
genes like me logo Genes that share phenotypes with DRD5: view

Animal Models for DRD5 Gene

MGI Knock Outs for DRD5:

Animal Model Products

  • Taconic Biosciences Mouse Models for DRD5

CRISPR Products

miRNA for DRD5 Gene

miRTarBase miRNAs that target DRD5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD5

Clone Products

  • Addgene plasmids for DRD5
  • R&D Systems cDNA Clones for DRD5 (Dopamine D5 R/DRD5)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD5 Gene

Localization for DRD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9457173
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with DRD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD5 Gene

Pathways & Interactions for DRD5 Gene

genes like me logo Genes that share pathways with DRD5: view

Gene Ontology (GO) - Biological Process for DRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic NAS 11036203
GO:0001975 response to amphetamine IEA --
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0006874 cellular calcium ion homeostasis TAS 9457173
genes like me logo Genes that share ontologies with DRD5: view

No data available for SIGNOR curated interactions for DRD5 Gene

Drugs & Compounds for DRD5 Gene

(157) Drugs for DRD5 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist, agonist, Target, Target 4008
Apomorphine Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, agonist, Target 40
Bromocriptine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target 33
Cabergoline Approved Pharma Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target, Target 50
Lisuride Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, agonist, Target, antagonist 5

(4) Additional Compounds for DRD5 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-HT
Full agonist, Agonist, Inhibition, Inhibitor
cis flupentixol
Antagonist
NPA
Full agonist, Agonist

(5) Tocris Compounds for DRD5 Gene

Compound Action Cas Number
CY 208-243 Selective D1-like agonist 100999-26-6
Dihydrexidine hydrochloride Selective D1-like agonist 158704-02-0
SCH 23390 hydrochloride Standard selective D1-like antagonist; also 5-HT2C and 5-HT1C agonist and Kir3 channel blocker 125941-87-9
SKF 38393 hydrobromide Selective D1-like agonist 20012-10-6
SKF 81297 hydrobromide D1 agonist 67287-39-2

(97) ApexBio Compounds for DRD5 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride 202646-03-5
4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride 6109-35-9
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
7-Hydroxy-PIPAT maleate 200722-46-9
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Bromocriptine mesylate 22260-51-1
BTCP maleate 207455-25-2
Cariprazine hydrochloride Antipsychotic drug 1083076-69-0
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Cocaine hydrochloride 53-21-4
CY 208-243 100999-26-6
D-Amphetamine sulfate 51-63-8
Dexpramipexole Neuroprotective agent 104632-28-2
Dexpramipexole dihydrochloride Neuroprotective agent 104632-27-1
Diclofensine hydrochloride 34041-84-4
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Eticlopride hydrochloride 97612-24-3
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 Dopamine inhibitor 76778-22-8
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GR 103691 162408-66-4
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Mephedrone hydrochloride 1189726-22-4
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Pemoline 2152-34-3
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
RuBi-Dopa
SB 277011A dihydrochloride 1226917-67-4
SB-277011 215803-78-4
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
Sonepiprazole 170858-33-0
ST-836 Dopamine receptor ligand 1148156-63-1
ST-836 hydrochloride Dopamine receptor ligand 1415564-68-9
Talipexole 101626-70-4
Threo-methylphenidate hydrochloride 298-59-9
U 99194 maleate 234757-41-6
genes like me logo Genes that share compounds with DRD5: view

Drug Products

Transcripts for DRD5 Gene

mRNA/cDNA for DRD5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD5 Gene

Dopamine receptor D5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD5

Clone Products

  • Addgene plasmids for DRD5
  • R&D Systems cDNA Clones for DRD5 (Dopamine D5 R/DRD5)

Alternative Splicing Database (ASD) splice patterns (SP) for DRD5 Gene

No ASD Table

Relevant External Links for DRD5 Gene

GeneLoc Exon Structure for
DRD5
ECgene alternative splicing isoforms for
DRD5

Expression for DRD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRD5 Gene

mRNA differential expression in normal tissues according to GTEx for DRD5 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x10.1), Brain - Cortex (x5.5), Brain - Hippocampus (x5.1), Brain - Frontal Cortex (BA9) (x4.7), Brain - Putamen (basal ganglia) (x4.6), and Brain - Amygdala (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of DRD5 Gene:

DRD5

SOURCE GeneReport for Unigene cluster for DRD5 Gene:

Hs.380681

mRNA Expression by UniProt/SwissProt for DRD5 Gene:

P21918-DRD5_HUMAN
Tissue specificity: Neuron-specific, localized primarily within limbic regions of the brain.

Evidence on tissue expression from TISSUES for DRD5 Gene

  • Nervous system(4.5)
  • Spleen(4)
genes like me logo Genes that share expression patterns with DRD5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD5 Gene

Orthologs for DRD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD5 34 33
  • 98.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DRD5 34 33
  • 89.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DRD5 33
  • 86.84 (n)
DBDR 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd5 16 34 33
  • 83.16 (n)
rat
(Rattus norvegicus)
Mammalia Drd5 33
  • 82.91 (n)
oppossum
(Monodelphis domestica)
Mammalia DRD5 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRD5 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD5 34
  • 76 (a)
OneToOne
SPATA2L 33
  • 75.67 (n)
lizard
(Anolis carolinensis)
Reptilia DRD5 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495174 33
  • 69.35 (n)
zebrafish
(Danio rerio)
Actinopterygii DRD5 (2 of 2) 34
  • 70 (a)
OneToMany
drd7 33
  • 64.2 (n)
DRD5 (1 of 2) 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 35
  • 34 (a)
DopR 34 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-1 34
  • 29 (a)
OneToMany
Species where no ortholog for DRD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD5 Gene

ENSEMBL:
Gene Tree for DRD5 (if available)
TreeFam:
Gene Tree for DRD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRD5: view image

Paralogs for DRD5 Gene

Paralogs for DRD5 Gene

(10) SIMAP similar genes for DRD5 Gene using alignment to 1 proteins:

  • DRD5_HUMAN
genes like me logo Genes that share paralogs with DRD5: view

Variants for DRD5 Gene

Sequence variations from dbSNP and Humsavar for DRD5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs753296791 uncertain-significance, not specified 9,783,213(+) C/T coding_sequence_variant, missense_variant
rs1000448412 -- 9,780,068(+) G/A upstream_transcript_variant
rs1000776213 -- 9,784,375(+) T/C downstream_transcript_variant
rs1003356627 -- 9,781,381(+) A/C upstream_transcript_variant
rs1004658201 -- 9,781,758(+) C/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for DRD5 Gene

Variant ID Type Subtype PubMed ID
nsv999102 CNV gain 25217958
nsv964032 CNV duplication 23825009
nsv482087 CNV gain 20164927
nsv1014335 CNV gain 25217958
nsv1005698 CNV gain 25217958
esv3599593 CNV gain 21293372
esv3599589 CNV gain 21293372
esv2763860 CNV gain+loss 21179565
esv2759222 CNV gain+loss 17122850
dgv5117n100 CNV gain 25217958
dgv5108n100 CNV gain 25217958

Variation tolerance for DRD5 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD5 Gene

Human Gene Mutation Database (HGMD)
DRD5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRD5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD5 Gene

Disorders for DRD5 Gene

MalaCards: The human disease database

(24) MalaCards diseases for DRD5 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
blepharospasm, benign essential
  • blepharospasm, benign essential, susceptibility to
attention deficit-hyperactivity disorder
  • adhd
blepharospasm
focal dystonia
  • dystonia, focal, task-specific
cranio-facial dystonia
  • craniofacial dystonia
- elite association - COSMIC cancer census association via MalaCards
Search DRD5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DRD5_HUMAN
  • Benign essential blepharospasm (BEB) [MIM:606798]: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. {ECO:0000269 PubMed:11781417}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for DRD5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DRD5: view

No data available for Genatlas for DRD5 Gene

Publications for DRD5 Gene

  1. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. (PMID: 18563476) Langley K … Thapar A (European child & adolescent psychiatry 2009) 3 22 44 58
  2. Candidate gene studies of ADHD: a meta-analytic review. (PMID: 19506906) Gizer IR … Waldman ID (Human genetics 2009) 3 22 44 58
  3. Two-stage case-control association study of dopamine-related genes and migraine. (PMID: 19772578) Corominas R … Macaya A (BMC medical genetics 2009) 3 22 44 58
  4. Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. (PMID: 17579368) Langley K … Thapar A (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 44 58
  5. Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes. (PMID: 18665883) Loo SK … Smalley SL (Journal of child psychology and psychiatry, and allied disciplines 2008) 3 22 44 58

Products for DRD5 Gene

  • Addgene plasmids for DRD5

Sources for DRD5 Gene

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