Aliases for DRD5 Gene
External Ids for DRD5 Gene
Previous HGNC Symbols for DRD5 Gene
Previous GeneCards Identifiers for DRD5 Gene
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD5 Gene
DRD5 (Dopamine Receptor D5) is a Protein Coding gene. Diseases associated with DRD5 include Blepharospasm, Benign Essential and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Signaling by GPCR and Development Ligand-independent activation of ESR1 and ESR2. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled amine receptor activity. An important paralog of this gene is DRD1.
UniProtKB/Swiss-Prot Summary for DRD5 Gene
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.