This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorde... See more...

Aliases for DRD4 Gene

Aliases for DRD4 Gene

  • Dopamine Receptor D4 2 3 5
  • D(2C) Dopamine Receptor 3 4
  • D(4) Dopamine Receptor 3 4
  • Dopamine D4 Receptor 3 4
  • Seven Transmembrane Helix Receptor 3
  • D4DR 3

External Ids for DRD4 Gene

Previous GeneCards Identifiers for DRD4 Gene

  • GC11P001092
  • GC11M000923
  • GC11M000559
  • GC11P000627
  • GC11P000452
  • GC11P000638
  • GC11P000646
  • GC11P000653
  • GC11P000656
  • GC11P000644
  • GC11P000645
  • GC11P000661
  • GC11P000666
  • GC11P000647
  • GC11P000649
  • GC11P000650
  • GC11P000652
  • GC11P000655
  • GC11P000657
  • GC11P000659
  • GC11P000660

Summaries for DRD4 Gene

Entrez Gene Summary for DRD4 Gene

  • This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD4 Gene

DRD4 (Dopamine Receptor D4) is a Protein Coding gene. Diseases associated with DRD4 include Attention Deficit-Hyperactivity Disorder and Autonomic Nervous System Disease. Among its related pathways are Circadian entrainment and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and SH3 domain binding. An important paralog of this gene is DRD3.

UniProtKB/Swiss-Prot Summary for DRD4 Gene

  • Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

Tocris Summary for DRD4 Gene

  • D4 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3 and D5. They are located primarily in the frontal cortex, midbrain, amygdala and the cardiovascular system. A role in cognition and emotion has been proposed.

Gene Wiki entry for DRD4 Gene

Additional gene information for DRD4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRD4 Gene

Genomics for DRD4 Gene

GeneHancer (GH) Regulatory Elements for DRD4 Gene

Promoters and enhancers for DRD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000636 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 750.6 +0.0 8 1 EZH2 POLR2A DRD4 NONHSAG007330.2 TMEM80 NONHSAG007331.2
GH11J000443 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -189.5 -189479 8.4 SIN3A SP1 ZBTB40 CTCF SIX5 LCORL MLX RBPJ SMARCE1 POLR2A PTDSS2 PHRF1 SNORA52 TSPAN4 RNH1 RIC8A ENSG00000255237 TMEM80 BET1L LRRC56
GH11J000839 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +206.5 206488 7.6 SIN3A SP1 ZBTB40 SREBF1 SIX5 ZBTB6 LCORL MLX RBPJ POLR2A TSPAN4 POLR2L CD151 TMEM80 SNORA52 ENSG00000255237 RPLP2 PIDD1 RIC8A BET1L
GH11J000234 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -400.6 -400601 3.8 SIN3A SP1 ZBTB40 SMARCE1 RBPJ POLR2A ATF1 CREB1 HCFC1 ELF1 PSMD13 HSALNG0081942 SIRT3 RIC8A SNORA52 PHRF1 TMEM80 ENSG00000255237 BET1L TSPAN4
GH11J000574 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -59.1 -59074 7.2 ZNF785 ZNF24 ZBTB40 SP1 SREBF1 SIX5 MLX RBPJ SMARCE1 POLR2A PHRF1 piR-42043-001 TMEM80 GATD1 SNORA52 BET1L ENSG00000255237 TSPAN4 ENSG00000254739 DRD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRD4 gene promoter:
  • C/EBPalpha
  • p300
  • Sp1

Genomic Locations for DRD4 Gene

Genomic Locations for DRD4 Gene
chr11:637,293-640,706
(GRCh38/hg38)
Size:
3,414 bases
Orientation:
Plus strand
chr11:637,293-640,706
(GRCh37/hg19)
Size:
3,414 bases
Orientation:
Plus strand

Genomic View for DRD4 Gene

Genes around DRD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD4 Gene

Proteins for DRD4 Gene

  • Protein details for DRD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21917-DRD4_HUMAN
    Recommended name:
    D(4) dopamine receptor
    Protein Accession:
    P21917
    Secondary Accessions:
    • B0M0J7
    • Q7Z7Q5
    • Q8NGM5

    Protein attributes for DRD4 Gene

    Size:
    419 amino acids
    Molecular mass:
    43901 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. and 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CLIC6 (By similarity). Interacts with GPRASP1 (PubMed:12142540). May interact with ADORA2A (PubMed:20836733). Interacts with KLHL12 (PubMed:18303015).
    SequenceCaution:
    • Sequence=AAL58637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DRD4 Gene

neXtProt entry for DRD4 Gene

Post-translational modifications for DRD4 Gene

  • Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein.
  • Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane.
  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD4 Gene

Domains & Families for DRD4 Gene

Gene Families for DRD4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DRD4 Gene

GenScript: Design optimal peptide antigens:
  • Dopamine D4 receptor (A4LB49_HUMAN)
  • Dopamine D4 receptor (A4LB54_HUMAN)
  • Dopamine D4 receptor (A4LB56_HUMAN)
  • Dopamine D4 receptor (A4LBB9_HUMAN)
  • Dopamine D4 receptor (DRD4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21917

UniProtKB/Swiss-Prot:

DRD4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD4: view

Function for DRD4 Gene

Molecular function for DRD4 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
Signaling in response to agonists such as dopamine, epinephrine and norepinephrine is modulated by Na(+); lower Na(+) levels result in higher receptor activity (in vitro).
GENATLAS Biochemistry:
dopamine receptor D4,with high affinity for antagonist clozapine,G protein coupled receptor superfamily,not imprinted in the human brain (putatively involved in the susceptibility to Gilles de la Tourette syndrome),and a wide range of neuropsychiatric disorders and normal behavioural variation

Phenotypes From GWAS Catalog for DRD4 Gene

Gene Ontology (GO) - Molecular Function for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS,IMP --
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004952 dopamine neurotransmitter receptor activity IDA 8413587
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0005515 protein binding IPI 12297500
genes like me logo Genes that share ontologies with DRD4: view
genes like me logo Genes that share phenotypes with DRD4: view

Animal Models for DRD4 Gene

MGI Knock Outs for DRD4:
  • Drd4 Drd4<tm1Dkg>
  • Drd4 Drd4<tm1(IL2RA)Tao>

Animal Model Products

CRISPR Products

miRNA for DRD4 Gene

miRTarBase miRNAs that target DRD4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD4

Clone Products

  • Addgene plasmids for DRD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD4 Gene

Localization for DRD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane IBA,IDA 8413587
GO:0016020 membrane IDA 7512953
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with DRD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD4 Gene

Pathways & Interactions for DRD4 Gene

genes like me logo Genes that share pathways with DRD4: view

SIGNOR curated interactions for DRD4 Gene

Activates:

Gene Ontology (GO) - Biological Process for DRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 9843378
GO:0001662 behavioral fear response NAS 12860355
GO:0001975 response to amphetamine IEA,ISS --
GO:0006874 cellular calcium ion homeostasis IC 7921596
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with DRD4: view

Drugs & Compounds for DRD4 Gene

(204) Drugs for DRD4 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist, Target, agonist 4684
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, Target, antagonist Antipsychotic medication 132
Apomorphine Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, Target, agonist 46
Pramipexole Approved, Investigational Pharma Full agonist, Agonist, Target, agonist Dopamine agonist 153
Bromocriptine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Partial agonist, Target, antagonist, agonist 39

(22) Additional Compounds for DRD4 Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SKF-82526
Full agonist, Agonist
Promazine 5-sulfoxide

(5) Tocris Compounds for DRD4 Gene

Compound Action Cas Number
A 412997 dihydrochloride Selective D4 agonist 1347744-96-0
ABT 724 trihydrochloride Potent, selective D4 partial agonist; proerectile 587870-77-7
PD 168077 maleate High affinity, selective D4 agonist 630117-19-0
PNU 96415E D4 and 5-HT2A antagonist; antipsychotic 170856-41-4
Ro 10-5824 dihydrochloride Selective D4 receptor partial agonist 189744-94-3

(105) ApexBio Compounds for DRD4 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride 202646-03-5
4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride 6109-35-9
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
7-Hydroxy-PIPAT maleate 200722-46-9
A 412997 dihydrochloride Selective D4 agonist 1347744-96-0
ABT 724 trihydrochloride Dopamine D4 receptor agonist,potent and selective 587870-77-7
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Bromocriptine mesylate 22260-51-1
BTCP maleate 207455-25-2
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Cariprazine hydrochloride Antipsychotic drug 1083076-69-0
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Cocaine hydrochloride 53-21-4
CY 208-243 100999-26-6
D-Amphetamine sulfate 51-63-8
Dexpramipexole Neuroprotective agent 104632-28-2
Dexpramipexole dihydrochloride Neuroprotective agent 104632-27-1
Diclofensine hydrochloride 34041-84-4
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Eticlopride hydrochloride 97612-24-3
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 Dopamine inhibitor 76778-22-8
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GR 103691 162408-66-4
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
Loxapine Succinate 27833-64-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Mephedrone hydrochloride 1189726-22-4
Mesoridazine 0 5588-33-0
Mesoridazine Besylate 0 32672-69-8
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Pemoline 2152-34-3
Penfluridol 26864-56-2
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
RuBi-Dopa
SB 277011A dihydrochloride 1226917-67-4
SB-277011 215803-78-4
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
Sonepiprazole 170858-33-0
ST-836 Dopamine receptor ligand 1148156-63-1
ST-836 hydrochloride Dopamine receptor ligand 1415564-68-9
Talipexole 101626-70-4
Threo-methylphenidate hydrochloride 298-59-9
U 99194 maleate 234757-41-6
genes like me logo Genes that share compounds with DRD4: view

Drug Products

Transcripts for DRD4 Gene

mRNA/cDNA for DRD4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD4

Clone Products

  • Addgene plasmids for DRD4

Alternative Splicing Database (ASD) splice patterns (SP) for DRD4 Gene

No ASD Table

Relevant External Links for DRD4 Gene

GeneLoc Exon Structure for
DRD4
ECgene alternative splicing isoforms for
DRD4

Expression for DRD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DRD4 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DRD4 Gene



Protein tissue co-expression partners for DRD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DRD4 Gene:

DRD4

SOURCE GeneReport for Unigene cluster for DRD4 Gene:

Hs.99922

mRNA Expression by UniProt/SwissProt for DRD4 Gene:

P21917-DRD4_HUMAN
Tissue specificity: Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.

Evidence on tissue expression from TISSUES for DRD4 Gene

  • Nervous system(4.5)
  • Gall bladder(4.1)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with DRD4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD4 Gene

Orthologs for DRD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD4 33
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd4 17 33 32
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Drd4 32
  • 81.77 (n)
oppossum
(Monodelphis domestica)
Mammalia DRD4 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD4 33 32
  • 66.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD4 33
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drd4 32
  • 66.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6249 32
zebrafish
(Danio rerio)
Actinopterygii drd4a 33 32
  • 61.93 (n)
OneToMany
drd4b 33
  • 54 (a)
OneToMany
drd4-rs 33
  • 50 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDOP3 32
  • 51.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta D2R 33
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-3 33
  • 20 (a)
ManyToMany
dop-2 33
  • 15 (a)
ManyToMany
Species where no ortholog for DRD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD4 Gene

ENSEMBL:
Gene Tree for DRD4 (if available)
TreeFam:
Gene Tree for DRD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRD4: view image

Paralogs for DRD4 Gene

(1) SIMAP similar genes for DRD4 Gene using alignment to 81 proteins:

  • DRD4_HUMAN
  • A4LB49_HUMAN
  • A4LB54_HUMAN
  • A4LB56_HUMAN
  • A4LBB9_HUMAN
  • F6K0T3_HUMAN
  • F6K0T7_HUMAN
  • F6K0T8_HUMAN
  • F6K0T9_HUMAN
  • F6K0U0_HUMAN
  • G5CTX6_HUMAN
  • G9HV62_HUMAN
  • G9HV63_HUMAN
  • G9HV64_HUMAN
  • G9HV65_HUMAN
  • K9MAQ3_HUMAN
  • K9MAQ4_HUMAN
  • K9MAQ5_HUMAN
  • K9MAU6_HUMAN
  • K9MAU8_HUMAN
  • K9MAZ0_HUMAN
  • K9MAZ1_HUMAN
  • K9MB44_HUMAN
  • K9MB45_HUMAN
  • K9MB71_HUMAN
  • K9MB72_HUMAN
  • Q0MTB8_HUMAN
  • Q0MTB9_HUMAN
  • Q76E76_HUMAN
  • Q8IZB1_HUMAN
  • Q8IZB2_HUMAN
  • Q8IZB3_HUMAN
  • Q8IZB4_HUMAN
  • Q8IZB5_HUMAN
  • Q8IZB6_HUMAN
  • Q8IZB7_HUMAN
  • Q8IZB8_HUMAN
  • Q8IZB9_HUMAN
  • Q8IZC0_HUMAN
  • Q8WTQ0_HUMAN
  • Q8WTQ5_HUMAN
  • Q8WTR3_HUMAN
  • Q8WTR5_HUMAN
  • Q8WTR9_HUMAN
  • Q8WTS5_HUMAN
  • Q8WTS7_HUMAN
  • Q8WTT3_HUMAN
  • Q8WTT6_HUMAN
  • Q8WTT7_HUMAN
  • Q8WXL5_HUMAN
  • Q8WXL6_HUMAN
  • Q8WXL7_HUMAN
  • Q8WXL8_HUMAN
  • Q8WXL9_HUMAN
  • Q8WXM0_HUMAN
  • Q8WXM1_HUMAN
  • Q8WXM3_HUMAN
  • Q8WXM4_HUMAN
  • Q8WXM5_HUMAN
  • Q8WXM6_HUMAN
  • Q8WXM7_HUMAN
  • Q8WXM8_HUMAN
  • Q8WXM9_HUMAN
  • Q8WXN0_HUMAN
  • Q8WXN1_HUMAN
  • Q8WXN2_HUMAN
  • Q8WXN3_HUMAN
  • Q8WXN4_HUMAN
  • Q8WXN5_HUMAN
  • Q8WXN6_HUMAN
  • Q8WXN7_HUMAN
  • Q8WXN8_HUMAN
  • Q8WXN9_HUMAN
  • Q8WXP0_HUMAN
  • Q8WXP1_HUMAN
  • Q8WXP2_HUMAN
  • Q8WXP3_HUMAN
  • Q8WXP4_HUMAN
  • Q8WXP5_HUMAN
  • Q8WXP6_HUMAN
  • Q8WXP7_HUMAN
genes like me logo Genes that share paralogs with DRD4: view

Variants for DRD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DRD4 Gene

DRD4_HUMAN-P21917
The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.4. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.

Sequence variations from dbSNP and Humsavar for DRD4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1800443 benign, DOPAMINE RECEPTOR D4 POLYMORPHISM, - 639,830(+) T/G coding_sequence_variant, missense_variant
rs587776842 pathogenic, Autonomic nervous system dysfunction 637,537(+) CCGCCGACCTCCTCC/CC coding_sequence_variant, frameshift
rs886039342 uncertain-significance, not provided 640,417(+) CT/GG coding_sequence_variant, missense_variant
rs200996360 benign, not provided 640,253(+) C/G coding_sequence_variant, missense_variant
rs1000155908 -- 638,474(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DRD4 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
esv2743857 CNV deletion 23290073
esv2759794 CNV loss 17122850
esv2762889 CNV loss 21179565
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1069992 CNV deletion 25765185
nsv1159791 CNV deletion 26073780
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv552861 CNV loss 21841781
nsv552866 CNV loss 21841781
nsv832043 CNV loss 17160897
nsv951271 CNV deletion 24416366

Variation tolerance for DRD4 Gene

Gene Damage Index Score: 6.52; 77.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD4 Gene

Human Gene Mutation Database (HGMD)
DRD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRD4

SNP Genotyping and Copy Number Assay Products

Disorders for DRD4 Gene

MalaCards: The human disease database

(45) MalaCards diseases for DRD4 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DRD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DRD4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DRD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRD4 Gene

Publications for DRD4 Gene

  1. Dopamine receptor D4 polymorphism predicts the effect of L-DOPA on gambling behavior. (PMID: 19914604) Eisenegger C … Fehr E (Biological psychiatry 2010) 3 23 43 56
  2. Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts. (PMID: 20218801) Chien CC … Lung FW (The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2010) 3 23 43 56
  3. Candidate gene studies of ADHD: a meta-analytic review. (PMID: 19506906) Gizer IR … Waldman ID (Human genetics 2009) 3 23 43 56
  4. Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. (PMID: 19219857) Bousman CA … Tsuang MT (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 23 43 56
  5. [Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression]. (PMID: 19827313) Kótyuk E … Székely A (Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 2009) 3 23 43 56

Products for DRD4 Gene

Sources for DRD4 Gene