Aliases for DRD3 Gene
External Ids for DRD3 Gene
Previous GeneCards Identifiers for DRD3 Gene
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD3 Gene
DRD3 (Dopamine Receptor D3) is a Protein Coding gene. Diseases associated with DRD3 include Tremor, Hereditary Essential, 1 and Schizophrenia. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and drug binding. An important paralog of this gene is DRD4.
UniProtKB/Swiss-Prot Summary for DRD3 Gene
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion.