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Aliases for DRD3 Gene

Aliases for DRD3 Gene

  • Dopamine Receptor D3 2 3 5
  • D(3) Dopamine Receptor 3
  • Dopamine D3 Receptor 4
  • Essential Tremor 1 3
  • D3DR 3
  • ETM1 3
  • FET1 3

External Ids for DRD3 Gene

Previous GeneCards Identifiers for DRD3 Gene

  • GC03M110629
  • GC03M113418
  • GC03M115128
  • GC03M115168
  • GC03M115330
  • GC03M113847
  • GC03M111221

Summaries for DRD3 Gene

Entrez Gene Summary for DRD3 Gene

  • This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD3 Gene

DRD3 (Dopamine Receptor D3) is a Protein Coding gene. Diseases associated with DRD3 include Tremor, Hereditary Essential, 1 and Schizophrenia. Among its related pathways are GPCRs, Other and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is DRD2.

UniProtKB/Swiss-Prot for DRD3 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Tocris Summary for DRD3 Gene

  • D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion.

Gene Wiki entry for DRD3 Gene

Additional gene information for DRD3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD3 Gene

Genomics for DRD3 Gene

GeneHancer (GH) Regulatory Elements for DRD3 Gene

Promoters and enhancers for DRD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J114220 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 24.6 -24.9 -24876 6.7 MEIS2 JUN CEBPG GABPA FOSL1 ATF4 IKZF1 ETV6 NR2C2 DRD3 TIGIT ZNF80 ENSG00000241490 GC03P114229
GH03J114212 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -16.0 -15952 6.5 PKNOX1 STAT5A BMI1 FEZF1 BATF IRF4 ZNF121 SCRT2 ATF7 FOS ENSG00000241490 TIGIT DRD3 ZNF80 GC03P114229
GH03J114290 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10 -94.2 -94220 6.4 HDGF PKNOX1 RB1 STAT5A BMI1 BATF KLF5 RAD21 ZNF143 ATF7 TIGIT DRD3 ZBTB20 MIR568
GH03J114152 Enhancer 1.1 Ensembl ENCODE 10.9 +45.6 45558 3.6 SIN3A ZNF2 ZBTB7B ZNF48 ETS1 GLIS2 ZNF213 ZNF207 ZNF143 RXRA DRD3 GC03M114172 GC03M114171 GC03M113853 LOC391566
GH03J114121 Enhancer 0.7 Ensembl ENCODE 11.1 +77.0 76988 2.1 JUND RXRA JUN NR2F2 DRD3 LOC391566 GC03M114172 GC03M114171 GC03M113853
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRD3 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • POU3F2
  • HOXA5
  • POU3F1
  • POU2F1
  • POU2F1a

Genomic Locations for DRD3 Gene

Genomic Locations for DRD3 Gene
71,611 bases
Minus strand
70,756 bases
Minus strand

Genomic View for DRD3 Gene

Genes around DRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD3 Gene

Proteins for DRD3 Gene

  • Protein details for DRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    D(3) dopamine receptor
    Protein Accession:
    Secondary Accessions:
    • A1A4V5
    • Q4VBM8

    Protein attributes for DRD3 Gene

    400 amino acids
    Molecular mass:
    44225 Da
    Quaternary structure:
    • Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).
    • Sequence=AAA03543.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305}; Sequence=AAA64369.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DRD3 Gene

    Alternative splice isoforms for DRD3 Gene


neXtProt entry for DRD3 Gene

Post-translational modifications for DRD3 Gene

Other Protein References for DRD3 Gene

No data available for DME Specific Peptides for DRD3 Gene

Domains & Families for DRD3 Gene

Gene Families for DRD3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD3: view

Function for DRD3 Gene

Molecular function for DRD3 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
GENATLAS Biochemistry:
dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for association of sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence for association with schizophrenia,at least in Caucasians

Phenotypes From GWAS Catalog for DRD3 Gene

Gene Ontology (GO) - Molecular Function for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA,ISS --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004952 dopamine neurotransmitter receptor activity IEA --
GO:0005515 protein binding IPI 10692483
genes like me logo Genes that share ontologies with DRD3: view
genes like me logo Genes that share phenotypes with DRD3: view

Animal Models for DRD3 Gene

MGI Knock Outs for DRD3:

Animal Model Products

CRISPR Products

miRNA for DRD3 Gene

miRTarBase miRNAs that target DRD3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD3

Clone Products

  • Addgene plasmids for DRD3
  • R&D Systems cDNA Clones for DRD3 (Dopamine D3 R/DRD3)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD3 Gene

Localization for DRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD3 Gene

Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8413587
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with DRD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD3 Gene

Pathways & Interactions for DRD3 Gene

genes like me logo Genes that share pathways with DRD3: view

Gene Ontology (GO) - Biological Process for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001975 response to amphetamine IEA --
GO:0002016 regulation of blood volume by renin-angiotensin IEA --
GO:0002031 G-protein coupled receptor internalization IDA 18424554
genes like me logo Genes that share ontologies with DRD3: view

No data available for SIGNOR curated interactions for DRD3 Gene

Drugs & Compounds for DRD3 Gene

(206) Drugs for DRD3 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramipexole Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Dopamine agonist 140
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, antagonist, Target Antipsychotic medication 121
Haloperidol Approved Pharma Antagonist, Pore Blocker, antagonist, Target, inverse agonist Antipsychotic drug 155
Domperidone Approved, Investigational, Vet_approved Pharma Antagonist, antagonist, Target Drug for gastroparesis 51
Amisulpride Approved, Investigational Pharma Antagonist, antagonist, Target Dopamine D2/D3 receptor antagonist 0

(17) Additional Compounds for DRD3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis flupentixol
trans flupenthixol
(+)-PD 128907 hydrochloride

(5) Tocris Compounds for DRD3 Gene

Compound Action Cas Number
(+)-PD 128907 hydrochloride D3 agonist (D3 ? D2 > D4) 300576-59-4
7-Hydroxy-DPAT hydrobromide Dopamine agonist (D3 > D2 < > D4) 76135-30-3
7-Hydroxy-PIPAT maleate D3 agonist (D3 > D2) 200722-46-9
GSK 789472 hydrochloride D3 antagonist. Also D2 partial agonist 1257326-24-1
Pramipexole dihydrochloride Selective D3 agonist 104632-25-9
genes like me logo Genes that share compounds with DRD3: view

Transcripts for DRD3 Gene

mRNA/cDNA for DRD3 Gene

Unigene Clusters for DRD3 Gene

Dopamine receptor D3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD3

Clone Products

  • Addgene plasmids for DRD3
  • R&D Systems cDNA Clones for DRD3 (Dopamine D3 R/DRD3)

Alternative Splicing Database (ASD) splice patterns (SP) for DRD3 Gene

No ASD Table

Relevant External Links for DRD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRD3 Gene

mRNA differential expression in normal tissues according to GTEx for DRD3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x25.6), Brain - Caudate (basal ganglia) (x9.2), and Brain - Putamen (basal ganglia) (x8.7).

NURSA nuclear receptor signaling pathways regulating expression of DRD3 Gene:


SOURCE GeneReport for Unigene cluster for DRD3 Gene:


mRNA Expression by UniProt/SwissProt for DRD3 Gene:

Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for DRD3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with DRD3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD3 Gene

Orthologs for DRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DRD3 34 33
  • 99.17 (n)
(Canis familiaris)
Mammalia DRD3 34 33
  • 89.67 (n)
(Bos Taurus)
Mammalia DRD3 34 33
  • 89.19 (n)
(Mus musculus)
Mammalia Drd3 16 34 33
  • 87.13 (n)
(Rattus norvegicus)
Mammalia Drd3 33
  • 85.71 (n)
(Monodelphis domestica)
Mammalia DRD3 34
  • 71 (a)
(Gallus gallus)
Aves DRD3 34 33
  • 70.94 (n)
(Anolis carolinensis)
Reptilia DRD3 34
  • 65 (a)
(Danio rerio)
Actinopterygii drd3 34 33
  • 63.27 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta D2R 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea dop-2 34 33
  • 46.84 (n)
C09B7.1a 35
  • 31 (a)
C09B7.1b 35
  • 31 (a)
dop-3 34
  • 22 (a)
Species where no ortholog for DRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRD3 Gene

Gene Tree for DRD3 (if available)
Gene Tree for DRD3 (if available)
Evolutionary constrained regions (ECRs) for DRD3: view image

Paralogs for DRD3 Gene

Paralogs for DRD3 Gene

(33) SIMAP similar genes for DRD3 Gene using alignment to 6 proteins:

  • A1A4V4_HUMAN
  • Q13167_HUMAN
  • Q9NY31_HUMAN
genes like me logo Genes that share paralogs with DRD3: view

Variants for DRD3 Gene

Sequence variations from dbSNP and Humsavar for DRD3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1047969695 uncertain-significance, Hereditary Essential Tremor 114,178,735(-) T/C 5_prime_UTR_variant
rs150042478 uncertain-significance, Hereditary Essential Tremor 114,139,532(-) A/T coding_sequence_variant, missense_variant
rs190248679 likely-benign, Hereditary Essential Tremor 114,178,907(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs199852439 uncertain-significance, Hereditary Essential Tremor 114,178,902(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs200206712 uncertain-significance, Hereditary Essential Tremor 114,159,748(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DRD3 Gene

Variant ID Type Subtype PubMed ID
dgv2579n106 CNV deletion 24896259
dgv25e197 CNV deletion 19546169
esv1006467 CNV deletion 20482838
esv1358990 CNV insertion 17803354
esv1654104 CNV deletion 17803354
esv2537070 CNV deletion 19546169
esv2725782 CNV deletion 23290073
esv2841 CNV loss 18987735
esv3302515 CNV tandem duplication 20981092
esv3331967 CNV insertion 20981092
esv3342920 CNV insertion 20981092
esv3562402 CNV deletion 23714750
esv9452 CNV loss 19470904
esv990133 CNV deletion 20482838
nsv1009866 CNV loss 25217958
nsv1073671 CNV deletion 25765185
nsv1142369 CNV tandem duplication 24896259
nsv236315 CNV deletion 16902084
nsv237833 CNV deletion 16902084
nsv956815 CNV deletion 24416366

Variation tolerance for DRD3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD3 Gene

Disorders for DRD3 Gene

MalaCards: The human disease database

(35) MalaCards diseases for DRD3 Gene - From: HGMD, OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tremor, hereditary essential, 1
  • etm1
  • sczd
essential tremor
  • benign essential tremor
  • tremors
obsessive-compulsive personality disorder
  • anankastic personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search DRD3 in MalaCards View complete list of genes associated with diseases


  • Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:16650084, ECO:0000269 PubMed:16809426}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:1362221, ECO:0000269 PubMed:9514583}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for DRD3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DRD3: view

No data available for Genatlas for DRD3 Gene

Publications for DRD3 Gene

  1. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (PMID: 16809426) Jeanneteau F … Sokoloff P (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 44 58
  2. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. (PMID: 9034004) Chen CH … Hsiao KJ (American journal of medical genetics 1997) 3 4 22 44 58
  3. Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium. (PMID: 19309018) van Munster BC … Korevaar JC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 22 44 58
  4. Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study. (PMID: 19766158) Sáiz PA … Bobes J (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 22 44 58
  5. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B … Busto UE (Psychiatry research 2010) 3 22 44 58

Products for DRD3 Gene

  • Addgene plasmids for DRD3

Sources for DRD3 Gene

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