This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to her... See more...

Aliases for DRD3 Gene

Aliases for DRD3 Gene

  • Dopamine Receptor D3 2 3 5
  • D(3) Dopamine Receptor 3 4
  • Dopamine D3 Receptor 4
  • Essential Tremor 1 3
  • D3DR 3
  • ETM1 3
  • FET1 3

External Ids for DRD3 Gene

Previous GeneCards Identifiers for DRD3 Gene

  • GC03M110629
  • GC03M113418
  • GC03M115128
  • GC03M115168
  • GC03M115330
  • GC03M113847
  • GC03M111221

Summaries for DRD3 Gene

Entrez Gene Summary for DRD3 Gene

  • This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD3 Gene

DRD3 (Dopamine Receptor D3) is a Protein Coding gene. Diseases associated with DRD3 include Tremor, Hereditary Essential, 1 and Schizophrenia. Among its related pathways are Monoamine GPCRs and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and drug binding. An important paralog of this gene is DRD4.

UniProtKB/Swiss-Prot Summary for DRD3 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Tocris Summary for DRD3 Gene

  • D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion.

Gene Wiki entry for DRD3 Gene

Additional gene information for DRD3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRD3 Gene

Genomics for DRD3 Gene

GeneHancer (GH) Regulatory Elements for DRD3 Gene

Promoters and enhancers for DRD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J114220 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 24.6 -24.9 -24876 6.7 GABPA CEBPG FOSL1 FOS ZNF584 ATF4 MEIS2 JUN TRIM28 SPI1 DRD3 TIGIT ZNF80 FAM214BP1 ENSG00000241490 lnc-ZNF80-1
GH03J114212 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -16.0 -15952 6.5 EP300 ZIC2 TRIM22 POLR2A HDAC2 CTBP1 BCL11A MYC ZBTB17 TCF7L2 ENSG00000241490 HSALNG0028156 TIGIT DRD3 ZNF80 lnc-ZNF80-1 FAM214BP1
GH03J114290 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10 -94.7 -94711 7.4 CTCF SP1 EP300 ZIC2 ZBTB11 GABPA RELA MEF2C RCOR1 RAD21 TIGIT DRD3 ZBTB20 HSALNG0028163 piR-45932-069
GH03J114152 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 10.9 +45.6 45558 3.6 ZNF217 EP300 CTCF TCF12 USF1 TEAD4 ZNF10 ZIC2 ZNF423 ZBTB26 DRD3 piR-35674-360 lnc-ZNF80-2
GH03J114121 Enhancer 0.7 Ensembl ENCODE 11.1 +76.9 76931 2.2 EP300 NR2F2 JUND MAFK FOS FOXP2 RXRA GATA2 JUN POLR2A DRD3 piR-35674-360 H2BP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRD3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DRD3

Top Transcription factor binding sites by QIAGEN in the DRD3 gene promoter:
  • HOXA5
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • POU3F1
  • POU3F2

Genomic Locations for DRD3 Gene

Genomic Locations for DRD3 Gene
chr3:114,127,797-114,199,407
(GRCh38/hg38)
Size:
71,611 bases
Orientation:
Minus strand
chr3:113,847,499-113,918,254
(GRCh37/hg19)
Size:
70,756 bases
Orientation:
Minus strand

Genomic View for DRD3 Gene

Genes around DRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD3 Gene

Proteins for DRD3 Gene

  • Protein details for DRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35462-DRD3_HUMAN
    Recommended name:
    D(3) dopamine receptor
    Protein Accession:
    P35462
    Secondary Accessions:
    • A1A4V5
    • Q4VBM8

    Protein attributes for DRD3 Gene

    Size:
    400 amino acids
    Molecular mass:
    44225 Da
    Quaternary structure:
    • Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).
    SequenceCaution:
    • Sequence=AAA03543.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA64369.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DRD3 Gene

    Alternative splice isoforms for DRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRD3 Gene

Post-translational modifications for DRD3 Gene

Other Protein References for DRD3 Gene

No data available for DME Specific Peptides for DRD3 Gene

Domains & Families for DRD3 Gene

Gene Families for DRD3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for DRD3 Gene

Blocks:
  • Dopamine receptor signature
  • Dopamine D3 receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRD3 Gene

GenScript: Design optimal peptide antigens:
  • DRD3 protein (A1A4V4_HUMAN)
  • Dopamine D3 receptor (DRD3_HUMAN)
  • Dopamine D3 receptor (Q13167_HUMAN)
  • Dopamine D3 receptor (Q9BXX6_HUMAN)
  • Dopamine D3 receptor (Q9NY31_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35462

UniProtKB/Swiss-Prot:

DRD3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD3: view

Function for DRD3 Gene

Molecular function for DRD3 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
GENATLAS Biochemistry:
dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for association of sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence for association with schizophrenia,at least in Caucasians

Phenotypes From GWAS Catalog for DRD3 Gene

Gene Ontology (GO) - Molecular Function for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA,ISS --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA 21873635
GO:0004952 dopamine neurotransmitter receptor activity IEA --
GO:0005515 protein binding IPI 10692483
genes like me logo Genes that share ontologies with DRD3: view
genes like me logo Genes that share phenotypes with DRD3: view

Human Phenotype Ontology for DRD3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DRD3 Gene

MGI Knock Outs for DRD3:

Animal Model Products

CRISPR Products

miRNA for DRD3 Gene

miRTarBase miRNAs that target DRD3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD3

Clone Products

  • Addgene plasmids for DRD3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DRD3 Gene

Localization for DRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD3 Gene

Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8413587
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DRD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD3 Gene

Pathways & Interactions for DRD3 Gene

genes like me logo Genes that share pathways with DRD3: view

Pathways by source for DRD3 Gene

SIGNOR curated interactions for DRD3 Gene

Activates:

Gene Ontology (GO) - Biological Process for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001963 synaptic transmission, dopaminergic IEA,IBA 21873635
GO:0001975 response to amphetamine IEA --
GO:0002016 regulation of blood volume by renin-angiotensin IEA --
GO:0002031 G protein-coupled receptor internalization IDA 18424554
genes like me logo Genes that share ontologies with DRD3: view

Drugs & Compounds for DRD3 Gene

(207) Drugs for DRD3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramipexole Approved, Investigational Pharma Full agonist, Agonist, Target, agonist Dopamine agonist 155
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, Target, antagonist Antipsychotic medication 134
Haloperidol Approved Pharma Antagonist, Pore Blocker, Target, inverse agonist, antagonist Antipsychotic drug 167
Domperidone Approved, Investigational, Vet_approved Pharma Antagonist, Target, antagonist Drug for gastroparesis 64
Amisulpride Approved, Investigational Pharma Antagonist, Target, antagonist Dopamine D2/D3 receptor antagonist 57

(17) Additional Compounds for DRD3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis flupentixol
Antagonist
trans flupenthixol
Antagonist
(+)-PD 128907 hydrochloride
300576-59-4

(5) Tocris Compounds for DRD3 Gene

Compound Action Cas Number
(+)-PD 128907 hydrochloride D3 agonist (D3 ? D2 > D4) 300576-59-4
7-Hydroxy-DPAT hydrobromide Dopamine agonist (D3 > D2 < > D4) 76135-30-3
7-Hydroxy-PIPAT maleate D3 agonist (D3 > D2) 200722-46-9
GSK 789472 hydrochloride D3 antagonist. Also D2 partial agonist 1257326-24-1
Pramipexole dihydrochloride Selective D3 agonist 104632-25-9

(105) ApexBio Compounds for DRD3 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(R)-(+)-8-Hydroxy-DPAT hydrobromide 78095-19-9
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride 202646-03-5
4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride 6109-35-9
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
7-Hydroxy-PIPAT maleate 200722-46-9
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Amisulpride hydrochloride Dopamine D2/D3 receptor antagonist 81342-13-4
Aripiprazole Antipsychotic 129722-12-9
Bromocriptine mesylate 22260-51-1
BTCP maleate 207455-25-2
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Cariprazine D2/D3 partial agonist,antipsychotic drug 839712-12-8
Cariprazine hydrochloride Antipsychotic drug 1083076-69-0
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Cocaine hydrochloride 53-21-4
CY 208-243 100999-26-6
D-Amphetamine sulfate 51-63-8
Dexpramipexole Neuroprotective agent 104632-28-2
Dexpramipexole dihydrochloride Neuroprotective agent 104632-27-1
Diclofensine hydrochloride 34041-84-4
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Eticlopride hydrochloride 97612-24-3
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 Dopamine inhibitor 76778-22-8
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GR 103691 162408-66-4
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Mephedrone hydrochloride 1189726-22-4
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Pemoline 2152-34-3
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
rac-Rotigotine Hydrochloride Agonist of dopamine D2/D3 receptor 102120-99-0
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Rotigotine Agonist of dopamine D2/D3 receptor 99755-59-6
Rotigotine hydrochloride Agonist of dopamine D2/D3 receptor 125572-93-2
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
RuBi-Dopa
SB 277011A dihydrochloride 1226917-67-4
SB-277011 215803-78-4
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
Sonepiprazole 170858-33-0
ST-836 Dopamine receptor ligand 1148156-63-1
ST-836 hydrochloride Dopamine receptor ligand 1415564-68-9
Talipexole 101626-70-4
Threo-methylphenidate hydrochloride 298-59-9
U 99194 maleate 234757-41-6
genes like me logo Genes that share compounds with DRD3: view

Drug Products

Transcripts for DRD3 Gene

mRNA/cDNA for DRD3 Gene

7 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD3

Clone Products

  • Addgene plasmids for DRD3

Alternative Splicing Database (ASD) splice patterns (SP) for DRD3 Gene

No ASD Table

Relevant External Links for DRD3 Gene

GeneLoc Exon Structure for
DRD3

Expression for DRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRD3 Gene

mRNA differential expression in normal tissues according to GTEx for DRD3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x25.6), Brain - Caudate (basal ganglia) (x9.2), and Brain - Putamen (basal ganglia) (x8.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DRD3

SOURCE GeneReport for Unigene cluster for DRD3 Gene:

Hs.121478

mRNA Expression by UniProt/SwissProt for DRD3 Gene:

P35462-DRD3_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for DRD3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with DRD3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD3 Gene

Orthologs for DRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD3 31 30
  • 99.17 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DRD3 31 30
  • 89.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DRD3 31 30
  • 89.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Drd3 17 31 30
  • 87.13 (n)
rat
(Rattus norvegicus)
Mammalia Drd3 30
  • 85.71 (n)
oppossum
(Monodelphis domestica)
Mammalia DRD3 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves DRD3 31 30
  • 70.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD3 31
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii drd3 31 30
  • 63.27 (n)
OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
Insecta D2R 31
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-2 31 30
  • 46.84 (n)
ManyToMany
C09B7.1b 32
  • 31 (a)
C09B7.1a 32
  • 31 (a)
dop-3 31
  • 22 (a)
ManyToMany
Species where no ortholog for DRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DRD3 Gene

ENSEMBL:
Gene Tree for DRD3 (if available)
TreeFam:
Gene Tree for DRD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRD3: view image

Paralogs for DRD3 Gene

(33) SIMAP similar genes for DRD3 Gene using alignment to 6 proteins:

  • DRD3_HUMAN
  • A1A4V4_HUMAN
  • E9PCM4_HUMAN
  • Q13167_HUMAN
  • Q9BXX6_HUMAN
  • Q9NY31_HUMAN
genes like me logo Genes that share paralogs with DRD3: view

Variants for DRD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DRD3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
726241 Likely Benign: not provided 114,128,872(-) A/G SYNONYMOUS_VARIANT
739655 Likely Benign: not provided 114,159,814(-) G/T SYNONYMOUS_VARIANT
748261 Likely Benign: not provided 114,147,536(-) G/A SYNONYMOUS_VARIANT
748505 Likely Benign: not provided 114,131,170(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
760365 Likely Benign: not provided 114,131,203(-) C/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for DRD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DRD3 Gene

Variant ID Type Subtype PubMed ID
dgv2579n106 CNV deletion 24896259
dgv25e197 CNV deletion 19546169
esv1006467 CNV deletion 20482838
esv1358990 CNV insertion 17803354
esv1654104 CNV deletion 17803354
esv2537070 CNV deletion 19546169
esv2725782 CNV deletion 23290073
esv2841 CNV loss 18987735
esv3302515 CNV tandem duplication 20981092
esv3331967 CNV insertion 20981092
esv3342920 CNV insertion 20981092
esv3562402 CNV deletion 23714750
esv9452 CNV loss 19470904
esv990133 CNV deletion 20482838
nsv1009866 CNV loss 25217958
nsv1073671 CNV deletion 25765185
nsv1142369 CNV tandem duplication 24896259
nsv236315 CNV deletion 16902084
nsv237833 CNV deletion 16902084
nsv956815 CNV deletion 24416366

Variation tolerance for DRD3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD3 Gene

Human Gene Mutation Database (HGMD)
DRD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD3 Gene

Disorders for DRD3 Gene

MalaCards: The human disease database

(67) MalaCards diseases for DRD3 Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tremor, hereditary essential, 1
  • etm1
schizophrenia
  • sczd
essential tremor
  • tremor, hereditary essential, 1
tremor
  • tremors
schizoaffective disorder
  • schizo-affective psychosis
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UniProtKB/Swiss-Prot

DRD3_HUMAN
  • Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:16650084, ECO:0000269 PubMed:16809426}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:1362221, ECO:0000269 PubMed:9514583}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Additional Disease Information for DRD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DRD3: view

No data available for Genatlas for DRD3 Gene

Publications for DRD3 Gene

  1. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (PMID: 16809426) Jeanneteau F … Sokoloff P (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23 41 54
  2. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. (PMID: 9034004) Chen CH … Hsiao KJ (American journal of medical genetics 1997) 3 4 23 41 54
  3. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B … Busto UE (Psychiatry research 2010) 3 23 41 54
  4. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. (PMID: 19897343) Nunokawa A … Someya T (Schizophrenia research 2010) 3 23 41 54
  5. The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis. (PMID: 19358223) Tsai HT … Poole C (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 23 41 54

Products for DRD3 Gene

  • Addgene plasmids for DRD3

Sources for DRD3 Gene