This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to her... See more...

Aliases for DRD3 Gene

Aliases for DRD3 Gene

  • Dopamine Receptor D3 2 3 5
  • D(3) Dopamine Receptor 3 4
  • Dopamine D3 Receptor 4
  • Essential Tremor 1 3
  • D3DR 3
  • ETM1 3
  • FET1 3
  • DRD3 5

External Ids for DRD3 Gene

Previous GeneCards Identifiers for DRD3 Gene

  • GC03M110629
  • GC03M113418
  • GC03M115128
  • GC03M115168
  • GC03M115330
  • GC03M113847
  • GC03M111221

Summaries for DRD3 Gene

Entrez Gene Summary for DRD3 Gene

  • This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD3 Gene

DRD3 (Dopamine Receptor D3) is a Protein Coding gene. Diseases associated with DRD3 include Tremor, Hereditary Essential, 1 and Schizophrenia. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and drug binding. An important paralog of this gene is DRD4.

UniProtKB/Swiss-Prot Summary for DRD3 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

Tocris Summary for DRD3 Gene

  • D3 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D4 and D5. They are located primarily in the nucleus accumbens, olfactory tubercle and island of Calleja where they are involved in the modulation of locomotion.

Gene Wiki entry for DRD3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRD3 Gene

Genomics for DRD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DRD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J114220 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 24.6 -24.9 -24876 6.7 ATF4 MEIS2 TRIM28 NR2C1 ATF3 SPI1 IKZF1 ETV6 CEBPG DRD3 TIGIT ZNF80 lnc-ZNF80-1 LOC107986115 ENSG00000241490
GH03J114212 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -16.0 -15952 6.5 POLR2A ZIC2 BCL11A TRIM22 FEZF1 CTBP1 IRF4 EBF1 TCF7L2 MAX ENSG00000241490 HSALNG0028156 LOC107986115 TIGIT DRD3 ZNF80 HSALNG0028155 lnc-ZNF80-1
GH03J114290 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 -94.6 -94611 7.2 BCLAF1 SP1 POLR2A ZIC2 BCL11A CTCF TRIM22 RAD21 SMC3 YY1 TIGIT DRD3 ZBTB20 piR-45932-069 HSALNG0028163
GH03J114152 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 10.9 +45.6 45558 3.6 ZNF207 ZNF600 ZNF654 ZNF10 POLR2A NFIC ZIC2 CTCF REST ETS1 DRD3 piR-35674-360 lnc-ZNF80-2 CCDC191
GH03J114176 Enhancer 0.6 Ensembl 14.1 +21.6 21559 2.5 REST SIN3A ZNF610 EHMT2 MIER2 TFAP4 TGIF2 ZNF143 AFF1 MIER1 lnc-ZNF80-2 DRD3 piR-35674-360 CCDC191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DRD3

Top Transcription factor binding sites by QIAGEN in the DRD3 gene promoter:
  • HOXA5
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • POU3F1
  • POU3F2

Genomic Locations for DRD3 Gene

Latest Assembly
71,828 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
71,828 bases
Minus strand

(GRCh37/hg19 by Ensembl)
70,756 bases
Minus strand

Genomic View for DRD3 Gene

Genes around DRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD3 Gene

Proteins for DRD3 Gene

  • Protein details for DRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    D(3) dopamine receptor
    Protein Accession:
    Secondary Accessions:
    • A1A4V5
    • Q4VBM8

    Protein attributes for DRD3 Gene

    400 amino acids
    Molecular mass:
    44225 Da
    Quaternary structure:
    • Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).
    • Sequence=AAA03543.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAA64369.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DRD3 Gene

    Alternative splice isoforms for DRD3 Gene


neXtProt entry for DRD3 Gene

Post-translational modifications for DRD3 Gene

No data available for DME Specific Peptides for DRD3 Gene

Domains & Families for DRD3 Gene

Gene Families for DRD3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for DRD3 Gene

  • Dopamine receptor signature
  • Dopamine D3 receptor signature

Suggested Antigen Peptide Sequences for DRD3 Gene

GenScript: Design optimal peptide antigens:
  • DRD3 protein (A1A4V4_HUMAN)
  • Dopamine D3 receptor (DRD3_HUMAN)
  • Dopamine D3 receptor (Q13167_HUMAN)
  • Dopamine D3 receptor (Q9BXX6_HUMAN)
  • Dopamine D3 receptor (Q9NY31_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD3: view

Function for DRD3 Gene

Molecular function for DRD3 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
GENATLAS Biochemistry:
dopamine receptor D3,adenylate cyclase inhibiting,G protein coupled receptor superfamily (no evidence for association of sequence variants and bipolar disorder),or attention-deficit hyperactivity disorder,some evidence for association with schizophrenia,at least in Caucasians

Phenotypes From GWAS Catalog for DRD3 Gene

Gene Ontology (GO) - Molecular Function for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS --
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004952 dopamine neurotransmitter receptor activity IEA --
GO:0005515 protein binding IPI 10692483
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with DRD3: view
genes like me logo Genes that share phenotypes with DRD3: view

Human Phenotype Ontology for DRD3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DRD3 Gene

MGI Knock Outs for DRD3:

miRNA for DRD3 Gene

miRTarBase miRNAs that target DRD3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD3

Clone products for research

  • Addgene plasmids for DRD3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DRD3 Gene

Localization for DRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD3 Gene

Cell membrane. Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 8413587
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with DRD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD3 Gene

Pathways & Interactions for DRD3 Gene

genes like me logo Genes that share pathways with DRD3: view

SIGNOR curated interactions for DRD3 Gene


Gene Ontology (GO) - Biological Process for DRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0002031 G protein-coupled receptor internalization IDA 18424554
GO:0006874 cellular calcium ion homeostasis IDA 7911712
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with DRD3: view

Drugs & Compounds for DRD3 Gene

(188) Drugs for DRD3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramipexole Approved, Investigational Pharma Agonist, Full agonist, Target Dopamine agonist 158
Clozapine Approved Pharma Antagonist, Target Antipsychotic medication 140
Haloperidol Approved Pharma Antagonist, Target, inverse agonist Antipsychotic drug 174
Domperidone Approved, Investigational, Vet_approved Pharma Antagonist, Target Drug for gastroparesis 70
Apomorphine Approved, Investigational Pharma Agonist, Partial agonist, Target 49

(18) Additional Compounds for DRD3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis flupentixol
trans flupenthixol
(+)-PD 128907 hydrochloride
7-Hydroxy-PIPAT maleate

(5) Tocris Compounds for DRD3 Gene

Compound Action Cas Number
(+)-PD 128907 hydrochloride D3 agonist (D3 ? D2 > D4) 300576-59-4
7-Hydroxy-DPAT hydrobromide Dopamine agonist (D3 > D2 < > D4) 76135-30-3
7-Hydroxy-PIPAT maleate D3 agonist (D3 > D2) 200722-46-9
GSK 789472 hydrochloride D3 antagonist. Also D2 partial agonist 1257326-24-1
Pramipexole dihydrochloride Selective D3 agonist 104632-25-9

(83) ApexBio Compounds for DRD3 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(R)-(+)-8-Hydroxy-DPAT hydrobromide 78095-19-9
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Bromocriptine mesylate 22260-51-1
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Cariprazine D2/D3 partial agonist,antipsychotic drug 839712-12-8
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
CY 208-243 100999-26-6
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Eticlopride hydrochloride 97612-24-3
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Rotigotine Agonist of dopamine D2/D3 receptor 99755-59-6
Rotigotine hydrochloride Agonist of dopamine D2/D3 receptor 125572-93-2
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
Sonepiprazole 170858-33-0
U 99194 maleate 234757-41-6
genes like me logo Genes that share compounds with DRD3: view

Drug products for research

Transcripts for DRD3 Gene

mRNA/cDNA for DRD3 Gene

14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD3

Clone products for research

  • Addgene plasmids for DRD3

Alternative Splicing Database (ASD) splice patterns (SP) for DRD3 Gene

No ASD Table

Relevant External Links for DRD3 Gene

GeneLoc Exon Structure for

Expression for DRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRD3 Gene

mRNA differential expression in normal tissues according to GTEx for DRD3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x25.6), Brain - Caudate (basal ganglia) (x9.2), and Brain - Putamen (basal ganglia) (x8.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DRD3

SOURCE GeneReport for Unigene cluster for DRD3 Gene:


mRNA Expression by UniProt/SwissProt for DRD3 Gene:

Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for DRD3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with DRD3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD3 Gene

Orthologs for DRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DRD3 29 30
  • 99.17 (n)
(Canis familiaris)
Mammalia DRD3 29 30
  • 89.67 (n)
(Bos Taurus)
Mammalia DRD3 29 30
  • 89.19 (n)
(Mus musculus)
Mammalia Drd3 29 16 30
  • 87.13 (n)
(Rattus norvegicus)
Mammalia Drd3 29
  • 85.71 (n)
(Monodelphis domestica)
Mammalia DRD3 30
  • 71 (a)
(Gallus gallus)
Aves DRD3 29 30
  • 70.94 (n)
(Anolis carolinensis)
Reptilia DRD3 30
  • 65 (a)
(Danio rerio)
Actinopterygii drd3 29 30
  • 63.27 (n)
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta D2R 30
  • 24 (a)
(Caenorhabditis elegans)
Secernentea dop-2 29 30
  • 46.84 (n)
C09B7.1a 31
  • 31 (a)
C09B7.1b 31
  • 31 (a)
dop-3 30
  • 22 (a)
Species where no ortholog for DRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for DRD3 Gene

Gene Tree for DRD3 (if available)
Gene Tree for DRD3 (if available)
Evolutionary constrained regions (ECRs) for DRD3: view image
Alliance of Genome Resources:
Additional Orthologs for DRD3

Paralogs for DRD3 Gene

(33) SIMAP similar genes for DRD3 Gene using alignment to 6 proteins:

  • A1A4V4_HUMAN
  • Q13167_HUMAN
  • Q9NY31_HUMAN
genes like me logo Genes that share paralogs with DRD3: view

Variants for DRD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DRD3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
1013211 Likely Benign: not provided 114,171,864(-) G/A
NM_000796.6(DRD3):c.129C>T (p.Ile43=)
775897 Benign: not provided 114,139,503(-) C/.
NM_000796.6(DRD3):c.720= (p.Gln240=)
899696 Likely Benign: Hereditary essential tremor 1 114,147,535(-) C/T
NM_000796.6(DRD3):c.406G>A (p.Val136Ile)
899697 Likely Benign: Hereditary essential tremor 1 114,171,881(-) C/T
NM_000796.6(DRD3):c.112G>A (p.Ala38Thr)
rs139341493 Likely Benign: not provided 114,128,872(-) A/G
NM_000796.6(DRD3):c.1047T>C (p.His349=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DRD3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DRD3 Gene

Variant ID Type Subtype PubMed ID
dgv2579n106 CNV deletion 24896259
dgv25e197 CNV deletion 19546169
esv1006467 CNV deletion 20482838
esv1358990 CNV insertion 17803354
esv1654104 CNV deletion 17803354
esv2537070 CNV deletion 19546169
esv2725782 CNV deletion 23290073
esv2841 CNV loss 18987735
esv3302515 CNV tandem duplication 20981092
esv3331967 CNV insertion 20981092
esv3342920 CNV insertion 20981092
esv3562402 CNV deletion 23714750
esv9452 CNV loss 19470904
esv990133 CNV deletion 20482838
nsv1009866 CNV loss 25217958
nsv1073671 CNV deletion 25765185
nsv1142369 CNV tandem duplication 24896259
nsv236315 CNV deletion 16902084
nsv237833 CNV deletion 16902084
nsv956815 CNV deletion 24416366

Variation tolerance for DRD3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD3 Gene

Disorders for DRD3 Gene

MalaCards: The human disease database

(50) MalaCards diseases for DRD3 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
tremor, hereditary essential, 1
  • etm1
  • sczd
essential tremor
  • benign essential tremor
  • tremors
obsessive-compulsive personality disorder
  • anankastic personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search DRD3 in MalaCards View complete list of genes associated with diseases


  • Tremor, hereditary essential 1 (ETM1) [MIM:190300]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:16650084, ECO:0000269 PubMed:16809426}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
  • Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:1362221, ECO:0000269 PubMed:9514583}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Additional Disease Information for DRD3

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DRD3: view

No data available for Genatlas for DRD3 Gene

Publications for DRD3 Gene

  1. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (PMID: 16809426) Jeanneteau F … Sokoloff P (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 40 72
  2. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. (PMID: 9034004) Chen CH … Hsiao KJ (American journal of medical genetics 1997) 3 4 22 40
  3. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B … Busto UE (Psychiatry research 2010) 3 22 40
  4. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. (PMID: 19897343) Nunokawa A … Someya T (Schizophrenia research 2010) 3 22 40
  5. Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study. (PMID: 19766158) Sáiz PA … Bobes J (Progress in neuro-psychopharmacology & biological psychiatry 2010) 3 22 40

Products for DRD3 Gene

  • Addgene plasmids for DRD3

Sources for DRD3 Gene