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This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include Substance Dependence and Pathological Gambling. Among its related pathways are Signaling by GPCR and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and identical protein binding. An important paralog of this gene is ADRA2A.
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go | IDA | 8301582 |
GO:0004930 | G protein-coupled receptor activity | IEA,IBA | 21873635 |
GO:0004952 | dopamine neurotransmitter receptor activity | IEA | -- |
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10692483 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0001669 | acrosomal vesicle | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0005887 | integral component of plasma membrane | IDA | 8413587 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Methylphenidate Pathway, Pharmacodynamics | ||
4 | Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics | ||
5 | Monoamine GPCRs |
.75
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001659 | temperature homeostasis | IEA,ISS | -- |
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
GO:0001963 | synaptic transmission, dopaminergic | IEA | -- |
GO:0001964 | startle response | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Amisulpride | Approved, Investigational | Pharma | Antagonist, Target | Dopamine D2/D3 receptor antagonist | 65 | |
Aripiprazole | Approved, Investigational | Pharma | Target, antagonist, partial agonist, agonist | Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist | 401 | |
Clozapine | Approved | Pharma | Antagonist, Target | Antipsychotic medication | 140 | |
Chlorpromazine | Approved, Investigational, Vet_approved | Pharma | Antagonist, Target | 25 | ||
Domperidone | Approved, Investigational, Vet_approved | Pharma | Antagonist, Target | Drug for gastroparesis | 69 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
cis flupentixol |
|
Antagonist |
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trans flupenthixol |
|
Antagonist |
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Promazine 5-sulfoxide |
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|||||
Sumanirole maleate |
|
179386-44-8 |
|
|
Compound | Action | Cas Number |
---|---|---|
Aripiprazole | High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist | 129722-12-9 |
B-HT 920 | D2 receptor agonist. Also alpha2 agonist and 5-HT3 antagonist | 36085-73-1 |
Sumanirole maleate | D2-selective agonist | 179386-44-8 |
Compound | Action | Cas Number |
---|---|---|
(-)-Quinpirole hydrochloride | 85798-08-9 | |
(+)-AJ 76 hydrochloride | Dopamine receptor antagonist | 85378-82-1 |
(+)-UH 232 maleate | 1217473-50-1 | |
(R)-(-)-Apomorphine hydrochloride | 314-19-2 | |
(RS)-(±)-Sulpiride | 15676-16-1 | |
2-CMDO | 24140-98-5 | |
3-CPMT | 14008-79-8 | |
3'-Fluorobenzylspiperone maleate | 1135278-61-3 | |
6-Hydroxydopamine hydrobromide | 636-00-0 | |
7-Hydroxy-DPAT hydrobromide | 76135-30-3 | |
Alizapride HCl | 59338-87-3 | |
Amantadine HCl | 665-66-7 | |
Ambrisentan | ETA-receptor antagonist | 177036-94-1 |
AMI-193 | 5-HT/D2DR receptor antagonist | 510-74-7 |
Amisulpride | Dopamine D2/D3 receptor antagonist | 71675-85-9 |
Amoxapine | GLYT2a transport activity inhibitor | 14028-44-5 |
Aripiprazole | Antipsychotic | 129722-12-9 |
B-HT 920 | D2 receptor agonist | 36085-73-1 |
Brexpiprazole | 5-HT2A, α1B-, and α2C-adrenergic receptors antagonist | 913611-97-9 |
Bromocriptine mesylate | 22260-51-1 | |
Bupropion hydrochloride | Dopamine/norepinephrine inhibitor | 31677-93-7 |
Cariprazine | D2/D3 partial agonist,antipsychotic drug | 839712-12-8 |
Carmoxirole hydrochloride | 115092-85-8 | |
Chlorpromazine HCl | 69-09-0 | |
Chlorprothixene | 113-59-7 | |
Clozapine | Antipsychotic medication | 5786-21-0 |
CY 208-243 | 100999-26-6 | |
Dihydrexidine hydrochloride | 158704-02-0 | |
Domperidone | Drug for gastroparesis | 57808-66-9 |
Dopamine HCl | 62-31-7 | |
Droperidol | 548-73-2 | |
Eticlopride hydrochloride | 97612-24-3 | |
Flupenthixol dihydrochloride | Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors | 2413-38-9 |
GBR 12783 dihydrochloride | 67469-75-4 | |
GBR 12935 dihydrochloride | 67469-81-2 | |
GBR 13069 dihydrochloride | 67469-45-8 | |
GSK 789472 hydrochloride | 1257326-24-1 | |
Haloperidol | Antipsychotic drug | 52-86-8 |
Iloperidone | Dopamine (D2) and serotonin (5HT2) receptor antagonist | 133454-47-4 |
JHW 007 hydrochloride | 202645-74-7 | |
L-741,626 | 81226-60-0 | |
L-741,742 hydrochloride | 874882-93-6 | |
L-745,870 trihydrochloride | 866021-03-6 | |
LE 300 | 274694-98-3 | |
Levodapa | 59-92-7 | |
Levosulpiride | Antipsychotic drug | 23672-07-3 |
Loxapine Succinate | 27833-64-3 | |
Lurasidone HCl | Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor | 367514-88-3 |
LY404039 | MGlu2 and mGlu3 receptors agonist | 635318-11-5 |
Mesoridazine | 0 | 5588-33-0 |
Mesoridazine Besylate | 0 | 32672-69-8 |
Metoclopramide | Dopamine receptor antagonist | 364-62-5 |
Nemonapride | 75272-39-8 | |
NGB 2904 | 189061-11-8 | |
NGD 94-1 | 178928-68-2 | |
Nomifensine | 32795-47-4 | |
NPEC-caged-dopamine | 1257326-23-0 | |
OSU 6162 hydrochloride | 156907-84-5 | |
Paliperidone | 144598-75-4 | |
PAOPA | 114200-31-6 | |
PD 168077 maleate | 630117-19-0 | |
PD 168568 dihydrochloride | 210688-56-5 | |
PD128907 HCl | 112960-16-4 | |
Penfluridol | 26864-56-2 | |
Pergolide mesylate | 66104-23-2 | |
PG 01037 dihydrochloride | 675599-62-9 | |
Phenothiazine | 92-84-2 | |
Piribedil dihydrochloride | 1451048-94-4 | |
PNU 177864 hydrochloride | 250266-51-4 | |
PNU 96415E | 170856-41-4 | |
Pramipexole | Dopamine agonist | 104632-26-0 |
Pramipexole 2HCl Monohydrate | 191217-81-9 | |
Pramipexole dihydrochloride | Dopamine receptor agonist | 104632-25-9 |
Prochlorperazine | Dopamine (D2) receptor antagonist | 1984-02-6 |
Quetiapine | 111974-69-7 | |
Quetiapine Fumarate | 111974-72-2 | |
Quinelorane hydrochloride | 97548-97-5 | |
Raclopride | 84225-95-6 | |
Remoxipride hydrochloride | 73220-03-8 | |
Ro 10-5824 dihydrochloride | 189744-94-3 | |
Ropinirole HCl | 91374-20-8 | |
Rotigotine | Agonist of dopamine D2/D3 receptor | 99755-59-6 |
Rotigotine hydrochloride | Agonist of dopamine D2/D3 receptor | 125572-93-2 |
Rotundine | Dopamine D1 receptor antagonist,potent and selective | 483-14-7 |
Roxindole hydrochloride | 108050-82-4 | |
RuBi-Dopa | ||
SCH 23390 hydrochloride | 125941-87-9 | |
Sitaxentan sodium | 210421-74-2 | |
SKF 38393 hydrobromide | 20012-10-6 | |
SKF 77434 hydrobromide | 300561-58-4 | |
SKF 81297 hydrobromide | 67287-39-2 | |
SKF 83566 hydrobromide | 108179-91-5 | |
SKF 83822 hydrobromide | 74115-10-9 | |
SKF 83959 hydrobromide | 67287-95-0 | |
Sonepiprazole | 170858-33-0 | |
U 99194 maleate | 234757-41-6 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DRD2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DRD2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DRD2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Drd2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Drd2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DRD2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DRD2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DRD2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DRD2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100493063 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | drd2b 30 31 |
|
OneToMany | |
drd2a 31 |
|
OneToMany | |||
drd2l 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7431 32 |
|
|
|
5-HT2 32 |
|
|
|||
D2R 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | dop-3 30 31 |
|
ManyToMany | |
dop-2 31 |
|
ManyToMany | |||
dop-6 31 |
|
ManyToMany | |||
C24A8.6 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
862358 | Uncertain Significance: Dystonia | 113,414,404(-) |
C/T NM_000795.4(DRD2):c.781G>A (p.Gly261Arg) |
MISSENSE_VARIANT,INTRON | |
935222 | Uncertain Significance: Dystonia; none provided | 113,412,747(-) |
T/G NM_000795.4(DRD2):c.947A>C (p.His316Pro) |
MISSENSE | |
967464 | Uncertain Significance: Dystonia | 113,416,869(-) |
T/C NM_000795.4(DRD2):c.526A>G (p.Asn176Asp) |
MISSENSE | |
rs1027227661 | Uncertain Significance: Dystonia | 113,412,874(-) |
G/A NM_000795.4(DRD2):c.820C>T (p.Arg274Trp) |
MISSENSE | |
rs104894220 | Uncertain Significance: Myoclonic dystonia. - | 113,416,935(-) |
C/Tp.Val154Ile NM_000795.4(DRD2):c.460G>A (p.Val154Ile) |
MISSENSE |
Disorder | Aliases | PubMed IDs |
---|---|---|
substance dependence |
|
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pathological gambling |
|
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cocaine dependence |
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drug dependence |
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antisocial personality disorder |
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