DRD2 Gene (Protein Coding)

Dopamine Receptor D2

GC11M113409
GIFtS:
51
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, bu... See more...

Aliases for DRD2 Gene

Aliases for DRD2 Gene

  • Dopamine Receptor D2 2 3 5
  • D(2) Dopamine Receptor 3 4
  • Dopamine D2 Receptor 3 4
  • Seven Transmembrane Helix Receptor 3
  • D2DR 3
  • DRD2 5
  • D2R 3

External Ids for DRD2 Gene

Previous GeneCards Identifiers for DRD2 Gene

  • GC11M115633
  • GC11M114792
  • GC11M113314
  • GC11M112817
  • GC11M112785
  • GC11M109208
  • GC11M113280

Summaries for DRD2 Gene

Entrez Gene Summary for DRD2 Gene

  • This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD2 Gene

DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include Substance Dependence and Pathological Gambling. Among its related pathways are Signaling by GPCR and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and identical protein binding. An important paralog of this gene is ADRA2A.

UniProtKB/Swiss-Prot Summary for DRD2 Gene

  • Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).

Tocris Summary for DRD2 Gene

  • D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.

Gene Wiki entry for DRD2 Gene

PharmGKB "VIP" Summary for DRD2 Gene

Additional gene information for DRD2 Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for DRD2 Gene

Genomics for DRD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DRD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J113474 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.7 +0.7 690 1.2 ZBTB10 ZIC2 ZNF610 THAP11 SIN3A ZNF395 REST VEZF1 ZNF341 ZSCAN9 DRD2 HSALNG0087250 HSALNG0087251 MIR4301 LOC105369501 ANKK1
GH11J113467 Promoter 0.4 EPDnew 250.4 +8.1 8131 0.1 MNT DRD2 HSALNG0087250 MIR4301 ANKK1
GH11J113476 Enhancer 0.3 Ensembl 250.7 -0.6 -610 0.2 ZNF512 PRDM1 DRD2 HSALNG0087250 HSALNG0087251 LOC105369501 TMPRSS5
GH11J113680 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -206.5 -206469 2.5 FEZF1 ZIC2 ZNF610 ZNF341 ZNF843 TAL1 PRDM6 HDAC2 ZNF24 ZNF189 HSALNG0087264 TMPRSS5 DRD2 LRRC37A13P ENSG00000255129 TTC12 LOC107984390
GH11J113312 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 +161.3 161268 3.6 TBP ZBTB10 SP1 MXD4 NR2C1 MNT ZFP64 POLR2A THAP11 SIN3A TTC12 ENSG00000255129 DRD2 ENSG00000256757 ANKK1 NCAM1-AS1 NCAM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DRD2

Top Transcription factor binding sites by QIAGEN in the DRD2 gene promoter:
  • CREB
  • GR
  • GR-alpha
  • p300
  • Sp1

Genomic Locations for DRD2 Gene

Latest Assembly
chr11:113,409,605-113,475,691
(GRCh38/hg38)
Size:
66,087 bases
Orientation:
Minus strand

Previous Assembly
chr11:113,280,327-113,346,120
(GRCh37/hg19 by Entrez Gene)
Size:
65,794 bases
Orientation:
Minus strand

chr11:113,280,318-113,346,413
(GRCh37/hg19 by Ensembl)
Size:
66,096 bases
Orientation:
Minus strand

Genomic View for DRD2 Gene

Genes around DRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DRD2 Gene

Proteins for DRD2 Gene

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  • Protein details for DRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14416-DRD2_HUMAN
    Recommended name:
    D(2) dopamine receptor
    Protein Accession:
    P14416
    Secondary Accessions:
    • Q9NZR3
    • Q9UPA9

    Protein attributes for DRD2 Gene

    Size:
    443 amino acids
    Molecular mass:
    50619 Da
    Quaternary structure:
    • Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CADPS and CADPS2 (PubMed:15857609). Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with ARRB2 (By similarity). Interacts with HTR2A (PubMed:21645528). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964). Interacts with DRD1 (By similarity). Interacts with KCNA2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DRD2 Gene

    Alternative splice isoforms for DRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRD2 Gene

Protein Expression for DRD2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DRD2 Gene

  • Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.
  • Glycosylation at Asn5, Asn17, and Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD2 Gene

Domains & Families for DRD2 Gene

Gene Families for DRD2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for DRD2 Gene

InterPro:
Blocks:
  • Dopamine receptor signature
  • Dopamine D2 receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for DRD2 Gene

GenScript: Design optimal peptide antigens:
  • Dopamine receptor D2 isoform short (B5BUP4_HUMAN)
  • Dopamine D2 receptor (DRD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14416

UniProtKB/Swiss-Prot:

DRD2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD2: view

Function for DRD2 Gene

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Molecular function for DRD2 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
GENATLAS Biochemistry:
dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor superfamily,expressed in the basal ganglia (contradictory evidence for association of the S311C variant with schizophrenia),regulated by DNA methylation,involved in the regulation of appetite and growth hormone

Phenotypes From GWAS Catalog for DRD2 Gene

Gene Ontology (GO) - Molecular Function for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA 8301582
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004952 dopamine neurotransmitter receptor activity IEA --
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IPI 10692483
genes like me logo Genes that share ontologies with DRD2: view
genes like me logo Genes that share phenotypes with DRD2: view

Human Phenotype Ontology for DRD2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DRD2 Gene

MGI Knock Outs for DRD2:

Animal Models for research

  • Taconic Biosciences Mouse Models for DRD2

miRNA for DRD2 Gene

miRTarBase miRNAs that target DRD2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DRD2 Gene

Localization for DRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD2 Gene

Cell membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001669 acrosomal vesicle IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IDA 8413587
genes like me logo Genes that share ontologies with DRD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD2 Gene

Pathways & Interactions for DRD2 Gene

genes like me logo Genes that share pathways with DRD2: view

Pathways by source for DRD2 Gene

1 GeneGo (Thomson Reuters) pathway for DRD2 Gene
  • Development Dopamine D2 receptor transactivation of EGFR
3 Qiagen pathways for DRD2 Gene
  • CDK5 Pathway
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • Signaling in Gap Junctions

SIGNOR curated interactions for DRD2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA,ISS --
GO:0001666 response to hypoxia IEA --
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0001964 startle response IEA --
genes like me logo Genes that share ontologies with DRD2: view

Drugs & Compounds for DRD2 Gene

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(272) Drugs for DRD2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amisulpride Approved, Investigational Pharma Antagonist, Target Dopamine D2/D3 receptor antagonist 65
Aripiprazole Approved, Investigational Pharma Target, antagonist, partial agonist, agonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 401
Clozapine Approved Pharma Antagonist, Target Antipsychotic medication 140
Chlorpromazine Approved, Investigational, Vet_approved Pharma Antagonist, Target 25
Domperidone Approved, Investigational, Vet_approved Pharma Antagonist, Target Drug for gastroparesis 69

(28) Additional Compounds for DRD2 Gene - From: Novoseek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cis flupentixol
Antagonist
trans flupenthixol
Antagonist
Promazine 5-sulfoxide
  • Promazine 5-sulphoxide
Sumanirole maleate
179386-44-8

(3) Tocris Compounds for DRD2 Gene

Compound Action Cas Number
Aripiprazole High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 129722-12-9
B-HT 920 D2 receptor agonist. Also alpha2 agonist and 5-HT3 antagonist 36085-73-1
Sumanirole maleate D2-selective agonist 179386-44-8

(96) ApexBio Compounds for DRD2 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
AMI-193 5-HT/D2DR receptor antagonist 510-74-7
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Amoxapine GLYT2a transport activity inhibitor 14028-44-5
Aripiprazole Antipsychotic 129722-12-9
B-HT 920 D2 receptor agonist 36085-73-1
Brexpiprazole 5-HT2A, α1B-, and α2C-adrenergic receptors antagonist 913611-97-9
Bromocriptine mesylate 22260-51-1
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Cariprazine D2/D3 partial agonist,antipsychotic drug 839712-12-8
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
CY 208-243 100999-26-6
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Droperidol 548-73-2
Eticlopride hydrochloride 97612-24-3
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
Iloperidone Dopamine (D2) and serotonin (5HT2) receptor antagonist 133454-47-4
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
Loxapine Succinate 27833-64-3
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Mesoridazine 0 5588-33-0
Mesoridazine Besylate 0 32672-69-8
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Penfluridol 26864-56-2
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Phenothiazine 92-84-2
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Prochlorperazine Dopamine (D2) receptor antagonist 1984-02-6
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Ropinirole HCl 91374-20-8
Rotigotine Agonist of dopamine D2/D3 receptor 99755-59-6
Rotigotine hydrochloride Agonist of dopamine D2/D3 receptor 125572-93-2
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
RuBi-Dopa
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
Sonepiprazole 170858-33-0
U 99194 maleate 234757-41-6
genes like me logo Genes that share compounds with DRD2: view

Drug products for research

Transcripts for DRD2 Gene

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mRNA/cDNA for DRD2 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRD2

Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2: - -
SP3:
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for DRD2 Gene

GeneLoc Exon Structure for
DRD2

Expression for DRD2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DRD2 Gene

mRNA expression in normal human tissues for DRD2 Gene
mRNA expression by GTEx for DRD2 GenemRNA expression by BioGPS for DRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRD2 Gene

This gene is overexpressed in Pituitary (x12.9), Brain - Putamen (basal ganglia) (x12.2), Brain - Nucleus accumbens (basal ganglia) (x9.7), and Brain - Caudate (basal ganglia) (x7.8).

Protein differential expression in normal tissues from HIPED for DRD2 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DRD2 Gene



Protein tissue co-expression partners for DRD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DRD2

SOURCE GeneReport for Unigene cluster for DRD2 Gene:

Hs.73893

mRNA Expression by UniProt/SwissProt for DRD2 Gene:

P14416-DRD2_HUMAN
Tissue specificity: [Isoform 1]: Expressed in the anterior pituitary gland.

Evidence on tissue expression from TISSUES for DRD2 Gene

  • Nervous system(4.7)
  • Eye(4.3)
  • Lung(4.3)
  • Adrenal gland(2.4)
  • Skin(2.3)
  • Blood(2.2)
  • Intestine(2.2)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • neck
Limb:
  • digit
  • finger
  • hand
  • upper limb
  • wrist
genes like me logo Genes that share expression patterns with DRD2: view

Orthologs for DRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DRD2 30 31
  • 99.7 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DRD2 30 31
  • 93.98 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DRD2 30 31
  • 93 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Drd2 30 17 31
  • 90.82 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Drd2 30
  • 90.29 (n)
Oppossum
(Monodelphis domestica)
 Mammalia DRD2 31
  • 87 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia DRD2 31
  • 69 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DRD2 30 31
  • 78.67 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia DRD2 31
  • 74 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100493063 30
  • 69.6 (n)
Zebrafish
(Danio rerio)
 Actinopterygii drd2b 30 31
  • 68.89 (n)
 OneToMany
drd2a 31
  • 67 (a)
 OneToMany
drd2l 31
  • 56 (a)
 OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG7431 32
  • 39 (a)
5-HT2 32
  • 37 (a)
D2R 31
  • 25 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea dop-3 30 31
  • 48.47 (n)
 ManyToMany
dop-2 31
  • 17 (a)
 ManyToMany
dop-6 31
  • 15 (a)
 ManyToMany
C24A8.6 31
  • 12 (a)
 ManyToMany
Species where no ortholog for DRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DRD2 Gene

ENSEMBL:
Gene Tree for DRD2 (if available)
TreeFam:
Gene Tree for DRD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRD2: view image

Paralogs for DRD2 Gene

Paralogs for DRD2 Gene

(28) SIMAP similar genes for DRD2 Gene using alignment to 4 proteins:

  • DRD2_HUMAN
  • B5BUP4_HUMAN
  • F8VUV1_HUMAN
  • Q6LDH7_HUMAN
genes like me logo Genes that share paralogs with DRD2: view

Variants for DRD2 Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for DRD2 Gene

DRD2_HUMAN-P14416
Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DRD2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
862358 Uncertain Significance: Dystonia 113,414,404(-) C/T
NM_000795.4(DRD2):c.781G>A (p.Gly261Arg) 		MISSENSE_VARIANT,INTRON
935222 Uncertain Significance: Dystonia; none provided 113,412,747(-) T/G
NM_000795.4(DRD2):c.947A>C (p.His316Pro) 		MISSENSE
967464 Uncertain Significance: Dystonia 113,416,869(-) T/C
NM_000795.4(DRD2):c.526A>G (p.Asn176Asp) 		MISSENSE
rs1027227661 Uncertain Significance: Dystonia 113,412,874(-) G/A
NM_000795.4(DRD2):c.820C>T (p.Arg274Trp) 		MISSENSE
rs104894220 Uncertain Significance: Myoclonic dystonia. - 113,416,935(-) C/Tp.Val154Ile
NM_000795.4(DRD2):c.460G>A (p.Val154Ile) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DRD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DRD2 Gene

Variant ID Type Subtype PubMed ID
nsv1040152 CNV loss 25217958
nsv473342 CNV novel sequence insertion 20440878
nsv523683 CNV loss 19592680
nsv556444 CNV gain 21841781

Variation tolerance for DRD2 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD2 Gene

Human Gene Mutation Database (HGMD)
DRD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRD2

SNP Genotyping and Copy Number Assays for research

Disorders for DRD2 Gene

MalaCards: The human disease database

(115) MalaCards diseases for DRD2 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
substance dependence
pathological gambling
  • compulsive gambling
cocaine dependence
drug dependence
antisocial personality disorder
  • asocial personality
- elite association - COSMIC cancer census association via MalaCards
Search DRD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DRD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DRD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRD2 Gene

Publications for DRD2 Gene

  1. Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. (PMID: 16867246) Wu SN … He L (Acta pharmacologica Sinica 2006) 3 23 26 41
  2. Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PMID: 15389757) Johann M … Wodarz N (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005) 3 4 23 41
  3. Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. (PMID: 15694263) Wu S … He L (Neuroscience letters 2005) 3 23 26 41
  4. Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PMID: 10220438) Klein C … Ozelius LJ (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 23 41
  5. Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study. (PMID: 20146828) Prasad P … Vaswani M (BMC medical genetics 2010) 3 23 41

ExternalLinks

View latest publications for DRD2 gene in Mastermind

Products for DRD2 Gene

  • Addgene plasmids for DRD2

Sources for DRD2 Gene