Aliases for DRD2 Gene
External Ids for DRD2 Gene
Previous GeneCards Identifiers for DRD2 Gene
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRD2 Gene
DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include Substance Dependence and Pathological Gambling. Among its related pathways are Signaling by GPCR and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and identical protein binding. An important paralog of this gene is ADRA2A.
UniProtKB/Swiss-Prot Summary for DRD2 Gene
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
D2 receptors are members of the dopamine receptor G-protein-coupled receptor family that also includes D1, D3, D4 and D5. They are involved in the modulation of locomotion, reward, reinforcement and memory and learning.