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Aliases for DRD1 Gene

Aliases for DRD1 Gene

  • Dopamine Receptor D1 2 3 5
  • Dopamine D1 Receptor 3 4
  • D(1A) Dopamine Receptor 3
  • DRD1A 3
  • DADR 3

External Ids for DRD1 Gene

Previous GeneCards Identifiers for DRD1 Gene

  • GC05M175180
  • GC05M175606
  • GC05M174803
  • GC05M174848
  • GC05M174800
  • GC05M169967

Summaries for DRD1 Gene

Entrez Gene Summary for DRD1 Gene

  • This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRD1 Gene

DRD1 (Dopamine Receptor D1) is a Protein Coding gene. Diseases associated with DRD1 include Cerebral Meningioma and Pathological Gambling. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling and Gap junction. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled amine receptor activity. An important paralog of this gene is DRD5.

UniProtKB/Swiss-Prot for DRD1 Gene

  • Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for DRD1 Gene

  • D1 and D5 receptors (also known as D1-like receptors) are a subset of the dopamine receptor G-protein-coupled receptor family that also includes D2, D3 and D4. The two receptor subtypes are highly homologous and very few ligands are selective between them.

Gene Wiki entry for DRD1 Gene

Additional gene information for DRD1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRD1 Gene

Genomics for DRD1 Gene

GeneHancer (GH) Regulatory Elements for DRD1 Gene

Promoters and enhancers for DRD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J175875 Enhancer 0.4 FANTOM5 dbSUPER 3.9 -431.4 -431360 0.4 DRD1 CPLX2 SIMC1 PIR61181 GC05M175888 PIR44146
GH05J175377 Enhancer 1 ENCODE 0.2 +65.4 65416 2.4 PKNOX1 ARNT FEZF1 GLI4 ZNF2 YY1 GLIS2 ZNF213 KLF7 ZNF548 ENSG00000250909 ENSG00000251414 NIFKP2 ENSG00000248293 OR1X1P ENSG00000251670 ENSG00000270989 LOC105377747 DRD1 ARL2BPP6
GH05J175464 Enhancer 0.6 ENCODE 0.3 -20.6 -20625 0.2 CTCF RNF2 TRIM22 CEBPB ELF1 CEBPG ZNF2 RAD21 XRCC5 ZNF143 SFXN1 DRD1
GH05J175343 Enhancer 0.6 ENCODE 0.2 +99.6 99560 1.5 USF2 REST SP1 ZNF664 JUND ATF3 ZBTB33 FOSL2 FOXP2 ARL2BPP6 DRD1
GH05J175344 Enhancer 0.4 ENCODE 0.1 +100.7 100655 0.2 FOXP2 MAFK ARL2BPP6 DRD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DRD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DRD1 gene promoter:

Genomic Locations for DRD1 Gene

Genomic Locations for DRD1 Gene
chr5:175,440,039-175,444,208
(GRCh38/hg38)
Size:
4,170 bases
Orientation:
Minus strand
chr5:174,867,042-174,871,211
(GRCh37/hg19)

Genomic View for DRD1 Gene

Genes around DRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRD1 Gene

Proteins for DRD1 Gene

  • Protein details for DRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21728-DRD1_HUMAN
    Recommended name:
    D(1A) dopamine receptor
    Protein Accession:
    P21728
    Secondary Accessions:
    • B2RA44
    • Q4QRJ0

    Protein attributes for DRD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49293 Da
    Quaternary structure:
    • Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.

    Three dimensional structures from OCA and Proteopedia for DRD1 Gene

neXtProt entry for DRD1 Gene

Post-translational modifications for DRD1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for DRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRD1 Gene

Domains & Families for DRD1 Gene

Gene Families for DRD1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21728

UniProtKB/Swiss-Prot:

DRD1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with DRD1: view

Function for DRD1 Gene

Molecular function for DRD1 Gene

UniProtKB/Swiss-Prot Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GENATLAS Biochemistry:
dopamine receptor D1,mainly expressed in hypophysis and parathyroid in ovary and granulosa luteal cells,adenylate cyclase stimulating,G protein coupled receptor superfamily,involved in the control of vascular tone

Phenotypes From GWAS Catalog for DRD1 Gene

Gene Ontology (GO) - Molecular Function for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IMP 1282671
GO:0001965 G-protein alpha-subunit binding IBA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004952 dopamine neurotransmitter receptor activity IDA 1831904
genes like me logo Genes that share ontologies with DRD1: view
genes like me logo Genes that share phenotypes with DRD1: view

Animal Models for DRD1 Gene

MGI Knock Outs for DRD1:

Animal Model Products

miRNA for DRD1 Gene

miRTarBase miRNAs that target DRD1

Clone Products

  • Addgene plasmids for DRD1
  • R&D Systems cDNA Clones for DRD1 (Dopamine D1 R/DRD1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRD1 Gene

Localization for DRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRD1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRD1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 3
extracellular 1

Gene Ontology (GO) - Cellular Components for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 2144334
genes like me logo Genes that share ontologies with DRD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRD1 Gene

Pathways & Interactions for DRD1 Gene

genes like me logo Genes that share pathways with DRD1: view

Interacting Proteins for DRD1 Gene

Gene Ontology (GO) - Biological Process for DRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0001661 conditioned taste aversion IEA --
GO:0001662 behavioral fear response IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IEA --
genes like me logo Genes that share ontologies with DRD1: view

No data available for SIGNOR curated interactions for DRD1 Gene

Drugs & Compounds for DRD1 Gene

(223) Drugs for DRD1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clozapine Approved Pharma Antagonist, Positive, Allosteric regulator, Full agonist, Agonist, Inverse agonist, antagonist, Target Antipsychotic medication 121
Haloperidol Approved Pharma Antagonist, Pore Blocker, antagonist, Target Antipsychotic drug 155
Fenoldopam Approved Pharma agonist, Target D1-like dopamine receptor partial agonist 13
Apomorphine Approved, Investigational Pharma Antagonist, Partial agonist, Agonist, Full agonist, Activation, Activator, agonist, Target 40
Bromocriptine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Partial agonist, agonist, Target 33

(31) Additional Compounds for DRD1 Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-HT
Full agonist, Agonist, Inhibition, Inhibitor
cis flupentixol
Antagonist
NPA
Full agonist, Agonist
SKF-82526
Full agonist, Agonist
Promazine 5-sulfoxide

(5) Tocris Compounds for DRD1 Gene

Compound Action Cas Number
CY 208-243 Selective D1-like agonist 100999-26-6
Dihydrexidine hydrochloride Selective D1-like agonist 158704-02-0
SCH 23390 hydrochloride Standard selective D1-like antagonist; also 5-HT2C and 5-HT1C agonist and Kir3 channel blocker 125941-87-9
SKF 38393 hydrobromide Selective D1-like agonist 20012-10-6
SKF 81297 hydrobromide D1 agonist 67287-39-2

(109) ApexBio Compounds for DRD1 Gene

Compound Action Cas Number
(-)-Quinpirole hydrochloride 85798-08-9
(+)-AJ 76 hydrochloride Dopamine receptor antagonist 85378-82-1
(+)-UH 232 maleate 1217473-50-1
(R)-(-)-Apomorphine hydrochloride 314-19-2
(RS)-(±)-Sulpiride 15676-16-1
2-CMDO 24140-98-5
3-CPMT 14008-79-8
3'-Fluorobenzylspiperone maleate 1135278-61-3
3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride 202646-03-5
4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride 6109-35-9
6-Hydroxydopamine hydrobromide 636-00-0
7-Hydroxy-DPAT hydrobromide 76135-30-3
7-Hydroxy-PIPAT maleate 200722-46-9
A 68930 hydrochloride Agonist of D1-like dopamine receptor,potent and selective 130465-39-3
A 77636 hydrochloride Agonist of D1-like dopamine receptor,potent and selective 145307-34-2
Alizapride HCl 59338-87-3
Amantadine HCl 665-66-7
Ambrisentan ETA-receptor antagonist 177036-94-1
Amisulpride Dopamine D2/D3 receptor antagonist 71675-85-9
Aripiprazole Antipsychotic 129722-12-9
Brexpiprazole 5-HT2A, α1B-, and α2C-adrenergic receptors antagonist 913611-97-9
Bromocriptine mesylate 22260-51-1
BTCP maleate 207455-25-2
Bupropion hydrochloride Dopamine/norepinephrine inhibitor 31677-93-7
Cariprazine D2/D3 partial agonist,antipsychotic drug 839712-12-8
Cariprazine hydrochloride Antipsychotic drug 1083076-69-0
Carmoxirole hydrochloride 115092-85-8
Chlorpromazine HCl 69-09-0
Chlorprothixene 113-59-7
Clozapine Antipsychotic medication 5786-21-0
Cocaine hydrochloride 53-21-4
CY 208-243 100999-26-6
D-Amphetamine sulfate 51-63-8
Dexpramipexole Neuroprotective agent 104632-28-2
Dexpramipexole dihydrochloride Neuroprotective agent 104632-27-1
Diclofensine hydrochloride 34041-84-4
Dihydrexidine hydrochloride 158704-02-0
Domperidone Drug for gastroparesis 57808-66-9
Dopamine HCl 62-31-7
Eticlopride hydrochloride 97612-24-3
Fenoldopam D1-like dopamine receptor partial agonist 67227-56-9
Flupenthixol dihydrochloride Antipsychotic drug,exhibits antagonistic activity at dopamine D1-5 receptors 2413-38-9
GBR 12783 dihydrochloride 67469-75-4
GBR 12935 Dopamine inhibitor 76778-22-8
GBR 12935 dihydrochloride 67469-81-2
GBR 13069 dihydrochloride 67469-45-8
GR 103691 162408-66-4
GSK 789472 hydrochloride 1257326-24-1
Haloperidol Antipsychotic drug 52-86-8
Haloperidol hydrochloride Antipsychotic drug 1511-16-6
JHW 007 hydrochloride 202645-74-7
L-741,626 81226-60-0
L-741,742 hydrochloride 874882-93-6
L-745,870 trihydrochloride 866021-03-6
LE 300 274694-98-3
Levodapa 59-92-7
Levosulpiride Antipsychotic drug 23672-07-3
L-Stepholidine D2/D1 receptor agonist 16562-13-3
LY404039 MGlu2 and mGlu3 receptors agonist 635318-11-5
Mephedrone hydrochloride 1189726-22-4
Metoclopramide Dopamine receptor antagonist 364-62-5
Nemonapride 75272-39-8
NGB 2904 189061-11-8
NGD 94-1 178928-68-2
Nomifensine 32795-47-4
NPEC-caged-dopamine 1257326-23-0
OSU 6162 hydrochloride 156907-84-5
Paliperidone 144598-75-4
PAOPA 114200-31-6
PD 168077 maleate 630117-19-0
PD 168568 dihydrochloride 210688-56-5
PD128907 HCl 112960-16-4
Pemoline 2152-34-3
Pergolide mesylate 66104-23-2
PG 01037 dihydrochloride 675599-62-9
Piribedil dihydrochloride 1451048-94-4
PNU 177864 hydrochloride 250266-51-4
PNU 96415E 170856-41-4
Pramipexole Dopamine agonist 104632-26-0
Pramipexole 2HCl Monohydrate 191217-81-9
Pramipexole dihydrochloride Dopamine receptor agonist 104632-25-9
Quetiapine 111974-69-7
Quetiapine Fumarate 111974-72-2
Quinelorane hydrochloride 97548-97-5
Raclopride 84225-95-6
Remoxipride hydrochloride 73220-03-8
Ro 10-5824 dihydrochloride 189744-94-3
Rotundine Dopamine D1 receptor antagonist,potent and selective 483-14-7
Roxindole hydrochloride 108050-82-4
RuBi-Dopa
SB 277011A dihydrochloride 1226917-67-4
SB-277011 215803-78-4
SCH 23390 hydrochloride 125941-87-9
Sitaxentan sodium 210421-74-2
SKF 38393 hydrobromide 20012-10-6
SKF 77434 hydrobromide 300561-58-4
SKF 81297 hydrobromide 67287-39-2
SKF 83566 hydrobromide 108179-91-5
SKF 83822 hydrobromide 74115-10-9
SKF 83959 hydrobromide 67287-95-0
SKF38393 HCl dopamine D1 receptor agonist 62717-42-4
Sonepiprazole 170858-33-0
ST-836 Dopamine receptor ligand 1148156-63-1
ST-836 hydrochloride Dopamine receptor ligand 1415564-68-9
Talipexole 101626-70-4
Threo-methylphenidate hydrochloride 298-59-9
U 99194 maleate 234757-41-6
Vanoxerine DAT1 antagonist 67469-69-6
Vanoxerine dihydrochloride DAT1 antagonist 67469-78-7
genes like me logo Genes that share compounds with DRD1: view

Drug Products

Transcripts for DRD1 Gene

mRNA/cDNA for DRD1 Gene

(13) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DRD1 Gene

Dopamine receptor D1:
Representative Sequences:

Clone Products

  • Addgene plasmids for DRD1
  • R&D Systems cDNA Clones for DRD1 (Dopamine D1 R/DRD1)

Alternative Splicing Database (ASD) splice patterns (SP) for DRD1 Gene

No ASD Table

Relevant External Links for DRD1 Gene

GeneLoc Exon Structure for
DRD1
ECgene alternative splicing isoforms for
DRD1

Expression for DRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.4), Brain - Caudate (basal ganglia) (x13.8), and Brain - Putamen (basal ganglia) (x12.5).

NURSA nuclear receptor signaling pathways regulating expression of DRD1 Gene:

DRD1

SOURCE GeneReport for Unigene cluster for DRD1 Gene:

Hs.2624

mRNA Expression by UniProt/SwissProt for DRD1 Gene:

P21728-DRD1_HUMAN
Tissue specificity: Detected in caudate, nucleus accumbens and in the olfactory tubercle.

Evidence on tissue expression from TISSUES for DRD1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DRD1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRD1 Gene

Orthologs for DRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRD1 34 33
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DRD1 34 33
  • 91.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DRD1 34 33
  • 91.03 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DRD1 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Drd1a 34 33
  • 87.1 (n)
OneToOne
Drd1 16
rat
(Rattus norvegicus)
Mammalia Drd1 33
  • 85.97 (n)
chicken
(Gallus gallus)
Aves DRD1 33
  • 77.48 (n)
D1A 34
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DRD1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia drd1 33
  • 72.22 (n)
zebrafish
(Danio rerio)
Actinopterygii CT025914.2 34
  • 76 (a)
OneToMany
drd1b 34 33
  • 70.1 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6919 35
  • 39 (a)
CG6989 35
  • 34 (a)
DopR 34 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dop-1 34
  • 29 (a)
OneToMany
Species where no ortholog for DRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRD1 Gene

ENSEMBL:
Gene Tree for DRD1 (if available)
TreeFam:
Gene Tree for DRD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRD1: view image

Paralogs for DRD1 Gene

Paralogs for DRD1 Gene

(27) SIMAP similar genes for DRD1 Gene using alignment to 2 proteins:

  • DRD1_HUMAN
  • Q6FH34_HUMAN
genes like me logo Genes that share paralogs with DRD1: view

Variants for DRD1 Gene

Sequence variations from dbSNP and Humsavar for DRD1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000465307 -- 175,440,599(-) G/A downstream_transcript_variant
rs1000583674 -- 175,440,736(-) A/G 3_prime_UTR_variant
rs1000649587 -- 175,445,406(-) T/A upstream_transcript_variant
rs1001943086 -- 175,445,764(-) G/A upstream_transcript_variant
rs1001998450 -- 175,445,435(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DRD1 Gene

Variant ID Type Subtype PubMed ID
esv3607649 CNV gain 21293372

Variation tolerance for DRD1 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRD1 Gene

Human Gene Mutation Database (HGMD)
DRD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRD1 Gene

Disorders for DRD1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for DRD1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral meningioma
  • meningioma of cerebrum
pathological gambling
  • compulsive gambling
early-onset schizophrenia
  • early onset schizophrenia
bipolar i disorder
transient cerebral ischemia
  • tia
- elite association - COSMIC cancer census association via MalaCards
Search DRD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DRD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DRD1 Gene

Publications for DRD1 Gene

  1. Dopamine genes and pathological gambling in discordant sib-pairs. (PMID: 17394052) da Silva Lobo DS … Kennedy JL (Journal of gambling studies 2007) 3 22 25 44 58
  2. Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. (PMID: 17455212) Dolzan V … Breskvar K (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 25 44 58
  3. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B … Busto UE (Psychiatry research 2010) 3 22 44 58
  4. No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample. (PMID: 19647327) Manchia M … Del Zompo M (Psychiatry research 2009) 3 22 44 58
  5. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. (PMID: 19675531) Fung MM … O'Connor DT (Kidney international 2009) 3 22 44 58

Products for DRD1 Gene

  • Addgene plasmids for DRD1

Sources for DRD1 Gene

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