Aliases for DRC1 Gene
External Ids for DRC1 Gene
Previous HGNC Symbols for DRC1 Gene
Previous GeneCards Identifiers for DRC1 Gene
This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]
GeneCards Summary for DRC1 Gene
DRC1 (Dynein Regulatory Complex Subunit 1) is a Protein Coding gene. Diseases associated with DRC1 include Ciliary Dyskinesia, Primary, 21 and Primary Ciliary Dyskinesia. An important paralog of this gene is CCDC65.
UniProtKB/Swiss-Prot Summary for DRC1 Gene
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437).