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Aliases for DRAXIN Gene

Aliases for DRAXIN Gene

  • Dorsal Inhibitory Axon Guidance Protein 2 3 4 5
  • Dorsal Repulsive Axon Guidance Protein 2 3 4
  • Neural Tissue-Specific Cysteine-Rich Protein 2 3
  • C1orf187 3 4
  • Neucrin 3 4
  • Chromosome 1 Open Reading Frame 187 2
  • AGPA3119 3
  • UNQ3119 3
  • Draxin 3

External Ids for DRAXIN Gene

Previous HGNC Symbols for DRAXIN Gene

  • C1orf187

Previous GeneCards Identifiers for DRAXIN Gene

  • GC01P011753

Summaries for DRAXIN Gene

GeneCards Summary for DRAXIN Gene

DRAXIN (Dorsal Inhibitory Axon Guidance Protein) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling.

UniProtKB/Swiss-Prot for DRAXIN Gene

  • Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

Additional gene information for DRAXIN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAXIN Gene

Genomics for DRAXIN Gene

GeneHancer (GH) Regulatory Elements for DRAXIN Gene

Promoters and enhancers for DRAXIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I011689 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.4 +5.0 5024 4.7 SIN3A TCF12 FOS ATF7 SP3 REST ZNF623 ZNF592 MBD2 SMARCA4 MAD2L2 DRAXIN FBXO2 MTHFR CLCN6 TNFRSF1B
GH01I011735 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 +50.2 50239 3.4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 AGTRAP TARDBP TNFRSF1B ENSG00000226849 MAD2L2 DRAXIN EXOSC10 C1orf127 MTHFR CLCN6
GH01I011718 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.6 +32.9 32890 2 ATF1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF213 ARID2 ZNF207 ZNF143 ATF7 MAD2L2 DRAXIN GC01P011722
GH01I010777 Enhancer 1 ENCODE dbSUPER 9.9 -906.8 -906822 3.8 HDAC1 YBX3 NFIB ARNT NFXL1 ARID2 FOS ZNF680 ZBTB2 ELF1 CASZ1 DRAXIN GC01P010673
GH01I011738 Enhancer 0.8 FANTOM5 dbSUPER 12 +52.3 52316 0.2 CTCF STAT1 BHLHE40 IKZF1 ZNF341 ZBTB33 ZNF592 SPI1 TNFRSF1B MAD2L2 DRAXIN C1orf127 CLCN6 MTHFR FBXO6 AGTRAP TNFRSF8 MFN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DRAXIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for DRAXIN Gene

Genomic Locations for DRAXIN Gene
chr1:11,686,647-11,725,857
(GRCh38/hg38)
Size:
39,211 bases
Orientation:
Plus strand
chr1:11,751,781-11,785,914
(GRCh37/hg19)

Genomic View for DRAXIN Gene

Genes around DRAXIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRAXIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRAXIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DRAXIN Gene

Proteins for DRAXIN Gene

  • Protein details for DRAXIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBI3-DRAXI_HUMAN
    Recommended name:
    Draxin
    Protein Accession:
    Q8NBI3
    Secondary Accessions:
    • B6EV15
    • Q5SNX0
    • Q6UWK8

    Protein attributes for DRAXIN Gene

    Size:
    349 amino acids
    Molecular mass:
    38650 Da
    Quaternary structure:
    • Interacts with LRP6.

neXtProt entry for DRAXIN Gene

Post-translational modifications for DRAXIN Gene

  • Glycosylation at posLast=8484 and Asn264

Other Protein References for DRAXIN Gene

No data available for DME Specific Peptides for DRAXIN Gene

Domains & Families for DRAXIN Gene

Gene Families for DRAXIN Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DRAXIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRAXIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBI3

UniProtKB/Swiss-Prot:

DRAXI_HUMAN :
  • Belongs to the draxin family.
Family:
  • Belongs to the draxin family.
genes like me logo Genes that share domains with DRAXIN: view

Function for DRAXIN Gene

Molecular function for DRAXIN Gene

UniProtKB/Swiss-Prot Function:
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

Phenotypes From GWAS Catalog for DRAXIN Gene

Gene Ontology (GO) - Molecular Function for DRAXIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26190107
genes like me logo Genes that share ontologies with DRAXIN: view
genes like me logo Genes that share phenotypes with DRAXIN: view

Animal Models for DRAXIN Gene

MGI Knock Outs for DRAXIN:

miRNA for DRAXIN Gene

miRTarBase miRNAs that target DRAXIN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRAXIN Gene

Localization for DRAXIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAXIN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRAXIN gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DRAXIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS,IBA --
genes like me logo Genes that share ontologies with DRAXIN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRAXIN Gene

Pathways & Interactions for DRAXIN Gene

genes like me logo Genes that share pathways with DRAXIN: view

Pathways by source for DRAXIN Gene

1 R&D Systems pathway for DRAXIN Gene

Gene Ontology (GO) - Biological Process for DRAXIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0021516 dorsal spinal cord development ISS,IEA --
GO:0021528 commissural neuron differentiation in spinal cord ISS,IEA --
genes like me logo Genes that share ontologies with DRAXIN: view

No data available for SIGNOR curated interactions for DRAXIN Gene

Drugs & Compounds for DRAXIN Gene

No Compound Related Data Available

Transcripts for DRAXIN Gene

mRNA/cDNA for DRAXIN Gene

Unigene Clusters for DRAXIN Gene

Dorsal inhibitory axon guidance protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DRAXIN Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for DRAXIN Gene

GeneLoc Exon Structure for
DRAXIN
ECgene alternative splicing isoforms for
DRAXIN

Expression for DRAXIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRAXIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DRAXIN Gene

This gene is overexpressed in Whole Blood (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Cerebellum (x4.5), Brain - Amygdala (x4.4), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for DRAXIN Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DRAXIN Gene



Protein tissue co-expression partners for DRAXIN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DRAXIN Gene:

DRAXIN

SOURCE GeneReport for Unigene cluster for DRAXIN Gene:

Hs.632364

Evidence on tissue expression from TISSUES for DRAXIN Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DRAXIN: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRAXIN Gene

Orthologs for DRAXIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DRAXIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRAXIN 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia C16H1orf187 33
  • 86.73 (n)
DRAXIN 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DRAXIN 33 34
  • 85.63 (n)
mouse
(Mus musculus)
Mammalia Draxin 33 16 34
  • 80.7 (n)
rat
(Rattus norvegicus)
Mammalia Draxin 33
  • 79.86 (n)
oppossum
(Monodelphis domestica)
Mammalia DRAXIN 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DRAXIN 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C21H1ORF187 33
  • 65.31 (n)
DRAXIN 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia draxin 33
  • 56 (n)
zebrafish
(Danio rerio)
Actinopterygii draxin 34
  • 38 (a)
OneToMany
DRAXIN (2 of 2) 34
  • 33 (a)
OneToMany
Species where no ortholog for DRAXIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DRAXIN Gene

ENSEMBL:
Gene Tree for DRAXIN (if available)
TreeFam:
Gene Tree for DRAXIN (if available)

Paralogs for DRAXIN Gene

Pseudogenes.org Pseudogenes for DRAXIN Gene

genes like me logo Genes that share paralogs with DRAXIN: view

No data available for Paralogs for DRAXIN Gene

Variants for DRAXIN Gene

Sequence variations from dbSNP and Humsavar for DRAXIN Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014483 -- 11,696,728(+) C/A intron_variant
rs1000063516 -- 11,707,782(+) T/C 3_prime_UTR_variant, intron_variant
rs1000118155 -- 11,701,844(+) C/T intron_variant
rs1000234007 -- 11,699,798(+) G/A intron_variant
rs1000286240 -- 11,699,981(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DRAXIN Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV loss 17160897
nsv1076104 CNV deletion 25765185

Variation tolerance for DRAXIN Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRAXIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRAXIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAXIN Gene

Disorders for DRAXIN Gene

Additional Disease Information for DRAXIN

No disorders were found for DRAXIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRAXIN Gene

Publications for DRAXIN Gene

  1. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. (PMID: 19857465) Miyake A … Itoh N (Biochemical and biophysical research communications 2009) 3 4 58
  2. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. (PMID: 19150847) Islam SM … Tanaka H (Science (New York, N.Y.) 2009) 2 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58

Products for DRAXIN Gene

Sources for DRAXIN Gene

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