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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
DRAP1 (DR1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by NODAL. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is NFYC.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001046 | core promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0001091 | RNA polymerase II basal transcription factor binding | IPI | 8670811 |
GO:0003677 | contributes_to DNA binding | IDA | 8670811 |
GO:0003713 | transcription coactivator activity | IBA | 21873635 |
GO:0003714 | transcription corepressor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0017054 | negative cofactor 2 complex | IBA | 21873635 |
GO:0090575 | RNA polymerase II transcription factor complex | IDA | 8670811 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by NODAL | ||
2 | Developmental Biology | ||
3 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS,IDA | 8670811 |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
GO:0006366 | transcription by RNA polymerase II | IBA | 21873635 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DRAP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
DRAP1 30 |
|
||||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | DRAP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Drap1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Drap1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DRAP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | drap1 30 |
|
||
MGC75665 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23737 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | drap1 30 31 |
|
OneToOne | |
Dr.719 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | NC2alpha 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | drap-1 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BUR6 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9522 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.259 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs149754486 | Benign: not provided | 65,919,785(+) |
G/A NM_006442.4(DRAP1):c.48G>A (p.Arg16=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759834 | CNV | gain | 17122850 |
nsv1159905 | CNV | duplication | 26073780 |
nsv832191 | CNV | loss | 17160897 |
No disorders were found for DRAP1 Gene.