Aliases for DRAP1 Gene
Aliases for DRAP1 Gene
External Ids for DRAP1 Gene
- HGNC: 3019
- Entrez Gene: 10589
- Ensembl: ENSG00000175550
- OMIM: 602289
- UniProtKB: Q14919
Previous GeneCards Identifiers for DRAP1 Gene
- GC11P068221
- GC11P067368
- GC11P065462
- GC11P065443
- GC11P065686
- GC11P062013
Summaries for DRAP1 Gene
-
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRAP1 Gene
DRAP1 (DR1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by NODAL and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot for DRAP1 Gene
-
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DRAP1 Gene
Genomics for DRAP1 Gene
GeneHancer (GH) Regulatory Elements for DRAP1 Gene
Promoters and enhancers for DRAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DRAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DRAP1 gene promoter:
Regulatory Element Products
Genomic Locations for DRAP1 Gene
Genomic Locations for DRAP1 Gene
- chr11:65,919,257-65,921,577
- (GRCh38/hg38)
- Size:
- 2,321 bases
- Orientation:
- Plus strand
- chr11:65,686,728-65,689,048
- (GRCh37/hg19)
Genomic View for DRAP1 Gene
Genes around DRAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
DRAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DRAP1 Gene
Proteins for DRAP1 Gene
-
Protein details for DRAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14919-NC2A_HUMAN
- Recommended name:
- Dr1-associated corepressor
- Protein Accession:
- Q14919
- Q13448
Protein attributes for DRAP1 Gene
- Size:
- 205 amino acids
- Molecular mass:
- 22350 Da
- Quaternary structure:
-
- Heterodimer with DR1. Binds BTAF1.
Protein Expression for DRAP1 Gene
Post-translational modifications for DRAP1 Gene
- Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
Other Protein References for DRAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DRAP1
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-
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-
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Protein Products
-
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-
Abcam proteins for DRAP1
Assay Products
- antibodies-online: Search results for 4 available DRAP1 Elisa Kits ranked by validation data
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Quality Products:
No data available for DME Specific Peptides for DRAP1 Gene
Domains & Families for DRAP1 Gene
Gene Families for DRAP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DRAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DRAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14919- Family:
-
- Belongs to the NC2 alpha/DRAP1 family.
Function for DRAP1 Gene
Molecular function for DRAP1 Gene
- GENATLAS Biochemistry:
- Dr1-associated polypeptide,corepressor of transcription,expressed with higher levels in tissues with low mitotic index
- UniProtKB/Swiss-Prot Function:
- The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Phenotypes From GWAS Catalog for DRAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS,IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 8608938 |
| GO:0003714 | transcription corepressor activity | TAS | 8608938 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0042802 | identical protein binding | IPI | 25416956 |
Phenotypes for DRAP1 Gene
- MGI mutant phenotypes for DRAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DRAP1:
Animal Models for DRAP1 Gene
- MGI Knock Outs for DRAP1:
-
- Drap1 tm1Mms
Animal Model Products
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-
-
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-
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CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DRAP1
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miRNA for DRAP1 Gene
- miRTarBase miRNAs that target DRAP1
miRNA Products
- Search ViGene Biosciences for DRAP1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DRAP1
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Clone Products
- Sino Biological Human cDNA Clone for DRAP1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DRAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DRAP1
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRAP1 Gene
Localization for DRAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DRAP1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for DRAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NODAL | ||
| 2 | Developmental Biology | ||
| 3 | Signaling by GPCR | ||
Pathways by source for DRAP1 Gene
4 Reactome pathways for DRAP1 Gene
Interacting Proteins for DRAP1 Gene
Selected Interacting proteins:
Q14919-NC2A_HUMAN
ENSP00000307850
for DRAP1 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 8608938 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for DRAP1 Gene
Transcripts for DRAP1 Gene
mRNA/cDNA for DRAP1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (266) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DRAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DRAP1
- genomics-online: gRNA clones - Search results for 105 available DRAP1 gene related products
- Overview of 105 available DRAP1 gene related products
- Applied Biological Materials CRISPR for DRAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DRAP1
- GenScript: Design CRISPR guide RNA sequences for DRAP1
miRNA Products
- Search ViGene Biosciences for DRAP1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DRAP1
- Browse OriGene Inhibitory RNA Products For DRAP1
- genomics-online: shRNA clones - Search results for 105 available DRAP1 gene related products
- Overview of 105 available DRAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DRAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for DRAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DRAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DRAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DRAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: |
Expression for DRAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in CD8 Tcells (14.1), Blymphocyte (7.3), and Peripheral blood mononuclear cells (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DRAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DRAP1 Gene:
DRAP1SOURCE GeneReport for Unigene cluster for DRAP1 Gene:
Hs.356742mRNA Expression by UniProt/SwissProt for DRAP1 Gene:
Q14919-NC2A_HUMAN
Tissue specificity:
Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
Evidence on tissue expression from TISSUES for DRAP1 Gene
- Muscle(4.4)
- Lung(4)
- Nervous system(4)
- Pancreas(3.9)
- Skin(3.7)
- Eye(3.3)
- Intestine(3.3)
- Bone(2.9)
- Liver(2.4)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DRAP1
-
OriGene qPCR primer pairs for DRAP1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRAP1 Gene
Orthologs for DRAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DRAP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| DRAP1 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | DRAP1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Drap1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Drap1 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DRAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | drap1 33 |
|
||
| MGC75665 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23737 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | drap1 33 34 |
|
||
| Dr.719 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | NC2alpha 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | drap-1 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BUR6 34 36 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9522 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.259 33 |
|
- Species where no ortholog for DRAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DRAP1 Gene
No data available for Paralogs for DRAP1 Gene
Variants for DRAP1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000308235 | -- | 65,917,377(+) | C/A/T | upstream_transcript_variant | |
| rs1000508303 | -- | 65,921,606(+) | C/G | downstream_transcript_variant | |
| rs1001663632 | -- | 65,917,485(+) | G/A | upstream_transcript_variant | |
| rs1002002692 | -- | 65,919,076(+) | G/A | upstream_transcript_variant | |
| rs1002118650 | -- | 65,919,003(+) | G/A/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832191 | CNV | loss | 17160897 |
| nsv1159905 | CNV | duplication | 26073780 |
| esv2759834 | CNV | gain | 17122850 |
Residual Variation Intolerance Score:
49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DRAP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DRAP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAP1 Gene
Disorders for DRAP1 Gene
Additional Disease Information for DRAP1
No disorders were found for DRAP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRAP1 Gene
Publications for DRAP1 Gene
- NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. (PMID: 15509807) Klejman MP … Timmers HT (Molecular and cellular biology 2004) 3 4 22 58
- Requirement of a corepressor for Dr1-mediated repression of transcription. (PMID: 8608938) Mermelstein F … Reinberg D (Genes & development 1996) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. (PMID: 11461703) Kamada K … Burley SK (Cell 2001) 3 4 58
- A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. (PMID: 8670811) Goppelt A … Meisterernst M (The EMBO journal 1996) 3 4 58
Products for DRAP1 Gene
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- VectorBuilder custom plasmid, inducible vectors for DRAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DRAP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 44 available DRAP1 Antibodies ranked by validation data
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Sources for DRAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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