Aliases for DRAP1 Gene
External Ids for DRAP1 Gene
Previous GeneCards Identifiers for DRAP1 Gene
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRAP1 Gene
DRAP1 (DR1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by NODAL and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot for DRAP1 Gene
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.