Aliases for DRAM2 Gene
External Ids for DRAM2 Gene
Previous HGNC Symbols for DRAM2 Gene
Previous GeneCards Identifiers for DRAM2 Gene
The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
GeneCards Summary for DRAM2 Gene
DRAM2 (DNA Damage Regulated Autophagy Modulator 2) is a Protein Coding gene. Diseases associated with DRAM2 include Cone-Rod Dystrophy 21 and Inherited Retinal Disorder. An important paralog of this gene is DRAM1.
UniProtKB/Swiss-Prot Summary for DRAM2 Gene
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.