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The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017] See more...
Aliases for DRAM2 Gene
Aliases for DRAM2 Gene
External Ids for DRAM2 Gene
- HGNC: 28769
- Entrez Gene: 128338
- Ensembl: ENSG00000156171
- OMIM: 613360
- UniProtKB: Q6UX65
Previous HGNC Symbols for DRAM2 Gene
- TMEM77
Previous GeneCards Identifiers for DRAM2 Gene
- GC01M111461
- GC01M111659
- GC01M109531
Summaries for DRAM2 Gene
-
The protein encoded by this gene binds microtubule-associated protein 1 light chain 3 and is required for autophagy. Defects in this gene are a cause of retinal dystrophy. In addition, two microRNAs (microRNA 125b-1 and microRNA 144) can bind to the mRNA of this gene and produce the disease state. [provided by RefSeq, Mar 2017]
GeneCards Summary for DRAM2 Gene
DRAM2 (DNA Damage Regulated Autophagy Modulator 2) is a Protein Coding gene. Diseases associated with DRAM2 include Cone-Rod Dystrophy 21 and Inherited Retinal Disorder. An important paralog of this gene is DRAM1.
UniProtKB/Swiss-Prot Summary for DRAM2 Gene
-
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Additional gene information for DRAM2 Gene
- HGNC(28769)
- Entrez Gene(128338)
- Ensembl(ENSG00000156171)
- OMIM(613360)
- UniProtKB(Q6UX65)
- Open Targets Platform(ENSG00000156171)
- Monarch Initiative
- Search for DRAM2 at DataMed
- Search for DRAM2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRAM2 Gene
Genomics for DRAM2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DRAM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DRAM2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DRAM2
Genomic Locations for DRAM2 Gene
Genomic Locations for DRAM2 Gene
- chr1:111,117,163-111,140,216
- (GRCh38/hg38)
- Size:
- 23,054 bases
- Orientation:
- Minus strand
- chr1:111,659,954-111,682,838
- (GRCh37/hg19)
- Size:
- 22,885 bases
- Orientation:
- Minus strand
Genomic View for DRAM2 Gene
Genes around DRAM2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
DRAM2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DRAM2 Gene
Proteins for DRAM2 Gene
-
Protein details for DRAM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UX65-DRAM2_HUMAN
- Recommended name:
- DNA damage-regulated autophagy modulator protein 2
- Protein Accession:
- Q6UX65
- B3SUG9
- Q4VWF6
- Q86VD3
- Q8NBQ4
Protein attributes for DRAM2 Gene
- Size:
- 266 amino acids
- Molecular mass:
- 29766 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC11562.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DRAM2 Gene
Post-translational modifications for DRAM2 Gene
Other Protein References for DRAM2 Gene
Antibody Products
- Creative Diagnostics Anti-DRAM2 (aa 233-266) polyclonal antibody
- Creative Biolabs Mouse Anti-DRAM2 Recombinant Antibody (13A175)
- Novus Biologicals Antibodies for DRAM2
- Invitrogen Antibodies for DRAM2 (AFLGC-DRAM2)
- antibodies-online: Show 3 available DRAM2 Antibodies ranked by validation data
- Compare Top DRAM2 Antibodies
-
Quality Products:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DRAM2
- Origene Custom Protein Services for DRAM2
- Novus Biologicals proteins for DRAM2
No data available for DME Specific Peptides for DRAM2 Gene
Domains & Families for DRAM2 Gene
Gene Families for DRAM2 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for DRAM2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DRAM2 Gene
- GenScript: Design optimal peptide antigens:
-
- Transmembrane protein 77 (DRAM2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6UX65- Family:
-
- Belongs to the DRAM/TMEM150 family.
Function for DRAM2 Gene
Molecular function for DRAM2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
- UniProtKB/Swiss-Prot Induction:
- Not induced by p53/TP53 or TP73/p73.
Phenotypes From GWAS Catalog for DRAM2 Gene
Phenotypes for DRAM2 Gene
- MGI mutant phenotypes for DRAM2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DRAM2:
Animal Models for DRAM2 Gene
- MGI Knock Outs for DRAM2:
-
- Dram2 Dram2<tm1b(EUCOMM)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for DRAM2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DRAM2 - Select products 50% OFF >
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OriGene CRISPR knockouts for DRAM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DRAM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DRAM2
miRNA for DRAM2 Gene
- miRTarBase miRNAs that target DRAM2
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for DRAM2 - Select products 50% OFF >
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-
- MG201603
- MG218120
- MR201603
- MR201603L3
- MR201603L4
- MR218120
- MR218120L3
- MR218120L4
- MR228900
- MR228901
- RC213085
- RC213085L1
- RC213085L2
- RC213085L3
- RC213085L4
- RG213085
- RR212454
- RR212454L3
- RR212454L4
- MR201603L3V
- MR201603L4V
- MR218120L3V
- MR218120L4V
- RC213085L1V
- RC213085L2V
- RC213085L3V
- RC213085L4V
- RR212454L3V
- RR212454L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DRAM2
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Cell Line Products
-
Horizon Cell Lines for DRAM2
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DRAM2 Gene
Localization for DRAM2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DRAM2 Gene
- Lysosome membrane. Multi-pass membrane protein. Photoreceptor inner segment. Apical cell membrane. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250 UniProtKB:Q9CR48}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 5 |
| golgi apparatus | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
- Golgi apparatus (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001917 | photoreceptor inner segment | ISS | -- |
| GO:0005737 | cytoplasm | IDA | 19895784 |
| GO:0005764 | lysosome | IBA,IDA | 19556885 |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for DRAM2 Gene
Interacting Proteins for DRAM2 Gene
GPS-Prot Interaction Network for DRAM2
SIGNOR curated interactions for DRAM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006914 | autophagy | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007601 | visual perception | IMP | 25983245 |
| GO:0010506 | regulation of autophagy | IDA | 19895784 |
| GO:0045494 | photoreceptor cell maintenance | IMP | 25983245 |
No data available for Pathways by source for DRAM2 Gene
Transcripts for DRAM2 Gene
mRNA/cDNA for DRAM2 Gene
- 13 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000286692 2246 nts (view in UCSC)
- ENST00000484310 1872 nts (view in UCSC)
- ENST00000461449 611 nts (view in UCSC)
- ENST00000496430 767 nts (view in UCSC)
- ENST00000477588 502 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DRAM2 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for DRAM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DRAM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DRAM2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DRAM2
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Clone Products
- Applied Biological Materials (abm): Clones for DRAM2 - Select products 50% OFF >
- * DRAM2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201603
- MG218120
- MR201603
- MR201603L3
- MR201603L4
- MR218120
- MR218120L3
- MR218120L4
- MR228900
- MR228901
- RC213085
- RC213085L1
- RC213085L2
- RC213085L3
- RC213085L4
- RG213085
- RR212454
- RR212454L3
- RR212454L4
- MR201603L3V
- MR201603L4V
- MR218120L3V
- MR218120L4V
- RC213085L1V
- RC213085L2V
- RC213085L3V
- RC213085L4V
- RR212454L3V
- RR212454L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DRAM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DRAM2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
Relevant External Links for DRAM2 Gene
- GeneLoc Exon Structure for
- DRAM2
Expression for DRAM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Lung (26.5), Islet of Langerhans (17.6), and Blymphocyte (12.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DRAM2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DRAM2
SOURCE GeneReport for Unigene cluster for DRAM2 Gene:
Hs.485606mRNA Expression by UniProt/SwissProt for DRAM2 Gene:
Q6UX65-DRAM2_HUMAN
Tissue specificity:
Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Expressed in the retina. Not detected in brain or thymus.
Evidence on tissue expression from TISSUES for DRAM2 Gene
- Nervous system(4.7)
- Eye(4.4)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DRAM2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- lacrimal apparatus
- pituitary gland
Thorax:
- breast
Pelvis:
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vulva
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for DRAM2
-
OriGene qPCR primer pairs and template standards for DRAM2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for DRAM2 Gene
Orthologs for DRAM2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DRAM2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DRAM2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DRAM2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dram2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dram2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DRAM2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DRAM2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DRAM2 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | DRAM2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dram2b 30 31 |
|
OneToMany | |
| dram2a 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG4025 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C33A11.2 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2907 31 |
|
OneToOne |
- Species where no ortholog for DRAM2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for DRAM2 Gene
- ENSEMBL:
- Gene Tree for DRAM2 (if available)
- TreeFam:
- Gene Tree for DRAM2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DRAM2: view image
Paralogs for DRAM2 Gene
Variants for DRAM2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DRAM2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 677168 | Benign: not provided | 111,118,906(-) | T/C | INTRON_VARIANT | |
| 677169 | Benign: not provided | 111,118,791(-) | T/C | INTRON_VARIANT | |
| 733284 | Likely Benign: not provided | 111,124,775(-) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 735837 | Likely Benign: not provided | 111,131,516(-) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 786853 | Benign: not provided | 111,118,183(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Residual Variation Intolerance Score:
52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.28;
25.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DRAM2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAM2 Gene
Disorders for DRAM2 Gene
(6) MalaCards diseases for DRAM2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cone-rod dystrophy 21 |
|
|
| inherited retinal disorder |
|
|
| cone-rod dystrophy 2 |
|
|
| fundus dystrophy |
|
|
| cone-rod dystrophy 16 |
|
|
Search DRAM2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DRAM2_HUMAN- Cone-rod dystrophy 21 (CORD21) [MIM:616502]: A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. {ECO:0000269 PubMed:25983245}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for DRAM2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for DRAM2 Gene
Publications for DRAM2 Gene
- Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. (PMID: 19556885) O'Prey J … Ryan KM (Cell cycle (Georgetown, Tex.) 2009) 2 3 4
- Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement. (PMID: 25983245) El-Asrag ME … Ali M (American journal of human genetics 2015) 3 4
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death. (PMID: 19895784) Park SM … Park J (Biochemical and biophysical research communications 2009) 3 4
ExternalLinks
Products for DRAM2 Gene
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- Browse OriGene Inhibitory RNA Products For DRAM2
- OriGene qPCR primer pairs for DRAM2
- OriGene qPCR primer pairs and template standards for DRAM2
- OriGene CRISPR knockouts for DRAM2
- MG201603
- MG218120
- MR201603
- MR201603L3
- MR201603L4
- MR218120
- MR218120L3
- MR218120L4
- MR228900
- MR228901
- RC213085
- RC213085L1
- RC213085L2
- RC213085L3
- RC213085L4
- RG213085
- RR212454
- RR212454L3
- RR212454L4
- MR201603L3V
- MR201603L4V
- MR218120L3V
- MR218120L4V
- RC213085L1V
- RC213085L2V
- RC213085L3V
- RC213085L4V
- RR212454L3V
- RR212454L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Taconic Biosciences Mouse Models for DRAM2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DRAM2 (AFLGC-DRAM2)
- VectorBuilder Custom and pre-made DNA vectors for DRAM2 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 3 available DRAM2 Antibodies ranked by validation data
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DRAM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DRAM2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DRAM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRAM2
Sources for DRAM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB