DRAM1 Gene (Protein Coding)

DNA Damage Regulated Autophagy Modulator 1

GC12P101877
GIFtS:
32
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008] See more...

Aliases for DRAM1 Gene

Aliases for DRAM1 Gene

  • DNA Damage Regulated Autophagy Modulator 1 2 3 5
  • Damage-Regulated Autophagy Modulator 2 3 4
  • DNA Damage-Regulated Autophagy Modulator Protein 1 3 4
  • DRAM 3 4
  • DNA-Damage Regulated Autophagy Modulator 1 2

External Ids for DRAM1 Gene

Previous GeneCards Identifiers for DRAM1 Gene

  • GC12P100798
  • GC12P102271
  • GC12P099330

Summaries for DRAM1 Gene

Entrez Gene Summary for DRAM1 Gene

  • This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for DRAM1 Gene

DRAM1 (DNA Damage Regulated Autophagy Modulator 1) is a Protein Coding gene. An important paralog of this gene is DRAM2.

UniProtKB/Swiss-Prot Summary for DRAM1 Gene

  • Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.

Additional gene information for DRAM1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DRAM1 Gene

Genomics for DRAM1 Gene

GeneHancer (GH) Regulatory Elements for DRAM1 Gene

Promoters and enhancers for DRAM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DRAM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DRAM1 Gene

Genomic Locations for DRAM1 Gene
chr12:101,877,327-102,012,130
(GRCh38/hg38)
Size:
134,804 bases
Orientation:
Plus strand
chr12:102,271,105-102,405,908
(GRCh37/hg19)
Size:
134,804 bases
Orientation:
Plus strand

Genomic View for DRAM1 Gene

Genes around DRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DRAM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DRAM1 Gene

Proteins for DRAM1 Gene

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  • Protein details for DRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N682-DRAM1_HUMAN
    Recommended name:
    DNA damage-regulated autophagy modulator protein 1
    Protein Accession:
    Q8N682
    Secondary Accessions:
    • B7Z4T0
    • Q7L3E3
    • Q9NUN1

    Protein attributes for DRAM1 Gene

    Size:
    238 amino acids
    Molecular mass:
    26253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92091.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DRAM1 Gene

Post-translational modifications for DRAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DRAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DRAM1 Gene

Domains & Families for DRAM1 Gene

Gene Families for DRAM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DRAM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DRAM1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57538 (B7Z4T0_HUMAN)
  • Damage-regulated autophagy modulator (DRAM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N682

UniProtKB/Swiss-Prot:

DRAM1_HUMAN :
  • Belongs to the DRAM/TMEM150 family.
Family:
  • Belongs to the DRAM/TMEM150 family.
genes like me logo Genes that share domains with DRAM1: view

Function for DRAM1 Gene

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Molecular function for DRAM1 Gene

UniProtKB/Swiss-Prot Function:
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
UniProtKB/Swiss-Prot Induction:
By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.

Phenotypes From GWAS Catalog for DRAM1 Gene

Gene Ontology (GO) - Molecular Function for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DRAM1: view
genes like me logo Genes that share phenotypes with DRAM1: view

Animal Models for DRAM1 Gene

MGI Knock Outs for DRAM1:
  • Dram1 Dram1<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DRAM1 Gene

Localization for DRAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DRAM1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DRAM1 gene
Compartment Confidence
lysosome 5
plasma membrane 3
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19895784
GO:0005764 lysosome IBA,IDA 19895784
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DRAM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DRAM1 Gene

Pathways & Interactions for DRAM1 Gene

PathCards logo

SuperPathways for DRAM1 Gene

No Data Available

Interacting Proteins for DRAM1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 6)
STRING Interaction Network
Selected Interacting proteins: Q8N682-DRAM1_HUMAN ENSP00000258534 for DRAM1 Gene via UniProtKB STRING IID

GPS-Prot Interaction Network for DRAM1

Gene Ontology (GO) - Biological Process for DRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0010506 regulation of autophagy IDA 19895784
genes like me logo Genes that share ontologies with DRAM1: view

No data available for Pathways by source and SIGNOR curated interactions for DRAM1 Gene

Drugs & Compounds for DRAM1 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for DRAM1 Gene

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  1. CRISPR
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mRNA/cDNA for DRAM1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(145) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DRAM1

Alternative Splicing Database (ASD) splice patterns (SP) for DRAM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for DRAM1 Gene

GeneLoc Exon Structure for
DRAM1
ECgene alternative splicing isoforms for
DRAM1

Expression for DRAM1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DRAM1 Gene

mRNA expression in normal human tissues for DRAM1 Gene
mRNA expression by GTEx for DRAM1 GenemRNA expression by BioGPS for DRAM1 Gene

mRNA differential expression in normal tissues according to GTEx for DRAM1 Gene

This gene is overexpressed in Lung (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of DRAM1 Gene:

DRAM1

SOURCE GeneReport for Unigene cluster for DRAM1 Gene:

Hs.525634

Evidence on tissue expression from TISSUES for DRAM1 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with DRAM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DRAM1 Gene

Orthologs for DRAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DRAM1 33 32
  • 99.72 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FLJ11259 33
  • 96 (a)
 OneToOne
DRAM1 32
  • 89.92 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 91 (a)
 OneToMany
-- 33
  • 70 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia DRAM1 33 32
  • 88.8 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dram1 17 33 32
  • 88.47 (n)
rat
(Rattus norvegicus)
 Mammalia Dram1 32
  • 86.92 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 79 (a)
 OneToMany
-- 33
  • 55 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves DRAM1 33 32
  • 72.57 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DRAM1 33
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dram1 32
  • 65.52 (n)
zebrafish
(Danio rerio)
 Actinopterygii dram1 33 32
  • 55.32 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG4025 33 32
  • 49.44 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000808 32
  • 49.27 (n)
worm
(Caenorhabditis elegans)
 Secernentea C33A11.2 33
  • 21 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.6942 33
  • 14 (a)
 OneToOne
Species where no ortholog for DRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DRAM1 Gene

ENSEMBL:
Gene Tree for DRAM1 (if available)
TreeFam:
Gene Tree for DRAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DRAM1: view image

Paralogs for DRAM1 Gene

Paralogs for DRAM1 Gene

(1) SIMAP similar genes for DRAM1 Gene using alignment to 4 proteins:

  • DRAM1_HUMAN
  • B7Z4T0_HUMAN
  • H0YHJ0_HUMAN
  • H0YHV0_HUMAN
genes like me logo Genes that share paralogs with DRAM1: view

Variants for DRAM1 Gene

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Sequence variations from dbSNP and Humsavar for DRAM1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000085992 -- 101,912,326(+) G/A intron_variant
rs1000138272 -- 101,918,200(+) A/G intron_variant
rs1000188374 -- 101,895,714(+) G/A intron_variant
rs1000283280 -- 101,895,851(+) T/C intron_variant
rs1000349442 -- 101,889,882(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DRAM1 Gene

Variant ID Type Subtype PubMed ID
dgv308e199 CNV deletion 23128226
dgv88e215 CNV deletion 23714750
esv2318192 CNV deletion 18987734
esv2499618 CNV deletion 19546169
esv2665303 CNV deletion 23128226
esv2746281 CNV deletion 23290073
esv2746282 CNV deletion 23290073
esv2746283 CNV deletion 23290073
esv3361767 CNV insertion 20981092
esv3394643 CNV insertion 20981092
esv3450382 CNV insertion 20981092
esv3630581 CNV loss 21293372
esv3630582 CNV loss 21293372
esv3892258 CNV gain 25118596
esv4264 CNV loss 18987735
nsv1053046 CNV gain 25217958
nsv1125557 CNV tandem duplication 24896259
nsv560030 CNV gain 21841781
nsv560031 CNV gain 21841781
nsv983359 CNV duplication 23825009

Variation tolerance for DRAM1 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DRAM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DRAM1 Gene

Disorders for DRAM1 Gene

Additional Disease Information for DRAM1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DRAM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DRAM1 Gene

Publications for DRAM1 Gene

  1. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. (PMID: 16839881) Crighton D … Ryan KM (Cell 2006) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway. (PMID: 30902093) Lu T … Qin ZH (Cell communication and signaling : CCS 2019) 3 56
  4. Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells. (PMID: 29501488) Liu D … Liu K (Biochemical and biophysical research communications 2018) 3 56
  5. p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. (PMID: 28893313) Garufi A … D'Orazi G (Journal of experimental & clinical cancer research : CR 2017) 3 56

ExternalLinks

View latest publications for DRAM1 gene in Mastermind

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