Aliases for DRAM1 Gene
External Ids for DRAM1 Gene
Previous GeneCards Identifiers for DRAM1 Gene
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
GeneCards Summary for DRAM1 Gene
DRAM1 (DNA Damage Regulated Autophagy Modulator 1) is a Protein Coding gene. An important paralog of this gene is DRAM2.
UniProtKB/Swiss-Prot Summary for DRAM1 Gene
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.