Aliases for DQX1 Gene

Aliases for DQX1 Gene

  • DEAQ-Box RNA Dependent ATPase 1 2 3 5
  • DEAQ Box Polypeptide 1 (RNA-Dependent ATPase) 2 3
  • ATP-Dependent RNA Helicase DQX1 3 4
  • DEAQ RNA-Dependent ATPase DQX1 3
  • DEAQ Box Polypeptide 1 4
  • EC 3.6.4.12 4
  • FLJ23757 2
  • DQX1 5

External Ids for DQX1 Gene

Previous GeneCards Identifiers for DQX1 Gene

  • GC02M074882
  • GC02M074958
  • GC02M074702
  • GC02M074719
  • GC02M074658
  • GC02M074659
  • GC02M074598
  • GC02M074745
  • GC02M074481

Summaries for DQX1 Gene

GeneCards Summary for DQX1 Gene

DQX1 (DEAQ-Box RNA Dependent ATPase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ATP-dependent RNA helicase activity. An important paralog of this gene is DHX32.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DQX1 Gene

Genomics for DQX1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DQX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J074525 Enhancer 1.1 Ensembl ENCODE 250.7 +0.0 10 1.3 MXD4 SIX5 NR2C1 ETS1 ZFP64 ZNF217 POLR2A ELF1 HOMEZ KDM6A DQX1 RF00017-3241 AUP1 lnc-DQX1-1 TLX2
GH02J074550 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -27.5 -27477 5.7 ZBTB10 NR2C1 MNT IKZF1 BRCA1 NONO ZIC2 SIN3B ZNF740 VEZF1 DOK1 LOXL3 ACTG2 LBX2-AS1 HTRA2 AUP1 TLX2 PCGF1 DQX1 MRPL53
GH02J074548 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -23.1 -23073 2.1 ZSCAN16 TBP ZBTB10 SMAD5 ZFP64 POLR2A ELF1 NONO SIN3A REST DOK1 HSALNG0016078 DQX1 MRPL53 WBP1 MOGS TLX2 PCGF1 M1AP INO80B
GH02J074566 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -41.5 -41547 3.1 CEBPB EP300 EBF1 JUND IKZF1 GLIS1 POLR2A HLF SPI1 NFE2L2 RTKN HSALNG0016082 LBX2 WBP1 HTRA2 AUP1 TLX2 PCGF1 MRPL53 MOGS
GH02J074575 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -50.5 -50549 2.9 GABPA IRF4 GABPB1 RAD21 SPI1 BATF POLR2A MYC ZBTB40 MAX lnc-LOXL3-1 DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 TTC31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DQX1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DQX1

Top Transcription factor binding sites by QIAGEN in the DQX1 gene promoter:
  • AP-1
  • AP-4
  • Gfi-1
  • LCR-F1
  • Nkx2-5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Zic1

Genomic Locations for DQX1 Gene

Latest Assembly
chr2:74,518,131-74,526,281
(GRCh38/hg38)
Size:
8,151 bases
Orientation:
Minus strand

Previous Assembly
chr2:74,745,258-74,753,358
(GRCh37/hg19 by Entrez Gene)
Size:
8,101 bases
Orientation:
Minus strand

chr2:74,745,258-74,753,463
(GRCh37/hg19 by Ensembl)
Size:
8,206 bases
Orientation:
Minus strand

Genomic View for DQX1 Gene

Genes around DQX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DQX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DQX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DQX1 Gene

Proteins for DQX1 Gene

  • Protein details for DQX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE96-DQX1_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DQX1
    Protein Accession:
    Q8TE96
    Secondary Accessions:
    • Q6B017
    • Q8NAM8

    Protein attributes for DQX1 Gene

    Size:
    717 amino acids
    Molecular mass:
    79476 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DQX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DQX1 Gene

Post-translational modifications for DQX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DQX1 Gene

No data available for DME Specific Peptides for DQX1 Gene

Domains & Families for DQX1 Gene

Gene Families for DQX1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DQX1 Gene

Suggested Antigen Peptide Sequences for DQX1 Gene

GenScript: Design optimal peptide antigens:
  • DEAQ box polypeptide 1 (DQX1_HUMAN)
genes like me logo Genes that share domains with DQX1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DQX1 Gene

Function for DQX1 Gene

Molecular function for DQX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;.

Enzyme Numbers (IUBMB) for DQX1 Gene

Phenotypes From GWAS Catalog for DQX1 Gene

Gene Ontology (GO) - Molecular Function for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003678 DNA helicase activity IEA --
GO:0003723 RNA binding IBA 21873635
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DQX1: view
genes like me logo Genes that share phenotypes with DQX1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DQX1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DQX1 Gene

Localization for DQX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DQX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DQX1 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IBA 21873635
genes like me logo Genes that share ontologies with DQX1: view

Pathways & Interactions for DQX1 Gene

PathCards logo

SuperPathways for DQX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DQX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032508 DNA duplex unwinding IEA --
genes like me logo Genes that share ontologies with DQX1: view

No data available for Pathways by source and SIGNOR curated interactions for DQX1 Gene

Drugs & Compounds for DQX1 Gene

(3) Drugs for DQX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for DQX1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with DQX1: view

Transcripts for DQX1 Gene

mRNA/cDNA for DQX1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DQX1

Alternative Splicing Database (ASD) splice patterns (SP) for DQX1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: -

Relevant External Links for DQX1 Gene

GeneLoc Exon Structure for
DQX1

Expression for DQX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DQX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DQX1 Gene

This gene is overexpressed in Colon - Transverse (x17.0), Small Intestine - Terminal Ileum (x11.7), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for DQX1 Gene

This gene is overexpressed in Serum (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DQX1 Gene



Protein tissue co-expression partners for DQX1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DQX1

SOURCE GeneReport for Unigene cluster for DQX1 Gene:

Hs.191705

Evidence on tissue expression from TISSUES for DQX1 Gene

  • Intestine(2.2)
genes like me logo Genes that share expression patterns with DQX1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DQX1 Gene

Orthologs for DQX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DQX1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DQX1 30 31
  • 99.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DQX1 30 31
  • 88.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DQX1 30 31
  • 87.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dqx1 30
  • 84.27 (n)
Mouse
(Mus musculus)
Mammalia Dqx1 30 17 31
  • 84.08 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DQX1 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DQX1 30
  • 63.95 (n)
Lizard
(Anolis carolinensis)
Reptilia DQX1 31
  • 57 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01087670.1 31
  • 38 (a)
OneToOne
Dr.10422 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 31
  • 31 (a)
OneToMany
Species where no ortholog for DQX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DQX1 Gene

ENSEMBL:
Gene Tree for DQX1 (if available)
TreeFam:
Gene Tree for DQX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DQX1: view image

Paralogs for DQX1 Gene

(8) SIMAP similar genes for DQX1 Gene using alignment to 3 proteins:

  • DQX1_HUMAN
  • C9J0W1_HUMAN
  • H7BZE3_HUMAN
genes like me logo Genes that share paralogs with DQX1: view

Variants for DQX1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DQX1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs773689288 Uncertain Significance: Arthrogryposis multiplex congenita; Fetal akinesia sequence 74,523,970(-) G/A
NM_133637.3(DQX1):c.769C>T (p.Arg257Trp)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DQX1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DQX1 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1138785 CNV deletion 24896259
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for DQX1 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DQX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DQX1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DQX1 Gene

Disorders for DQX1 Gene

Additional Disease Information for DQX1

No disorders were found for DQX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DQX1 Gene

Publications for DQX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Integrative analysis of DNA methylation-driven genes for the prognosis of lung squamous cell carcinoma using MethylMix. (PMID: 32218699) Li R … Qu YQ (International journal of medical sciences 2020) 3
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for DQX1 Gene

Sources for DQX1 Gene