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Aliases for DPYSL5 Gene

Aliases for DPYSL5 Gene

  • Dihydropyrimidinase Like 5 2 3 5
  • UNC33-Like Phosphoprotein 6 3 4
  • CRMP3-Associated Molecule 3 4
  • CRMP-5 3 4
  • ULIP-6 3 4
  • Ulip6 3 4
  • CRMP5 3 4
  • DRP-5 3 4
  • CRAM 3 4
  • Collapsin Response Mediator Protein-5 3
  • Dihydropyrimidinase-Related Protein 5 3
  • Collapsin Response Mediator Protein 5 4
  • Dihydropyrimidinase-Like 5 2

External Ids for DPYSL5 Gene

Previous GeneCards Identifiers for DPYSL5 Gene

  • GC02P027163
  • GC02P027028
  • GC02P027045
  • GC02P026982
  • GC02P026812
  • GC02P027070

Summaries for DPYSL5 Gene

Entrez Gene Summary for DPYSL5 Gene

  • This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for DPYSL5 Gene

DPYSL5 (Dihydropyrimidinase Like 5) is a Protein Coding gene. Diseases associated with DPYSL5 include Thymoma and Thymus Cancer. Among its related pathways are Semaphorin interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. An important paralog of this gene is DPYS.

UniProtKB/Swiss-Prot for DPYSL5 Gene

  • May have a function in neuronal differentiation and/or axon growth.

Gene Wiki entry for DPYSL5 Gene

Additional gene information for DPYSL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL5 Gene

Genomics for DPYSL5 Gene

GeneHancer (GH) Regulatory Elements for DPYSL5 Gene

Promoters and enhancers for DPYSL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I026849 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 572.3 +1.6 1555 0.2 KLF1 ZNF76 SIN3A ZNF335 ZFHX2 GLIS2 POLR2A ZNF366 ZBTB48 KLF7 DPYSL5 KHK MAPRE3 OTOF DRC1 UCN PIR42524
GH02I026854 Promoter/Enhancer 1.2 EPDnew dbSUPER 550.8 +0.7 695 0.1 MXI1 KLF1 ZSCAN4 KLF17 ZNF335 GLIS2 PATZ1 KLF7 ZNF391 EZH2 DPYSL5 PIR42524
GH02I026848 Promoter/Enhancer 1.1 EPDnew dbSUPER 550.8 +0.4 366 0.1 MXI1 PKNOX1 MAZ SP3 SP2 SIX5 ZEB2 ETS1 FOXM1 ZNF335 DPYSL5 PIR42524
GH02I026847 Enhancer 1 ENCODE dbSUPER 550.8 +0.1 141 0.2 PKNOX1 KLF17 ZNF76 SIN3A ETS1 ZNF335 GLIS2 ZNF143 THAP11 SP3 DPYSL5 KHK PIR42524
GH02I026846 Enhancer 1 ENCODE dbSUPER 550.8 -1.3 -1259 0.2 ELF3 RB1 ARID4B SIN3A BMI1 ZNF2 DNMT3B ZNF48 RAD21 GLIS2 DPYSL5 PIR39724
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPYSL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPYSL5 gene promoter:

Genomic Locations for DPYSL5 Gene

Genomic Locations for DPYSL5 Gene
102,605 bases
Plus strand

Genomic View for DPYSL5 Gene

Genes around DPYSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL5 Gene

Proteins for DPYSL5 Gene

  • Protein details for DPYSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dihydropyrimidinase-related protein 5
    Protein Accession:
    Secondary Accessions:
    • Q8TCL6
    • Q9NQC4
    • Q9NRY9

    Protein attributes for DPYSL5 Gene

    564 amino acids
    Molecular mass:
    61421 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DPYSL5 Gene

neXtProt entry for DPYSL5 Gene

Post-translational modifications for DPYSL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL5 Gene

No data available for DME Specific Peptides for DPYSL5 Gene

Domains & Families for DPYSL5 Gene

Gene Families for DPYSL5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DPYSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYSL5: view

Function for DPYSL5 Gene

Molecular function for DPYSL5 Gene

UniProtKB/Swiss-Prot Function:
May have a function in neuronal differentiation and/or axon growth.

Phenotypes From GWAS Catalog for DPYSL5 Gene

Gene Ontology (GO) - Molecular Function for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with DPYSL5: view
genes like me logo Genes that share phenotypes with DPYSL5: view

Animal Models for DPYSL5 Gene

MGI Knock Outs for DPYSL5:

Animal Model Products

CRISPR Products

miRNA for DPYSL5 Gene

miRTarBase miRNAs that target DPYSL5

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPYSL5 Gene

Localization for DPYSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL5 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with DPYSL5: view

Pathways & Interactions for DPYSL5 Gene

genes like me logo Genes that share pathways with DPYSL5: view

Pathways by source for DPYSL5 Gene

1 KEGG pathway for DPYSL5 Gene

Gene Ontology (GO) - Biological Process for DPYSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10851247
GO:0007399 nervous system development TAS 10851247
GO:0007411 axon guidance IEA,TAS --
genes like me logo Genes that share ontologies with DPYSL5: view

No data available for SIGNOR curated interactions for DPYSL5 Gene

Drugs & Compounds for DPYSL5 Gene

No Compound Related Data Available

Transcripts for DPYSL5 Gene

mRNA/cDNA for DPYSL5 Gene

Unigene Clusters for DPYSL5 Gene

Dihydropyrimidinase-like 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL5 Gene

No ASD Table

Relevant External Links for DPYSL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPYSL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPYSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.4), Brain - Substantia nigra (x5.9), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Putamen (basal ganglia) (x5.0), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for DPYSL5 Gene

This gene is overexpressed in Fetal Brain (28.8), Spinal cord (11.2), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPYSL5 Gene

Protein tissue co-expression partners for DPYSL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPYSL5 Gene:


SOURCE GeneReport for Unigene cluster for DPYSL5 Gene:


Evidence on tissue expression from TISSUES for DPYSL5 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with DPYSL5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL5 Gene

Orthologs for DPYSL5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPYSL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPYSL5 33 34
  • 99.59 (n)
(Monodelphis domestica)
Mammalia DPYSL5 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia DPYSL5 34
  • 95 (a)
(Canis familiaris)
Mammalia DPYSL5 33 34
  • 92.43 (n)
(Bos Taurus)
Mammalia DPYSL5 33 34
  • 92.02 (n)
(Rattus norvegicus)
Mammalia Dpysl5 33
  • 91.08 (n)
(Mus musculus)
Mammalia Dpysl5 33 16 34
  • 90.43 (n)
(Gallus gallus)
Aves DPYSL5 34
  • 72 (a)
(Anolis carolinensis)
Reptilia DPYSL5 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl5 33
  • 76.28 (n)
(Danio rerio)
Actinopterygii dpysl5b 34
  • 76 (a)
dpysl5a 33 34
  • 74.41 (n)
Dr.11133 33
fruit fly
(Drosophila melanogaster)
Insecta CRMP 34
  • 45 (a)
(Caenorhabditis elegans)
Secernentea dhp-2 34
  • 47 (a)
unc-33 34
  • 23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C19107g 33
  • 45.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL1 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for DPYSL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL5 Gene

Gene Tree for DPYSL5 (if available)
Gene Tree for DPYSL5 (if available)

Paralogs for DPYSL5 Gene

Paralogs for DPYSL5 Gene

(5) SIMAP similar genes for DPYSL5 Gene using alignment to 6 proteins: Pseudogenes for DPYSL5 Gene

genes like me logo Genes that share paralogs with DPYSL5: view

Variants for DPYSL5 Gene

Sequence variations from dbSNP and Humsavar for DPYSL5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000014281 -- 26,857,781(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000091783 -- 26,849,406(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000123583 -- 26,894,748(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000152359 -- 26,867,244(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000187712 -- 26,848,410(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL5 Gene

Variant ID Type Subtype PubMed ID
esv1009796 CNV insertion 20482838
esv1993351 CNV deletion 18987734
esv275060 CNV loss 21479260
esv3416312 CNV insertion 20981092
esv3423223 CNV duplication 20981092
nsv214236 CNV insertion 16902084

Variation tolerance for DPYSL5 Gene

Residual Variation Intolerance Score: 8.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPYSL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL5 Gene

Disorders for DPYSL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DPYSL5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • thymus neoplasms
thymus cancer
  • neoplasm of thymus
  • focal retinitis and retinochoroiditis, juxtapapillary
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DPYSL5

genes like me logo Genes that share disorders with DPYSL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL5 Gene

Publications for DPYSL5 Gene

  1. Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain. (PMID: 11034345) Horiuchi M … Betz H (FEBS letters 2000) 2 3 4 22 58
  2. Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma. (PMID: 18769332) Meyronet D … Thomasset N (The American journal of surgical pathology 2008) 3 22 58
  3. High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. (PMID: 18347453) Margolin E … Trobe JD (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2008) 3 22 58
  4. Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G. (PMID: 18306241) Keegan BM … Lennon VA (Annals of neurology 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DPYSL5 Gene

Sources for DPYSL5 Gene

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