Aliases for DPYSL4 Gene

Aliases for DPYSL4 Gene

  • Dihydropyrimidinase Like 4 2 3 5
  • Collapsin Response Mediator Protein 3 3 4
  • Dihydropyrimidinase-Related Protein 4 3 4
  • UNC33-Like Phosphoprotein 4 3 4
  • CRMP-3 3 4
  • ULIP-4 3 4
  • CRMP3 3 4
  • DRP-4 3 4
  • ULIP4 3 4
  • Dihydropyrimidinase-Like 4 2

External Ids for DPYSL4 Gene

Previous GeneCards Identifiers for DPYSL4 Gene

  • GC10P132911
  • GC10P133133
  • GC10P133877
  • GC10P133434
  • GC10P133850
  • GC10P134000
  • GC10P127552

Summaries for DPYSL4 Gene

GeneCards Summary for DPYSL4 Gene

DPYSL4 (Dihydropyrimidinase Like 4) is a Protein Coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL2.

UniProtKB/Swiss-Prot Summary for DPYSL4 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL4 Gene

Additional gene information for DPYSL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPYSL4 Gene

Genomics for DPYSL4 Gene

GeneHancer (GH) Regulatory Elements for DPYSL4 Gene

Promoters and enhancers for DPYSL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J132185 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 806.1 +2.1 2062 2.7 MNT NCOA6 EGR1 GMEB1 GLIS2 ZIC2 REST ZBTB8A TARDBP CTBP1 DPYSL4 ENSG00000235010 JAKMIP3 piR-36588-056
GH10J132175 Enhancer 0.8 Ensembl CraniofacialAtlas 58.4 -8.6 -8587 1.2 NR2F6 GLIS2 ZIC2 SP2 SOX13 ZBTB20 ZBTB48 OSR2 ZBTB17 USF1 DPYSL4 BNIP3 JAKMIP3 LOC105378567 piR-49549-001
GH10J132223 Enhancer 1 Ensembl ENCODE 36.2 +40.1 40101 4.2 CTCF RBPJ MYC CC2D1A L3MBTL2 MAX ZNF121 RAD21 MNT ZBTB33 DPYSL4 STK32C C10orf91 ENSG00000234311 JAKMIP3 piR-36588-056 lnc-LRRC27-1
GH10J132164 Enhancer 0.7 ENCODE 42 -21.4 -21385 0.2 MNT SP1 MYC POLR2A KLF14 HDGF PKNOX1 CREB1 TARDBP SP2 DPYSL4 JAKMIP3 piR-49549-001 LOC105378567
GH10J132158 Enhancer 0.4 ENCODE 42 -25.6 -25624 2.5 PATZ1 TCF7L2 GLIS1 SP3 DPYSL4 JAKMIP3 piR-49549-001 LOC105378567
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPYSL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPYSL4 gene promoter:
  • ATF-2
  • c-Jun
  • COMP1
  • NRSF form 1
  • NRSF form 2
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for DPYSL4 Gene

Genomic Locations for DPYSL4 Gene
chr10:132,184,987-132,205,776
(GRCh38/hg38)
Size:
20,790 bases
Orientation:
Plus strand
chr10:134,000,404-134,019,280
(GRCh37/hg19)
Size:
18,877 bases
Orientation:
Plus strand

Genomic View for DPYSL4 Gene

Genes around DPYSL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL4 Gene

Proteins for DPYSL4 Gene

  • Protein details for DPYSL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14531-DPYL4_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 4
    Protein Accession:
    O14531
    Secondary Accessions:
    • B2RMQ1
    • D3DRG5
    • O00240
    • Q5T0Q7

    Protein attributes for DPYSL4 Gene

    Size:
    572 amino acids
    Molecular mass:
    61878 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DPYSL4 Gene

neXtProt entry for DPYSL4 Gene

Post-translational modifications for DPYSL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL4 Gene

No data available for DME Specific Peptides for DPYSL4 Gene

Domains & Families for DPYSL4 Gene

Gene Families for DPYSL4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DPYSL4 Gene

GenScript: Design optimal peptide antigens:
  • Dihydropyrimidinase-like 4, isoform CRA_a (D3DRG7_HUMAN)
  • UNC33-like phosphoprotein 4 (DPYL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14531

UniProtKB/Swiss-Prot:

DPYL4_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYSL4: view

Function for DPYSL4 Gene

Molecular function for DPYSL4 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Phenotypes From GWAS Catalog for DPYSL4 Gene

Gene Ontology (GO) - Molecular Function for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004157 NOT dihydropyrimidinase activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0031005 filamin binding IPI 25358863
genes like me logo Genes that share ontologies with DPYSL4: view
genes like me logo Genes that share phenotypes with DPYSL4: view

Animal Models for DPYSL4 Gene

MGI Knock Outs for DPYSL4:

Animal Model Products

  • Taconic Biosciences Mouse Models for DPYSL4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPYSL4 Gene

Localization for DPYSL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL4 gene
Compartment Confidence
cytosol 4
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPYSL4: view

Pathways & Interactions for DPYSL4 Gene

PathCards logo

SuperPathways for DPYSL4 Gene

genes like me logo Genes that share pathways with DPYSL4: view

Pathways by source for DPYSL4 Gene

Gene Ontology (GO) - Biological Process for DPYSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006208 NOT pyrimidine nucleobase catabolic process IBA 21873635
GO:0007399 nervous system development TAS 9652388
GO:0070997 neuron death IEA --
GO:0097485 neuron projection guidance IEA --
genes like me logo Genes that share ontologies with DPYSL4: view

No data available for SIGNOR curated interactions for DPYSL4 Gene

Drugs & Compounds for DPYSL4 Gene

No Compound Related Data Available

Transcripts for DPYSL4 Gene

mRNA/cDNA for DPYSL4 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL4

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3:

Relevant External Links for DPYSL4 Gene

GeneLoc Exon Structure for
DPYSL4
ECgene alternative splicing isoforms for
DPYSL4

Expression for DPYSL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPYSL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL4 Gene

This gene is overexpressed in Brain - Cortex (x4.8) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for DPYSL4 Gene

This gene is overexpressed in Brain (33.6), Fetal Brain (14.9), and Retina (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPYSL4 Gene



Protein tissue co-expression partners for DPYSL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPYSL4 Gene:

DPYSL4

SOURCE GeneReport for Unigene cluster for DPYSL4 Gene:

Hs.100058

Evidence on tissue expression from TISSUES for DPYSL4 Gene

  • Nervous system(4.7)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with DPYSL4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL4 Gene

Orthologs for DPYSL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPYSL4 33 32
  • 98.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPYSL4 33 32
  • 87.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dpysl4 17 33 32
  • 86.31 (n)
cow
(Bos Taurus)
Mammalia DPYSL4 33 32
  • 86.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpysl4 32
  • 86.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL4 33
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPYSL4 33
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPYSL4 33
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL4 33
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl4 32
  • 71.97 (n)
zebrafish
(Danio rerio)
Actinopterygii dpysl4 33
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CRMP 34
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-1 34
  • 48 (a)
dhp-2 34
  • 47 (a)
unc-33 34
  • 34 (a)
Species where no ortholog for DPYSL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL4 Gene

ENSEMBL:
Gene Tree for DPYSL4 (if available)
TreeFam:
Gene Tree for DPYSL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPYSL4: view image

Paralogs for DPYSL4 Gene

Paralogs for DPYSL4 Gene

(5) SIMAP similar genes for DPYSL4 Gene using alignment to 3 proteins:

  • DPYL4_HUMAN
  • D3DRG7_HUMAN
  • Q5T0Q6_HUMAN
genes like me logo Genes that share paralogs with DPYSL4: view

Variants for DPYSL4 Gene

Sequence variations from dbSNP and Humsavar for DPYSL4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000082329 -- 132,188,867(+) G/A 5_prime_UTR_variant, intron_variant
rs1000120555 -- 132,183,286(+) T/C upstream_transcript_variant
rs1000128060 -- 132,204,303(+) C/T intron_variant
rs1000160771 -- 132,204,551(+) G/A/C intron_variant
rs1000318235 -- 132,201,040(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL4 Gene

Variant ID Type Subtype PubMed ID
dgv115e201 CNV deletion 23290073
esv1008205 CNV deletion 20482838
esv1089089 CNV deletion 17803354
esv1577545 CNV deletion 17803354
esv21677 CNV loss 19812545
esv2743628 CNV deletion 23290073
esv2743632 CNV deletion 23290073
esv2743633 CNV deletion 23290073
esv2743634 CNV deletion 23290073
esv2743635 CNV deletion 23290073
esv2761642 CNV gain 21179565
esv3624956 CNV gain 21293372
nsv1054569 CNV gain 25217958
nsv1054934 CNV gain 25217958
nsv1069524 CNV deletion 25765185
nsv1143525 CNV deletion 24896259
nsv552502 CNV loss 21841781
nsv552504 CNV loss 21841781
nsv825652 CNV gain 20364138
nsv832030 CNV loss 17160897
nsv951885 CNV deletion 24416366

Variation tolerance for DPYSL4 Gene

Residual Variation Intolerance Score: 4.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPYSL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYSL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL4 Gene

Disorders for DPYSL4 Gene

Additional Disease Information for DPYSL4

No disorders were found for DPYSL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPYSL4 Gene

Publications for DPYSL4 Gene

  1. The Ulip family phosphoproteins--common and specific properties. (PMID: 9652388) Byk T … Sobel A (European journal of biochemistry 1998) 2 3 4 56
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 56
  3. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 56
  4. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 56
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56

Products for DPYSL4 Gene

Sources for DPYSL4 Gene