Aliases for DPYSL3 Gene

Aliases for DPYSL3 Gene

  • Dihydropyrimidinase Like 3 2 3 5
  • Dihydropyrimidinase-Related Protein 3 3 4
  • Unc-33-Like Phosphoprotein 1 3 4
  • CRMP-4 3 4
  • ULIP-1 3 4
  • CRMP4 3 4
  • DRP-3 3 4
  • DRP3 3 4
  • ULIP 3 4
  • Collapsin Response Mediator Protein 4 Long 3
  • Collapsin Response Mediator Protein 4 4
  • Testicular Secretory Protein Li 7 3
  • Dihydropyrimidinase-Like 3 2
  • LCRMP 3
  • ULIP1 4

External Ids for DPYSL3 Gene

Previous GeneCards Identifiers for DPYSL3 Gene

  • GC05M146798
  • GC05M147352
  • GC05M146750
  • GC05M141917

Summaries for DPYSL3 Gene

GeneCards Summary for DPYSL3 Gene

DPYSL3 (Dihydropyrimidinase Like 3) is a Protein Coding gene. Diseases associated with DPYSL3 include Lung Meningioma. Among its related pathways are Semaphorin interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein binding. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot Summary for DPYSL3 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Gene Wiki entry for DPYSL3 Gene

Additional gene information for DPYSL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPYSL3 Gene

Genomics for DPYSL3 Gene

GeneHancer (GH) Regulatory Elements for DPYSL3 Gene

Promoters and enhancers for DPYSL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J147451 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 526.2 +56.6 56587 6.1 HNRNPK EP300 CTCF MYC USF1 ZBTB10 ZBTB26 SAP30 KLF7 RAD21 DPYSL3 STK32A STK32A-AS1 JAKMIP2 PPP2R2B RF00017-4990 piR-59804-022
GH05J147507 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 502.6 +1.5 1517 3.9 ZSCAN5C RBAK FOS CTCF ZBTB10 GABPA ZBTB26 MXI1 ZNF341 POLR2A DPYSL3 lnc-JAKMIP2-2 piR-59804-022
GH05J147480 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 12.8 +25.4 25402 7.5 EP300 FOS REST ATF2 BCL11A NR2F2 EZH2 BATF JUND IKZF1 DPYSL3 piR-59804-022 lnc-JAKMIP2-2 RF00017-4990
GH05J147534 Enhancer 1 FANTOM5 Ensembl ENCODE 14.4 -25.3 -25285 3.1 JUND FOS ZEB1 FOSL2 GATA2 JUN ZNF366 SP3 POLR2A PRDM10 DPYSL3 JAKMIP2-AS1
GH05J147560 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -50.7 -50741 2.4 TEAD4 HDAC2 POLR2A CTCF NANOG RAD21 CHD1 TAF1 CHD7 TBP JAKMIP2-AS1 DPYSL3 STK32A STK32A-AS1 piR-44878-014
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPYSL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPYSL3

Top Transcription factor binding sites by QIAGEN in the DPYSL3 gene promoter:
  • AML1a
  • Cart-1
  • E4BP4
  • Evi-1
  • FOXO1
  • FOXO1a
  • HNF-1A
  • Pbx1a
  • Sox9

Genomic Locations for DPYSL3 Gene

Genomic Locations for DPYSL3 Gene
chr5:147,390,808-147,510,260
(GRCh38/hg38)
Size:
119,453 bases
Orientation:
Minus strand
chr5:146,770,371-146,889,619
(GRCh37/hg19)
Size:
119,249 bases
Orientation:
Minus strand

Genomic View for DPYSL3 Gene

Genes around DPYSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL3 Gene

Proteins for DPYSL3 Gene

  • Protein details for DPYSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14195-DPYL3_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 3
    Protein Accession:
    Q14195
    Secondary Accessions:
    • B3SXQ8
    • Q93012

    Protein attributes for DPYSL3 Gene

    Size:
    570 amino acids
    Molecular mass:
    61963 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). Interacts with FLNA (PubMed:25358863).

    Three dimensional structures from OCA and Proteopedia for DPYSL3 Gene

    Alternative splice isoforms for DPYSL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPYSL3 Gene

Post-translational modifications for DPYSL3 Gene

  • Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPYSL3 Gene

No data available for DME Specific Peptides for DPYSL3 Gene

Domains & Families for DPYSL3 Gene

Gene Families for DPYSL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DPYSL3 Gene

Blocks:
  • Amidohydrolase-like
  • Dihydroorotase region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPYSL3 Gene

GenScript: Design optimal peptide antigens:
  • Unc-33-like phosphoprotein 1 (DPYL3_HUMAN)
  • DPYSL3 protein (Q6DEN2_HUMAN)
  • Dihydropyrimidinase-like 3 (Q8IXW6_HUMAN)
  • ULIP (Q9NR93_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14195

UniProtKB/Swiss-Prot:

DPYL3_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYSL3: view

Function for DPYSL3 Gene

Molecular function for DPYSL3 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Phenotypes From GWAS Catalog for DPYSL3 Gene

Gene Ontology (GO) - Molecular Function for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004157 NOT dihydropyrimidinase activity IBA 21873635
GO:0005515 protein binding IPI 21044950
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA 21873635
genes like me logo Genes that share ontologies with DPYSL3: view
genes like me logo Genes that share phenotypes with DPYSL3: view

Animal Models for DPYSL3 Gene

MGI Knock Outs for DPYSL3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPYSL3 Gene

Localization for DPYSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL3 Gene

Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL3 gene
Compartment Confidence
cytosol 5
extracellular 4
cytoskeleton 4
nucleus 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030027 lamellipodium ISS --
GO:0030426 growth cone ISS --
genes like me logo Genes that share ontologies with DPYSL3: view

Pathways & Interactions for DPYSL3 Gene

PathCards logo

SuperPathways for DPYSL3 Gene

genes like me logo Genes that share pathways with DPYSL3: view

Pathways by source for DPYSL3 Gene

SIGNOR curated interactions for DPYSL3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DPYSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006208 NOT pyrimidine nucleobase catabolic process IBA 21873635
GO:0010975 regulation of neuron projection development IEA --
GO:0010976 positive regulation of neuron projection development ISS --
GO:0010977 negative regulation of neuron projection development ISS --
GO:0030334 regulation of cell migration IEA --
genes like me logo Genes that share ontologies with DPYSL3: view

Drugs & Compounds for DPYSL3 Gene

(1) Drugs for DPYSL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DPYSL3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ureidopropionic acid
  • 3-[(Aminocarbonyl)amino]propanoic acid
  • 3-Ureidopropanoate
  • 3-Ureidopropanoic acid
  • 3-Ureidopropionate
  • 3-Ureidopropionic acid
462-88-4
genes like me logo Genes that share compounds with DPYSL3: view

Transcripts for DPYSL3 Gene

mRNA/cDNA for DPYSL3 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL3 Gene

No ASD Table

Relevant External Links for DPYSL3 Gene

GeneLoc Exon Structure for
DPYSL3

Expression for DPYSL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPYSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYSL3 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.4).

Protein differential expression in normal tissues from HIPED for DPYSL3 Gene

This gene is overexpressed in Fetal Brain (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPYSL3 Gene



Protein tissue co-expression partners for DPYSL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPYSL3

SOURCE GeneReport for Unigene cluster for DPYSL3 Gene:

Hs.519659

mRNA Expression by UniProt/SwissProt for DPYSL3 Gene:

Q14195-DPYL3_HUMAN
Tissue specificity: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Evidence on tissue expression from TISSUES for DPYSL3 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Liver(4.2)
  • Eye(4)
  • Skin(3.3)
  • Pancreas(3.2)
  • Bone(2.4)
genes like me logo Genes that share expression patterns with DPYSL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL3 Gene

Orthologs for DPYSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPYSL3 31 30
  • 99.11 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPYSL3 31
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL3 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPYSL3 31 30
  • 91.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPYSL3 31 30
  • 90.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpysl3 30
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Dpysl3 17 31 30
  • 90.43 (n)
chicken
(Gallus gallus)
Aves DPYSL3 31 30
  • 81.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPYSL3 31
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl3 30
  • 79.26 (n)
Str.2981 30
African clawed frog
(Xenopus laevis)
Amphibia dpysl3-prov 30
zebrafish
(Danio rerio)
Actinopterygii dpysl3 31 30
  • 73.89 (n)
OneToOne
Dr.18061 30
fruit fly
(Drosophila melanogaster)
Insecta CRMP 32
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea dhp-2 32
  • 50 (a)
dhp-1 32
  • 47 (a)
unc-33 32
  • 32 (a)
Species where no ortholog for DPYSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL3 Gene

ENSEMBL:
Gene Tree for DPYSL3 (if available)
TreeFam:
Gene Tree for DPYSL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPYSL3: view image

Paralogs for DPYSL3 Gene

Paralogs for DPYSL3 Gene

(5) SIMAP similar genes for DPYSL3 Gene using alignment to 7 proteins:

  • DPYL3_HUMAN
  • D6RF19_HUMAN
  • F5GWI3_HUMAN
  • H0YB87_HUMAN
  • H0YBT4_HUMAN
  • Q6DEN2_HUMAN
  • Q8IXW6_HUMAN
genes like me logo Genes that share paralogs with DPYSL3: view

Variants for DPYSL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPYSL3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
711933 Likely Benign: not provided 147,395,716(-) T/G SYNONYMOUS_VARIANT
776074 Benign: not provided 147,399,154(-) C/G SYNONYMOUS_VARIANT
777398 Benign: not provided 147,400,843(-) G/A INTRON_VARIANT
785145 Benign: not provided 147,415,701(-) G/A INTRON_VARIANT
786065 Benign: not provided 147,408,788(-) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DPYSL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DPYSL3 Gene

Variant ID Type Subtype PubMed ID
esv2678822 CNV deletion 23128226
esv27495 CNV loss 19812545
esv3607093 CNV loss 21293372
esv992285 CNV deletion 20482838
nsv1137034 CNV deletion 24896259
nsv5055 CNV deletion 18451855
nsv519847 CNV gain+loss 19592680
nsv599938 CNV gain 21841781

Variation tolerance for DPYSL3 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPYSL3 Gene

Human Gene Mutation Database (HGMD)
DPYSL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL3 Gene

Disorders for DPYSL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPYSL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lung meningioma
  • lung primary meningioma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DPYSL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DPYSL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL3 Gene

Publications for DPYSL3 Gene

  1. Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. (PMID: 9115293) Gaetano C … Thiele CJ (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 4 23 54
  3. Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. (PMID: 16611631) Cole AR … Sutherland C (The Journal of biological chemistry 2006) 3 4 23 54
  4. Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. (PMID: 25358863) Nakamura F … Goshima Y (Nature communications 2014) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for DPYSL3 Gene

Sources for DPYSL3 Gene