This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with ca... See more...

Aliases for DPYSL2 Gene

Aliases for DPYSL2 Gene

  • Dihydropyrimidinase Like 2 2 3 5
  • CRMP2 2 3 4
  • DRP-2 2 3 4
  • Dihydropyrimidinase-Related Protein 2 3 4
  • Unc-33-Like Phosphoprotein 2 3 4
  • CRMP-2 3 4
  • DHPRP2 2 3
  • ULIP-2 3 4
  • ULIP2 3 4
  • DRP2 2 3
  • N2A3 3 4
  • Collapsin Response Mediator Protein HCRMP-2 3
  • Collapsin Response Mediator Protein 2 4
  • Dihydropyrimidinase-Like 2 2
  • DPYSL2 5

External Ids for DPYSL2 Gene

Previous GeneCards Identifiers for DPYSL2 Gene

  • GC08P026208
  • GC08P026792
  • GC08P026457
  • GC08P026491
  • GC08P024980
  • GC08P026371

Summaries for DPYSL2 Gene

Entrez Gene Summary for DPYSL2 Gene

  • This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DPYSL2 Gene

DPYSL2 (Dihydropyrimidinase Like 2) is a Protein Coding gene. Diseases associated with DPYSL2 include Alzheimer Disease and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Neuroscience and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is CRMP1.

UniProtKB/Swiss-Prot Summary for DPYSL2 Gene

  • Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Gene Wiki entry for DPYSL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPYSL2 Gene

Genomics for DPYSL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DPYSL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J026575 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 612.1 +64.0 64017 5.5 RNF2 SP1 GATAD2A PRDM10 TFE3 ZNF512 IKZF1 KDM1A CTCF ZNF692 DPYSL2 NONHSAG049810.2 PNMA2 SDAD1P1 lnc-BNIP3L-2 PSME2P5 ADRA1A
GH08J026517 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.7 -0.2 -178 3.5 PRDM10 ZNF629 REST ZNF692 ZIC2 ZSCAN4 POLR2A PATZ1 EZH2 ZNF239 PNMA2 DPYSL2 lnc-PNMA2-2 ENSG00000254362 MN298489 BNIP3L
GH08J026447 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -63.6 -63604 5.5 CREB1 TEAD4 ZNF629 PRDM10 ZNF512 IKZF1 KDM1A ZNF692 BACH1 PRDM1 SDAD1P1 PNMA2 DPYSL2 BNIP3L MN298488 RF00017-6906 lnc-DPYSL2-1
GH08J026462 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -49.2 -49230 7.6 CTCF TEAD4 PRDM10 RFX1 FOXA1 POLR2A ZNF341 SCRT2 RAD21 RUNX3 PNMA2 DPYSL2 MN298489 BNIP3L
GH08J026437 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.5 -74.2 -74195 4.3 CEBPG CTCF PRDM10 JUND PKNOX1 REST HDAC1 SOX6 CEBPA EP300 ENSG00000254362 LOC105379337 SDAD1P1 PNMA2 DPYSL2 BNIP3L DNAJB6P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPYSL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPYSL2

Top Transcription factor binding sites by QIAGEN in the DPYSL2 gene promoter:
  • aMEF-2
  • GATA-2
  • HNF-1
  • HNF-1A
  • HOXA3
  • NF-1
  • NF-kappaB1
  • Sox9
  • TBP
  • Zic3

Genomic Locations for DPYSL2 Gene

Genomic Locations for DPYSL2 Gene
chr8:26,514,031-26,658,178
(GRCh38/hg38)
Size:
144,148 bases
Orientation:
Plus strand
chr8:26,371,709-26,515,694
(GRCh37/hg19)
Size:
143,986 bases
Orientation:
Plus strand

Genomic View for DPYSL2 Gene

Genes around DPYSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL2 Gene

Proteins for DPYSL2 Gene

  • Protein details for DPYSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16555-DPYL2_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 2
    Protein Accession:
    Q16555
    Secondary Accessions:
    • A8K5H2
    • B4DR31
    • D3DSS7
    • O00424

    Protein attributes for DPYSL2 Gene

    Size:
    572 amino acids
    Molecular mass:
    62294 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.

    Three dimensional structures from OCA and Proteopedia for DPYSL2 Gene

    Alternative splice isoforms for DPYSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPYSL2 Gene

Post-translational modifications for DPYSL2 Gene

  • 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
  • Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
  • Ubiquitination at Lys345 and Lys472
  • Modification sites at PhosphoSitePlus

Other Protein References for DPYSL2 Gene

Antibody Products

  • Abcam antibodies for DPYSL2

No data available for DME Specific Peptides for DPYSL2 Gene

Domains & Families for DPYSL2 Gene

Gene Families for DPYSL2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DPYSL2 Gene

InterPro:
Blocks:
  • Amidohydrolase-like
  • Dihydroorotase region
ProtoNet:

Suggested Antigen Peptide Sequences for DPYSL2 Gene

GenScript: Design optimal peptide antigens:
  • Dihydropyrimidinase-like 2 short form (A9CQZ2_HUMAN)
  • Dihydropyrimidinase-like 2 long form (A9CQZ4_HUMAN)
  • cDNA FLJ53166, highly similar to Dihydropyrimidinase-related protein 2 (B4DR31_HUMAN)
  • Unc-33-like phosphoprotein 2 (DPYL2_HUMAN)
  • cDNA FLJ35058 fis, clone OCBBF2018707, highly similar to DIHYDROPYRIMIDINASE RELATED PROTEIN-2 (Q8NAN9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16555

UniProtKB/Swiss-Prot:

DPYL2_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYSL2: view

Function for DPYSL2 Gene

Molecular function for DPYSL2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
GENATLAS Biochemistry:
dihydropyrimidinase related protein 2,mainly expressed in the fetal and neonatal brain,involved in the developmental process of the nervous system

Phenotypes From GWAS Catalog for DPYSL2 Gene

Gene Ontology (GO) - Molecular Function for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004157 NOT dihydropyrimidinase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 16260607
GO:0008017 microtubule binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with DPYSL2: view
genes like me logo Genes that share phenotypes with DPYSL2: view

Animal Model Products

CRISPR Products

miRNA for DPYSL2 Gene

miRTarBase miRNAs that target DPYSL2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPYSL2 Gene

Localization for DPYSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
cytoskeleton 4
nucleus 4
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 colocalizes_with microtubule IDA 20801876
genes like me logo Genes that share ontologies with DPYSL2: view

Pathways & Interactions for DPYSL2 Gene

PathCards logo

SuperPathways for DPYSL2 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Semaphorin interactions
3 Development Slit-Robo signaling
.44
.44
4 Cytoskeletal Signaling
5 Neuroscience
genes like me logo Genes that share pathways with DPYSL2: view

Pathways by source for DPYSL2 Gene

2 GeneGo (Thomson Reuters) pathways for DPYSL2 Gene
  • Development Slit-Robo signaling
  • Neurophysiological process Receptor-mediated axon growth repulsion
3 Cell Signaling Technology pathways for DPYSL2 Gene

SIGNOR curated interactions for DPYSL2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 8973361
GO:0006208 NOT pyrimidine nucleobase catabolic process IBA 21873635
GO:0006897 endocytosis IMP 20801876
GO:0007010 cytoskeleton organization ISS --
genes like me logo Genes that share ontologies with DPYSL2: view

Drugs & Compounds for DPYSL2 Gene

(3) Drugs for DPYSL2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lacosamide Approved Pharma Checkpoint kinase inhibitor,ATP competitive, Checkpoint kinase (Chk) inhibitor 90
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 115

(5) Additional Compounds for DPYSL2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ureidopropionic acid
  • 3-[(Aminocarbonyl)amino]propanoic acid
  • 3-Ureidopropanoate
  • 3-Ureidopropanoic acid
  • 3-Ureidopropionate
  • 3-Ureidopropionic acid
462-88-4
genes like me logo Genes that share compounds with DPYSL2: view

Transcripts for DPYSL2 Gene

mRNA/cDNA for DPYSL2 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL2

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - -
SP2: -
SP3:
SP4: - -
SP5: -
SP6: -

Relevant External Links for DPYSL2 Gene

GeneLoc Exon Structure for
DPYSL2

Expression for DPYSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPYSL2 Gene

Protein differential expression in normal tissues from HIPED for DPYSL2 Gene

This gene is overexpressed in Spinal cord (10.6), Fetal Brain (10.1), Frontal cortex (9.9), Brain (8.0), and Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPYSL2 Gene



Protein tissue co-expression partners for DPYSL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPYSL2

SOURCE GeneReport for Unigene cluster for DPYSL2 Gene:

Hs.593187

mRNA Expression by UniProt/SwissProt for DPYSL2 Gene:

Q16555-DPYL2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DPYSL2 Gene

  • Nervous system(5)
  • Eye(4.6)
  • Liver(4.4)
  • Lung(3.3)
  • Heart(3.3)
  • Skin(2.7)
  • Kidney(2.7)
  • Adrenal gland(2.6)
  • Muscle(2.5)
  • Blood(2.4)
  • Intestine(2.2)
  • Spleen(2.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DPYSL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL2 Gene

Orthologs for DPYSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPYSL2 30 31
  • 99.36 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DPYSL2 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia DPYSL2 30 31
  • 92.12 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DPYSL2 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia DPYSL2 30 31
  • 90.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dpysl2 30 17 31
  • 90.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dpysl2 30
  • 90.2 (n)
Chicken
(Gallus gallus)
Aves DPYSL2 30 31
  • 83.09 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DPYSL2 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dpysl2 30
  • 78.15 (n)
Str.15312 30
Zebrafish
(Danio rerio)
Actinopterygii dpysl2b 31
  • 90 (a)
OneToOne
Dr.29680 30
Fruit Fly
(Drosophila melanogaster)
Insecta CRMP 32
  • 46 (a)
Worm
(Caenorhabditis elegans)
Secernentea dhp-2 32
  • 48 (a)
dhp-1 32
  • 47 (a)
unc-33 32
  • 34 (a)
Species where no ortholog for DPYSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DPYSL2 Gene

ENSEMBL:
Gene Tree for DPYSL2 (if available)
TreeFam:
Gene Tree for DPYSL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPYSL2: view image

Paralogs for DPYSL2 Gene

Paralogs for DPYSL2 Gene

(5) SIMAP similar genes for DPYSL2 Gene using alignment to 4 proteins:

  • DPYL2_HUMAN
  • A9CQZ2_HUMAN
  • A9CQZ4_HUMAN
  • E5RFU4_HUMAN
genes like me logo Genes that share paralogs with DPYSL2: view

Variants for DPYSL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPYSL2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
708360 Benign: not provided 26,624,181(+) G/A MISSENSE_VARIANT
711497 Benign: not provided 26,653,223(+) G/A INTRON_VARIANT
712013 Benign: not provided 26,634,815(+) C/T SYNONYMOUS_VARIANT
716283 Benign: not provided 26,655,652(+) C/G SYNONYMOUS_VARIANT
718924 Likely Benign: not provided 26,624,306(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DPYSL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DPYSL2 Gene

Variant ID Type Subtype PubMed ID
esv3572649 CNV loss 25503493
esv3616666 OTHER inversion 21293372
esv988025 CNV insertion 20482838
nsv1117814 CNV deletion 24896259
nsv1119175 CNV deletion 24896259
nsv465626 CNV loss 19166990
nsv610862 CNV loss 21841781
nsv610863 CNV loss 21841781
nsv6130 CNV insertion 18451855
nsv824581 CNV gain 20364138

Variation tolerance for DPYSL2 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPYSL2 Gene

Human Gene Mutation Database (HGMD)
DPYSL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL2 Gene

Disorders for DPYSL2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DPYSL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
neuronal ceroid lipofuscinosis
  • batten disease
bipolar disorder
  • major affective disorder 1
schizophrenia
  • sczd
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DPYSL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DPYSL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL2 Gene

Publications for DPYSL2 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 4 23
  2. An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. (PMID: 16321170) Zhao X … He L (The international journal of neuropsychopharmacology 2006) 3 23 41
  3. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. (PMID: 16260607) Kawano Y … Kaibuchi K (Molecular and cellular biology 2005) 3 4 23
  4. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. (PMID: 10757975) Gu Y … Ihara Y (Biochemistry 2000) 3 4 23
  5. Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. (PMID: 10574455) Kitamura K … Nonaka M (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 23

Products for DPYSL2 Gene

Sources for DPYSL2 Gene