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Aliases for DPYSL2 Gene

Aliases for DPYSL2 Gene

  • Dihydropyrimidinase Like 2 2 3 5
  • Unc-33-Like Phosphoprotein 2 3 4
  • CRMP-2 3 4
  • ULIP-2 3 4
  • CRMP2 3 4
  • DRP-2 3 4
  • ULIP2 3 4
  • N2A3 3 4
  • Collapsin Response Mediator Protein HCRMP-2 3
  • Dihydropyrimidinase-Related Protein 2 3
  • Collapsin Response Mediator Protein 2 4
  • Dihydropyrimidinase-Like 2 2
  • DHPRP2 3
  • DRP2 3

External Ids for DPYSL2 Gene

Previous GeneCards Identifiers for DPYSL2 Gene

  • GC08P026208
  • GC08P026792
  • GC08P026457
  • GC08P026491
  • GC08P024980
  • GC08P026371

Summaries for DPYSL2 Gene

Entrez Gene Summary for DPYSL2 Gene

  • This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DPYSL2 Gene

DPYSL2 (Dihydropyrimidinase Like 2) is a Protein Coding gene. Diseases associated with DPYSL2 include Alzheimer Disease and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Cytoskeletal Signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot for DPYSL2 Gene

  • Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Gene Wiki entry for DPYSL2 Gene

Additional gene information for DPYSL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPYSL2 Gene

Genomics for DPYSL2 Gene

GeneHancer (GH) Regulatory Elements for DPYSL2 Gene

Promoters and enhancers for DPYSL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J026575 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662.1 +63.9 63884 5.2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 DPYSL2 LOC100132229 RNA5SP258 ENSG00000253342 LOC105379332 PNMA2 LOC105379337 SDAD1P1 PSME2P5 GC08M026683
GH08J026513 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 0.0 -21 0.4 ZNF473 ZSCAN4 KLF17 KLF14 ZNF2 YY1 ZNF335 GLIS2 ZNF366 KLF7 PNMA2 DPYSL2 LOC105379337
GH08J026518 Promoter/Enhancer 1.2 Ensembl ENCODE 650.7 +0.6 579 0.4 CTCF MXI1 KLF1 ZNF473 KLF17 SIN3A KLF14 ZNF335 ZFHX2 ZBTB48 PNMA2 DPYSL2 GC08P026534
GH08J026517 Enhancer 0.9 ENCODE 650.7 -1.8 -1812 0.2 INSM2 KLF17 MZF1 FEZF1 ZNF2 ZNF335 ZNF213 ZNF366 ZSCAN5C ZNF362 PNMA2 DPYSL2 LOC105379337
GH08J026519 Enhancer 0.8 ENCODE 650.7 -0.4 -402 0.2 ZSCAN4 KLF14 ZNF2 YY1 ZNF335 ZNF280D SP3 ZBTB11 ZNF398 TSHZ1 PNMA2 DPYSL2 LOC105379337
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPYSL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPYSL2 gene promoter:

Genomic Locations for DPYSL2 Gene

Genomic Locations for DPYSL2 Gene
144,157 bases
Plus strand

Genomic View for DPYSL2 Gene

Genes around DPYSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYSL2 Gene

Proteins for DPYSL2 Gene

  • Protein details for DPYSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dihydropyrimidinase-related protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K5H2
    • B4DR31
    • D3DSS7
    • O00424

    Protein attributes for DPYSL2 Gene

    572 amino acids
    Molecular mass:
    62294 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.

    Three dimensional structures from OCA and Proteopedia for DPYSL2 Gene

    Alternative splice isoforms for DPYSL2 Gene


neXtProt entry for DPYSL2 Gene

Post-translational modifications for DPYSL2 Gene

  • 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
  • Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
  • Ubiquitination at Lys472 and Lys345
  • Modification sites at PhosphoSitePlus

Other Protein References for DPYSL2 Gene

No data available for DME Specific Peptides for DPYSL2 Gene

Domains & Families for DPYSL2 Gene

Gene Families for DPYSL2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYSL2: view

Function for DPYSL2 Gene

Molecular function for DPYSL2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
GENATLAS Biochemistry:
dihydropyrimidinase related protein 2,mainly expressed in the fetal and neonatal brain,involved in the developmental process of the nervous system

Phenotypes From GWAS Catalog for DPYSL2 Gene

Gene Ontology (GO) - Molecular Function for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004157 dihydropyrimidinase activity TAS 8973361
GO:0005515 protein binding IPI 16260607
GO:0008017 microtubule binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
genes like me logo Genes that share ontologies with DPYSL2: view
genes like me logo Genes that share phenotypes with DPYSL2: view

Animal Model Products

CRISPR Products

miRNA for DPYSL2 Gene

miRTarBase miRNAs that target DPYSL2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPYSL2 Gene

Localization for DPYSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPYSL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYSL2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 colocalizes_with microtubule IDA 20801876
genes like me logo Genes that share ontologies with DPYSL2: view

Pathways & Interactions for DPYSL2 Gene

genes like me logo Genes that share pathways with DPYSL2: view

Pathways by source for DPYSL2 Gene

3 Cell Signaling Technology pathways for DPYSL2 Gene

SIGNOR curated interactions for DPYSL2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DPYSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 8973361
GO:0006897 endocytosis IMP 20801876
GO:0007010 cytoskeleton organization ISS --
GO:0007165 signal transduction TAS 8973361
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with DPYSL2: view

Drugs & Compounds for DPYSL2 Gene

(3) Drugs for DPYSL2 Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lacosamide Approved Pharma Checkpoint kinase inhibitor,ATP competitive, Checkpoint kinase (Chk) inhibitor 82
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100

(5) Additional Compounds for DPYSL2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ureidopropionic acid
  • 3-[(Aminocarbonyl)amino]propanoic acid
  • 3-Ureidopropanoate
  • 3-Ureidopropanoic acid
  • 3-Ureidopropionate
  • 3-Ureidopropionic acid
genes like me logo Genes that share compounds with DPYSL2: view

Transcripts for DPYSL2 Gene

mRNA/cDNA for DPYSL2 Gene

Unigene Clusters for DPYSL2 Gene

Dihydropyrimidinase-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYSL2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPYSL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - -
SP2: -
SP4: - -
SP5: -
SP6: -

Relevant External Links for DPYSL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPYSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPYSL2 Gene

Protein differential expression in normal tissues from HIPED for DPYSL2 Gene

This gene is overexpressed in Spinal cord (10.6), Fetal Brain (10.1), Frontal cortex (9.9), Brain (8.0), and Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPYSL2 Gene

Protein tissue co-expression partners for DPYSL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPYSL2 Gene:


SOURCE GeneReport for Unigene cluster for DPYSL2 Gene:


mRNA Expression by UniProt/SwissProt for DPYSL2 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DPYSL2 Gene

  • Nervous system(5)
  • Eye(4.5)
  • Liver(4.2)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with DPYSL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYSL2 Gene

Orthologs for DPYSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPYSL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPYSL2 34 33
  • 99.36 (n)
(Monodelphis domestica)
Mammalia DPYSL2 34
  • 98 (a)
(Canis familiaris)
Mammalia DPYSL2 34 33
  • 92.12 (n)
(Ornithorhynchus anatinus)
Mammalia DPYSL2 34
  • 92 (a)
(Bos Taurus)
Mammalia DPYSL2 34 33
  • 90.85 (n)
(Mus musculus)
Mammalia Dpysl2 16 34 33
  • 90.67 (n)
(Rattus norvegicus)
Mammalia Dpysl2 33
  • 90.2 (n)
(Gallus gallus)
Aves DPYSL2 34 33
  • 83.09 (n)
(Anolis carolinensis)
Reptilia DPYSL2 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpysl2 33
  • 78.15 (n)
Str.15312 33
(Danio rerio)
Actinopterygii dpysl2b 34
  • 90 (a)
Dr.29680 33
fruit fly
(Drosophila melanogaster)
Insecta CRMP 35
  • 46 (a)
(Caenorhabditis elegans)
Secernentea dhp-2 35
  • 48 (a)
dhp-1 35
  • 47 (a)
unc-33 35
  • 34 (a)
Species where no ortholog for DPYSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPYSL2 Gene

Gene Tree for DPYSL2 (if available)
Gene Tree for DPYSL2 (if available)
Evolutionary constrained regions (ECRs) for DPYSL2: view image

Paralogs for DPYSL2 Gene

Paralogs for DPYSL2 Gene

(5) SIMAP similar genes for DPYSL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPYSL2: view

Variants for DPYSL2 Gene

Sequence variations from dbSNP and Humsavar for DPYSL2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs138340807 likely-pathogenic, Inborn genetic diseases 26,581,971(+) C/A/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, synonymous_variant
VAR_036316 A colorectal cancer sample p.Arg481Cys
rs1000030896 -- 26,603,182(+) A/T intron_variant
rs1000090048 -- 26,578,450(+) T/C 5_prime_UTR_variant, intron_variant
rs1000097471 -- 26,650,998(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPYSL2 Gene

Variant ID Type Subtype PubMed ID
esv3572649 CNV loss 25503493
esv3616666 OTHER inversion 21293372
esv988025 CNV insertion 20482838
nsv1117814 CNV deletion 24896259
nsv1119175 CNV deletion 24896259
nsv465626 CNV loss 19166990
nsv610862 CNV loss 21841781
nsv610863 CNV loss 21841781
nsv6130 CNV insertion 18451855
nsv824581 CNV gain 20364138

Variation tolerance for DPYSL2 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPYSL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYSL2 Gene

Disorders for DPYSL2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DPYSL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
neuronal ceroid lipofuscinosis
  • batten disease
bipolar disorder
  • major affective disorder 1
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DPYSL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DPYSL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPYSL2 Gene

Publications for DPYSL2 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 4 22 58
  2. An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. (PMID: 16321170) Zhao X … He L (The international journal of neuropsychopharmacology 2006) 3 22 44 58
  3. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. (PMID: 16260607) Kawano Y … Kaibuchi K (Molecular and cellular biology 2005) 3 4 22 58
  4. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. (PMID: 10757975) Gu Y … Ihara Y (Biochemistry 2000) 3 4 22 58
  5. Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. (PMID: 10574455) Kitamura K … Nonaka M (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 22 58

Products for DPYSL2 Gene

Sources for DPYSL2 Gene

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