Aliases for DPYS Gene
External Ids for DPYS Gene
Previous GeneCards Identifiers for DPYS Gene
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
GeneCards Summary for DPYS Gene
DPYS (Dihydropyrimidinase) is a Protein Coding gene. Diseases associated with DPYS include Dihydropyrimidinase Deficiency and Dihydropyrimidine Dehydrogenase Deficiency. Among its related pathways are Beta-alanine metabolism (TR) and Pantothenate and CoA biosynthesis. Gene Ontology (GO) annotations related to this gene include hydrolase activity and amino acid binding. An important paralog of this gene is DPYSL2.
UniProtKB/Swiss-Prot Summary for DPYS Gene
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.