Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008] See more...

Aliases for DPYS Gene

Aliases for DPYS Gene

  • Dihydropyrimidinase 2 3 4 5
  • DHPase 2 3 4
  • Dihydropyrimidine Amidohydrolase 3 4
  • Hydantoinase 3 4
  • EC 3.5.2.2 4 50
  • DHP 3 4
  • DPYS 5

External Ids for DPYS Gene

Previous GeneCards Identifiers for DPYS Gene

  • GC08M104397
  • GC08M105459
  • GC08M105060
  • GC08M105348
  • GC08M105460
  • GC08M105391
  • GC08M100592

Summaries for DPYS Gene

Entrez Gene Summary for DPYS Gene

  • Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPYS Gene

DPYS (Dihydropyrimidinase) is a Protein Coding gene. Diseases associated with DPYS include Dihydropyrimidinase Deficiency and Dihydropyrimidine Dehydrogenase Deficiency. Among its related pathways are Beta-alanine metabolism (TR) and Pantothenate and CoA biosynthesis. Gene Ontology (GO) annotations related to this gene include hydrolase activity and amino acid binding. An important paralog of this gene is DPYSL2.

UniProtKB/Swiss-Prot Summary for DPYS Gene

  • Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.

Gene Wiki entry for DPYS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPYS Gene

Genomics for DPYS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DPYS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J104467 Promoter 0.6 EPDnew 250.7 0.0 -1 0.1 YY1 RXRA HNF4A REST SP1 DPYS HSALNG0067564 LOC105375691 RF00017-6688 LRP12
GH08J104466 Promoter 0.6 Ensembl 250.7 +0.3 273 0.4 YY1 RXRA HNF4A REST SP1 DPYS HSALNG0067564 LOC105375691 DCSTAMP
GH08J104418 Promoter 0.4 EPDnew 250.3 +48.2 48165 0.1 PRDM10 lnc-DPYS-1 DPYS DCSTAMP piR-38537-058
GH08J104437 Enhancer 0.8 FANTOM5 Ensembl 10.3 +27.5 27514 6.7 ZNF654 REST TRIM22 CTCF RAD21 SMC3 STAT5A SP1 ZBTB40 CEBPB DCSTAMP DPYS LRP12 RF01061-177 lnc-LRP12-3
GH08J104686 Enhancer 0.7 Ensembl 10.1 -219.3 -219327 0.4 REST TRIM22 CTCF IRF4 SMC3 ZNF316 NFE2 EHMT2 MAFG MAFK LRP12 DPYS ENSG00000283157 piR-53063-254 ZFPM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPYS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPYS

Top Transcription factor binding sites by QIAGEN in the DPYS gene promoter:
  • Chx10
  • CUTL1
  • E4BP4
  • Egr-4
  • FOXO1
  • FOXO1a
  • GATA-1
  • GATA-2
  • GATA-3
  • Msx-1

Genomic Locations for DPYS Gene

Latest Assembly
chr8:104,330,324-104,467,074
(GRCh38/hg38)
Size:
136,751 bases
Orientation:
Minus strand

Previous Assembly
chr8:105,391,659-105,479,283
(GRCh37/hg19 by Entrez Gene)
Size:
87,625 bases
Orientation:
Minus strand

chr8:105,342,552-105,479,281
(GRCh37/hg19 by Ensembl)
Size:
136,730 bases
Orientation:
Minus strand

Genomic View for DPYS Gene

Genes around DPYS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPYS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPYS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPYS Gene

Proteins for DPYS Gene

  • Protein details for DPYS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14117-DPYS_HUMAN
    Recommended name:
    Dihydropyrimidinase
    Protein Accession:
    Q14117

    Protein attributes for DPYS Gene

    Size:
    519 amino acids
    Molecular mass:
    56630 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for DPYS Gene

neXtProt entry for DPYS Gene

Selected DME Specific Peptides for DPYS Gene

Q14117:
  • CDYSLHVA
  • AVGSDADIV
  • GGTTMIIDF
  • LPGGIDTHTH
  • FVAVTST
  • GKDDFTKIPNGVNGVEDRMS
  • DIVIWDP

Post-translational modifications for DPYS Gene

  • Carboxylation allows a single lysine to coordinate two zinc ions.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DPYS Gene

Gene Families for DPYS Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for DPYS Gene

Suggested Antigen Peptide Sequences for DPYS Gene

GenScript: Design optimal peptide antigens:
  • Hydantoinase (DPYS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14117

UniProtKB/Swiss-Prot:

DPYS_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
genes like me logo Genes that share domains with DPYS: view

Function for DPYS Gene

Molecular function for DPYS Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+); Xref=Rhea:RHEA:16121, ChEBI:CHEBI:11892, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15901; EC=3.5.2.2; Evidence={ECO:0000250|UniProtKB:Q55DL0};.
GENATLAS Biochemistry:
dihydropyrimidinase

Enzyme Numbers (IUBMB) for DPYS Gene

Phenotypes From GWAS Catalog for DPYS Gene

Gene Ontology (GO) - Molecular Function for DPYS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002058 uracil binding IEA --
GO:0002059 thymine binding IEA --
GO:0004157 dihydropyrimidinase activity IBA,IMP 18075467
GO:0005515 protein binding IPI 32296183
GO:0008270 zinc ion binding IEA,NAS 9718352
genes like me logo Genes that share ontologies with DPYS: view
genes like me logo Genes that share phenotypes with DPYS: view

Human Phenotype Ontology for DPYS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYS

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPYS Gene

Localization for DPYS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPYS gene
Compartment Confidence
cytosol 5
extracellular 4
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DPYS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,TAS --
GO:0032991 protein-containing complex IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with DPYS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DPYS Gene

Pathways & Interactions for DPYS Gene

genes like me logo Genes that share pathways with DPYS: view

Pathways by source for DPYS Gene

Gene Ontology (GO) - Biological Process for DPYS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006208 pyrimidine nucleobase catabolic process IBA,IDA 9718352
GO:0006210 thymine catabolic process IEA,ISS --
GO:0006212 uracil catabolic process IEA,IMP 18075467
GO:0019482 beta-alanine metabolic process IEA --
GO:0019860 uracil metabolic process IEA --
genes like me logo Genes that share ontologies with DPYS: view

No data available for SIGNOR curated interactions for DPYS Gene

Drugs & Compounds for DPYS Gene

(9) Drugs for DPYS Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma 120
Water Approved Pharma 0
Dihydrouracil Experimental Pharma 0

(14) Additional Compounds for DPYS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,6-Dihydro-5-fluorouracil
  • 5-Fluorodihydrouracil
  • (R)-5-Fluoro-5,6-dihydrouracil
  • DHFU
  • 5,6-Dihydrofluorouracil
  • 5-Dihydrofluorouracil
alpha-Fluoro-beta-ureidopropionic acid
  • 2-Fluoro-3-ureidopropionic acid
  • 2-Fluoro-3-ureidopropionate
  • a-Fluoro-b-ureidopropionate
  • a-Fluoro-b-ureidopropionic acid
  • alpha-Fluoro-beta-ureidopropionate
Dihydrothymine
  • (-)-(S)-5,6-Dihydrothymine
  • (5S)-5-Methyl-1,3-diazinane-2,4-dione
  • 5,6-Dihydro-5-methyluracil
  • 5,6-Dihydrothymine
  • 5-Methyl-5,6-dihydrouracil
19140-80-8
Ureidoisobutyric acid
  • (2S)-3-[(C-Hydroxycarbonimidoyl)amino]-2-methylpropanoate
  • (2S)-3-(Carbamoylamino)-2-methylpropanoic acid
  • (2S)-3-(Carbamoylamino)-2-methylpropionic acid
  • 3-((Aminocarbonyl)amino)-2-methylpropanoic acid
  • 3-((Aminocarbonyl)amino)-2-methylpropionic acid
19140-82-0
Ureidopropionic acid
  • 3-[(Aminocarbonyl)amino]propanoic acid
  • 3-Ureidopropanoate
  • 3-Ureidopropanoic acid
  • 3-Ureidopropionate
  • 3-Ureidopropionic acid
462-88-4
genes like me logo Genes that share compounds with DPYS: view

Transcripts for DPYS Gene

mRNA/cDNA for DPYS Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPYS

Alternative Splicing Database (ASD) splice patterns (SP) for DPYS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for DPYS Gene

GeneLoc Exon Structure for
DPYS

Expression for DPYS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPYS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPYS Gene

This gene is overexpressed in Liver (x36.6) and Kidney - Cortex (x11.8).

Protein differential expression in normal tissues from HIPED for DPYS Gene

This gene is overexpressed in Liver, secretome (42.6) and Liver (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPYS Gene



Protein tissue co-expression partners for DPYS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPYS

SOURCE GeneReport for Unigene cluster for DPYS Gene:

Hs.443161

mRNA Expression by UniProt/SwissProt for DPYS Gene:

Q14117-DPYS_HUMAN
Tissue specificity: Liver and kidney.

Evidence on tissue expression from TISSUES for DPYS Gene

  • Liver(4.7)
  • Kidney(4.6)
  • Intestine(4.4)
  • Stomach(4.2)
  • Nervous system(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DPYS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • face
  • head
  • skull
Abdomen:
  • intestine
  • large intestine
Pelvis:
  • anus
  • rectum
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with DPYS: view

Primer products for research

Orthologs for DPYS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPYS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPYS 29 30
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DPYS 29 30
  • 89.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DPYS 29 30
  • 88.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DPYS 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dpys 29
  • 86.49 (n)
Mouse
(Mus musculus)
Mammalia Dpys 29 16 30
  • 86.04 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DPYS 30
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DPYS 29 30
  • 72.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DPYS 30
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dpys 29
  • 73.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii dpys 29 30
  • 69.69 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CRMP 29 31
  • 59.42 (n)
CG6106 30
  • 22 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003124 29
  • 59.01 (n)
Worm
(Caenorhabditis elegans)
Secernentea dhp-2 29 31
  • 57.78 (n)
dhp-1 30 31
  • 55 (a)
ManyToMany
unc-33 31
  • 35 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL1 30
  • 22 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PYD2 29
  • 53.53 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.718 29
Soybean
(Glycine max)
eudicotyledons Gma.3611 29
Rice
(Oryza sativa)
Liliopsida Os01g0807900 29
  • 55.18 (n)
Os.33610 29
Wheat
(Triticum aestivum)
Liliopsida Ta.18843 29
Corn
(Zea mays)
Liliopsida Zm.2131 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 63 (a)
OneToOne
Species where no ortholog for DPYS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DPYS Gene

ENSEMBL:
Gene Tree for DPYS (if available)
TreeFam:
Gene Tree for DPYS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPYS: view image
Alliance of Genome Resources:
Additional Orthologs for DPYS

Paralogs for DPYS Gene

Paralogs for DPYS Gene

(5) SIMAP similar genes for DPYS Gene using alignment to 3 proteins:

  • DPYS_HUMAN
  • E5RG28_HUMAN
  • H0YEV7_HUMAN
genes like me logo Genes that share paralogs with DPYS: view

Variants for DPYS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPYS Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
1001764 Uncertain Significance: not provided 104,428,062(-) A/G
NM_001385.3(DPYS):c.1010T>C (p.Leu337Pro)
MISSENSE
1029334 Pathogenic: Dihydropyrimidinase deficiency 104,381,290(-) G/A
NM_001385.3(DPYS):c.1468C>T (p.Arg490Cys)
MISSENSE
1033424 Pathogenic: Dihydropyrimidinase deficiency 104,392,971(-) TGA/T
NM_001385.3(DPYS):c.1254_1255del (p.His419fs)
FRAMESHIFT
863103 Pathogenic: Dihydropyrimidinase deficiency; not provided 104,392,834(-) G/A
NM_001385.3(DPYS):c.1393C>T (p.Arg465Ter)
NONSENSE
908871 Uncertain Significance: Dihydropyrimidinase deficiency 104,379,513(-) T/A
NM_001385.3(DPYS):c.*345A>T
THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DPYS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DPYS Gene

Variant ID Type Subtype PubMed ID
nsv1032775 CNV gain 25217958
nsv1075159 CNV deletion 25765185
nsv6337 CNV insertion 18451855
nsv831417 CNV loss 17160897

Variation tolerance for DPYS Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPYS Gene

Human Gene Mutation Database (HGMD)
DPYS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPYS
Leiden Open Variation Database (LOVD)
DPYS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPYS Gene

Disorders for DPYS Gene

MalaCards: The human disease database

(4) MalaCards diseases for DPYS Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
dihydropyrimidinase deficiency
  • dpysd
dihydropyrimidine dehydrogenase deficiency
  • dpd deficiency
pyrimidine metabolic disorder
  • disorder of pyrimidine metabolism
beta-ureidopropionase deficiency
  • upb1d
- elite association - COSMIC cancer census association via MalaCards
Search DPYS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DPYS_HUMAN
  • Dihydropyrimidinase deficiency (DPYSD) [MIM:222748]: An autosomal recessive disorder of pyrimidine metabolism characterized by dihydropyrimidinuria. It is associated with a variable clinical phenotype characterized by epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Most patients are, however, asymptomatic. {ECO:0000269 PubMed:9718352}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for DPYS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DPYS: view

No data available for Genatlas for DPYS Gene

Publications for DPYS Gene

  1. Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene. (PMID: 9718352) Hamajima N … Wada Y (American journal of human genetics 1998) 3 4 22 72
  2. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N … Nonaka M (Gene 1996) 2 3 4 22
  3. Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients. (PMID: 19649633) Fidlerova J … Kleibl Z (Cancer chemotherapy and pharmacology 2010) 3 22 40
  4. Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. (PMID: 18075467) Thomas HR … Diasio RB (Pharmacogenetics and genomics 2007) 3 22 40
  5. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PMID: 20797317) Kim HY … Kim H (BMB reports 2010) 3 40

Products for DPYS Gene

Sources for DPYS Gene