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Aliases for DPY19L4 Gene

Aliases for DPY19L4 Gene

  • Dpy-19 Like 4 2 3 5
  • Protein Dpy-19 Homolog 4 3 4
  • Dpy-19-Like Protein 4 3 4
  • Probable C-Mannosyltransferase DPY19L4 3
  • Dpy-19 Like 4 (C. Elegans) 2
  • EC 2.4.1.- 4

External Ids for DPY19L4 Gene

Previous GeneCards Identifiers for DPY19L4 Gene

  • GC08P095802
  • GC08P090940

Summaries for DPY19L4 Gene

GeneCards Summary for DPY19L4 Gene

DPY19L4 (Dpy-19 Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is DPY19L3.

UniProtKB/Swiss-Prot for DPY19L4 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Additional gene information for DPY19L4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPY19L4 Gene

Genomics for DPY19L4 Gene

GeneHancer (GH) Regulatory Elements for DPY19L4 Gene

Promoters and enhancers for DPY19L4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J094718 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 656.1 +0.4 378 2.9 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 DPY19L4 VIRMA INTS8 RBM12B C8orf37 ENSG00000254283 LINC01298 PSMA2P2 TMEM67 ENSG00000272509
GH08J094678 Promoter 0.6 EPDnew 650.3 -41.5 -41460 0.1 SOX13 GC08M094672 DPY19L4 ESRP1 RPS15AP26
GH08J093974 Enhancer 0.6 ENCODE 9.7 -745.4 -745375 0.2 LCORL NFIC SMAD1 NFIA NFIB ZNF350 ZNF195 ZNF112 ENSG00000275386 RPL34P18 VIRMA ENSG00000253854 INTS8 TMEM67 DPY19L4
GH08J094690 Enhancer 0.8 ENCODE 6.2 -27.2 -27206 3.2 FOXA2 INSM2 SIN3A FEZF1 RFX5 ZNF213 FOS ZEB2 ZNF518A ZNF843 ESRP1 DPY19L4 RPS15AP26 GC08P094705
GH08J094748 Enhancer 0.8 ENCODE 5.2 +29.5 29521 0.7 HDAC1 ATF1 TCF12 ZNF766 ATF7 EGR2 CEBPB GATAD2B NR2F2 MEF2D DPY19L4 ENSG00000254307
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPY19L4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPY19L4 gene promoter:
  • E2F
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F-5
  • deltaCREB
  • CREB
  • FOXJ2 (long isoform)
  • FOXJ2

Genomic Locations for DPY19L4 Gene

Genomic Locations for DPY19L4 Gene
chr8:94,719,703-94,793,848
(GRCh38/hg38)
Size:
74,146 bases
Orientation:
Plus strand
chr8:95,731,931-95,806,076
(GRCh37/hg19)
Size:
74,146 bases
Orientation:
Plus strand

Genomic View for DPY19L4 Gene

Genes around DPY19L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPY19L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPY19L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L4 Gene

Proteins for DPY19L4 Gene

  • Protein details for DPY19L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z388-D19L4_HUMAN
    Recommended name:
    Probable C-mannosyltransferase DPY19L4
    Protein Accession:
    Q7Z388
    Secondary Accessions:
    • Q6ZW32
    • Q6ZW42
    • Q7Z329

    Protein attributes for DPY19L4 Gene

    Size:
    723 amino acids
    Molecular mass:
    83756 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85664.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DPY19L4 Gene

Post-translational modifications for DPY19L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPY19L4 Gene

Domains & Families for DPY19L4 Gene

Gene Families for DPY19L4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DPY19L4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY19L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z388

UniProtKB/Swiss-Prot:

D19L4_HUMAN :
  • Belongs to the dpy-19 family.
Family:
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L4: view

Function for DPY19L4 Gene

Molecular function for DPY19L4 Gene

UniProtKB/Swiss-Prot Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L4 Gene

Gene Ontology (GO) - Molecular Function for DPY19L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DPY19L4: view
genes like me logo Genes that share phenotypes with DPY19L4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DPY19L4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPY19L4

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPY19L4 Gene

Localization for DPY19L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPY19L4 gene
Compartment Confidence
plasma membrane 3
nucleus 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPY19L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L4: view

Pathways & Interactions for DPY19L4 Gene

SuperPathways for DPY19L4 Gene

No Data Available

Interacting Proteins for DPY19L4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000389630%0d%0a9606.ENSP00000304843%0d%0a9606.ENSP00000384109%0d%0a
Selected Interacting proteins: ENSP00000389630 Q7Z388-D19L4_HUMAN for DPY19L4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DPY19L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018406 protein C-linked glycosylation via 2-alpha-mannosyl-L-tryptophan IBA --
genes like me logo Genes that share ontologies with DPY19L4: view

No data available for Pathways by source and SIGNOR curated interactions for DPY19L4 Gene

Drugs & Compounds for DPY19L4 Gene

No Compound Related Data Available

Transcripts for DPY19L4 Gene

Unigene Clusters for DPY19L4 Gene

Dpy-19-like 4 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPY19L4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for DPY19L4 Gene

GeneLoc Exon Structure for
DPY19L4
ECgene alternative splicing isoforms for
DPY19L4

Expression for DPY19L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPY19L4 Gene

Protein differential expression in normal tissues from HIPED for DPY19L4 Gene

This gene is overexpressed in Placenta (29.1), Retina (22.4), and Islet of Langerhans (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPY19L4 Gene



Protein tissue co-expression partners for DPY19L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPY19L4 Gene:

DPY19L4

SOURCE GeneReport for Unigene cluster for DPY19L4 Gene:

Hs.567828

mRNA Expression by UniProt/SwissProt for DPY19L4 Gene:

Q7Z388-D19L4_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for DPY19L4 Gene

  • Intestine(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with DPY19L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPY19L4 Gene

Orthologs for DPY19L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPY19L4 34 33
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPY19L4 34 33
  • 94.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPY19L4 34 33
  • 93.78 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPY19L4 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpy19l4 33
  • 87.21 (n)
mouse
(Mus musculus)
Mammalia Dpy19l4 16 34 33
  • 86.8 (n)
oppossum
(Monodelphis domestica)
Mammalia DPY19L4 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPY19L4 34 33
  • 79.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPY19L4 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpy19l4 33
  • 68.75 (n)
Str.16649 33
fruit fly
(Drosophila melanogaster)
Insecta CG6659 34
  • 15 (a)
OneToMany
Species where no ortholog for DPY19L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPY19L4 Gene

ENSEMBL:
Gene Tree for DPY19L4 (if available)
TreeFam:
Gene Tree for DPY19L4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPY19L4: view image

Paralogs for DPY19L4 Gene

Paralogs for DPY19L4 Gene

(1) SIMAP similar genes for DPY19L4 Gene using alignment to 8 proteins:

  • D19L4_HUMAN
  • E5RGB7_HUMAN
  • E5RGH1_HUMAN
  • H0YAT0_HUMAN
  • H0YBI1_HUMAN
  • H0YBK6_HUMAN
  • H0YBL6_HUMAN
  • H0YBV9_HUMAN

Pseudogenes.org Pseudogenes for DPY19L4 Gene

genes like me logo Genes that share paralogs with DPY19L4: view

Variants for DPY19L4 Gene

Sequence variations from dbSNP and Humsavar for DPY19L4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000069017 -- 94,787,053(+) T/A intron_variant
rs1000069688 -- 94,742,208(+) A/T intron_variant
rs1000130126 -- 94,748,692(+) A/G intron_variant
rs1000157835 -- 94,775,415(+) A/C intron_variant
rs1000191406 -- 94,757,471(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPY19L4 Gene

Variant ID Type Subtype PubMed ID
esv2657874 CNV deletion 23128226
esv2674010 CNV deletion 23128226
esv3306820 CNV mobile element insertion 20981092
esv3368483 CNV insertion 20981092
esv3403930 CNV insertion 20981092
esv3572910 CNV loss 25503493
esv3572911 CNV loss 25503493
esv3618087 CNV loss 21293372
esv3618088 CNV loss 21293372
esv3618089 CNV loss 21293372
esv3618090 CNV loss 21293372
nsv1124363 CNV deletion 24896259
nsv511392 CNV loss 21212237
nsv611751 CNV loss 21841781

Variation tolerance for DPY19L4 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPY19L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPY19L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L4 Gene

Disorders for DPY19L4 Gene

Additional Disease Information for DPY19L4

No disorders were found for DPY19L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPY19L4 Gene

Publications for DPY19L4 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58

Products for DPY19L4 Gene

Sources for DPY19L4 Gene

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