Aliases for DPY19L3 Gene

Aliases for DPY19L3 Gene

  • Dpy-19 Like C-Mannosyltransferase 3 2 3 5
  • Probable C-Mannosyltransferase DPY19L3 3 4
  • Protein Dpy-19 Homolog 3 3 4
  • Dpy-19-Like Protein 3 3 4
  • Dpy-19 Like 3 (C. Elegans) 2
  • Dpy-19 Like 3 3
  • Dpy-19-Like 3 3
  • EC 2.4.1.- 4
  • DPY19L3 5

External Ids for DPY19L3 Gene

Previous GeneCards Identifiers for DPY19L3 Gene

  • GC19P037591
  • GC19P032897
  • GC19P029399

Summaries for DPY19L3 Gene

GeneCards Summary for DPY19L3 Gene

DPY19L3 (Dpy-19 Like C-Mannosyltransferase 3) is a Protein Coding gene. Diseases associated with DPY19L3 include Spermatogenic Failure 9. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is DPY19L4.

UniProtKB/Swiss-Prot Summary for DPY19L3 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPY19L3 Gene

Genomics for DPY19L3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DPY19L3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPY19L3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPY19L3

Top Transcription factor binding sites by QIAGEN in the DPY19L3 gene promoter:
  • AP-1
  • FOXI1
  • HFH-3
  • Hlf
  • LCR-F1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • S8
  • TGIF

Genomic Locations for DPY19L3 Gene

Genomic Locations for DPY19L3 Gene
chr19:32,405,543-32,485,895
(GRCh38/hg38)
Size:
80,353 bases
Orientation:
Plus strand
chr19:32,896,449-32,976,801
(GRCh37/hg19)
Size:
80,353 bases
Orientation:
Plus strand

Genomic View for DPY19L3 Gene

Genes around DPY19L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPY19L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPY19L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L3 Gene

Proteins for DPY19L3 Gene

  • Protein details for DPY19L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZPD9-D19L3_HUMAN
    Recommended name:
    Probable C-mannosyltransferase DPY19L3
    Protein Accession:
    Q6ZPD9
    Secondary Accessions:
    • Q68DC7
    • Q6ZTB7
    • Q6ZTS2

    Protein attributes for DPY19L3 Gene

    Size:
    716 amino acids
    Molecular mass:
    83197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86508.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DPY19L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPY19L3 Gene

Post-translational modifications for DPY19L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPY19L3 Gene

Domains & Families for DPY19L3 Gene

Gene Families for DPY19L3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DPY19L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY19L3 Gene

GenScript: Design optimal peptide antigens:
  • Dpy-19-like protein 3 (D19L3_HUMAN)
  • Dpy-19-like 3 (C. elegans) (Q8N6Q4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZPD9

UniProtKB/Swiss-Prot:

D19L3_HUMAN :
  • Belongs to the dpy-19 family.
Family:
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L3: view

Function for DPY19L3 Gene

Molecular function for DPY19L3 Gene

UniProtKB/Swiss-Prot Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L3 Gene

Phenotypes From GWAS Catalog for DPY19L3 Gene

Gene Ontology (GO) - Molecular Function for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DPY19L3: view
genes like me logo Genes that share phenotypes with DPY19L3: view

Animal Models for DPY19L3 Gene

MGI Knock Outs for DPY19L3:
  • Dpy19l3 Dpy19l3<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPY19L3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPY19L3 Gene

Localization for DPY19L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPY19L3 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytoskeleton 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L3: view

Pathways & Interactions for DPY19L3 Gene

PathCards logo

SuperPathways for DPY19L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPY19L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018406 protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA 21873635
genes like me logo Genes that share ontologies with DPY19L3: view

No data available for Pathways by source and SIGNOR curated interactions for DPY19L3 Gene

Drugs & Compounds for DPY19L3 Gene

No Compound Related Data Available

Transcripts for DPY19L3 Gene

mRNA/cDNA for DPY19L3 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPY19L3

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7: -
SP8:

ExUns: 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for DPY19L3 Gene

GeneLoc Exon Structure for
DPY19L3

Expression for DPY19L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPY19L3 Gene

Protein differential expression in normal tissues from HIPED for DPY19L3 Gene

This gene is overexpressed in Testis (13.2), Adrenal (11.3), Ovary (10.7), and Fetal Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPY19L3 Gene



Protein tissue co-expression partners for DPY19L3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPY19L3

SOURCE GeneReport for Unigene cluster for DPY19L3 Gene:

Hs.194392

mRNA Expression by UniProt/SwissProt for DPY19L3 Gene:

Q6ZPD9-D19L3_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for DPY19L3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DPY19L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPY19L3 Gene

Orthologs for DPY19L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPY19L3 30 31
  • 99.58 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DPY19L3 30 31
  • 91.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DPY19L3 30 31
  • 90.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dpy19l3 30 17 31
  • 84.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dpy19l3 30
  • 84.22 (n)
Oppossum
(Monodelphis domestica)
Mammalia DPY19L3 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DPY19L3 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DPY19L3 30 31
  • 73.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DPY19L3 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dpy19l3 30
  • 67.61 (n)
Str.17229 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8176 30
Zebrafish
(Danio rerio)
Actinopterygii dpy19l3 30
  • 63.43 (n)
DPY19L3 31
  • 62 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6659 31
  • 16 (a)
OneToMany
Species where no ortholog for DPY19L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DPY19L3 Gene

ENSEMBL:
Gene Tree for DPY19L3 (if available)
TreeFam:
Gene Tree for DPY19L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPY19L3: view image

Paralogs for DPY19L3 Gene

Paralogs for DPY19L3 Gene

(3) SIMAP similar genes for DPY19L3 Gene using alignment to 6 proteins:

  • D19L3_HUMAN
  • K7ELB5_HUMAN
  • K7ELG1_HUMAN
  • K7ELH8_HUMAN
  • Q8N6Q4_HUMAN
  • S4R3D3_HUMAN

Pseudogenes.org Pseudogenes for DPY19L3 Gene

genes like me logo Genes that share paralogs with DPY19L3: view

Variants for DPY19L3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPY19L3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs8105178 - p.Met350Val

Additional dbSNP identifiers (rs#s) for DPY19L3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DPY19L3 Gene

Variant ID Type Subtype PubMed ID
nsv510471 OTHER sequence alteration 20534489

Variation tolerance for DPY19L3 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPY19L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPY19L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L3 Gene

Disorders for DPY19L3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPY19L3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatogenic failure 9
  • globozoospermia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DPY19L3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DPY19L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPY19L3 Gene

Publications for DPY19L3 Gene

  1. Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. (PMID: 26764097) Niwa Y … Simizu S (Molecular biology of the cell 2016) 2 3
  2. Genome-wide association study of bipolar disorder in European American and African American individuals. (PMID: 19488044) Smith EN … Kelsoe JR (Molecular psychiatry 2009) 3 41
  3. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  4. Topological analysis of DPY19L3, a human C-mannosyltransferase. (PMID: 29405629) Niwa Y … Simizu S (The FEBS journal 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for DPY19L3 Gene

  • Signalway Proteins for DPY19L3

Sources for DPY19L3 Gene