Aliases for DPY19L1 Gene

Aliases for DPY19L1 Gene

  • Dpy-19 Like C-Mannosyltransferase 1 2 3 5
  • Probable C-Mannosyltransferase DPY19L1 3 4
  • Protein Dpy-19 Homolog 1 3 4
  • Dpy-19 Like 1 (C. Elegans) 2
  • DPY-19-Like Protein 1 3
  • Dpy-19-Like Protein 1 4
  • Dpy-19 Like 1 2
  • EC 2.4.1.- 4
  • KIAA0877 4
  • GA0500 4

External Ids for DPY19L1 Gene

Previous GeneCards Identifiers for DPY19L1 Gene

  • GC07M034742

Summaries for DPY19L1 Gene

GeneCards Summary for DPY19L1 Gene

DPY19L1 (Dpy-19 Like C-Mannosyltransferase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is DPY19L2.

UniProtKB/Swiss-Prot Summary for DPY19L1 Gene

  • Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Additional gene information for DPY19L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPY19L1 Gene

Genomics for DPY19L1 Gene

GeneHancer (GH) Regulatory Elements for DPY19L1 Gene

Promoters and enhancers for DPY19L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J035034 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 764 +1.4 1397 3.9 ZNF24 ZBTB40 CTCF SMARCE1 POLR2A L3MBTL2 RAD21 MNT ZNF148 NKRF DPY19L1 ENSG00000287249 LOC105375228 lnc-DPY19L1-1 lnc-NPSR1-4 HERPUD2
GH07J035024 Enhancer 1.1 Ensembl ENCODE dbSUPER 15.2 +12.6 12564 3.8 GATA3 TCF7L2 ZNF217 ETV6 HLF NFIB CEBPG IKZF1 GATAD2B TARDBP DPY19L1 LOC105375228 lnc-DPY19L1-1 lnc-TBX20-4
GH07J034939 Enhancer 1 Ensembl ENCODE 16.6 +99.1 99073 0.8 CREB1 MIXL1 HLF MNT ELF3 CEBPG ZNF644 KAT8 CEBPA CTBP1 MIR548N LOC102724723 DPY19L1 NPSR1-AS1
GH07J034990 Enhancer 1 Ensembl ENCODE dbSUPER 14.4 +46.3 46270 2.8 L3MBTL2 MLLT1 ZNF687 ZNF7 ZNF143 MGA GABPA JUNB NBN FOSL1 DPY19L1 lnc-TBX20-4 MIR548N
GH07J035248 Promoter/Enhancer 1.8 VISTA EPDnew Ensembl ENCODE dbSUPER 8 -215.3 -215285 10.1 ZBTB6 POLR2A SP1 ELF1 PRDM1 ZIC2 ZBTB8A SMARCC1 ZEB2 CEBPB TBX20 DPY19L1 ENSG00000226063 RF00017-6113 piR-43105-602
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPY19L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPY19L1 gene promoter:
  • AP-2gamma
  • E47
  • Hand1
  • MyoD
  • Pax-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • TBP

Genomic Locations for DPY19L1 Gene

Genomic Locations for DPY19L1 Gene
chr7:34,928,876-35,038,271
(GRCh38/hg38)
Size:
109,396 bases
Orientation:
Minus strand
chr7:34,968,488-35,077,883
(GRCh37/hg19)
Size:
109,396 bases
Orientation:
Minus strand

Genomic View for DPY19L1 Gene

Genes around DPY19L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPY19L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPY19L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPY19L1 Gene

Proteins for DPY19L1 Gene

  • Protein details for DPY19L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2PZI1-D19L1_HUMAN
    Recommended name:
    Probable C-mannosyltransferase DPY19L1
    Protein Accession:
    Q2PZI1
    Secondary Accessions:
    • O94954
    • Q4G151

    Protein attributes for DPY19L1 Gene

    Size:
    675 amino acids
    Molecular mass:
    77319 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It has been suggested that DPY19L1 has a related pseudogene DPY19L1P1.

    Alternative splice isoforms for DPY19L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPY19L1 Gene

Post-translational modifications for DPY19L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPY19L1 Gene

No data available for DME Specific Peptides for DPY19L1 Gene

Domains & Families for DPY19L1 Gene

Gene Families for DPY19L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DPY19L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPY19L1 Gene

GenScript: Design optimal peptide antigens:
  • Dpy-19-like protein 1 (D19L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2PZI1

UniProtKB/Swiss-Prot:

D19L1_HUMAN :
  • Belongs to the dpy-19 family.
Family:
  • Belongs to the dpy-19 family.
genes like me logo Genes that share domains with DPY19L1: view

Function for DPY19L1 Gene

Molecular function for DPY19L1 Gene

UniProtKB/Swiss-Prot Function:
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

Enzyme Numbers (IUBMB) for DPY19L1 Gene

Phenotypes From GWAS Catalog for DPY19L1 Gene

Gene Ontology (GO) - Molecular Function for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DPY19L1: view

Phenotypes for DPY19L1 Gene

genes like me logo Genes that share phenotypes with DPY19L1: view

Animal Model Products

CRISPR Products

miRNA for DPY19L1 Gene

miRTarBase miRNAs that target DPY19L1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPY19L1 Gene

Localization for DPY19L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPY19L1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPY19L1 gene
Compartment Confidence
plasma membrane 3
nucleus 3
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IBA 21873635
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPY19L1: view

Pathways & Interactions for DPY19L1 Gene

PathCards logo

SuperPathways for DPY19L1 Gene

No Data Available

Interacting Proteins for DPY19L1 Gene

Gene Ontology (GO) - Biological Process for DPY19L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018406 protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA 21873635
genes like me logo Genes that share ontologies with DPY19L1: view

No data available for Pathways by source and SIGNOR curated interactions for DPY19L1 Gene

Drugs & Compounds for DPY19L1 Gene

No Compound Related Data Available

Transcripts for DPY19L1 Gene

mRNA/cDNA for DPY19L1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPY19L1 Gene

No ASD Table

Relevant External Links for DPY19L1 Gene

GeneLoc Exon Structure for
DPY19L1
ECgene alternative splicing isoforms for
DPY19L1

Expression for DPY19L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPY19L1 Gene

Protein differential expression in normal tissues from HIPED for DPY19L1 Gene

This gene is overexpressed in Serum (25.7) and Urine (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPY19L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DPY19L1 Gene:

DPY19L1

SOURCE GeneReport for Unigene cluster for DPY19L1 Gene:

Hs.408623

mRNA Expression by UniProt/SwissProt for DPY19L1 Gene:

Q2PZI1-D19L1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for DPY19L1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DPY19L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPY19L1 Gene

Orthologs for DPY19L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPY19L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPY19L1 33 32
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPY19L1 33 32
  • 93.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPY19L1 33 32
  • 91.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dpy19l1 17 33 32
  • 87.48 (n)
rat
(Rattus norvegicus)
Mammalia Dpy19l1 32
  • 86.6 (n)
oppossum
(Monodelphis domestica)
Mammalia DPY19L1 33
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPY19L1 33
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPY19L1 32
  • 75.9 (n)
-- 33
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.658 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.4207 32
zebrafish
(Danio rerio)
Actinopterygii dpy19l1l 33 32
  • 66.31 (n)
ManyToMany
AL935296.1 33
  • 61 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpy-19 33 32
  • 53.35 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9857 33
  • 49 (a)
OneToMany
Cin.4862 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4862 32
Species where no ortholog for DPY19L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPY19L1 Gene

ENSEMBL:
Gene Tree for DPY19L1 (if available)
TreeFam:
Gene Tree for DPY19L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPY19L1: view image

Paralogs for DPY19L1 Gene

Paralogs for DPY19L1 Gene

(4) SIMAP similar genes for DPY19L1 Gene using alignment to 3 proteins:

  • D19L1_HUMAN
  • H7C1I8_HUMAN
  • H7C3M5_HUMAN

Pseudogenes.org Pseudogenes for DPY19L1 Gene

genes like me logo Genes that share paralogs with DPY19L1: view

Variants for DPY19L1 Gene

Sequence variations from dbSNP and Humsavar for DPY19L1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000018393 -- 35,019,821(-) T/C intron_variant
rs1000069848 -- 34,940,565(-) C/T intron_variant
rs1000070745 -- 35,019,527(-) A/G intron_variant
rs1000085979 -- 35,025,639(-) T/C intron_variant
rs1000106047 -- 35,002,709(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPY19L1 Gene

Variant ID Type Subtype PubMed ID
dgv1080e201 CNV deletion 23290073
dgv3525n106 CNV deletion 24896259
dgv6320n100 CNV gain 25217958
esv23431 CNV loss 19812545
esv3612750 OTHER inversion 21293372
nsv1076887 CNV deletion 25765185
nsv436907 CNV insertion 17901297
nsv830952 CNV gain 17160897
nsv830953 CNV gain 17160897
nsv951626 CNV deletion 24416366
nsv966775 CNV duplication 23825009

Variation tolerance for DPY19L1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPY19L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPY19L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPY19L1 Gene

Disorders for DPY19L1 Gene

Additional Disease Information for DPY19L1

No disorders were found for DPY19L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPY19L1 Gene

Publications for DPY19L1 Gene

  1. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. (PMID: 28202721) Shcherbakova A … Bakker H (Proceedings of the National Academy of Sciences of the United States of America 2017) 2 3 56
  2. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. (PMID: 22028030) Watanabe K … Tamamaki N (Development (Cambridge, England) 2011) 2 3 56
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 56

Products for DPY19L1 Gene

Sources for DPY19L1 Gene