Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008] See more...

Aliases for DPT Gene

Aliases for DPT Gene

  • Dermatopontin 2 3 4 5
  • Tyrosine-Rich Acidic Matrix Protein 3 4
  • TRAMP 3 4

External Ids for DPT Gene

Previous GeneCards Identifiers for DPT Gene

  • GC01M166300
  • GC01M164315
  • GC01M165360
  • GC01M165852
  • GC01M165396
  • GC01M166931
  • GC01M139910

Summaries for DPT Gene

Entrez Gene Summary for DPT Gene

  • Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPT Gene

DPT (Dermatopontin) is a Protein Coding gene. Diseases associated with DPT include Anisometropia and Cycloplegia.

UniProtKB/Swiss-Prot Summary for DPT Gene

  • Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).

Gene Wiki entry for DPT Gene

Additional gene information for DPT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPT Gene

Genomics for DPT Gene

GeneHancer (GH) Regulatory Elements for DPT Gene

Promoters and enhancers for DPT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J168728 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 757.5 +0.7 748 2.5 HLF DPT HSALNG0008299 lnc-DPT-2 ENSG00000285622
GH01J167933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.6 +792.7 792696 5.8 SIN3A SP1 ZBTB40 SREBF1 SIX5 LCORL FOXA1 RBPJ SMARCE1 POLR2A MPC2 DCAF6 ADCY10 POU2F1 MPZL1 DPT TIPRL CREG1
GH01J168225 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.4 +502.1 502105 4.6 ZNF785 ZBTB40 ZBTB6 POLR2A USF2 HDAC2 HCFC1 MIXL1 ZNF362 MYC TBX19 NONHSAG003392.2 SFT2D2 lnc-GPR161-2 MPZL1 DPT RNU6-1310P TIPRL piR-31871
GH01J169101 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -379.0 -378996 14 SIN3A CTCF FOXA1 RBPJ POLR2A TCF7L2 CTBP1 USF2 ATF1 CREB1 ATP1B1 METTL18 NME7 RN7SL333P LINC00970 DPT CCDC181 ENSG00000229757 XCL2 ENSG00000237707
GH01J169707 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.2 -980.5 -980489 6.2 ZNF785 ZNF24 CTCF TRIM22 ELF1 RELA RAD21 MTA3 ZNF652 IKZF1 SELL lnc-SELE-1 METTL18 C1orf112 RN7SL333P SCYL3 GORAB SELP F5 DPT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPT gene promoter:
  • AML1a
  • Arnt
  • E47
  • FOXJ2 (long isoform)
  • FOXL1
  • HNF-1
  • HNF-1A
  • NF-1
  • Tal-1
  • Zic3

Genomic Locations for DPT Gene

Genomic Locations for DPT Gene
chr1:168,695,457-168,729,206
(GRCh38/hg38)
Size:
33,750 bases
Orientation:
Minus strand
chr1:168,664,695-168,698,502
(GRCh37/hg19)
Size:
33,808 bases
Orientation:
Minus strand

Genomic View for DPT Gene

Genes around DPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPT Gene

Proteins for DPT Gene

  • Protein details for DPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07507-DERM_HUMAN
    Recommended name:
    Dermatopontin
    Protein Accession:
    Q07507
    Secondary Accessions:
    • A8K981
    • Q8N4R2
    • Q9UIX8

    Protein attributes for DPT Gene

    Size:
    201 amino acids
    Molecular mass:
    24005 Da
    Quaternary structure:
    • Interacts with TGFB1, DCN and collagen.

neXtProt entry for DPT Gene

Post-translational modifications for DPT Gene

Other Protein References for DPT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPT Gene

Domains & Families for DPT Gene

Gene Families for DPT Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DPT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPT Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-rich acidic matrix protein (DERM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q07507

UniProtKB/Swiss-Prot:

DERM_HUMAN :
  • Belongs to the dermatopontin family.
Family:
  • Belongs to the dermatopontin family.
genes like me logo Genes that share domains with DPT: view

Function for DPT Gene

Molecular function for DPT Gene

UniProtKB/Swiss-Prot Function:
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced by TGFB1, repressed by IL4/interleukin-4.
GENATLAS Biochemistry:
dermatopontin,human proteoglycan binding cell adhesion protein,22kDa

Phenotypes From GWAS Catalog for DPT Gene

Gene Ontology (GO) - Molecular Function for DPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent RCA 20551380
GO:0005515 protein binding IPI 30082873
genes like me logo Genes that share ontologies with DPT: view
genes like me logo Genes that share phenotypes with DPT: view

Animal Models for DPT Gene

MGI Knock Outs for DPT:
  • Dpt Dpt<tm1Hsh>

Animal Model Products

CRISPR Products

miRNA for DPT Gene

miRTarBase miRNAs that target DPT

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPT Gene

Localization for DPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPT Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPT gene
Compartment Confidence
extracellular 3
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA 20551380
GO:0062023 colocalizes_with collagen-containing extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with DPT: view

Pathways & Interactions for DPT Gene

PathCards logo

SuperPathways for DPT Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0030199 collagen fibril organization IBA,IEA 21873635
genes like me logo Genes that share ontologies with DPT: view

No data available for Pathways by source and SIGNOR curated interactions for DPT Gene

Drugs & Compounds for DPT Gene

No Compound Related Data Available

Transcripts for DPT Gene

mRNA/cDNA for DPT Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(201) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPT Gene

No ASD Table

Relevant External Links for DPT Gene

GeneLoc Exon Structure for
DPT
ECgene alternative splicing isoforms for
DPT

Expression for DPT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPT Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.8) and Colon - Sigmoid (x4.7).

Protein differential expression in normal tissues from HIPED for DPT Gene

This gene is overexpressed in Adipocyte (10.3), Rectum (7.3), and Colon muscle (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPT Gene



Protein tissue co-expression partners for DPT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPT Gene:

DPT

SOURCE GeneReport for Unigene cluster for DPT Gene:

Hs.80552

mRNA Expression by UniProt/SwissProt for DPT Gene:

Q07507-DERM_HUMAN
Tissue specificity: Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.

Evidence on tissue expression from TISSUES for DPT Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(2.7)
  • Heart(2.6)
  • Skin(2.4)
  • Intestine(2.3)
  • Eye(2.2)
  • Lymph node(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DPT: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DPT Gene

Orthologs for DPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for DPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPT 33 32
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPT 33 32
  • 92.04 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPT 33
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPT 33 32
  • 90.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dpt 17 33 32
  • 88.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DPT 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPT 33 32
  • 77.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPT 33
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpt 32
  • 73.01 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-98p3.2 32
  • 66.47 (n)
dpt 33
  • 61 (a)
OneToOne
Species where no ortholog for DPT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPT Gene

ENSEMBL:
Gene Tree for DPT (if available)
TreeFam:
Gene Tree for DPT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPT: view image

Paralogs for DPT Gene

No data available for Paralogs for DPT Gene

Variants for DPT Gene

Sequence variations from dbSNP and Humsavar for DPT Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs748718975 pathogenic, Progressive sensorineural hearing impairment 168,696,611(-) G/A coding_sequence_variant, missense_variant
rs1000136838 -- 168,728,037(-) A/G intron_variant
rs1000159762 -- 168,707,747(-) A/G intron_variant
rs1000162577 -- 168,707,497(-) A/G intron_variant
rs1000212793 -- 168,713,800(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPT Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185
nsv831836 CNV gain+loss 17160897
nsv831847 CNV gain 17160897

Variation tolerance for DPT Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPT Gene

Human Gene Mutation Database (HGMD)
DPT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPT Gene

Disorders for DPT Gene

MalaCards: The human disease database

(18) MalaCards diseases for DPT Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anisometropia
cycloplegia
  • ciliary muscle paresis
eye accommodation disease
regular astigmatism
aniseikonia
- elite association - COSMIC cancer census association via MalaCards
Search DPT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPT Gene

Publications for DPT Gene

  1. Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin). (PMID: 8104875) Superti-Furga A … Gitzelmann R (Genomics 1993) 2 3 4 23 56
  2. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. (PMID: 10233760) Kuroda K … Shinkai H (The Journal of investigative dermatology 1999) 3 4 23 56
  3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 43 56
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 43 56
  5. Dermatopontin is expressed in human liver and is downregulated in hepatocellular carcinoma. (PMID: 19916908) Li X … Zhang C (Biochemistry. Biokhimiia 2009) 3 23 56

Products for DPT Gene

  • Boster Bio Antibodies for DPT
  • Boster Bio ELISA Kits for DPT

Sources for DPT Gene