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Aliases for DPRX Gene

Aliases for DPRX Gene

  • Divergent-Paired Related Homeobox 2 3 5

External Ids for DPRX Gene

Previous GeneCards Identifiers for DPRX Gene

  • GC19U900486
  • GC19P058828
  • GC19P054136
  • GC19P053632

Summaries for DPRX Gene

Entrez Gene Summary for DPRX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPRX Gene

DPRX (Divergent-Paired Related Homeobox) is a Protein Coding gene. Diseases associated with DPRX include Vesicoureteral Reflux 1. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for DPRX Gene

  • Putative transcription factor.

Additional gene information for DPRX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPRX Gene

Genomics for DPRX Gene

GeneHancer (GH) Regulatory Elements for DPRX Gene

Promoters and enhancers for DPRX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053631 Promoter 0.5 EPDnew 550.3 +30.8 30847 0.1 DPRX RN7SL317P GC19P053655
GH19I054095 Promoter/Enhancer 1.4 Ensembl ENCODE 10 +495.5 495485 1.9 PKNOX1 RB1 GLI4 ZNF48 RARA ZNF335 GLIS2 ARID2 ZNF366 THAP11 CNOT3 LENG8-AS1 ZNF525 LENG8 PRPF31 ENSG00000235681 ZNF761 ZNF160 ZNF845 ZNF765
GH19I053656 Enhancer 1 ENCODE dbSUPER 11.8 +57.1 57081 2.4 CTCF ELF3 SOX13 FOXA2 SAP130 MLX ZNF644 THRB RAD21 RARA LOC100288093 RN7SL317P DPRX RNU6-698P
GH19I053840 Enhancer 1.1 Ensembl ENCODE 10.5 +241.0 241010 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR520A MIR1283-1 MIR515-2 MIR519C MIR515-1
GH19I053506 Enhancer 0.9 ENCODE 10.7 -92.7 -92687 3.1 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 SLC30A9 ATF7 RUNX3 DPRX RN7SL317P VN1R103P RNU6-698P ENSG00000274892 ZNF331
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPRX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPRX gene promoter:

Genomic Locations for DPRX Gene

Genomic Locations for DPRX Gene
35,920 bases
Plus strand

Genomic View for DPRX Gene

Genes around DPRX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPRX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPRX Gene

Proteins for DPRX Gene

  • Protein details for DPRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Divergent paired-related homeobox
    Protein Accession:

    Protein attributes for DPRX Gene

    191 amino acids
    Molecular mass:
    21648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPRX Gene

Post-translational modifications for DPRX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPRX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPRX Gene

Domains & Families for DPRX Gene

Gene Families for DPRX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DPRX Gene

Suggested Antigen Peptide Sequences for DPRX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paired homeobox family.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DPRX: view

Function for DPRX Gene

Molecular function for DPRX Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Gene Ontology (GO) - Molecular Function for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DPRX: view
genes like me logo Genes that share phenotypes with DPRX: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPRX Gene

Localization for DPRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPRX Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPRX gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPRX Gene

Pathways & Interactions for DPRX Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with DPRX: view

Pathways by source for DPRX Gene

1 BioSystems pathway for DPRX Gene

Interacting Proteins for DPRX Gene

Gene Ontology (GO) - Biological Process for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for SIGNOR curated interactions for DPRX Gene

Drugs & Compounds for DPRX Gene

No Compound Related Data Available

Transcripts for DPRX Gene

mRNA/cDNA for DPRX Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPRX Gene

No ASD Table

Relevant External Links for DPRX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPRX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPRX Gene

mRNA differential expression in normal tissues according to GTEx for DPRX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.8), Muscle - Skeletal (x5.4), Testis (x4.4), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for DPRX Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPRX Gene

Protein tissue co-expression partners for DPRX Gene

NURSA nuclear receptor signaling pathways regulating expression of DPRX Gene:


SOURCE GeneReport for Unigene cluster for DPRX Gene:

genes like me logo Genes that share expression patterns with DPRX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPRX Gene

Orthologs for DPRX Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPRX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPRX 33 34
  • 98.95 (n)
(Canis familiaris)
Mammalia DPRX 33
  • 71.57 (n)
-- 34
  • 59 (a)
-- 34
  • 55 (a)
Species where no ortholog for DPRX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPRX Gene

Gene Tree for DPRX (if available)
Gene Tree for DPRX (if available)

Paralogs for DPRX Gene

(2) SIMAP similar genes for DPRX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPRX: view

No data available for Paralogs for DPRX Gene

Variants for DPRX Gene

Sequence variations from dbSNP and Humsavar for DPRX Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000060939 -- 53,616,719(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000074107 -- 53,616,910(+) TGGTGGTGGTG/TGGTGGTG genic_upstream_transcript_variant, intron_variant
rs1000083046 -- 53,623,492(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000118340 -- 53,606,956(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000125779 -- 53,611,799(+) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPRX Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv1055718 CNV gain 25217958
nsv515586 CNV loss 19592680
nsv580107 CNV gain 21841781

Variation tolerance for DPRX Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPRX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPRX Gene

Disorders for DPRX Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPRX Gene - From: DISEASES

Disorder Aliases PubMed IDs
vesicoureteral reflux 1
  • vur1
- elite association - COSMIC cancer census association via MalaCards
Search DPRX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPRX

genes like me logo Genes that share disorders with DPRX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPRX Gene

Publications for DPRX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  3. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3

Products for DPRX Gene

Sources for DPRX Gene

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