Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes ha... See more...

Aliases for DPRX Gene

Aliases for DPRX Gene

  • Divergent-Paired Related Homeobox 2 3 5
  • Divergent Paired-Related Homeobox 3 4
  • DPRX 5

External Ids for DPRX Gene

Previous GeneCards Identifiers for DPRX Gene

  • GC19U900486
  • GC19P058828
  • GC19P054136
  • GC19P053632

Summaries for DPRX Gene

Entrez Gene Summary for DPRX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPRX Gene

DPRX (Divergent-Paired Related Homeobox) is a Protein Coding gene. Diseases associated with DPRX include Non-Gestational Choriocarcinoma. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ARGFX.

UniProtKB/Swiss-Prot Summary for DPRX Gene

Additional gene information for DPRX Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPRX Gene

Genomics for DPRX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DPRX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053599 Enhancer 0.3 Ensembl 600.7 -0.4 -413 2.2 JUN DPRX LOC284379 ENSG00000268864 piR-49731-007 ZNF331
GH19J053602 Enhancer 0.2 Ensembl 600.7 +1.0 987 0.2 DPRX LOC284379 ENSG00000268864 NLRP12
GH19J054095 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10 +497.2 497187 5.8 RNF2 HNRNPL TFE3 ZNF512 CTCF ZNF692 LARP7 MTA2 PRDM1 PKNOX1 OSCAR CNOT3 NDUFA3 LENG8-AS1 ZNF525 LENG8 PRPF31 ENSG00000235681 ZNF761 ZNF160
GH19J053656 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 +59.2 59180 6.6 GATAD2A CTCF KDM1A RCOR2 RXRB REST PBX2 SOX13 RFX3 TCF7 ENSG00000270347 LOC100288093 lnc-NLRP12-5 MIR515-2 MIR1283-1 MIR519C MIR520A RN7SL317P DPRX MIR519B
GH19J053506 Enhancer 1.1 Ensembl ENCODE 10.7 -92.7 -92682 3.1 SP1 GATAD2A TFE3 NFKBIZ RCOR2 ZNF7 RXRB IRF2 IKZF2 TRIM22 DPRX RN7SL317P VN1R103P RNU6-698P ENSG00000274892 ZNF331 lnc-ZNF813-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPRX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPRX

Top Transcription factor binding sites by QIAGEN in the DPRX gene promoter:
  • E4BP4

Genomic Locations for DPRX Gene

Genomic Locations for DPRX Gene
chr19:53,601,114-53,637,057
(GRCh38/hg38)
Size:
35,944 bases
Orientation:
Plus strand
chr19:54,135,310-54,140,263
(GRCh37/hg19)
Size:
4,954 bases
Orientation:
Plus strand

Genomic View for DPRX Gene

Genes around DPRX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPRX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPRX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPRX Gene

Proteins for DPRX Gene

  • Protein details for DPRX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFQ7-DPRX_HUMAN
    Recommended name:
    Divergent paired-related homeobox
    Protein Accession:
    A6NFQ7

    Protein attributes for DPRX Gene

    Size:
    191 amino acids
    Molecular mass:
    21648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPRX Gene

Post-translational modifications for DPRX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPRX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPRX Gene

Domains & Families for DPRX Gene

Gene Families for DPRX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DPRX Gene

Suggested Antigen Peptide Sequences for DPRX Gene

GenScript: Design optimal peptide antigens:
  • Divergent paired-related homeobox (DPRX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NFQ7

UniProtKB/Swiss-Prot:

DPRX_HUMAN :
  • Belongs to the paired homeobox family.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DPRX: view

Function for DPRX Gene

Molecular function for DPRX Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Phenotypes From GWAS Catalog for DPRX Gene

Gene Ontology (GO) - Molecular Function for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DPRX: view
genes like me logo Genes that share phenotypes with DPRX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPRX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPRX Gene

Localization for DPRX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPRX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPRX gene
Compartment Confidence
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPRX Gene

Pathways & Interactions for DPRX Gene

PathCards logo

SuperPathways for DPRX Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with DPRX: view

Pathways by source for DPRX Gene

1 BioSystems pathway for DPRX Gene

Gene Ontology (GO) - Biological Process for DPRX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with DPRX: view

No data available for SIGNOR curated interactions for DPRX Gene

Drugs & Compounds for DPRX Gene

No Compound Related Data Available

Transcripts for DPRX Gene

mRNA/cDNA for DPRX Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPRX

Alternative Splicing Database (ASD) splice patterns (SP) for DPRX Gene

No ASD Table

Relevant External Links for DPRX Gene

GeneLoc Exon Structure for
DPRX

Expression for DPRX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPRX Gene

mRNA differential expression in normal tissues according to GTEx for DPRX Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.8), Muscle - Skeletal (x5.4), Testis (x4.4), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for DPRX Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPRX Gene



Protein tissue co-expression partners for DPRX Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPRX

SOURCE GeneReport for Unigene cluster for DPRX Gene:

Hs.579941
genes like me logo Genes that share expression patterns with DPRX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPRX Gene

Orthologs for DPRX Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPRX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPRX 30 31
  • 98.95 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DPRX 30
  • 71.57 (n)
-- 31
  • 59 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
Species where no ortholog for DPRX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for DPRX Gene

ENSEMBL:
Gene Tree for DPRX (if available)
TreeFam:
Gene Tree for DPRX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPRX: view image

Paralogs for DPRX Gene

(2) SIMAP similar genes for DPRX Gene using alignment to 1 proteins:

  • DPRX_HUMAN
genes like me logo Genes that share paralogs with DPRX: view

Variants for DPRX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPRX Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs201435914 Pathogenic: Short stature 53,636,878(+) C/T NONSENSE

Additional dbSNP identifiers (rs#s) for DPRX Gene

Structural Variations from Database of Genomic Variants (DGV) for DPRX Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv1055718 CNV gain 25217958
nsv515586 CNV loss 19592680
nsv580107 CNV gain 21841781

Variation tolerance for DPRX Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPRX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPRX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPRX Gene

Disorders for DPRX Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPRX Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
- elite association - COSMIC cancer census association via MalaCards
Search DPRX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPRX

genes like me logo Genes that share disorders with DPRX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPRX Gene

Publications for DPRX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 3 4
  2. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4

Products for DPRX Gene

Sources for DPRX Gene