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Aliases for DPPA2 Gene

Aliases for DPPA2 Gene

  • Developmental Pluripotency Associated 2 2 3 5
  • Pluripotent Embryonic Stem Cell-Related Gene 1 Protein 3 4
  • Cancer/Testis Antigen 100 2 3
  • PESCRG1 3 4
  • Embryonic Stem Cell (ESC) Associated Transcript 15-2 3
  • Developmental Pluripotency-Associated Protein 2 3
  • ECAT15-2 3
  • CT100 3

External Ids for DPPA2 Gene

Previous GeneCards Identifiers for DPPA2 Gene

  • GC00U909443
  • GC03M110496
  • GC03M109012
  • GC03M106386

Summaries for DPPA2 Gene

GeneCards Summary for DPPA2 Gene

DPPA2 (Developmental Pluripotency Associated 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is DPPA4.

UniProtKB/Swiss-Prot for DPPA2 Gene

  • Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.

Gene Wiki entry for DPPA2 Gene

Additional gene information for DPPA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA2 Gene

Genomics for DPPA2 Gene

GeneHancer (GH) Regulatory Elements for DPPA2 Gene

Promoters and enhancers for DPPA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J109332 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.4 -19.8 -19762 7.9 NANOG RXRA TAF1 SIN3A REST RAD21 YY1 ETS1 SP1 JUND DPPA4 DPPA2 PIR39830
GH03J109316 Promoter/Enhancer 1 EPDnew ENCODE 650.7 +0.1 98 0.7 GATA3 NFIC PKNOX1 POLR2A DPPA2 ENSG00000277635
GH03J109325 Enhancer 0.3 ENCODE 0.4 -9.1 -9074 0.9 POLR2A DPPA4 DPPA2 PIR39830
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPPA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPPA2 gene promoter:
  • AML1a
  • POU2F1a
  • POU2F1
  • Elk-1
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP-TF
  • COUP
  • c-Ets-1

Genomic Locations for DPPA2 Gene

Genomic Locations for DPPA2 Gene
chr3:109,293,788-109,316,535
(GRCh38/hg38)
Size:
22,748 bases
Orientation:
Minus strand
chr3:109,012,635-109,035,364
(GRCh37/hg19)
Size:
22,730 bases
Orientation:
Minus strand

Genomic View for DPPA2 Gene

Genes around DPPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA2 Gene

Proteins for DPPA2 Gene

  • Protein details for DPPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7J5-DPPA2_HUMAN
    Recommended name:
    Developmental pluripotency-associated protein 2
    Protein Accession:
    Q7Z7J5
    Secondary Accessions:
    • Q8WVF0

    Protein attributes for DPPA2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33784 Da
    Quaternary structure:
    • Interacts with DPPA4.

neXtProt entry for DPPA2 Gene

Post-translational modifications for DPPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA2 Gene

No data available for DME Specific Peptides for DPPA2 Gene

Domains & Families for DPPA2 Gene

Gene Families for DPPA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DPPA2 Gene

Suggested Antigen Peptide Sequences for DPPA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DPPA2: view

No data available for UniProtKB/Swiss-Prot for DPPA2 Gene

Function for DPPA2 Gene

Molecular function for DPPA2 Gene

UniProtKB/Swiss-Prot Function:
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.

Gene Ontology (GO) - Molecular Function for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DPPA2: view
genes like me logo Genes that share phenotypes with DPPA2: view

Animal Models for DPPA2 Gene

MGI Knock Outs for DPPA2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPPA2 Gene

Localization for DPPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPPA2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with DPPA2: view

Pathways & Interactions for DPPA2 Gene

SuperPathways for DPPA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DPPA2: view

No data available for Pathways by source and SIGNOR curated interactions for DPPA2 Gene

Drugs & Compounds for DPPA2 Gene

No Compound Related Data Available

Transcripts for DPPA2 Gene

mRNA/cDNA for DPPA2 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DPPA2 Gene

Developmental pluripotency associated 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA2 Gene

No ASD Table

Relevant External Links for DPPA2 Gene

GeneLoc Exon Structure for
DPPA2
ECgene alternative splicing isoforms for
DPPA2

Expression for DPPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPPA2 Gene

This gene is overexpressed in Testis (x48.8).

Protein differential expression in normal tissues from HIPED for DPPA2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPPA2 Gene



Protein tissue co-expression partners for DPPA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPPA2 Gene:

DPPA2

SOURCE GeneReport for Unigene cluster for DPPA2 Gene:

Hs.351113

mRNA Expression by UniProt/SwissProt for DPPA2 Gene:

Q7Z7J5-DPPA2_HUMAN
Tissue specificity: Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues.

Evidence on tissue expression from TISSUES for DPPA2 Gene

  • Nervous system(4.2)
  • Blood(2.6)
genes like me logo Genes that share expression patterns with DPPA2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DPPA2 Gene

Orthologs for DPPA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPPA2 34 33
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPPA2 34 33
  • 74.44 (n)
OneToMany
-- 34
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC683282 33
  • 66.1 (n)
mouse
(Mus musculus)
Mammalia Dppa2 16 34 33
  • 60.45 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 59 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
OneToMany
Species where no ortholog for DPPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA2 Gene

ENSEMBL:
Gene Tree for DPPA2 (if available)
TreeFam:
Gene Tree for DPPA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPPA2: view image

Paralogs for DPPA2 Gene

Paralogs for DPPA2 Gene

(1) SIMAP similar genes for DPPA2 Gene using alignment to 1 proteins:

  • DPPA2_HUMAN
genes like me logo Genes that share paralogs with DPPA2: view

Variants for DPPA2 Gene

Sequence variations from dbSNP and Humsavar for DPPA2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000105048 -- 109,298,709(-) C/G intron_variant
rs1000232737 -- 109,313,943(-) G/A intron_variant
rs1000530206 -- 109,316,069(-) TTTTTTT/TTTTTT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000598517 -- 109,314,862(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000842087 -- 109,304,929(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPPA2 Gene

Variant ID Type Subtype PubMed ID
dgv4836n100 CNV gain 25217958
nsv1001807 CNV gain 25217958
nsv1002080 CNV loss 25217958
nsv1117350 CNV tandem duplication 24896259
nsv829665 CNV gain 17160897
nsv967049 CNV duplication 23825009

Variation tolerance for DPPA2 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPPA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPPA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPPA2 Gene

Disorders for DPPA2 Gene

Additional Disease Information for DPPA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DPPA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA2 Gene

Publications for DPPA2 Gene

  1. [Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell]. (PMID: 15583978) Du J … Lu GX (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2004) 2 3 4 58
  2. Identification of DPPA4 and DPPA2 as a novel family of pluripotency-related oncogenes. (PMID: 23963736) Tung PY … Knoepfler PS (Stem cells (Dayton, Ohio) 2013) 2 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Diagnostic clinical relevance of developmental pluripotency-associated 2 (DPPA2) in colorectal cancer. (PMID: 25497006) Ghodsi M … Forghanifard MM (International journal of surgery (London, England) 2015) 3 58

Products for DPPA2 Gene

Sources for DPPA2 Gene

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