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Aliases for DPP7 Gene

Aliases for DPP7 Gene

  • Dipeptidyl Peptidase 7 2 3 4 5
  • Quiescent Cell Proline Dipeptidase 3 4
  • Dipeptidyl Aminopeptidase II 3 4
  • DPP II 3 4
  • DPP2 3 4
  • QPP 3 4
  • Dipeptidyl Arylamidase II 3
  • Dipeptidyl-Peptidase II 3
  • Dipeptidyl Peptidase II 4
  • Dipeptidyl Peptidase 2 3
  • Dipeptidylpeptidase 7 2
  • Carboxytripeptidase 3
  • EC 3.4.14.2 4
  • DPPII 3

External Ids for DPP7 Gene

Previous GeneCards Identifiers for DPP7 Gene

  • GC00U990681
  • GC09M131696
  • GC09M133446
  • GC09M135362
  • GC09M137280
  • GC09M139124
  • GC09M140004
  • GC09M109466

Summaries for DPP7 Gene

Entrez Gene Summary for DPP7 Gene

  • The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP7 Gene

DPP7 (Dipeptidyl Peptidase 7) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is PRCP.

UniProtKB/Swiss-Prot for DPP7 Gene

  • Plays an important role in the degradation of some oligopeptides.

Gene Wiki entry for DPP7 Gene

Additional gene information for DPP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP7 Gene

Genomics for DPP7 Gene

GeneHancer (GH) Regulatory Elements for DPP7 Gene

Promoters and enhancers for DPP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137126 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 661.7 -10.8 -10821 4.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 DPP7 EHMT1 DPH7 ENTR1 ANAPC2 SNHG7 SEC16A NDOR1 UAP1L1 INPP5E
GH09J137113 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 664.3 +3.3 3292 1.8 HDGF CLOCK ATF1 SIN3A GLIS2 FOS ATF7 DEK ZNF263 REST DPP7 MAN1B1 UAP1L1 DPH7 SNHG7 ANAPC2 EHMT1 EXD3 ENTR1 SEC16A
GH09J137118 Enhancer 1 Ensembl ENCODE 655.5 -0.9 -921 0.6 HDGF PKNOX1 RB1 ARID4B KLF17 YBX1 ZNF2 KLF5 RAD21 RFX5 DPP7 UAP1L1 GC09M137131
GH09J137116 Enhancer 0.7 ENCODE 650.7 +1.0 1016 0.2 DRAP1 ELF3 IRF2 SAP130 ZFP64 TEAD3 NR2F6 MIXL1 SOX5 PHF21A DPP7 LOC101930307
GH09J137085 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.2 +31.4 31363 2.9 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MAN1B1-DT MAN1B1 GC09M137086 DPP7 FUT7 PIR60888
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPP7 gene promoter:
  • AP-4
  • Pax-2a
  • Pax-2
  • GR
  • GR-alpha
  • GR-beta
  • AhR
  • Arnt
  • ATF
  • Lmo2

Genomic Locations for DPP7 Gene

Genomic Locations for DPP7 Gene
chr9:137,110,540-137,117,980
(GRCh38/hg38)
Size:
7,441 bases
Orientation:
Minus strand
chr9:140,004,992-140,009,629
(GRCh37/hg19)
Size:
4,638 bases
Orientation:
Minus strand

Genomic View for DPP7 Gene

Genes around DPP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP7 Gene

Proteins for DPP7 Gene

  • Protein details for DPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHL4-DPP2_HUMAN
    Recommended name:
    Dipeptidyl peptidase 2
    Protein Accession:
    Q9UHL4
    Secondary Accessions:
    • A8K7U7
    • Q5VSF1
    • Q969X4

    Protein attributes for DPP7 Gene

    Size:
    492 amino acids
    Molecular mass:
    54341 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DPP7 Gene

neXtProt entry for DPP7 Gene

Post-translational modifications for DPP7 Gene

  • N-glycosylated.
  • Glycosylation at posLast=428428, posLast=363363, posLast=356356, posLast=315315, posLast=8686, and Asn50
  • Ubiquitination at posLast=228228 and Lys112
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for DPP7 (DPPII/QPP/DPP7)
  • Boster Bio Antibodies for DPP7
  • Santa Cruz Biotechnology (SCBT) Antibodies for DPP7

No data available for DME Specific Peptides for DPP7 Gene

Domains & Families for DPP7 Gene

Gene Families for DPP7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for DPP7 Gene

Suggested Antigen Peptide Sequences for DPP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHL4

UniProtKB/Swiss-Prot:

DPP2_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with DPP7: view

Function for DPP7 Gene

Molecular function for DPP7 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the degradation of some oligopeptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide, Xaa-Yaa- -, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8.;

Enzyme Numbers (IUBMB) for DPP7 Gene

Phenotypes From GWAS Catalog for DPP7 Gene

Gene Ontology (GO) - Molecular Function for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA,IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DPP7: view
genes like me logo Genes that share phenotypes with DPP7: view

Animal Model Products

CRISPR Products

miRNA for DPP7 Gene

miRTarBase miRNAs that target DPP7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPP7 Gene

Localization for DPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP7 Gene

Lysosome. Cytoplasmic vesicle. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP7 gene
Compartment Confidence
extracellular 5
lysosome 5
golgi apparatus 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005764 lysosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DPP7: view

Pathways & Interactions for DPP7 Gene

genes like me logo Genes that share pathways with DPP7: view

Pathways by source for DPP7 Gene

3 Reactome pathways for DPP7 Gene

Gene Ontology (GO) - Biological Process for DPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA,IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with DPP7: view

No data available for SIGNOR curated interactions for DPP7 Gene

Drugs & Compounds for DPP7 Gene

(5) Drugs for DPP7 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UAMC00039 Pharma 0

(2) Additional Compounds for DPP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DPP7: view

Transcripts for DPP7 Gene

Unigene Clusters for DPP7 Gene

Dipeptidyl-peptidase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP7

Alternative Splicing Database (ASD) splice patterns (SP) for DPP7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - -
SP2: - -
SP3: - - - - - - - - - -
SP4:
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DPP7 Gene

GeneLoc Exon Structure for
DPP7
ECgene alternative splicing isoforms for
DPP7

Expression for DPP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPP7 Gene

This gene is overexpressed in Adrenal (7.2) and Salivary gland (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPP7 Gene



Protein tissue co-expression partners for DPP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPP7 Gene:

DPP7

SOURCE GeneReport for Unigene cluster for DPP7 Gene:

Hs.37916

mRNA Expression by UniProt/SwissProt for DPP7 Gene:

Q9UHL4-DPP2_HUMAN
Tissue specificity: Detected in seminal plasma (at protein level).

Evidence on tissue expression from TISSUES for DPP7 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Kidney(2.8)
  • Lung(2.7)
  • Skin(2.5)
  • Muscle(2.4)
  • Stomach(2.4)
  • Spleen(2.3)
  • Heart(2.2)
  • Blood(2.1)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with DPP7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP7 Gene

Orthologs for DPP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP7 34 33
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPP7 34 33
  • 82.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPP7 34 33
  • 81.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dpp7 16 34 33
  • 80.01 (n)
rat
(Rattus norvegicus)
Mammalia Dpp7 33
  • 79.68 (n)
oppossum
(Monodelphis domestica)
Mammalia DPP7 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves DPP7 34 33
  • 66.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPP7 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dpp7 34 33
  • 62.51 (n)
OneToOne
wufb19g02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11198 33
fruit fly
(Drosophila melanogaster)
Insecta CG9953 34
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F56F10.1 35
  • 27 (a)
F19C7.4 34
  • 19 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os11g0156200 33
  • 56.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9152 34
  • 38 (a)
OneToOne
Cin.3666 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3666 33
Species where no ortholog for DPP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DPP7 Gene

ENSEMBL:
Gene Tree for DPP7 (if available)
TreeFam:
Gene Tree for DPP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPP7: view image

Paralogs for DPP7 Gene

Paralogs for DPP7 Gene

(1) SIMAP similar genes for DPP7 Gene using alignment to 7 proteins:

  • DPP2_HUMAN
  • R4GMR2_HUMAN
  • R4GMU5_HUMAN
  • R4GMV4_HUMAN
  • R4GN05_HUMAN
  • R4GN23_HUMAN
  • R4GNE8_HUMAN
genes like me logo Genes that share paralogs with DPP7: view

Variants for DPP7 Gene

Sequence variations from dbSNP and Humsavar for DPP7 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000152032 -- 137,110,936(-) C/T coding_sequence_variant, missense_variant, synonymous_variant
rs1000534307 -- 137,117,961(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000928527 -- 137,113,788(-) G/A intron_variant
rs1001201395 -- 137,110,049(-) G/A/C downstream_transcript_variant
rs1001229725 -- 137,112,337(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPP7 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv1004020 CNV insertion 20482838
esv1271276 CNV insertion 17803354
esv2422220 CNV deletion 17116639
esv2739410 CNV deletion 23290073
esv2761561 CNV gain 21179565
nsv1075287 CNV deletion 25765185
nsv1142714 CNV deletion 24896259
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616005 CNV loss 21841781
nsv616007 CNV loss 21841781
nsv616008 CNV gain 21841781
nsv831761 CNV loss 17160897
nsv951206 CNV deletion 24416366

Variation tolerance for DPP7 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP7 Gene

Disorders for DPP7 Gene

Additional Disease Information for DPP7

No disorders were found for DPP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPP7 Gene

Publications for DPP7 Gene

  1. Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase. (PMID: 11067927) Chiravuri M … Huber BT (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  2. Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. (PMID: 10567372) Underwood R … Huber BT (The Journal of biological chemistry 1999) 3 4 22 58
  3. A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. (PMID: 10477574) Chiravuri M … Huber BT (Journal of immunology (Baltimore, Md. : 1950) 1999) 2 3 22 58
  4. Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. (PMID: 19556882) Mele DA … Huber BT (Cell cycle (Georgetown, Tex.) 2009) 3 22 58
  5. Dipeptidyl peptidase II is not a marker for progression in melanoma. (PMID: 18823758) Fröhlich E … Garbe C (Journal of dermatological science 2009) 3 22 58

Products for DPP7 Gene

Sources for DPP7 Gene

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