The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism,... See more...

Aliases for DPP4 Gene

Aliases for DPP4 Gene

  • Dipeptidyl Peptidase 4 2 3 4 5
  • Adenosine Deaminase Complexing Protein 2 2 3 4
  • Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2) 2 3
  • T-Cell Activation Antigen CD26 3 4
  • Dipeptidyl Peptidase IV 3 4
  • EC 3.4.14.5 4 50
  • ADCP-2 3 4
  • DPP IV 3 4
  • ADABP 3 4
  • ADCP2 3 4
  • DPPIV 2 3
  • TP103 3 4
  • CD26 3 4
  • Post-Proline Dipeptidyl Aminopeptidase IV 3
  • Xaa-Pro-Dipeptidylaminopeptidase 3
  • Gly-Pro Naphthylamidase 3
  • Dipeptidyl-Peptidase 4 2
  • Dipeptidylpeptidase 4 3
  • CD26 Antigen 4
  • DPP4 5

External Ids for DPP4 Gene

Previous HGNC Symbols for DPP4 Gene

  • CD26
  • ADCP2

Previous GeneCards Identifiers for DPP4 Gene

  • GC02M160902
  • GC02M161376
  • GC02M162812
  • GC02M163051
  • GC02M162674
  • GC02M162557
  • GC02M154730
  • GC02M162848

Summaries for DPP4 Gene

Entrez Gene Summary for DPP4 Gene

  • The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

GeneCards Summary for DPP4 Gene

DPP4 (Dipeptidyl Peptidase 4) is a Protein Coding gene. Diseases associated with DPP4 include Middle East Respiratory Syndrome and Nasopharyngitis. Among its related pathways are Incretin synthesis, secretion, and inactivation and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and signaling receptor binding. An important paralog of this gene is FAP.

UniProtKB/Swiss-Prot Summary for DPP4 Gene

  • Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948).
  • (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.

Tocris Summary for DPP4 Gene

  • Dipeptidyl Peptidase IV (DPP-IV) (also known as CD26) is a ubiquitous, membrane-bound enzyme that has several roles including in nutrition, metabolism, bone marrow mobilization, cancer growth, cell adhesion and within both the immune and endocrine systems.

Gene Wiki entry for DPP4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPP4 Gene

Genomics for DPP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DPP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J162062 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 255.9 +5.1 5103 13.9 ZMYM3 CEBPA POLR2A NFIC YY1 MXD4 ZNF592 TRIM22 HOMEZ KMT2B DPP4 TANK DPP4-DT HSALNG0020015 lnc-GCG-3 lnc-GCG-4 SLC4A10
GH02J162027 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.2 +45.4 45430 3.3 SSRP1 JUND CEBPA ATF3 YY1 MXD4 CEBPB HOMEZ MAX THAP11 DPP4-DT DPP4 lnc-GCG-4 HSALNG0020015 SLC4A10
GH02J162112 Enhancer 1.1 Ensembl ENCODE 11.2 -38.8 -38766 3.8 SSRP1 KLF9 CEBPA ATF3 MXD4 CEBPB ZFP64 HOMEZ KMT2B EP300 ENSG00000236841 LOC101929532 TIMM8AP1 DPP4 HSALNG0020019 GCG
GH02J161995 Enhancer 0.9 ENCODE dbSUPER 11.5 +78.6 78573 1.1 CEBPA RAD51 THAP11 FOXA2 KDM6A MAFF SAP130 SOX5 HMG20A RFX5 DPP4 DPP4-DT HSALNG0020012 lnc-GCG-4 SLC4A10
GH02J162126 Enhancer 0.8 Ensembl ENCODE 11.9 -51.5 -51507 3 BCL11A IRF4 SPI1 IKZF1 BMI1 ATF2 TCF12 PKNOX1 TARDBP IKZF2 GCG DPP4 ENSG00000224076 ENSG00000251621 SLC4A10 TIMM8AP1 ENSG00000236841 LOC101929532 lnc-FAP-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPP4

Top Transcription factor binding sites by QIAGEN in the DPP4 gene promoter:
  • AML1a

Genomic Locations for DPP4 Gene

Latest Assembly
chr2:161,992,245-162,074,394
(GRCh38/hg38)
Size:
82,150 bases
Orientation:
Minus strand

Previous Assembly
chr2:162,848,755-162,930,725
(GRCh37/hg19 by Entrez Gene)
Size:
81,971 bases
Orientation:
Minus strand

chr2:162,848,751-162,931,052
(GRCh37/hg19 by Ensembl)
Size:
82,302 bases
Orientation:
Minus strand

Genomic View for DPP4 Gene

Genes around DPP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP4 Gene

Proteins for DPP4 Gene

  • Protein details for DPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27487-DPP4_HUMAN
    Recommended name:
    Dipeptidyl peptidase 4
    Protein Accession:
    P27487
    Secondary Accessions:
    • Q53TN1

    Protein attributes for DPP4 Gene

    Size:
    766 amino acids
    Molecular mass:
    88279 Da
    Quaternary structure:
    • Monomer. Homodimer (PubMed:12832764, PubMed:15448155, PubMed:17287217, PubMed:12646248, PubMed:12483204, PubMed:12906826). Heterodimer with Seprase (FAP) (PubMed:16651416). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Associates with collagen (PubMed:8526932). Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959). Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity (PubMed:15016824, PubMed:10951221, PubMed:14691230, PubMed:7907293, PubMed:8101391). Interacts with CAV1 (via the N-terminus); the interaction is direct (PubMed:17287217). Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11 (PubMed:17287217). Interacts with IGF2R; the interaction is direct (PubMed:10900005). Interacts with GPC3 (PubMed:17549790). Interacts with human coronavirus-EMC spike protein and acts as a receptor for this virus (PubMed:23486063).
    • (Microbial infection) Interacts with MERS coronavirus/MERS-CoV spike protein.
    Miscellaneous:
    • Level of plasma concentrations of the soluble form (SDPP) can be managed as a colon carcinoma diagnostic and prognostic marker.

    Three dimensional structures from OCA and Proteopedia for DPP4 Gene

neXtProt entry for DPP4 Gene

Selected DME Specific Peptides for DPP4 Gene

P27487:
  • VPLIEYSFYSDESLQYP
  • FDKSKKYP
  • IEALTSDYLYYISN
  • TFLAYAQFNDT
  • LRVLEDNSALDKMLQ
  • MWYTDEDHGIAS
  • GPGLPLYTLH
  • YDSVYTERYM
  • GDHYLCDV
  • RNLYKIQL
  • VYAGPCSQK
  • FNAEYGNSS

Post-translational modifications for DPP4 Gene

  • The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
  • N- and O-Glycosylated.
  • Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
  • Glycosylation at Asn85, Asn92, Asn150, Asn219, Asn229, Asn281, Asn321, Asn520, and Asn685
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibodies for research

  • Abcam antibodies for DPP4

Domains & Families for DPP4 Gene

Gene Families for DPP4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for DPP4 Gene

InterPro:
Blocks:
  • Dipeptidylpeptidase IV (CD26), N-terminal
  • Prolyl endopeptidase, serine active site

Suggested Antigen Peptide Sequences for DPP4 Gene

GenScript: Design optimal peptide antigens:
  • TP103 (DPP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P27487

UniProtKB/Swiss-Prot:

DPP4_HUMAN :
  • The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.
  • Belongs to the peptidase S9B family. DPPIV subfamily.
Domain:
  • The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.
genes like me logo Genes that share domains with DPP4: view

Function for DPP4 Gene

Molecular function for DPP4 Gene

UniProtKB/Swiss-Prot Function:
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10084, ECO:0000269|PubMed:10593948};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL12/interleukin-12 on activated T-cells. IL12-activated cells expressed enhanced levels of DPP4 but not mRNAs. Down-regulated by TNF. Up-regulated in migratory endothelial cells and in the invasive endothelial cells in tumors. Induced by hypoxia (PubMed:16670267).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by GPC3 and diprotin A.
GENATLAS Biochemistry:
peptidase,dipeptidyl IV (intestinal),regulated by hepatocyte nuclear factor 1 alpha

Enzyme Numbers (IUBMB) for DPP4 Gene

Phenotypes From GWAS Catalog for DPP4 Gene

Gene Ontology (GO) - Molecular Function for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 23486063
GO:0002020 protease binding IPI 16651416
GO:0004177 aminopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity IEA,EXP 8100523
GO:0005102 signaling receptor binding IPI 10900005
genes like me logo Genes that share ontologies with DPP4: view
genes like me logo Genes that share phenotypes with DPP4: view

Animal Models for DPP4 Gene

MGI Knock Outs for DPP4:
  • Dpp4 Dpp4<tm1b(EUCOMM)Wtsi>
  • Dpp4 Dpp4<tm1(DPP4)Vlcg>
  • Dpp4 Dpp4<tm1Lex>
  • Dpp4 Dpp4<tm1Nwa>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP4

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DPP4 Gene

Localization for DPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP4 Gene

[Dipeptidyl peptidase 4 soluble form]: Secreted. Note=Detected in the serum and the seminal fluid. {ECO:0000269 PubMed:10951221, ECO:0000269 PubMed:16254193}.
Cell membrane. Single-pass type II membrane protein. Apical cell membrane. Single-pass type II membrane protein. Cell projection, invadopodium membrane. Single-pass type II membrane protein. Cell projection, lamellipodium membrane. Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269 PubMed:10900005, ECO:0000269 PubMed:11772392, ECO:0000269 PubMed:11773049, ECO:0000269 PubMed:12676959, ECO:0000269 PubMed:16651416, ECO:0000269 PubMed:17287217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
mitochondrion 3
nucleus 3
cytosol 3
golgi apparatus 3
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
endosome 2

Gene Ontology (GO) - Cellular Components for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion HDA 21423176
GO:0009986 cell surface IDA 7594462
genes like me logo Genes that share ontologies with DPP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPP4 Gene

Pathways & Interactions for DPP4 Gene

genes like me logo Genes that share pathways with DPP4: view

SIGNOR curated interactions for DPP4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001666 response to hypoxia IDA 16670267
GO:0006508 proteolysis IEA,IDA 27198182
GO:0007155 cell adhesion IEA --
GO:0008284 positive regulation of cell proliferation IDA 17549790
genes like me logo Genes that share ontologies with DPP4: view

Drugs & Compounds for DPP4 Gene

(126) Drugs for DPP4 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Saxagliptin Approved Pharma Target, inhibitor Selective DPP4 inhibitor 143
Sitagliptin Approved, Investigational Pharma Target, inhibitor 0
Vildagliptin Approved, Investigational Pharma Target, inhibitor 179
Linagliptin Approved Pharma Target, inhibitor 179
Alogliptin Approved Pharma Target, inhibitor 73

(40) Additional Compounds for DPP4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diprotin A
90614-48-5

(5) Tocris Compounds for DPP4 Gene

Compound Action Cas Number
Diprotin A Dipeptidyl peptidase IV (DPP-IV) inhibitor 90614-48-5
DPPI 1c hydrochloride Dipeptidyl peptidase IV (DPP-IV) inhibitor 866396-70-5
K 579 Dipeptidyl peptidase IV (DPP-IV) inhibitor 440100-64-1
NVP DPP 728 dihydrochloride Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor 207556-62-5
PK 44 phosphate Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor 1017682-66-4

(8) ApexBio Compounds for DPP4 Gene

Compound Action Cas Number
Alogliptin (SYR-322) DPP-4 inhibitor,potent and highly selective 850649-61-5
Glimepiride Sulfonylurea compound 93479-97-1
Linagliptin (BI-1356) DDP-4 inhibitor,highly potent and competitive 668270-12-0
NVP DPP 728 dihydrochloride DPP-IV inhibitor 247016-69-9
Saxagliptin Selective DPP4 inhibitor 361442-04-8
Sitagliptin phosphate monohydrate Potent DPP-4 inhibitor 654671-77-9
Trelagliptin DPP-4 inhibitor,long-acting and selective 865759-25-7
Vildagliptin (LAF-237) DPP-4 inhibitor 274901-16-5
genes like me logo Genes that share compounds with DPP4: view

Transcripts for DPP4 Gene

mRNA/cDNA for DPP4 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP4

Alternative Splicing Database (ASD) splice patterns (SP) for DPP4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7: - - - -
SP8:
SP9: - - -
SP10:
SP11: -
SP12: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DPP4 Gene

GeneLoc Exon Structure for
DPP4

Expression for DPP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPP4 Gene

mRNA differential expression in normal tissues according to GTEx for DPP4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.8), Kidney - Cortex (x4.6), and Prostate (x4.1).

Protein differential expression in normal tissues from HIPED for DPP4 Gene

This gene is overexpressed in Serum (11.5), Pancreatic juice (10.3), Placenta (7.7), Urine (6.2), and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPP4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPP4

SOURCE GeneReport for Unigene cluster for DPP4 Gene:

Hs.368912

mRNA Expression by UniProt/SwissProt for DPP4 Gene:

P27487-DPP4_HUMAN
Tissue specificity: Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.

Evidence on tissue expression from TISSUES for DPP4 Gene

  • Kidney(4.8)
  • Liver(4.7)
  • Blood(4.6)
  • Intestine(4.6)
  • Bone marrow(4.4)
  • Pancreas(3.4)
  • Heart(2.9)
  • Skin(2.8)
  • Muscle(2.7)
  • Lung(2.7)
  • Nervous system(2.7)
  • Spleen(2.6)
  • Stomach(2.5)
  • Urine(2.3)
  • Thyroid gland(2.3)
  • Lymph node(2.3)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with DPP4: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP4 Gene

Orthologs for DPP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPP4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPP4 29 30
  • 99.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DPP4 29 30
  • 90.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dpp4 29 16 30
  • 86.65 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dpp4 29
  • 85.71 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 84 (a)
OneToMany
DPP4 30
  • 59 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia DPP4 30
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DPP4 30
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DPP4 29 30
  • 68.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DPP4 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dpp4 29
  • 62.84 (n)
Str.19218 29
African clawed frog
(Xenopus laevis)
Amphibia LOC397888 29
Zebrafish
(Danio rerio)
Actinopterygii dpp4 29 30
  • 61.23 (n)
ManyToMany
fap 30
  • 53 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG11034 29 30 31
  • 46.68 (n)
ManyToMany
CG11319 30 31
  • 26 (a)
ManyToMany
ome 30
  • 23 (a)
ManyToMany
CG9059 30 31
  • 23 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008176 29
  • 36.09 (n)
Worm
(Caenorhabditis elegans)
Secernentea dpf-2 29 30
  • 43.08 (n)
ManyToMany
C27C12.7 31
  • 30 (a)
T23F1.7a 31
  • 29 (a)
T23F1.7b 31
  • 29 (a)
dpf-1 30
  • 24 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP2 29 30 32
  • 45.53 (n)
ManyToMany
STE13 30
  • 20 (a)
ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11485g 29
  • 44.64 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR073C 29
  • 43.75 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02515 29
  • 46.36 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPACUNK4.08 29
  • 46.14 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 45 (a)
ManyToMany
-- 30
  • 37 (a)
ManyToMany
-- 30
  • 33 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1344 29
Species where no ortholog for DPP4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DPP4 Gene

ENSEMBL:
Gene Tree for DPP4 (if available)
TreeFam:
Gene Tree for DPP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPP4: view image
Alliance of Genome Resources:
Additional Orthologs for DPP4

Paralogs for DPP4 Gene

Paralogs for DPP4 Gene

(3) SIMAP similar genes for DPP4 Gene using alignment to 4 proteins:

  • DPP4_HUMAN
  • F8WBB6_HUMAN
  • F8WE17_HUMAN
  • H7C1N5_HUMAN
genes like me logo Genes that share paralogs with DPP4: view

Variants for DPP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPP4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1129599 Benign: not provided 162,018,839(-) C/G
NM_001935.4(DPP4):c.1310G>C (p.Ser437Thr)
MISSENSE
rs115450134 Benign: not provided 162,009,238(-) C/T
NM_001935.4(DPP4):c.1887+3G>A
INTRON
rs1280179299 Likely Benign: not provided 161,995,012(-) T/G
NM_001935.4(DPP4):c.2148A>C (p.Ser716=)
SYNONYMOUS
rs148524083 Benign: not provided 162,073,445(-) C/T
NM_001935.4(DPP4):c.48G>A (p.Ala16=)
SYNONYMOUS
rs1576056789 Not Provided: Hereditary angioedema with normal C1Inh 162,038,344(-) C/A
NM_001935.4(DPP4):c.571G>T (p.Glu191Ter)
NONSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DPP4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DPP4 Gene

Variant ID Type Subtype PubMed ID
esv3429795 CNV insertion 20981092
nsv3008 CNV insertion 18451855
nsv834439 CNV gain 17160897

Variation tolerance for DPP4 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPP4 Gene

Human Gene Mutation Database (HGMD)
DPP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP4
Leiden Open Variation Database (LOVD)
DPP4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP4 Gene

Disorders for DPP4 Gene

MalaCards: The human disease database

(61) MalaCards diseases for DPP4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
middle east respiratory syndrome
  • mers
nasopharyngitis
  • chronic nasopharyngitis
prediabetes syndrome
  • impaired glucose tolerance
angioedema
  • angioneurotic edema
mental depression
  • depression
- elite association - COSMIC cancer census association via MalaCards
Search DPP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPP4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DPP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPP4 Gene

Publications for DPP4 Gene

  1. Direct association of adenosine deaminase with a T cell activation antigen, CD26. (PMID: 8101391) Kameoka J … Morimoto C (Science (New York, N.Y.) 1993) 2 3 4 22
  2. Comprehensive genetic analysis of the dipeptidyl peptidase-4 gene and cardiovascular disease risk factors in obese individuals. (PMID: 18682883) Bouchard L … Vohl MC (Acta diabetologica 2009) 3 22 40
  3. Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. (PMID: 17287217) Ohnuma K … Morimoto C (The Journal of biological chemistry 2007) 3 4 22
  4. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. (PMID: 16670267) Eltzschig HK … Colgan SP (Blood 2006) 3 4 22
  5. The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices. (PMID: 16651416) Ghersi G … Chen WT (Cancer research 2006) 3 4 22

Products for DPP4 Gene

  • Addgene plasmids for DPP4

Sources for DPP4 Gene