This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alter... See more...

Aliases for DPP3 Gene

Aliases for DPP3 Gene

  • Dipeptidyl Peptidase 3 2 3 4 5
  • Dipeptidyl Aminopeptidase III 3 4
  • Dipeptidyl Arylamidase III 3 4
  • Dipeptidyl Peptidase III 3 4
  • Enkephalinase B 3 4
  • EC 3.4.14.4 4 50
  • DPP III 3 4
  • Dipeptidylpeptidase III 2
  • Dipeptidyl-Peptidase 3 2
  • Dipeptidylpeptidase 3 2
  • DPPIII 3
  • DPP3 5

External Ids for DPP3 Gene

Previous GeneCards Identifiers for DPP3 Gene

  • GC11P068782
  • GC11P067929
  • GC11P066497
  • GC11P066023
  • GC11P066005
  • GC11P066248
  • GC11P066249
  • GC11P066522

Summaries for DPP3 Gene

Entrez Gene Summary for DPP3 Gene

  • This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for DPP3 Gene

DPP3 (Dipeptidyl Peptidase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and dipeptidyl-peptidase activity.

UniProtKB/Swiss-Prot Summary for DPP3 Gene

  • Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).

Gene Wiki entry for DPP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPP3 Gene

Genomics for DPP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DPP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J066508 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 276.2 +30.2 30219 3.1 BCLAF1 SP1 MYC IKZF1 ZNF600 SIX5 SSRP1 ZNF580 CEBPA POLR2A DPP3 BBS1 ENSG00000256349 HSALNG0085029 RBM14 RBM4 PCNX3 MUS81 ENSG00000245156 RAD9A
GH11J066478 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 266.9 +0.3 330 3.3 SP1 ZNF654 ZNF207 MYC ZNF600 IKZF1 ZMYM3 POLR2A ZSCAN16 BRCA1 MRPL11 DPP3 DPP3-DT HSALNG0085026 lnc-MRPL11-2 ACTN3 EIF1AD RBM14 RBM4 PCNX3
GH11J066479 Enhancer 0.4 Ensembl 250.7 -1.9 -1912 0.2 ZNF341 ZNF189 POLR2A SCRT2 DPP3 DPP3-DT HSALNG0085026 piR-57418 MRPL11
GH11J066464 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 18 -13.2 -13239 3.7 SP1 ZMYM3 ZIC2 POLR2A NONO REST ETS1 ZNF341 MNT KLF7 MRPL11 PELI3 ACTN3 DPP3 DPP3-DT piR-57418
GH11J066542 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 14.3 +66.0 65979 6.2 SP1 ZNF207 MYC ZNF600 ZMYM3 BRCA1 POLR2A NFIC ZIC2 CHD4 ACTN3 lnc-BBS1-1 ZDHHC24 RBM14 ENSG00000254461 CTSF SF3B2 DPP3 ENSG00000254855 KDM2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPP3

Top Transcription factor binding sites by QIAGEN in the DPP3 gene promoter:
  • AML1a
  • AP-2gamma
  • Bach2
  • c-Myb
  • COMP1
  • E47
  • HEN1
  • Pax-4a
  • Spz1

Genomic Locations for DPP3 Gene

Latest Assembly
chr11:66,480,013-66,509,657
(GRCh38/hg38)
Size:
29,645 bases
Orientation:
Plus strand

Previous Assembly
chr11:66,247,905-66,277,128
(GRCh37/hg19 by Entrez Gene)
Size:
29,224 bases
Orientation:
Plus strand

chr11:66,247,484-66,277,130
(GRCh37/hg19 by Ensembl)
Size:
29,647 bases
Orientation:
Plus strand

Genomic View for DPP3 Gene

Genes around DPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP3 Gene

Proteins for DPP3 Gene

  • Protein details for DPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY33-DPP3_HUMAN
    Recommended name:
    Dipeptidyl peptidase 3
    Protein Accession:
    Q9NY33
    Secondary Accessions:
    • B2RDB5
    • B4DLX4
    • F5H8L6
    • O95748
    • Q969H2
    • Q9BV67
    • Q9HAL6

    Protein attributes for DPP3 Gene

    Size:
    737 amino acids
    Molecular mass:
    82589 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for DPP3 Gene

    Alternative splice isoforms for DPP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPP3 Gene

Selected DME Specific Peptides for DPP3 Gene

Q9NY33:
  • PDFTSLDVLTFAGSG
  • VILRVLLEAGE
  • GIPAGIN
  • LLQTSPEAP
  • YIGFIESYRDPFG
  • VQVGLHELLGHGSGKLF
  • GFKNVSLGN
  • YVNWLNMVRAGLL
  • PAGINIPNYD
  • KSFGDTKF
  • WRQAHMQAR

Post-translational modifications for DPP3 Gene

  • Ubiquitination at Lys202, Lys629, Lys257, and Lys727
  • Modification sites at PhosphoSitePlus

Domains & Families for DPP3 Gene

Gene Families for DPP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DPP3 Gene

InterPro:
Blocks:
  • Peptidase family M49

Suggested Antigen Peptide Sequences for DPP3 Gene

GenScript: Design optimal peptide antigens:
  • Dipeptidyl peptidase III (DPP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NY33

UniProtKB/Swiss-Prot:

DPP3_HUMAN :
  • Belongs to the peptidase M49 family.
Family:
  • Belongs to the peptidase M49 family.
genes like me logo Genes that share domains with DPP3: view

Function for DPP3 Gene

Molecular function for DPP3 Gene

UniProtKB/Swiss-Prot Function:
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.; EC=3.4.14.4; Evidence={ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.8. {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Co(2+). Inhibited by EDTA and o-phenanthroline (in vitro).

Enzyme Numbers (IUBMB) for DPP3 Gene

Phenotypes From GWAS Catalog for DPP3 Gene

Gene Ontology (GO) - Molecular Function for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0005515 protein binding IPI 19615732
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IBA,IDA 9425109
genes like me logo Genes that share ontologies with DPP3: view
genes like me logo Genes that share phenotypes with DPP3: view

Animal Models for DPP3 Gene

MGI Knock Outs for DPP3:
  • Dpp3 Dpp3<tm1d(EUCOMM)Hmgu>

miRNA for DPP3 Gene

miRTarBase miRNAs that target DPP3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPP3 Gene

Localization for DPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP3 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP3 gene
Compartment Confidence
extracellular 4
cytosol 4
lysosome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IEA,IDA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with DPP3: view

Pathways & Interactions for DPP3 Gene

PathCards logo

SuperPathways for DPP3 Gene

No Data Available

Interacting Proteins for DPP3 Gene

Gene Ontology (GO) - Biological Process for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 9425109
genes like me logo Genes that share ontologies with DPP3: view

No data available for Pathways by source and SIGNOR curated interactions for DPP3 Gene

Drugs & Compounds for DPP3 Gene

(2) Drugs for DPP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DPP3: view

Transcripts for DPP3 Gene

mRNA/cDNA for DPP3 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPP3

Alternative Splicing Database (ASD) splice patterns (SP) for DPP3 Gene

No ASD Table

Relevant External Links for DPP3 Gene

GeneLoc Exon Structure for
DPP3

Expression for DPP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPP3 Gene

This gene is overexpressed in Lymph node (9.6) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPP3 Gene



Protein tissue co-expression partners for DPP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPP3

SOURCE GeneReport for Unigene cluster for DPP3 Gene:

Hs.502914

mRNA Expression by UniProt/SwissProt for DPP3 Gene:

Q9NY33-DPP3_HUMAN
Tissue specificity: Detected in placenta (at protein level) (PubMed:3233187). Detected in erythrocytes (at protein level) (PubMed:1515063).

Evidence on tissue expression from TISSUES for DPP3 Gene

  • Nervous system(4.3)
  • Blood(4.3)
  • Liver(4.2)
  • Kidney(4.2)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with DPP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP3 Gene

Orthologs for DPP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPP3 29
  • 99.4 (n)
Cow
(Bos Taurus)
Mammalia DPP3 29 30
  • 90.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DPP3 29 30
  • 90.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dpp3 29 16 30
  • 87.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dpp3 29
  • 87.43 (n)
Oppossum
(Monodelphis domestica)
Mammalia DPP3 30
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DPP3 30
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DPP3 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dpp3 29
  • 63.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia dpp3-A-prov 29
Zebrafish
(Danio rerio)
Actinopterygii dpp3 29 30
  • 68.37 (n)
OneToOne
wufb64b04 29
Fruit Fly
(Drosophila melanogaster)
Insecta DppIII 29 30
  • 56.87 (n)
OneToOne
CG7415 31
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004394 29
  • 54.59 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_F02E9.9 29
  • 52.89 (n)
dpt-1 30
  • 48 (a)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER229C 29
  • 48.16 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04059g 29
  • 46.74 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOL057W 29
  • 45.17 (n)
-- 30
  • 36 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU02701 29
  • 52.11 (n)
Species where no ortholog for DPP3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DPP3 Gene

ENSEMBL:
Gene Tree for DPP3 (if available)
TreeFam:
Gene Tree for DPP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPP3: view image
Alliance of Genome Resources:
Additional Orthologs for DPP3

Paralogs for DPP3 Gene

(1) SIMAP similar genes for DPP3 Gene using alignment to 8 proteins:

  • DPP3_HUMAN
  • E9PKK8_HUMAN
  • E9PNX5_HUMAN
  • E9PPK9_HUMAN
  • E9PQ14_HUMAN
  • E9PQF2_HUMAN
  • G3V180_HUMAN
  • G3V1D3_HUMAN

Pseudogenes.org Pseudogenes for DPP3 Gene

genes like me logo Genes that share paralogs with DPP3: view

No data available for Paralogs for DPP3 Gene

Variants for DPP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPP3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs112484606 Benign: not provided 66,486,666(+) C/A
NM_130443.4(DPP3):c.487C>A (p.Leu163Met)
MISSENSE
rs113216220 Benign: not provided 66,486,686(+) C/G
NM_130443.4(DPP3):c.498+9C>G
INTRON
rs114407249 Benign: not provided 66,504,657(+) G/A
NM_130443.4(DPP3):c.1924G>A (p.Glu642Lys)
MISSENSE
rs11826683 Benign: not provided 66,482,427(+) G/Ap.Arg76His
NM_130443.4(DPP3):c.227G>A (p.Arg76His)
MISSENSE
rs147519149 Benign: not provided 66,493,086(+) G/A
NM_130443.4(DPP3):c.1203G>A (p.Thr401=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DPP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DPP3 Gene

Variant ID Type Subtype PubMed ID
esv2744637 CNV deletion 23290073
nsv468601 CNV loss 19166990
nsv476256 CNV novel sequence insertion 20440878
nsv522277 CNV loss 19592680
nsv555224 CNV loss 21841781
nsv832193 CNV loss 17160897

Variation tolerance for DPP3 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.35; 95.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPP3 Gene

Human Gene Mutation Database (HGMD)
DPP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP3
Leiden Open Variation Database (LOVD)
DPP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP3 Gene

Disorders for DPP3 Gene

Additional Disease Information for DPP3

No disorders were found for DPP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPP3 Gene

Publications for DPP3 Gene

  1. Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences. (PMID: 11209758) Abramić M … Vitale L (Biological chemistry 2000) 3 4 22
  2. Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression. (PMID: 9425109) Fukasawa K … Harada M (The Biochemical journal 1998) 3 4 22
  3. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. (PMID: 22493238) Bezerra GA … Gruber K (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4
  4. Ets-1/Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells. (PMID: 20236318) Shukla AA … Chauhan SS (The FEBS journal 2010) 3 22
  5. Functional tyrosine residue in the active center of human dipeptidyl peptidase III. (PMID: 18163885) Salopek-Sondi B … Abramić M (Biological chemistry 2008) 3 22

Products for DPP3 Gene

Sources for DPP3 Gene