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Aliases for DPP3 Gene

Aliases for DPP3 Gene

  • Dipeptidyl Peptidase 3 2 3 3 5
  • Dipeptidyl Aminopeptidase III 3 4
  • Dipeptidyl Arylamidase III 3 4
  • Dipeptidyl Peptidase III 3 4
  • Enkephalinase B 3 4
  • DPP III 3 4
  • Dipeptidylpeptidase III 2
  • Dipeptidyl-Peptidase 3 2
  • Dipeptidylpeptidase 3 2
  • EC 4
  • DPPIII 3

External Ids for DPP3 Gene

Previous GeneCards Identifiers for DPP3 Gene

  • GC11P068782
  • GC11P067929
  • GC11P066023
  • GC11P066005
  • GC11P066248
  • GC11P066249

Summaries for DPP3 Gene

Entrez Gene Summary for DPP3 Gene

  • This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for DPP3 Gene

DPP3 (Dipeptidyl Peptidase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and dipeptidyl-peptidase activity.

UniProtKB/Swiss-Prot for DPP3 Gene

  • Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).

Gene Wiki entry for DPP3 Gene

Additional gene information for DPP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP3 Gene

Genomics for DPP3 Gene

GeneHancer (GH) Regulatory Elements for DPP3 Gene

Promoters and enhancers for DPP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J066508 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 676.1 +30.1 30116 2.9 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 DPP3 BBS1 ENSG00000256349 ENSG00000258297 RBM14 RBM4 EIF1AD KDM2A PCNX3 ENSG00000245156
GH11J066478 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 666.9 +0.3 330 3.3 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 MRPL11 DPP3 LOC101928069 EIF1AD ACTN3 RBM14 RBM4 PCNX3 KDM2A ENSG00000258297
GH11J066464 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 18 -13.5 -13497 3.1 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 ETS1 GLIS2 ZNF143 ATF7 MRPL11 PELI3 ACTN3 DPP3 LOC101928069
GH11J066342 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -131.5 -131468 11.8 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 LOC102724064 B4GAT1 TRS-GCT3-1 RBM14 ENSG00000258297 LOC105369352 RBM4 EIF1AD RIN1 ENSG00000255320
GH11J066542 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.3 +66.0 65979 6.2 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 E2F8 ZNF207 ZNF143 FOS ACTN3 ZDHHC24 RBM14 ENSG00000258297 RBM4 LOC105369352 KAT5 SF3B2 EIF1AD MUS81
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPP3 gene promoter:
  • Bach2
  • Spz1
  • COMP1
  • c-Myb
  • HEN1
  • AP-2gamma
  • E47
  • Pax-4a
  • AML1a

Genomic Locations for DPP3 Gene

Genomic Locations for DPP3 Gene
29,647 bases
Plus strand
29,647 bases
Plus strand

Genomic View for DPP3 Gene

Genes around DPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP3 Gene

Proteins for DPP3 Gene

  • Protein details for DPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dipeptidyl peptidase 3
    Protein Accession:
    Secondary Accessions:
    • B2RDB5
    • B4DLX4
    • F5H8L6
    • O95748
    • Q969H2
    • Q9BV67
    • Q9HAL6

    Protein attributes for DPP3 Gene

    737 amino acids
    Molecular mass:
    82589 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPP3 Gene

    Alternative splice isoforms for DPP3 Gene


neXtProt entry for DPP3 Gene

Post-translational modifications for DPP3 Gene

  • Ubiquitination at Lys727, posLast=629629, posLast=257257, and Lys202
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DPP3 Gene

Domains & Families for DPP3 Gene

Gene Families for DPP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DPP3 Gene


Suggested Antigen Peptide Sequences for DPP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M49 family.
  • Belongs to the peptidase M49 family.
genes like me logo Genes that share domains with DPP3: view

Function for DPP3 Gene

Molecular function for DPP3 Gene

UniProtKB/Swiss-Prot Function:
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Co(2+). Inhibited by EDTA and o-phenanthroline (in vitro).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.8. {ECO:0000269 PubMed:11209758, ECO:0000269 PubMed:3233187, ECO:0000269 PubMed:9425109};

Enzyme Numbers (IUBMB) for DPP3 Gene

Phenotypes From GWAS Catalog for DPP3 Gene

Gene Ontology (GO) - Molecular Function for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19615732
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IDA 9425109
GO:0008270 zinc ion binding IDA 9425109
genes like me logo Genes that share ontologies with DPP3: view
genes like me logo Genes that share phenotypes with DPP3: view

Animal Model Products

miRNA for DPP3 Gene

miRTarBase miRNAs that target DPP3

Clone Products

  • Addgene plasmids for DPP3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPP3 Gene

Localization for DPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP3 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP3 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear speckles (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016607 nuclear speck IDA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with DPP3: view

Pathways & Interactions for DPP3 Gene

No Data Available

Interacting Proteins for DPP3 Gene

Gene Ontology (GO) - Biological Process for DPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 9425109
genes like me logo Genes that share ontologies with DPP3: view

No data available for Pathways by source and SIGNOR curated interactions for DPP3 Gene

Drugs & Compounds for DPP3 Gene

(2) Drugs for DPP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DPP3: view

Transcripts for DPP3 Gene

mRNA/cDNA for DPP3 Gene

Unigene Clusters for DPP3 Gene

Dipeptidyl-peptidase 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for DPP3

Alternative Splicing Database (ASD) splice patterns (SP) for DPP3 Gene

No ASD Table

Relevant External Links for DPP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPP3 Gene

This gene is overexpressed in Lymph node (9.6) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPP3 Gene

Protein tissue co-expression partners for DPP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPP3 Gene:


SOURCE GeneReport for Unigene cluster for DPP3 Gene:


mRNA Expression by UniProt/SwissProt for DPP3 Gene:

Tissue specificity: Detected in placenta (at protein level) (PubMed:3233187). Detected in erythrocytes (at protein level) (PubMed:1515063).

Evidence on tissue expression from TISSUES for DPP3 Gene

  • Nervous system(4.3)
  • Blood(4.1)
  • Liver(4.1)
  • Intestine(4)
  • Kidney(4)
genes like me logo Genes that share expression patterns with DPP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP3 Gene

Orthologs for DPP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPP3 33
  • 99.4 (n)
(Bos Taurus)
Mammalia DPP3 34 33
  • 90.99 (n)
(Canis familiaris)
Mammalia DPP3 34 33
  • 90.45 (n)
(Mus musculus)
Mammalia Dpp3 16 34 33
  • 87.56 (n)
(Rattus norvegicus)
Mammalia Dpp3 33
  • 87.43 (n)
(Monodelphis domestica)
Mammalia DPP3 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia DPP3 34
  • 73 (a)
(Anolis carolinensis)
Reptilia DPP3 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp3 33
  • 63.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia dpp3-A-prov 33
(Danio rerio)
Actinopterygii dpp3 34 33
  • 68.37 (n)
wufb64b04 33
fruit fly
(Drosophila melanogaster)
Insecta DppIII 34 33
  • 56.87 (n)
CG7415 35
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004394 33
  • 54.59 (n)
(Caenorhabditis elegans)
Secernentea CELE_F02E9.9 33
  • 52.89 (n)
dpt-1 34
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER229C 33
  • 48.16 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04059g 33
  • 46.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOL057W 33
  • 45.17 (n)
-- 34
  • 36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02701 33
  • 52.11 (n)
Species where no ortholog for DPP3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP3 Gene

Gene Tree for DPP3 (if available)
Gene Tree for DPP3 (if available)
Evolutionary constrained regions (ECRs) for DPP3: view image

Paralogs for DPP3 Gene

(1) SIMAP similar genes for DPP3 Gene using alignment to 8 proteins:

  • E9PQ14_HUMAN
  • G3V180_HUMAN
  • G3V1D3_HUMAN Pseudogenes for DPP3 Gene

genes like me logo Genes that share paralogs with DPP3: view

No data available for Paralogs for DPP3 Gene

Variants for DPP3 Gene

Sequence variations from dbSNP and Humsavar for DPP3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000017758 -- 66,491,501(+) C/T coding_sequence_variant, missense_variant
rs1000170720 -- 66,492,053(+) G/A intron_variant
rs1000234996 -- 66,493,998(+) G/C intron_variant
rs1000334444 -- 66,487,943(+) C/G coding_sequence_variant, missense_variant
rs1000388080 -- 66,488,087(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPP3 Gene

Variant ID Type Subtype PubMed ID
esv2744637 CNV deletion 23290073
nsv468601 CNV loss 19166990
nsv476256 CNV novel sequence insertion 20440878
nsv522277 CNV loss 19592680
nsv555224 CNV loss 21841781
nsv832193 CNV loss 17160897

Variation tolerance for DPP3 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.35; 95.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP3 Gene

Disorders for DPP3 Gene

Additional Disease Information for DPP3

No disorders were found for DPP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPP3 Gene

Publications for DPP3 Gene

  1. Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences. (PMID: 11209758) Abramić M … Vitale L (Biological chemistry 2000) 3 4 22 58
  2. Dipeptidyl peptidase III is a zinc metallo-exopeptidase. Molecular cloning and expression. (PMID: 9425109) Fukasawa K … Harada M (The Biochemical journal 1998) 3 4 22 58
  3. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. (PMID: 22493238) Bezerra GA … Gruber K (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 58
  4. Ets-1/Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells. (PMID: 20236318) Shukla AA … Chauhan SS (The FEBS journal 2010) 3 22 58
  5. Functional tyrosine residue in the active center of human dipeptidyl peptidase III. (PMID: 18163885) Salopek-Sondi B … Abramić M (Biological chemistry 2008) 3 22 58

Products for DPP3 Gene

Sources for DPP3 Gene

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