Aliases for DPM2 Gene
External Ids for DPM2 Gene
Previous GeneCards Identifiers for DPM2 Gene
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
GeneCards Summary for DPM2 Gene
DPM2 (Dolichyl-Phosphate Mannosyltransferase Subunit 2, Regulatory) is a Protein Coding gene. Diseases associated with DPM2 include Congenital Disorder Of Glycosylation, Type Iu and Congenital Disorder Of Glycosylation, Type In. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and N-Glycan biosynthesis. Gene Ontology (GO) annotations related to this gene include enzyme regulator activity and dolichyl-phosphate beta-D-mannosyltransferase activity.
UniProtKB/Swiss-Prot Summary for DPM2 Gene
Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:10835346). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:10835346). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the GPI-GNT complex (PubMed:10944123).