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Aliases for DPM1 Gene

Aliases for DPM1 Gene

  • Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic 2 3 5
  • Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 1 3 4
  • Dolichol-Phosphate Mannose Synthase Subunit 1 3 4
  • DPM Synthase Complex, Catalytic Subunit 2 3
  • Mannose-P-Dolichol Synthase Subunit 1 3 4
  • DPM Synthase Subunit 1 3 4
  • MPD Synthase Subunit 1 3 4
  • Dolichyl-Phosphate Mannosyltransferase Polypeptide 1, Catalytic Subunit 2
  • Dolichyl-Phosphate Mannosyltransferase Polypeptide 1 Catalytic Subunit 3
  • Dolichol-Phosphate Mannosyltransferase Subunit 1 3
  • Dolichol Monophosphate Mannose Synthase 3
  • EC 2.4.1.83 4
  • CDGIE 3
  • MPDS 3

External Ids for DPM1 Gene

Previous GeneCards Identifiers for DPM1 Gene

  • GC20M049279
  • GC20M050189
  • GC20M050236
  • GC20M048985
  • GC20M049551
  • GC20M046299

Summaries for DPM1 Gene

Entrez Gene Summary for DPM1 Gene

  • Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for DPM1 Gene

DPM1 (Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic) is a Protein Coding gene. Diseases associated with DPM1 include Congenital Disorder Of Glycosylation, Type Ie and Multiple Personality Disorder. Among its related pathways are N-Glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and dolichyl-phosphate-mannose-protein mannosyltransferase activity.

UniProtKB/Swiss-Prot for DPM1 Gene

  • Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

Gene Wiki entry for DPM1 Gene

Additional gene information for DPM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPM1 Gene

Genomics for DPM1 Gene

GeneHancer (GH) Regulatory Elements for DPM1 Gene

Promoters and enhancers for DPM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J050956 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 674.9 +0.1 103 3.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DPM1 MOCS3 PIR61443 ADNP ENSG00000232043 PSMD10P1 CEBPB BCAS4 PTPN1
GH20J050186 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 73.9 +767.3 767283 10.3 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 CEBPB CEBPB-AS1 GC20P050191 ADNP DDX27 DPM1 ENSG00000232043 MOCS3 PSMD10P1 RNF114
GH20J050507 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.1 +443.2 443210 14.7 MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF143 ZNF548 SP3 PTPN1 GC20P050514 ADNP ENSG00000232043 DPM1 CEBPB PSMD10P1 MOCS3 LINC01273 MIR645
GH20J051797 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.7 -841.7 -841711 6 HDGF PKNOX1 ARID4B NEUROD1 SIN3A FEZF1 ZBTB7B YY1 ZNF213 E2F8 SALL4 DPM1 ADNP MOCS3 ZFP64 PSMD10P1 RNU7-6P ATP9A PIR39254 GC20M051835
GH20J050140 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.2 +810.8 810842 14.1 ZFP64 YBX1 DMAP1 IRF4 YY1 E2F8 ZNF143 NFYC SSRP1 GLIS1 TMEM189 TMEM189-UBE2V1 DPM1 SNAI1 SLC9A8 DDX27 LINC01273 ADNP B4GALT5 PTPN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPM1 gene promoter:

Genomic Locations for DPM1 Gene

Genomic Locations for DPM1 Gene
chr20:50,934,855-50,958,561
(GRCh38/hg38)
Size:
23,707 bases
Orientation:
Minus strand
chr20:49,551,404-49,575,092
(GRCh37/hg19)

Genomic View for DPM1 Gene

Genes around DPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPM1 Gene

Proteins for DPM1 Gene

  • Protein details for DPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60762-DPM1_HUMAN
    Recommended name:
    Dolichol-phosphate mannosyltransferase subunit 1
    Protein Accession:
    O60762
    Secondary Accessions:
    • O15157
    • Q6IB78
    • Q96HK0

    Protein attributes for DPM1 Gene

    Size:
    260 amino acids
    Molecular mass:
    29634 Da
    Quaternary structure:
    • Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.

neXtProt entry for DPM1 Gene

Post-translational modifications for DPM1 Gene

  • Ubiquitination at posLast=240240, posLast=9595, posLast=8080, and Lys26
  • Modification sites at PhosphoSitePlus

Other Protein References for DPM1 Gene

No data available for DME Specific Peptides for DPM1 Gene

Domains & Families for DPM1 Gene

Gene Families for DPM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for DPM1 Gene

Graphical View of Domain Structure for InterPro Entry

O60762

UniProtKB/Swiss-Prot:

DPM1_HUMAN :
  • Belongs to the glycosyltransferase 2 family.
Family:
  • Belongs to the glycosyltransferase 2 family.
genes like me logo Genes that share domains with DPM1: view

Function for DPM1 Gene

Molecular function for DPM1 Gene

UniProtKB/Swiss-Prot Function:
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.

Enzyme Numbers (IUBMB) for DPM1 Gene

Phenotypes From GWAS Catalog for DPM1 Gene

Gene Ontology (GO) - Molecular Function for DPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity IDA 9535917
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity IEA,IDA 9535917
GO:0005515 protein binding IPI 10835346
GO:0005537 mannose binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DPM1: view
genes like me logo Genes that share phenotypes with DPM1: view

Human Phenotype Ontology for DPM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DPM1 Gene

MGI Knock Outs for DPM1:
  • Dpm1 Dpm1<tm1b(KOMP)Wtsi>

Animal Model Products

miRNA for DPM1 Gene

miRTarBase miRNAs that target DPM1

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for DPM1 Gene

Localization for DPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPM1 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPM1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005783 endoplasmic reticulum IDA 9724629
GO:0005789 endoplasmic reticulum membrane TAS,IDA --
GO:0016020 membrane IDA 9535917
GO:0033185 dolichol-phosphate-mannose synthase complex IDA 9724629
genes like me logo Genes that share ontologies with DPM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPM1 Gene

Pathways & Interactions for DPM1 Gene

genes like me logo Genes that share pathways with DPM1: view

UniProtKB/Swiss-Prot O60762-DPM1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for DPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006506 GPI anchor biosynthetic process IDA 9535917
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0019348 dolichol metabolic process IDA,IEA 9535917
GO:0019673 GDP-mannose metabolic process IEA --
genes like me logo Genes that share ontologies with DPM1: view

No data available for SIGNOR curated interactions for DPM1 Gene

Drugs & Compounds for DPM1 Gene

(3) Drugs for DPM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
dolichol phosphate Pharma Competitive, Inhibitor 0

(4) Additional Compounds for DPM1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
2067-66-5
Dolichyl beta-D-mannosyl phosphate
  • b-D-Mannopyranose-1-ester with dolichol dihydrogen phosphate
  • beta-D-Mannopyranose-1-ester with dolichol dihydrogen phosphate
  • D-Mannose ester with dolichol dihydrogen phosphate
  • Dolichol monophosphate mannose
  • Dolichyl D-mannosyl phosphate
Dolichyl phosphate D-mannose
  • Dolichol phosphate mannose
  • Dolichyl D-mannosyl phosphate
  • DPM
908211-94-9
Guanosine diphosphate mannose
  • GDP-D-Mannose
  • GDPmannose
  • Guanosine 5'-(trihydrogen diphosphate), mono-alpha-D-mannopyranosyl ester
  • Guanosine diphosphomannose
  • Guanosine pyrophosphate mannose
3123-67-9
genes like me logo Genes that share compounds with DPM1: view

Transcripts for DPM1 Gene

Unigene Clusters for DPM1 Gene

Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPM1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2:
SP3: - -
SP4: -
SP5: - - -
SP6:

Relevant External Links for DPM1 Gene

GeneLoc Exon Structure for
DPM1
ECgene alternative splicing isoforms for
DPM1

Expression for DPM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPM1 Gene

This gene is overexpressed in Bone (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPM1 Gene



Protein tissue co-expression partners for DPM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPM1 Gene:

DPM1

SOURCE GeneReport for Unigene cluster for DPM1 Gene:

Hs.654951

Evidence on tissue expression from TISSUES for DPM1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Blood(2.8)
  • Bone marrow(2.7)
  • Spleen(2.2)
  • Kidney(2.1)
  • Muscle(2.1)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DPM1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • skull
Thorax:
  • heart
  • lung
Abdomen:
  • liver
  • spleen
Limb:
  • ankle
  • digit
  • finger
  • foot
  • hand
  • knee
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with DPM1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPM1 Gene

Orthologs for DPM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPM1 34 33
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPM1 34 33
  • 93.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPM1 34 33
  • 91.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm20716 34
  • 91 (a)
OneToMany
Dpm1 16 34 33
  • 88.93 (n)
rat
(Rattus norvegicus)
Mammalia Dpm1 33
  • 87.69 (n)
oppossum
(Monodelphis domestica)
Mammalia DPM1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPM1 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPM1 34 33
  • 81.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPM1 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpm1 33
  • 76.41 (n)
Str.19938 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2812 33
zebrafish
(Danio rerio)
Actinopterygii dpm1 34 33
  • 75.07 (n)
OneToOne
Dr.12934 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009866 33
  • 67.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10166 34 35 33
  • 65.68 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dpm-1 34 33
  • 64.07 (n)
OneToOne
Y66H1A.2 35
  • 64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPM1 36 34
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G20575 33
  • 61.32 (n)
rice
(Oryza sativa)
Liliopsida Os03g0824400 33
  • 63.69 (n)
Os.7448 33
barley
(Hordeum vulgare)
Liliopsida Hv.7423 33
wheat
(Triticum aestivum)
Liliopsida Ta.617 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2945 34
  • 74 (a)
OneToOne
Cin.2411 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dpm1 33
  • 60.94 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07965 33
  • 55.46 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2411 33
Species where no ortholog for DPM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DPM1 Gene

ENSEMBL:
Gene Tree for DPM1 (if available)
TreeFam:
Gene Tree for DPM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPM1: view image

Paralogs for DPM1 Gene

No data available for Paralogs for DPM1 Gene

Variants for DPM1 Gene

Sequence variations from dbSNP and Humsavar for DPM1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs11480415 likely-benign, benign, Congenital disorder of glycosylation, not provided, Congenital disorder of glycosylation type 1E 50,935,243(-) /A/AA/AAA genic_downstream_transcript_variant, intron_variant
rs117175017 uncertain-significance, likely-benign, Congenital disorder of glycosylation, not specified, Congenital disorder of glycosylation type 1E 50,958,484(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121908583 pathogenic, Congenital disorder of glycosylation type 1E, Congenital disorder of glycosylation 1E (CDG1E) [MIM:608799] 50,948,650(-) G/C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs146262101 uncertain-significance, Congenital disorder of glycosylation 50,935,136(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs16995639 uncertain-significance, likely-benign, benign, Congenital disorder of glycosylation, not specified, Congenital disorder of glycosylation type 1E 50,958,440(-) C/G/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for DPM1 Gene

Variant ID Type Subtype PubMed ID
esv3646049 CNV gain 21293372
nsv834002 CNV loss 17160897

Variation tolerance for DPM1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPM1 Gene

Human Gene Mutation Database (HGMD)
DPM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPM1 Gene

Disorders for DPM1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for DPM1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type ie
  • cdg1e
multiple personality disorder
  • dissociative identity disorder
facial neuralgia
dissociative disorder
  • dissociative disease
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1
  • myeloid and lymphoid neoplasms with eosinophilia and abnormalities of platelet-derived growth factor receptor alpha , platelet-derived growth factor receptor beta , and fibroblast growth factor receptor-1 are a group of hematologic neoplasms
- elite association - COSMIC cancer census association via MalaCards
Search DPM1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DPM1_HUMAN
  • Congenital disorder of glycosylation 1E (CDG1E) [MIM:608799]: A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Some CDG1E patients have features consistent with a dystroglycanopathy and congenital muscular dystrophy, including O-mannosylation defect, camptodactyly, elevated creatine kinase, motor delay and dystrophic changes on muscel biopsy. {ECO:0000269 PubMed:10642597, ECO:0000269 PubMed:10642602, ECO:0000269 PubMed:15669674, ECO:0000269 PubMed:23856421}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DPM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DPM1: view

No data available for Genatlas for DPM1 Gene

Publications for DPM1 Gene

  1. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. (PMID: 9535917) Tomita S … Kinoshita T (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe. (PMID: 9223280) Colussi PA … Orlean P (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  3. Congenital disorder of glycosylation (CDG) type Ie. A new patient. (PMID: 15669674) García-Silva MT … Briones P (Journal of inherited metabolic disease 2004) 3 4 22 58
  4. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PMID: 10835346) Maeda Y … Kinoshita T (The EMBO journal 2000) 3 4 22 58
  5. Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie. (PMID: 10642602) Imbach T … Hennet T (The Journal of clinical investigation 2000) 3 4 22 58

Products for DPM1 Gene

Sources for DPM1 Gene

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