Aliases for DPH7 Gene
External Ids for DPH7 Gene
Previous HGNC Symbols for DPH7 Gene
Previous GeneCards Identifiers for DPH7 Gene
Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]
GeneCards Summary for DPH7 Gene
DPH7 (Diphthamide Biosynthesis 7) is a Protein Coding gene. Diseases associated with DPH7 include Diphtheria. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include diphthine methylesterase activity.
UniProtKB/Swiss-Prot for DPH7 Gene
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).