Aliases for DPH3 Gene
- ZCSL2 3 4
- Deafness Locus Putative Guanine Nucleotide Exchange Factor Interacting Protein 1 3
- Diphtheria Toxin And Pseudomonas Exotoxin A Sensitivity Required Gene 1 3
- DPH3A, KTI11 Homolog A (S. Cerevisiae) 2
- Zinc Finger, CSL Domain Containing 2 3
- DPH3, KTI11 Homolog (S. Cerevisiae) 2
- Del-GEF Interacting Protein 3
- DPH3A, KTI11 Homolog A 3
- DPH3, KTI11 Homolog 3
- MGC20197 2
- DelGIP1 4
- DPH3 5
External Ids for DPH3 Gene
Previous HGNC Symbols for DPH3 Gene
Previous GeneCards Identifiers for DPH3 Gene
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
GeneCards Summary for DPH3 Gene
DPH3 (Diphthamide Biosynthesis 3) is a Protein Coding gene. Diseases associated with DPH3 include Diphtheria and Melanoma, Cutaneous Malignant 1. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation.
UniProtKB/Swiss-Prot Summary for DPH3 Gene
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.