Aliases for DPF2 Gene
Aliases for DPF2 Gene
External Ids for DPF2 Gene
- HGNC: 9964
- Entrez Gene: 5977
- Ensembl: ENSG00000133884
- OMIM: 601671
- UniProtKB: Q92785
Previous HGNC Symbols for DPF2 Gene
- REQ
Previous GeneCards Identifiers for DPF2 Gene
- GC11P064876
- GC11P064858
- GC11P065103
- GC11P061428
Summaries for DPF2 Gene
-
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
GeneCards Summary for DPF2 Gene
DPF2 (Double PHD Fingers 2) is a Protein Coding gene. Diseases associated with DPF2 include Hemopneumothorax. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is DPF1.
UniProtKB/Swiss-Prot for DPF2 Gene
-
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF2 Gene
Genomics for DPF2 Gene
GeneHancer (GH) Regulatory Elements for DPF2 Gene
Promoters and enhancers for DPF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DPF2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DPF2 gene promoter:
-
- SEF-1 (1)
- LCR-F1
- Sp1
- Elk-1
- STAT5A
- Sox5
- AML1a
- NRF-2
- IRF-2
Regulatory Element Products
Genomic Locations for DPF2 Gene
Genomic Locations for DPF2 Gene
- chr11:65,333,754-65,353,249
- (GRCh38/hg38)
- Size:
- 19,496 bases
- Orientation:
- Plus strand
- chr11:65,101,225-65,120,720
- (GRCh37/hg19)
- Size:
- 19,496 bases
- Orientation:
- Plus strand
Genomic View for DPF2 Gene
Genes around DPF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
DPF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DPF2 Gene
Proteins for DPF2 Gene
-
Protein details for DPF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92785-REQU_HUMAN
- Recommended name:
- Zinc finger protein ubi-d4
- Protein Accession:
- Q92785
- A8K7C9
- B4DT58
Protein attributes for DPF2 Gene
- Size:
- 391 amino acids
- Molecular mass:
- 44155 Da
- Quaternary structure:
- No Data Available
Protein Expression for DPF2 Gene
Post-translational modifications for DPF2 Gene
Other Protein References for DPF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DPF2
- Novus Biologicals Antibodies for DPF2
-
Abcam antibodies for DPF2
- Invitrogen Antibodies for DPF2 (AFLGC-DPF2)
- antibodies-online: Search results for available dpf2 related products ranked by validation data
- GeneTex DPF2 Antibody for DPF2
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for DPF2
Protein Products
-
OriGene Purified Proteins for DPF2
- Search Origene for MassSpec and Protein Over-expression Lysates for DPF2
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- Search GeneTex for Proteins for DPF2
-
Abcam proteins for DPF2
Assay Products
- antibodies-online: Search results for available dpf2 related products ranked by validation data
No data available for DME Specific Peptides for DPF2 Gene
Domains & Families for DPF2 Gene
Gene Families for DPF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DPF2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DPF2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92785- Family:
-
- Belongs to the requiem/DPF family.
Function for DPF2 Gene
Molecular function for DPF2 Gene
- UniProtKB/Swiss-Prot Function:
- May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
Phenotypes From GWAS Catalog for DPF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | HDA | 16217013 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for DPF2 Gene
- MGI mutant phenotypes for DPF2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DPF2:
-
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased cell death HMECs cells
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for DPF2 Gene
- MGI Knock Outs for DPF2:
-
- Dpf2 Dpf2<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DPF2
-
CRISPR Products
-
OriGene CRISPR knockouts for DPF2
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- Applied Biological Materials CRISPR for DPF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DPF2
- GenScript: Design CRISPR guide RNA sequences for DPF2
miRNA for DPF2 Gene
- miRTarBase miRNAs that target DPF2
-
- hsa-mir-124-3p (MIRT022792)
- hsa-let-7b-5p (MIRT032431)
- hsa-mir-10b-5p (MIRT439128)
- hsa-mir-5006-3p (MIRT615251)
- hsa-mir-4755-5p (MIRT615252)
- hsa-mir-4642 (MIRT615253)
- hsa-mir-211-5p (MIRT615254)
- hsa-mir-204-5p (MIRT615255)
- hsa-mir-623 (MIRT615256)
- hsa-mir-670-5p (MIRT615257)
- hsa-mir-642b-5p (MIRT615258)
- hsa-mir-5588-5p (MIRT615259)
- hsa-mir-4799-3p (MIRT615260)
- hsa-mir-4720-5p (MIRT615261)
- hsa-mir-6868-5p (MIRT615262)
- hsa-mir-3128 (MIRT615263)
- hsa-mir-6734-3p (MIRT615264)
- hsa-mir-5088-3p (MIRT615265)
- hsa-mir-6752-3p (MIRT615266)
- hsa-mir-3126-3p (MIRT615267)
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available dpf2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DPF2
- Addgene plasmids for DPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DPF2
- genomics-online: cdna clones - Search results for available dpf2 gene related products
- orf clones - Search results for available dpf2 gene related products
- Applied Biological Materials Clones for DPF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DPF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPF2 Gene
Localization for DPF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DPF2 Gene
- Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | HDA | 16217013 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | -- |
Pathways & Interactions for DPF2 Gene
No Data Available
Interacting Proteins for DPF2 Gene
Selected Interacting proteins:
Q92785-REQU_HUMAN
ENSP00000436901
for DPF2 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for DPF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006915 | apoptotic process | TAS | 8812431 |
| GO:0097190 | apoptotic signaling pathway | TAS | 7961935 |
No data available for Pathways by source and SIGNOR curated interactions for DPF2 Gene
Transcripts for DPF2 Gene
mRNA/cDNA for DPF2 Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (275) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000528416 2799 bps (uc001odm.4)
- ENST00000444314 940 bps (uc031xrw.2)
- ENST00000415073 2085 bps (uc010roe.3)
- ENST00000530993 624 bps (uc058dim.1)
- ENST00000252268 2462 bps (uc058din.1)
Unigene Clusters for DPF2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DPF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DPF2
- genomics-online: gRNA clones - Search results for available dpf2 gene related products
- Applied Biological Materials CRISPR for DPF2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DPF2
- GenScript: Design CRISPR guide RNA sequences for DPF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DPF2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPF2
- genomics-online: shRNA clones - Search results for available dpf2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DPF2
- Addgene plasmids for DPF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DPF2
- genomics-online: cdna clones - Search results for available dpf2 gene related products
- orf clones - Search results for available dpf2 gene related products
- Applied Biological Materials Clones for DPF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: |
Expression for DPF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Ovary (Reproductive System)
This gene is overexpressed in Peripheral blood mononuclear cells (24.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPF2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DPF2 Gene:
DPF2SOURCE GeneReport for Unigene cluster for DPF2 Gene:
Hs.13495mRNA Expression by UniProt/SwissProt for DPF2 Gene:
Q92785-REQU_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for DPF2 Gene
- Nervous system(4.4)
- Liver(4.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for DPF2
-
OriGene qPCR primer pairs and template standards for DPF2
- genomics-online: primer clones - Search results for available dpf2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPF2 Gene
Orthologs for DPF2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DPF2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DPF2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | DPF2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DPF2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Dpf2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dpf2 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DPF2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DPF2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dpf2 33 |
|
||
| Str.10851 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | req-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dpf2l 34 |
|
OneToMany | |
| dpf2 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | d4 34 |
|
ManyToMany | |
| tth 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | dpff-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| Cin.12010 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12010 33 |
|
- Species where no ortholog for DPF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DPF2 Gene
- ENSEMBL:
- Gene Tree for DPF2 (if available)
- TreeFam:
- Gene Tree for DPF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DPF2: view image
Paralogs for DPF2 Gene
Variants for DPF2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000077930 | -- | 65,341,010(+) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000323963 | -- | 65,334,903(+) | G/A | intron_variant | |
| rs1000657096 | -- | 65,333,735(+) | G/A | upstream_transcript_variant | |
| rs1000771548 | -- | 65,333,853(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000872657 | -- | 65,342,336(+) | G/ | intron_variant |
Residual Variation Intolerance Score:
17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.16;
3.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DPF2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DPF2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPF2 Gene
Disorders for DPF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hemopneumothorax |
|
|
Search DPF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DPF2
No data available for UniProtKB/Swiss-Prot and Genatlas for DPF2 Gene
Publications for DPF2 Gene
- Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. (PMID: 21888896) Zhang W … Qi C (Biochemical and biophysical research communications 2011) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PMID: 11845289) Ninkina NN … Buchman VL (Mammalian genome : official journal of the International Mammalian Genome Society 2001) 2 3 58
- Expression and chromosomal localization of the Requiem gene. (PMID: 9680388) Gabig TG … Weber G (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 3 4 58
Products for DPF2 Gene
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- antibodies-online: Search results for available dpf2 related products ranked by validation data
- GeneTex DPF2 Antibody for DPF2
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- Horizon Cell Lines for DPF2
- genomics-online: cdna clones - Search results for available dpf2 gene related products
- orf clones - Search results for available dpf2 gene related products
- genomics-online: gRNA clones - Search results for available dpf2 gene related products
- genomics-online: primer clones - Search results for available dpf2 gene related products
- genomics-online: shRNA clones - Search results for available dpf2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DPF2
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Sources for DPF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
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