Aliases for DPF2 Gene
External Ids for DPF2 Gene
Previous HGNC Symbols for DPF2 Gene
Previous GeneCards Identifiers for DPF2 Gene
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
GeneCards Summary for DPF2 Gene
DPF2 (Double PHD Fingers 2) is a Protein Coding gene. Diseases associated with DPF2 include Coffin-Siris Syndrome 7 and Coffin-Siris Syndrome 1. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is DPF1.
UniProtKB/Swiss-Prot Summary for DPF2 Gene
Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684).