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The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
DPF2 (Double PHD Fingers 2) is a Protein Coding gene. Diseases associated with DPF2 include Coffin-Siris Syndrome 7 and Coffin-Siris Syndrome 1. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is DPF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | HDA | 16217013 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003714 | transcription corepressor activity | TAS | 28533407 |
GO:0004402 | histone acetyltransferase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000123 | histone acetyltransferase complex | IBA | 21873635 |
GO:0000790 | nuclear chromatin | IDA | 28533407 |
GO:0005634 | nucleus | IBA,IDA | 29429572 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 28533407 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006915 | apoptotic process | TAS | 8812431 |
GO:0007399 | nervous system development | IBA | 21873635 |
GO:0016573 | histone acetylation | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DPF2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DPF2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DPF2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DPF2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dpf2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dpf2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DPF2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DPF2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dpf2 30 |
|
||
Str.10851 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | req-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dpf2l 31 |
|
OneToMany | |
dpf2 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | d4 31 |
|
ManyToMany | |
tth 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | dpff-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12010 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1555031372 | Pathogenic: COFFIN-SIRIS SYNDROME 7; Coffin-Siris syndrome 1. Coffin-Siris syndrome 7 (CSS7) [MIM:618027] | 65,345,981(+) | G/Tp.Cys276Phe | MISSENSE_VARIANT | |
rs1555031500 | Pathogenic: COFFIN-SIRIS SYNDROME 7. Coffin-Siris syndrome 7 (CSS7) [MIM:618027] | 65,346,332(+) | C/Gp.Cys330Trp | MISSENSE_VARIANT | |
rs1555032044 | Pathogenic: COFFIN-SIRIS SYNDROME 7. Coffin-Siris syndrome 7 (CSS7) [MIM:618027] | 65,348,869(+) | A/Gp.Asp346Gly | MISSENSE_VARIANT | |
rs1555032051 | Pathogenic: COFFIN-SIRIS SYNDROME 7. Coffin-Siris syndrome 7 (CSS7) [MIM:618027] | 65,348,881(+) | G/Ap.Arg350His | MISSENSE_VARIANT | |
rs1555032074 | Pathogenic: COFFIN-SIRIS SYNDROME 7 | 65,348,932(+) | G/A | SPLICE_DONOR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
coffin-siris syndrome 7 |
|
|
coffin-siris syndrome 1 |
|
|
multiple endocrine neoplasia |
|
|
flinders island spotted fever |
|
|
hemopneumothorax |
|
|