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Aliases for DPF2 Gene

Aliases for DPF2 Gene

  • Double PHD Fingers 2 2 3 5
  • D4, Zinc And Double PHD Fingers Family 2 2 3 4
  • Apoptosis Response Zinc Finger Protein 3 4
  • BRG1-Associated Factor 45D 3 4
  • Protein Requiem 3 4
  • BAF45D 3 4
  • UBID4 3 4
  • REQ 3 4
  • Requiem, Apoptosis Response Zinc Finger Gene 2
  • Requiem, Apoptosis Response Zinc Finger 3
  • Zinc Finger Protein Ubi-D4 3
  • Ubi-D4 3

External Ids for DPF2 Gene

Previous HGNC Symbols for DPF2 Gene

  • REQ

Previous GeneCards Identifiers for DPF2 Gene

  • GC11P064876
  • GC11P064858
  • GC11P065103
  • GC11P061428

Summaries for DPF2 Gene

Entrez Gene Summary for DPF2 Gene

  • The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPF2 Gene

DPF2 (Double PHD Fingers 2) is a Protein Coding gene. Diseases associated with DPF2 include Hemopneumothorax. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is DPF1.

UniProtKB/Swiss-Prot for DPF2 Gene

  • May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Gene Wiki entry for DPF2 Gene

Additional gene information for DPF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF2 Gene

Genomics for DPF2 Gene

GeneHancer (GH) Regulatory Elements for DPF2 Gene

Promoters and enhancers for DPF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065333 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 680 2.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B GLIS2 ZNF143 DPF2 LOC105369352 POLA2 PCNX3 EIF1AD SF1 ZFPL1 ENSG00000255038 MUS81 SF3B2
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 47.7 +561.7 561704 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
GH11J065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 34.8 +156.3 156330 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 POLA2 PCNX3 ZFPL1 EIF1AD SART1 LOC105369352 MUS81 KAT5
GH11J065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 41.2 +90.4 90427 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000278050 GC11P065538 ENSG00000278144 ENSG00000277599 SF1 LOC105369352 ZFPL1 POLA2 EIF1AD
GH11J065910 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.4 +582.0 581973 11.4 CLOCK MLX ZFP64 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 DRAP1 C11orf68 RBM14 LOC105369352 ZFPL1 ENSG00000254461 MUS81 ENSG00000258297 EIF1AD PCNX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPF2 gene promoter:
  • SEF-1 (1)
  • LCR-F1
  • Sp1
  • Elk-1
  • STAT5A
  • Sox5
  • AML1a
  • NRF-2
  • IRF-2

Genomic Locations for DPF2 Gene

Genomic Locations for DPF2 Gene
chr11:65,333,754-65,353,249
(GRCh38/hg38)
Size:
19,496 bases
Orientation:
Plus strand
chr11:65,101,225-65,120,720
(GRCh37/hg19)
Size:
19,496 bases
Orientation:
Plus strand

Genomic View for DPF2 Gene

Genes around DPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPF2 Gene

Proteins for DPF2 Gene

  • Protein details for DPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92785-REQU_HUMAN
    Recommended name:
    Zinc finger protein ubi-d4
    Protein Accession:
    Q92785
    Secondary Accessions:
    • A8K7C9
    • B4DT58

    Protein attributes for DPF2 Gene

    Size:
    391 amino acids
    Molecular mass:
    44155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPF2 Gene

    Alternative splice isoforms for DPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPF2 Gene

Post-translational modifications for DPF2 Gene

  • Ubiquitination at posLast=108108 and posLast=5959
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DPF2

No data available for DME Specific Peptides for DPF2 Gene

Domains & Families for DPF2 Gene

Gene Families for DPF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92785

UniProtKB/Swiss-Prot:

REQU_HUMAN :
  • Belongs to the requiem/DPF family.
Family:
  • Belongs to the requiem/DPF family.
genes like me logo Genes that share domains with DPF2: view

Function for DPF2 Gene

Molecular function for DPF2 Gene

UniProtKB/Swiss-Prot Function:
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Phenotypes From GWAS Catalog for DPF2 Gene

Gene Ontology (GO) - Molecular Function for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA 16217013
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DPF2: view
genes like me logo Genes that share phenotypes with DPF2: view

Animal Models for DPF2 Gene

MGI Knock Outs for DPF2:
  • Dpf2 Dpf2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPF2 Gene

Localization for DPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPF2 Gene

Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPF2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin HDA 16217013
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with DPF2: view

Pathways & Interactions for DPF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006915 apoptotic process TAS 8812431
GO:0097190 apoptotic signaling pathway TAS 7961935
genes like me logo Genes that share ontologies with DPF2: view

No data available for Pathways by source and SIGNOR curated interactions for DPF2 Gene

Drugs & Compounds for DPF2 Gene

No Compound Related Data Available

Transcripts for DPF2 Gene

Unigene Clusters for DPF2 Gene

D4, zinc and double PHD fingers family 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPF2

Alternative Splicing Database (ASD) splice patterns (SP) for DPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for DPF2 Gene

GeneLoc Exon Structure for
DPF2
ECgene alternative splicing isoforms for
DPF2

Expression for DPF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPF2 Gene



Protein tissue co-expression partners for DPF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPF2 Gene:

DPF2

SOURCE GeneReport for Unigene cluster for DPF2 Gene:

Hs.13495

mRNA Expression by UniProt/SwissProt for DPF2 Gene:

Q92785-REQU_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DPF2 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with DPF2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPF2 Gene

Orthologs for DPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPF2 34 33
  • 99.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPF2 34 33
  • 93.86 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPF2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPF2 34 33
  • 92.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpf2 33
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Dpf2 16 34 33
  • 90.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DPF2 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPF2 34 33
  • 82.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 96 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dpf2 33
  • 76.28 (n)
Str.10851 33
African clawed frog
(Xenopus laevis)
Amphibia req-A 33
zebrafish
(Danio rerio)
Actinopterygii dpf2l 34
  • 74 (a)
OneToMany
dpf2 34 33
  • 72.15 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta d4 34
  • 32 (a)
ManyToMany
tth 34
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpff-1 34
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Cin.12010 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12010 33
Species where no ortholog for DPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPF2 Gene

ENSEMBL:
Gene Tree for DPF2 (if available)
TreeFam:
Gene Tree for DPF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPF2: view image

Paralogs for DPF2 Gene

Paralogs for DPF2 Gene

(2) SIMAP similar genes for DPF2 Gene using alignment to 5 proteins:

  • REQU_HUMAN
  • B4DT58_HUMAN
  • E9PN04_HUMAN
  • H0YEI1_HUMAN
  • J3KMZ8_HUMAN

Pseudogenes.org Pseudogenes for DPF2 Gene

genes like me logo Genes that share paralogs with DPF2: view

Variants for DPF2 Gene

Sequence variations from dbSNP and Humsavar for DPF2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000077930 -- 65,341,010(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000323963 -- 65,334,903(+) G/A intron_variant
rs1000657096 -- 65,333,735(+) G/A upstream_transcript_variant
rs1000771548 -- 65,333,853(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000872657 -- 65,342,336(+) G/ intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPF2 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680
nsv825950 CNV gain 20364138
nsv832190 CNV loss 17160897

Variation tolerance for DPF2 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPF2 Gene

Disorders for DPF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemopneumothorax
- elite association - COSMIC cancer census association via MalaCards
Search DPF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPF2

genes like me logo Genes that share disorders with DPF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPF2 Gene

Publications for DPF2 Gene

  1. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. (PMID: 21888896) Zhang W … Qi C (Biochemical and biophysical research communications 2011) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PMID: 11845289) Ninkina NN … Buchman VL (Mammalian genome : official journal of the International Mammalian Genome Society 2001) 2 3 58
  5. Expression and chromosomal localization of the Requiem gene. (PMID: 9680388) Gabig TG … Weber G (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 3 4 58

Products for DPF2 Gene

Sources for DPF2 Gene