Aliases for DPF1 Gene
External Ids for DPF1 Gene
Previous GeneCards Identifiers for DPF1 Gene
GeneCards Summary for DPF1 Gene
DPF1 (Double PHD Fingers 1) is a Protein Coding gene. Diseases associated with DPF1 include Spinal Meningioma and Spinal Canal And Spinal Cord Meningioma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Gastric cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is DPF2.
UniProtKB/Swiss-Prot Summary for DPF1 Gene
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).