This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this ge... See more...

Aliases for DPEP3 Gene

Aliases for DPEP3 Gene

  • Dipeptidase 3 2 3 4 5
  • EC 3.4.13.19 4 52
  • Testis Secretory Sperm-Binding Protein Li 211a 3
  • Metallopeptidase (Family M19) 3
  • Membrane-Bound Dipeptidase 3 3
  • MBD3 3

External Ids for DPEP3 Gene

Previous GeneCards Identifiers for DPEP3 Gene

  • GC16M067745
  • GC16M067785
  • GC16M066567
  • GC16M068009
  • GC16M053885

Summaries for DPEP3 Gene

Entrez Gene Summary for DPEP3 Gene

  • This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPEP3 Gene

DPEP3 (Dipeptidase 3) is a Protein Coding gene. Diseases associated with DPEP3 include Peliosis Hepatis. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP2.

UniProtKB/Swiss-Prot Summary for DPEP3 Gene

  • Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Gene Wiki entry for DPEP3 Gene

Additional gene information for DPEP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPEP3 Gene

Genomics for DPEP3 Gene

GeneHancer (GH) Regulatory Elements for DPEP3 Gene

Promoters and enhancers for DPEP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067981 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 500.7 -0.1 -60 0.5 USF1 CTCF GABPA HDAC2 SIN3A RAD21 ZBTB33 ATF3 TBP EGR1 DPEP3 piR-61539-004
GH16J068077 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -105.1 -105132 16 FOXK2 HNRNPK ZNF217 EP300 ZSCAN5C SIN3A NRF1 POLR2G USF1 SP1 NFATC3 lnc-DDX28-2 CTCF E2F4 EDC4 PSKH1 ZDHHC1 ENSG00000263276 PRMT7 ENSG00000270165
GH16J067934 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +44.3 44282 4 FOXK2 ZBTB40 SIN3A NRF1 MYC POLR2G USF1 SP1 NCOR1 GTF2E2 ENSG00000261884 PSMB10 lnc-PSKH1-1 PSKH1 E2F4 CTCF EDC4 NFATC3 SLC12A4 RANBP10
GH16J067892 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10 +87.0 87005 2.9 ZBTB40 EP300 POLR2G SP1 PHF8 ZFX POLR2A CLOCK ZBTB11 ZBTB26 PSKH1 lnc-CTRL-3 piR-57133-235 DUS2 EDC4 PRMT7 C16orf86 ENKD1 DDX28 DPEP3
GH16J067942 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11.8 +36.5 36460 3.8 CTCF POLR2G NCOR1 ZNF10 ZIC2 KDM6A TCF7 TGIF2 RAD21 CTBP1 HSALNG0112245 LCAT lnc-LCAT-1 SLC12A4 NFATC3 DUS2 THAP11 E2F4 CTCF ENSG00000263276
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPEP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPEP3

Top Transcription factor binding sites by QIAGEN in the DPEP3 gene promoter:
  • AP-1
  • AP-4
  • AREB6
  • GATA-1
  • GATA-2
  • p53
  • Roaz
  • RREB-1
  • YY1

Genomic Locations for DPEP3 Gene

Genomic Locations for DPEP3 Gene
chr16:67,975,663-67,980,549
(GRCh38/hg38)
Size:
4,887 bases
Orientation:
Minus strand
chr16:68,009,566-68,014,732
(GRCh37/hg19)
Size:
5,167 bases
Orientation:
Minus strand

Genomic View for DPEP3 Gene

Genes around DPEP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP3 Gene

Proteins for DPEP3 Gene

  • Protein details for DPEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4B8-DPEP3_HUMAN
    Recommended name:
    Dipeptidase 3
    Protein Accession:
    Q9H4B8
    Secondary Accessions:
    • B3KQ48
    • Q6PEZ5
    • Q6UXE4

    Protein attributes for DPEP3 Gene

    Size:
    488 amino acids
    Molecular mass:
    53687 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).
    SequenceCaution:
    • Sequence=AAH57789.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC15385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83198.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DPEP3 Gene

Selected DME Specific Peptides for DPEP3 Gene

Q9H4B8:
  • APVIFSHS
  • GLTSFGEKVV
  • LQLLKKNGGIVMVT
  • DGHNDLP
  • ELQGVLRGNLLRVFRQ
  • CASYSELELVTS
  • ANVSTVADHFDHI

Post-translational modifications for DPEP3 Gene

  • Glycosylation at Asn334
  • Modification sites at PhosphoSitePlus

Other Protein References for DPEP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DPEP3 Gene

Gene Families for DPEP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DPEP3 Gene

Blocks:
  • Renal dipeptidase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPEP3 Gene

GenScript: Design optimal peptide antigens:
  • Dipeptidase 3 (DPEP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H4B8

UniProtKB/Swiss-Prot:

DPEP3_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
genes like me logo Genes that share domains with DPEP3: view

Function for DPEP3 Gene

Molecular function for DPEP3 Gene

UniProtKB/Swiss-Prot Function:
Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of dipeptides.; EC=3.4.13.19; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.

Enzyme Numbers (IUBMB) for DPEP3 Gene

Phenotypes From GWAS Catalog for DPEP3 Gene

Gene Ontology (GO) - Molecular Function for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IDA --
GO:0008235 metalloexopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DPEP3: view
genes like me logo Genes that share phenotypes with DPEP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DPEP3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPEP3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPEP3 Gene

Localization for DPEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP3 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPEP3 gene
Compartment Confidence
plasma membrane 4
mitochondrion 1
nucleus 1
golgi apparatus 1
extracellular 0
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005886 plasma membrane ISS,IDA --
GO:0016020 membrane IDA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with DPEP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPEP3 Gene

Pathways & Interactions for DPEP3 Gene

genes like me logo Genes that share pathways with DPEP3: view

Gene Ontology (GO) - Biological Process for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007140 male meiotic nuclear division IEP,ISS --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with DPEP3: view

No data available for SIGNOR curated interactions for DPEP3 Gene

Drugs & Compounds for DPEP3 Gene

No Compound Related Data Available

Transcripts for DPEP3 Gene

mRNA/cDNA for DPEP3 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPEP3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for DPEP3 Gene

GeneLoc Exon Structure for
DPEP3

Expression for DPEP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP3 Gene

This gene is overexpressed in Testis (x39.8) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for DPEP3 Gene

This gene is overexpressed in Ovary (54.4) and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPEP3 Gene



Protein tissue co-expression partners for DPEP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPEP3

SOURCE GeneReport for Unigene cluster for DPEP3 Gene:

Hs.302028
genes like me logo Genes that share expression patterns with DPEP3: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPEP3 Gene

Orthologs for DPEP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPEP3 31 30
  • 97.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP3 31 30
  • 85.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DPEP3 31 30
  • 81.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpep3 30
  • 80.18 (n)
mouse
(Mus musculus)
Mammalia Dpep3 17 31 30
  • 79.58 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100534995 30
  • 57.52 (n)
DPEP3 31
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34420 31 30
  • 52.84 (n)
ManyToMany
CG6154 31
  • 39 (a)
ManyToMany
CG5282 31
  • 23 (a)
ManyToMany
CG42750 31
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
Species where no ortholog for DPEP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP3 Gene

ENSEMBL:
Gene Tree for DPEP3 (if available)
TreeFam:
Gene Tree for DPEP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPEP3: view image

Paralogs for DPEP3 Gene

Paralogs for DPEP3 Gene

(2) SIMAP similar genes for DPEP3 Gene using alignment to 1 proteins:

  • DPEP3_HUMAN
genes like me logo Genes that share paralogs with DPEP3: view

Variants for DPEP3 Gene

Additional dbSNP identifiers (rs#s) for DPEP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DPEP3 Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680

Variation tolerance for DPEP3 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPEP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPEP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPEP3 Gene

Disorders for DPEP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPEP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
peliosis hepatis
  • hepatic peliosis
- elite association - COSMIC cancer census association via MalaCards
Search DPEP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPEP3

genes like me logo Genes that share disorders with DPEP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPEP3 Gene

Publications for DPEP3 Gene

  1. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C … Peltonen L (Nature genetics 2009) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for DPEP3 Gene

Sources for DPEP3 Gene