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Aliases for DPEP3 Gene

Aliases for DPEP3 Gene

  • Dipeptidase 3 2 3 5
  • EC 4 56
  • Testis Secretory Sperm-Binding Protein Li 211a 3
  • Metallopeptidase (Family M19) 3
  • Membrane-Bound Dipeptidase 3 3
  • MBD3 3

External Ids for DPEP3 Gene

Previous GeneCards Identifiers for DPEP3 Gene

  • GC16M067745
  • GC16M067785
  • GC16M066567
  • GC16M068009
  • GC16M053885

Summaries for DPEP3 Gene

Entrez Gene Summary for DPEP3 Gene

  • This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPEP3 Gene

DPEP3 (Dipeptidase 3) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include peptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP2.

UniProtKB/Swiss-Prot for DPEP3 Gene

  • Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Gene Wiki entry for DPEP3 Gene

Additional gene information for DPEP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP3 Gene

Genomics for DPEP3 Gene

GeneHancer (GH) Regulatory Elements for DPEP3 Gene

Promoters and enhancers for DPEP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067981 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +0.3 296 0.2 CTCF USF1 ZNF143 BACH1 SIN3A ZBTB33 DPEP3 SLC12A4
GH16I067980 Promoter 0.7 EPDnew 550.8 +0.0 19 0.1 CTCF SIN3A DPEP3 SLC12A4
GH16I068077 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -104.9 -104852 16 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC NFATC3 GC16M068083 PRMT7 CTCF EDC4 TRADD ZDHHC1 DPEP2 DUS2 E2F4
GH16I067934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +44.6 44562 4 HDGF PKNOX1 SMAD1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 ENSG00000261884 PSMB10 GC16P067936 EDC4 E2F4 NFATC3 RANBP10 ENSG00000263276 ENSG00000260891 ENSG00000270165
GH16I067892 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10 +87.1 87123 2.6 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 POLR2B PSKH1 DUS2 EDC4 PRMT7 C16orf86 ENKD1 DDX28 DPEP3 PARD6A ACD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPEP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPEP3 gene promoter:

Genomic Locations for DPEP3 Gene

Genomic Locations for DPEP3 Gene
5,167 bases
Minus strand

Genomic View for DPEP3 Gene

Genes around DPEP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP3 Gene

Proteins for DPEP3 Gene

  • Protein details for DPEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dipeptidase 3
    Protein Accession:
    Secondary Accessions:
    • B3KQ48
    • Q6PEZ5
    • Q6UXE4

    Protein attributes for DPEP3 Gene

    488 amino acids
    Molecular mass:
    53687 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).
    • Sequence=AAH57789.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC15385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83198.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DPEP3 Gene

Selected DME Specific Peptides for DPEP3 Gene


Post-translational modifications for DPEP3 Gene

  • Glycosylation at posLast=334334
  • Modification sites at PhosphoSitePlus

Other Protein References for DPEP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DPEP3 Gene

Gene Families for DPEP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for DPEP3 Gene

Suggested Antigen Peptide Sequences for DPEP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
genes like me logo Genes that share domains with DPEP3: view

Function for DPEP3 Gene

Molecular function for DPEP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function:
Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Enzyme Numbers (IUBMB) for DPEP3 Gene

Phenotypes From GWAS Catalog for DPEP3 Gene

Gene Ontology (GO) - Molecular Function for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DPEP3: view
genes like me logo Genes that share phenotypes with DPEP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DPEP3

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPEP3 Gene

Localization for DPEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP3 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPEP3 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005886 plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with DPEP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPEP3 Gene

Pathways & Interactions for DPEP3 Gene

genes like me logo Genes that share pathways with DPEP3: view

Interacting Proteins for DPEP3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)
Selected Interacting proteins: Q9H4B8-DPEP3_HUMAN ENSP00000268793 for DPEP3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007140 male meiotic nuclear division ISS,IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with DPEP3: view

No data available for SIGNOR curated interactions for DPEP3 Gene

Drugs & Compounds for DPEP3 Gene

No Compound Related Data Available

Transcripts for DPEP3 Gene

mRNA/cDNA for DPEP3 Gene

Unigene Clusters for DPEP3 Gene

Dipeptidase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10

Relevant External Links for DPEP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPEP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP3 Gene

This gene is overexpressed in Testis (x39.8) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for DPEP3 Gene

This gene is overexpressed in Ovary (54.4) and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPEP3 Gene

Protein tissue co-expression partners for DPEP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPEP3 Gene:


SOURCE GeneReport for Unigene cluster for DPEP3 Gene:

genes like me logo Genes that share expression patterns with DPEP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPEP3 Gene

Orthologs for DPEP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPEP3 33 34
  • 97.86 (n)
(Canis familiaris)
Mammalia DPEP3 33 34
  • 85.16 (n)
(Bos Taurus)
Mammalia DPEP3 33 34
  • 81.07 (n)
(Rattus norvegicus)
Mammalia Dpep3 33
  • 80.18 (n)
(Mus musculus)
Mammalia Dpep3 33 16 34
  • 79.58 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
(Gallus gallus)
Aves -- 34
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
(Danio rerio)
Actinopterygii LOC100534995 33
  • 57.52 (n)
DPEP3 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34420 33 34
  • 52.84 (n)
CG6154 34
  • 39 (a)
CG5282 34
  • 23 (a)
CG42750 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
-- 34
  • 46 (a)
Species where no ortholog for DPEP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP3 Gene

Gene Tree for DPEP3 (if available)
Gene Tree for DPEP3 (if available)

Paralogs for DPEP3 Gene

Paralogs for DPEP3 Gene

(2) SIMAP similar genes for DPEP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPEP3: view

Variants for DPEP3 Gene

Sequence variations from dbSNP and Humsavar for DPEP3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000294362 -- 67,980,517(-) C/CC 5_prime_UTR_variant
rs1000948786 -- 67,982,491(-) T/C/G upstream_transcript_variant
rs1001148203 -- 67,977,188(-) G/A/T intron_variant
rs1002243074 -- 67,977,445(-) C/T intron_variant
rs1002646570 -- 67,978,968(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPEP3 Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680

Variation tolerance for DPEP3 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPEP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP3 Gene

Disorders for DPEP3 Gene

Additional Disease Information for DPEP3

No disorders were found for DPEP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPEP3 Gene

Publications for DPEP3 Gene

  1. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C … Peltonen L (Nature genetics 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for DPEP3 Gene

Sources for DPEP3 Gene

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